Heritability estimates for psychotic symptom dimensions in twins with psychotic disorders

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 156, Issue 1, 2011, Pages 89-98

  Rijsdijk, Frühling V ^a   Gottesman, Irving I ^b   Mcguffin, Peter ^a   Cardno, Alastair G ^c  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF MINNESOTA   (United States)

^c UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

Biometrical modeling; Disorganization; Factor; Liability

Indexed keywords

ADULT; ARTICLE; CLINICAL ASSESSMENT; DIZYGOTIC TWINS; DSM-III-R; ENVIRONMENTAL FACTOR; FEMALE; GENE LOCUS; HERITABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; MONOZYGOTIC TWINS; PRIORITY JOURNAL; PSYCHOSIS; SYMPTOM; BIOLOGICAL MODEL; GENETICS; INHERITANCE; PHENOTYPE; TWINS;

HUMANS; INHERITANCE PATTERNS; MODELS, GENETIC; PHENOTYPE; PSYCHOTIC DISORDERS; TWINS;

EID: 79953670369     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.31145     Document Type: Article

References (65)

1. Allan CL, Cardno AG, Rijsdijk FV, Kalidindi S, Farmer A, Murray RM, McGuffin P. 2009. Twin study of illness history variables in psychosis. Schizophr Res 115: 237-244.
2. Andreasen NC, Arndt S, Alliger R, Miller D, Flaum M. 1995. Symptoms of schizophrenia: Methods, meanings, and mechanisms. Arch Gen Psychiatry 52: 341-351.
3. American Psychiatric Association. 1987. DSM-III-R: Diagnostic and statistical manual of mental disorders. 3rd revised edition. Washington, DC: American Psychiatric Press.
4. Arajärvi R, Varilo T, Haukka J, Suvisaari J, Suokas J, Juvonen H, Muhonen M, Suominen K, Hintikka J, Schreck M, Tuulio-Henriksson A, Partonen T, Lönnqvist J. 2006. Affective flattening and alogia associate with the familial form of schizophrenia. Psychiatry Res 141: 161-172.
5. Burke JG, Murphy BM, Bray JC, Walsh D, Kendler KS. 1996. Clinical similarities in siblings with schizophrenia. Am J Med Genet Part B 67B: 239-243.
6. Cardno AG, McGuffin P. 2006. Genetics and delusional disorder. Behav Sci Law 24: 257-276.
7. Cardno AG, Holmans PA, Harvey I, Williams MB, Owen MJ, McGuffin P. 1997. Factor-derived subsyndromes of schizophrenia and familial morbid risks. Schizophr Res 23: 231-238.
8. Cardno AG, Jones LA, Murphy KC, Sanders RD, Asherson P, Owen MJ, McGuffin P. 1999a. Dimensions of psychosis in affected sibling pairs. Schizophr Bull 25: 841-850.
9. Cardno AG, Marshall EJ, Coid B, Macdonald AM, Ribchester TR, Davies NJ, Venturi P, Jones LA, Lewis SW, Sham PC, Gottesman II, Farmer AE, McGuffin P, Reveley AM, Murray RM. 1999b. Heritability estimates for psychotic disorders: The Maudsley twin psychosis series. Arch Gen Psychiatry 56: 162-168.
10. Cardno AG, Sham PC, Murray RM, McGuffin P. 2001. Twin study of symptom dimensions in psychoses. Br J Psychiatry 179: 39-45.
11. Cardno AG, Thomas K, McGuffin P. 2002a. Clinical variables and genetic loading for schizophrenia: Analysis of published Danish adoption study data. Schizophr Bull 28: 393-399.
12. Cardno AG, Sham PC, Farmer AE, Murray RM, McGuffin P. 2002b. Heritability of Schneider's first-rank symptoms. Br J Psychiatry 180: 35-38.
13. Cardno AG, Rijsdijk FV, Sham PC, Murray RM, McGuffin P. 2002c. A twin study of genetic relationships between psychotic symptoms. Am J Psychiatry 159: 539-545.
14. Cardno AG, Rijsdijk FV, Murray RM, McGuffin P. 2008. Twin study refining psychotic symptom dimensions as phenotypes for genetic research. Am J Med Genet Part B 147B: 1213-1221.
15. Craddock N, O'Donovan MC, Owen MJ. 2005. The genetics of schizophrenia and bipolar disorder: Dissecting psychosis. J Med Genet 42: 193-204.
16. Dikeos DG, Wickham H, McDonald C, Walshe M, Sigmundsson T, Bramon E, Grech A, Toulopoulou T, Murray R, Sham PC. 2006. Distribution of symptom dimensions across Kraepelinian divisions. Br J Psychiatry 189: 346-353.
17. Dworkin RH, Lenzenweger MF. 1984. Symptoms and the genetics of schizophrenia: Implications for diagnosis. Am J Psychiatry 141: 1541-1546.
18. Esterberg ML, Trotman HD, Holtzman C, Compton MT, Walker EF. 2010. The impact of a family history of psychosis on age-at-onset and positive and negative symptoms of schizophrenia: A meta-analysis. Schizophr Res 120: 121-130.
19. Fanous AH, Kendler KS. 2005. Genetic heterogeneity, modifier genes, and quantitative phenotypes in psychiatric illness: Searching for a framework. Mol Psychiatry 10: 6-13.
20. Fanous A, Gardner C, Walsh D, Kendler KS. 2001. Relationship between positive and negative symptoms of schizophrenia and schizotypal symptoms in nonpsychotic relatives. Arch Gen Psychiatry 58: 669-673.
21. Fanous AH, Van den Oord EJ, Riley BP, Aggen SH, Neale MC, O'Neill FA, Walsh D, Kendler KS. 2005. Relationship between a high-risk haplotype in the DTNBP1 (dysbindin) gene and clinical features of schizophrenia. Am J Psychiatry 162: 1824-1832.
22. Farmer AE, McGuffin P, Gottesman II. 1987. Twin concordance for DSM-III schizophrenia: Scrutinising the validity of the definition. Arch Gen Psychiatry 44: 634-641.
23. Gottesman II, Shields J. 1972. Schizophrenia and genetics: A twin vantage point. New York: Academic Press.
24. Gottesman II, Laursen TM, Bertelsen A, Mortensen PB. 2010. Severe mental disorders in offspring with 2 psychiatrically ill parents. Arch Gen Psychiatry 67: 252-257.
25. Hwu H-G, Wu Y-C, Lee SF-C, Yeh L-L, Gwo S-C, Hsu H-C, Chang C-J, Chen WJ. 1997. Concordance of positive and negative symptoms in coaffected sib-pairs with schizophrenia. Am J Med Genet Part B 74B: 1-6.
26. International Schizophrenia Consortium. 2009. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 460: 748-752.
27. Kendler KS, McGuire M, Gruenberg AM, Walsh D. 1994. Clinical heterogeneity in schizophrenia and the pattern of psychopathology in relatives: Results from an epidemiologically based family study. Acta Psychiatr Scand 89: 294-300.
28. Kendler KS, Neale MC, Walsh D. 1995. Evaluating the spectrum concept of schizophrenia in the Roscommon family study. Am J Psychiatry 152: 749-754.
29. Kendler KS, Karkowski-Shuman L, O'Neill FA, Straub RE, MacLean CJ, Walsh D. 1997. Resemblance of psychotic symptoms and syndromes in affected sibling pairs from the Irish study of high-density schizophrenia families: Evidence for possible etiologic heterogeneity. Am J Psychiatry 154: 191-198.
30. Kendler KS, Neale MC, Sullivan P, Corey LA, Gardner CO, Prescott CA. 1999. A population-based twin study in women of smoking initiation and nicotine dependence. Psychol Med 29: 299-308.
31. Kieseppä T, Partonen T, Haukka J, Kaprio J, Lönnqvist J. 2004. High concordance of bipolar I disorder in a nationwide sample of twins. Am J Psychiatry 161: 1814-1821.
32. Lichtenstein P, Yip BH, Björk C, Pawitan Y, Cannon TD, Sullivan PF, Hultman CM. 2009. Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: A population-based study. Lancet 373: 234-239.
33. Liddle PF. 1987. The symptoms of chronic schizophrenia: A re-examination of the positive-negative dichotomy. Br J Psychiatry 151: 145-151.
34. Loftus J, DeLisi LE, Crow TJ. 1998. Familial associations of subsyndromes of psychosis in affected sibling pairs with schizophrenia and schizoaffective disorder. Psychiatry Res 80: 101-111.
35. Malaspina D, Goetz RR, Yale S, Berman A, Harkavy Friedman J, Tremeau F, Printz D, Amador X, Johnson J, Brown A, Gorman JM. 2000. Relation of familial schizophrenia to negative symptoms but not to the deficit syndrome. Am J Psychiatry 157: 994-1003.
36. McGrath JA, Nestadt G, Liang K-Y, Lasseter VK, Wolyniec PS, Fallin D, Thornquist MH, Luke JR, Pulver AE. 2004. Five latent factors underlying schizophrenia: Analysis and relationship to illnesses in relatives. Schizophr Bull 30: 855-873.
37. McGrath JA, Avramopoulos D, Lasseter VK, Wolyniec PS, Fallin MD, Liang K-Y, Nestadt G, Thornquist MH, Luke JR, Chen P-L, Valle D, Pulver AE. 2009. Familiality of novel factorial dimensions of schizophrenia. Arch Gen Psychiatry 66: 591-600.
38. McGuffin P, Farmer A, Harvey I. 1991. A polydiagnostic application of operational criteria in studies of psychotic illness: Development and reliability of the OPCRIT system. Arch Gen Psychiatry 48: 764-770.
39. McGuffin P, Rijsdijk F, Andrew M, Sham P, Katz R, Cardno A. 2003. The heritability of bipolar affective disorder and the genetic relationship to unipolar depression. Arch Gen Psychiatry 60: 497-502.
40. Mortensen PB, Pedersen CB, Melbye M, Mors O, Ewald H. 2003. Individual and familial risk factors for bipolar affective disorders in Denmark. Arch Gen Psychiatry 60: 1209-1215.
41. Mortensen PB, Pedersen MG, Pedersen CB. 2010. Psychiatric family history and schizophrenia risk in Denmark: Which mental disorders are relevant? Psychol Med 40: 201-210.
42. Murray RM, Sham P, Van Os J, Zanelli J, Cannon M, McDonald C. 2004. A developmental model for similarities and dissimilarities between schizophrenia and bipolar disorder. Schizophr Res 71: 405-416.
43. Murray V, McKee I, Miller PM, Young D, Muir WJ, Pelosi AJ, Blackwood DHR. 2005. Dimensions and classes of psychosis in a population cohort: A four-class, four-dimension model of schizophrenia and affective psychoses. Psychol Med 35: 499-510.
44. Neale MC, Cardon LR. 1992. Methodology for genetic studies of twins and families. Dordrecht, The Netherlands: Kluwer Academic Publishers.
45. Neale MC, Eaves LJ, Hewitt JK, MacLean CJ, Meyer JM, Kendler KS. 1989. Analysing the relationship between age at onset and risk to relatives. Am J Hum Genet 45: 226-239.
46. Neale MC, Boker SM, Xie G, Maes HH. 2003. Mx: Statistical modeling. 6th edition (VCU Box 900126). Richmond, VA: Dept of Psychiatry.
47. Peralta V, Cuesta MJ. 2007. The relationship between syndromes of the psychotic illness and familial liability to schizophrenia and major mood disorders. Schizophr Res 91: 200-209.
48. Peralta V, Cuesta MJ, Farre C. 1997. Factor structure of symptoms in functional psychoses. Biol Psychiatry 42: 806-815.
49. Prescott CA, Kuhn JW, Pedersen NL. 2007. Twin pair resemblance for psychiatric hospitalization in the Swedish Twin Registry: A 32-year follow-up study of 29, 602 twin pairs. Behav Genet 37: 547-558.
50. Ratakonda S, Gorman JM, Yale SA, Amador XF. 1998. Characterization of psychotic conditions: Use of the domains of psychopathology model. Arch Gen Psychiatry 55: 75-81.
51. Rietkerk T, Boks MPM, Sommer IE, Liddle PF, Ophoff RA, Kahn RS. 2008. The genetics of symptom dimensions of schizophrenia: Review and meta-analysis. Schizophr Res 102: 197-205.
52. Rijsdijk FV, Sham PC. 2002. Analytic approaches to twin data using structural equation models. Brief Bioinform 3: 119-133.
53. Ritsner M, Ratner Y, Gibel A, Weizman R. 2005. Familiality in a five-factor model of schizophrenia psychopathology: Findings from a 16-month follow-up study. Psychiatry Res 36: 173-179.
54. Ross DE, Kirkpatrick B, Karkowski LM, Straub RE, MacLean CJ, O'Neill FA, Compton AD, Murphy B, Walsh D, Kendler KS. 2000. Sibling correlation of deficit syndrome in the Irish study of high-density schizophrenia families. Am J Psychiatry 157: 1071-1076.
55. Serretti A, Macciardi F, Smeraldi E. 1998. Dopamine receptor D2 Ser/Cys311 variant associated with disorganized symptomatology of schizophrenia. Schizophr Res 34: 207-210.
56. Serretti A, Rietschel M, Lattuada E, Krauss H, Schulze TG, Müller DJ, Maier W, Smeraldi E. 2001. Major psychoses symptomatology: Factor analysis of 2241 psychotic subjects. Eur Arch Psychiatry Clin Neurosci 251: 193-198.
57. Smith DA, Mar CM, Turoff BK. 1998. The structure of schizophrenic symptoms: A meta-analytic confirmatory factor analysis. Schizophr Res 31: 57-70.
58. Spitzer RL, Endicott J. 1978. Schedule for affective disorders and schizophrenia: Lifetime version. New York: New York State Psychiatric Institute.
59. Sullivan PF, Kendler KS, Neale MC. 2003. Schizophrenia as a complex trait: Evidence from a meta-analysis of twin studies. Arch Gen Psychiatry 60: 1187-1192.
60. Van Os J, Marcelis M, Sham P, Jones P, Gilvarry K, Murray R. 1997. Psychopathological syndromes and familial morbid risk of psychosis. Br J Psychiatry 170: 241-246.
61. Van Os J, Linscott RJ, Myin-Germeys I, Delespaul P, Krabbendam L. 2009. A systematic review and meta-analysis of the psychosis continuum: Evidence for a psychosis proneness-persistence-impairment model of psychotic disorder. Psychol Med 39: 179-195.
62. Van Snellenberg JX, de Candia T. 2009. Meta-analytic evidence for familial coaggregation of schizophrenia and bipolar disorder. Arch Gen Psychiatry 66: 748-755.
63. Vassos E, Sham PC, Cai G, Deng H, Liu X, Sun X, Zhao J, Murray RM, Collier DA, Li T. 2008. Correlation and familial aggregation of dimensions of psychosis in affected sibling pairs from China. Br J Psychiatry 193: 305-310.
64. Wickham H, Walsh C, Asherson P, Taylor C, Sigmundson T, Gill M, Owen MJ, McGuffin P, Murray R, Sham P. 2001. Familiality of symptom dimensions in schizophrenia. Schizophr Res 47: 223-232.
65. Wilcox MA, Faraone SV, Su J, Van Eerdewegh P, Tsuang M. 2002. Genome scan of three quantitative traits in schizophrenia pedigrees. Biol Psychiatry 52: 847-854.