Rare copy number deletions predict individual variation in intelligence

PLoS ONE

Volumn 6, Issue 1, 2011, Pages

  Yeo, Ronald A ^a   Gangestad, Steven W ^a   Liu, Jingyu ^b,c   Calhoun, Vince D ^b,c   Hutchison, Kent E ^a,b,d  

^a UNIVERSITY OF NEW MEXICO   (United States)

^b MIND RESEARCH NETWORK   (United States)

^c University of New Mexico   (United States)

^d UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ALCOHOLISM; ARTICLE; BASE PAIRING; CONTROLLED STUDY; COPY NUMBER VARIATION; ETHNIC DIFFERENCE; FEMALE; GENE DELETION; GENE FREQUENCY; GENETIC VARIABILITY; HERITABILITY; HUMAN; INTELLIGENCE; MAJOR CLINICAL STUDY; MALE; MENTAL HEALTH; MUTATIONAL ANALYSIS; PHENOTYPIC VARIATION; POPULATION GENETICS; PSYCHOMETRY; SOCIAL STATUS; WECHSLER INTELLIGENCE SCALE; ETHNIC GROUP; GENETICS; MIDDLE AGED; SOCIAL CLASS;

ADULT; ALCOHOLISM; DNA COPY NUMBER VARIATIONS; ETHNIC GROUPS; HUMANS; INTELLIGENCE; MIDDLE AGED; SOCIAL CLASS; YOUNG ADULT;

EID: 79551563242     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0016339     Document Type: Article

References (73)

1. Deary IJ, Spinath FM, Bates TC (2006) Genetics of intelligence. European Journal of Human Genetics 14: 690-700.
2. Plomin R, Spinath FM (2004) Intelligence: Genetics, genes, and genomics. Journal of Personality and Social Psychology 86: 112-129.
3. Arden R, Gottfredson LS, Miller G (2009) Does a fitness factor contribute to the association between intelligence and health outcomes? Evidence from medical abnormality counts among 3654 US Veterans. Intelligence 37: 581-591.
4. Der G, Batty GD, Deary IJ (2009) The association between IQ in adolescence and a range of health outcomes at 40 in the 1979 US National Longitudinal Study of Youth. Intelligence 37: 573-580.
5. Batty GD, Deary IJ, Gottfredson LS (2007) Premorbid (early life) IQ and later mortality risk: Systematic review. Annals of Epidemiology 17: 278-288.
6. Batty GD, Wennerstad KM, Smith GD, Gunnell D, Deary IJ, et al. (2009) IQ in Early Adulthood and Mortality By Middle Age Cohort Study of 1 Million Swedish Men. Epidemiology 20: 100-109.
7. Gale CR, Hatch SL, Batty GD, Deary IJ (2009) Intelligence in childhood and risk of psychological distress in adulthood: The 1958 National Child Development Survey and the 1970 British Cohort Study. Intelligence 37: 592-599.
8. Koenen KC, Moffitt TE, Roberts AL, Martin LT, Kubzansky L, et al. (2009) Childhood IQ and Adult Mental Disorders: A Test of the Cognitive Reserve Hypothesis. American Journal of Psychiatry 166: 50-57.
9. Gottfredson LS (1997) Why g matters: The complexity of everyday life. Intelligence 24: 79-132.
10. Toulopoulou T, Picchioni M, Rijsdijk F, Hua-Hall M, Ettinger U, et al. (2007) Substantial genetic overlap between neurocognition and schizophrenia - Genetic modeling in twin samples. Archives of General Psychiatry 64: 1348-1355.
11. Arden R (2010) Using evolutionary theory to investigate Spearman's g and its relationship to fitness. London: King's College London.
12. Kuntsi J, Eley TC, Taylor A, Hughes C, Asherson P, et al. (2004) Co-occurrence of ADHD and low IQ has genetic origins. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics 124B: 41-47.
13. Luciano M, Batty GD, McGilchrist M, Linksted P, Fitzpatrick B, et al. (2010) Shared genetic aetiology between cognitive ability and cardiovascular disease risk factors: Generation Scotland's Scottish family health study. Intelligence 38: 304-313.
14. Gale CR, Batty GD, Tynelius P, Deary IJ, Rasmussen F (2010) Intelligence in Early Adulthood and Subsequent Hospitalization for Mental Disorders. Epidemiology 21: 70-77.
15. Batty GD, Deary IJ, Macintyre S (2006) Childhood IQ and life course socioeconomic position in relation to alcohol induced hangovers in adulthood: the Aberdeen children of the 1950s study. Journal of Epidemiology and Community Health 60: 872-874.
16. Hemmingsson T, Melin B, Allebeck P, Lundberg I (2006) The association between cognitive ability measured at ages 18-20 and mortality during 30 years of follow-up-a prospective observational study among Swedish males born 1949-51. Int J Epidemiol 35: 665-670.
17. Donovan DM, Kivlahan DR, Walker RD (1984) Clinical Limitations of Neuropsychological Testing in Predicting Treatment Outcome among Alcoholics. Alcoholism-Clinical and Experimental Research 8: 470-475.
18. Deary IJ, Johnson W, Houlihan LM (2009) Genetic foundations of human intelligence. Human Genetics 126: 215-232.
19. Gangestad SW (2010) Evolutionary biology looks at behavior genetics. Personality and Individual Differences 49: 289-295.
20. Yang JA, Benyamin B, McEvoy BP, Gordon S, Henders AK, et al. (2010) Common SNPs explain a large proportion of the heritability for human height. Nature Genetics 42: 565-U131.
21. Furlow FB, Armijo Prewitt T, Gangestad SW, Thornhill R (1997) Fluctuating asymmetry and psychometric intelligence. Proceedings of the Royal Society of London Series B-Biological Sciences 264: 823-829.
22. Gangestad SW, Thornhill R (1999) Individual differences in developmental precision and fluctuating asymmetry: a model and its implications. Journal of Evolutionary Biology 12: 402-416.
23. Prokosch MD, Yeo RA, Miller GF (2005) Intelligence tests with higher gloadings show higher correlations with body symmetry: Evidence for a general fitness factor mediated by developmental stability. Intelligence 33: 203-213.
24. Yeo RA, Gangestad SW, Edgar C, Thoma R (1999) The evolutionary genetic underpinnings of schizophrenia: the developmental instability model. Schizophrenia Research 39: 197-206.
25. Penke L, Denissen JJA, Miller GF (2007) The evolutionary genetics of personality. European Journal of Personality 21: 549-587.
26. Banks GC, Batchelor JH, McDaniel MA (2010) Smarter people are (a bit) more symmetrical: A meta-analysis of the relationship between intelligence and fluctuating asymmetry. Intelligence 38: 393-401.
27. Van Dongen S, Gangestad SW. Human fluctuating asymmetry in relation to health and quality: A meta-analysis. Evolution and Human Behavior. In press.
28. McCarthy M (2006) Allen Brain Atlas maps 21,000 genes of the mouse brain. The Lancet Neurology 5: 907-908.
29. Oti M, Huynen MA, Brunner HG (2008) Phenome connections. Trends in Genetics 24: 103-106.
30. Rzhetsky A, Wajngurt D, Park N, Zheng T (2007) Probing genetic overlap among complex human phenotypes. Proceedings of the National Academy of Sciences of the United States of America 104: 11694-11699.
31. Houle D (2010) Numbering the hairs on our heads: The shared challenge and promise of phenomics. Proceedings of the National Academy of Sciences of the United States of America 107: 1793-1799.
32. Iafrate AJ, Feuk L, Rivera MN, Listewnik ML, Donahoe PK, et al. (2004) Detection of large-scale variation in the human genome. Nature Genetics 36: 949-951.
33. Sebat J, Lakshmi B, Troge J, Alexander J, Young J, et al. (2004) Large-scale copy number polymorphism in the human genome. Science 305: 525-528.
34. Zhang F, Gu WL, Hurles ME, Lupski JR (2009) Copy Number Variation in Human Health, Disease, and Evolution. Annual Review of Genomics and Human Genetics 10: 451-481.
35. Itsara A, Cooper GM, Baker C, Girirajan S, Li J, et al. (2009) Population Analysis of Large Copy Number Variants and Hotspots of Human Genetic Disease (vol 84, pg 148, 2009). American Journal of Human Genetics 84: 550-551.
36. Lupski JR (2007) Structural variation in the human genome. New England Journal of Medicine 356: 1169-1171.
37. Beckmann JS, Estivill X, Antonarakis SE (2007) Copy number variants and genetic traits: closer to the resolution of phenotypic to genotypic variability. Nature Reviews Genetics 8: 639-646.
38. Guilmatre A, Dubourg C, Mosca AL, Legallic S, Goldenberg A, et al. (2009) Recurrent Rearrangements in Synaptic and Neurodevelopmental Genes and Shared Biologic Pathways in Schizophrenia, Autism, and Mental Retardation. Archives of General Psychiatry 66: 947-956.
39. Bi WM, Sapir T, Shchelochkov OA, Zhang F, Withers MA, et al. (2009) Increased LIS1 expression affects human and mouse brain development. Nature Genetics 41: 168-177.
40. Sebat J, Lakshmi B, Malhotra D, Troge J, Lese-Martin C, et al. (2007) Strong association of de novo copy number mutations with autism. Science 316: 445-449.
41. Stone JL, O'Donovan MC, Gurling H, Kirov GK, Blackwood DHR, et al. (2008) Rare chromosomal deletions and duplications increase risk of schizophrenia. Nature 455: 237-241.
42. Zhang D, Cheng L, Qian Y, Alliey-Rodriguez N, Kelsoe JR, et al. (2009) Singleton deletions throughout the genome increase risk of bipolar disorder. Molecular Psychiatry 14: 376-380.
43. Toulopoulou T, Picchioni M, Rijsdijk F, Hall M, Ettinger U, et al. (2007) The association between schizophrenia and intellectual impairment is of genetic origin. Schizophrenia Bulletin 33: 290-290.
44. Yeo RA, Gangestad SW, Thoma RJ (2007) Developmental instability and individual variation in brain development: Implications for the origin of neurodevelopmental disorders. Current Directions in Psychological Science 16: 245-249.
45. Craddock N, Hurles ME, Cardin N, Pearson RD, Plagnol V, et al. (2010) Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature 464: 713-U786.
46. Sharp AJ, Locke DP, McGrath SD, Cheng Z, Bailey JA, et al. (2005) Segmental duplications and copy-number variation in the human genome. American Journal of Human Genetics 77: 78-88.
47. Marques-Bonet T, Girirajan S, Eichler EE (2009) The origins and impact of primate segmental duplications. Trends in Genetics 25: 443-454.
48. Dumas L, Kim YH, Karimpour-Fard A, Cox M, Hopkins J, et al. (2007) Gene copy number variation spanning 60 million years of human and primate evolution. Genome Research 17: 1266-1277.
49. Sikela JM (2006) The jewels of our genome: The search for the genomic changes underlying the evolutionarily unique capacities of the human brain. Plos Genetics 2: 646-655.
50. Popesco MC, MacLaren EJ, Hopkins J, Dumas L, Cox M, et al. (2006) Human lineage-specific amplification, selection, and neuronal expression of DUF1220 domains. Science 313: 1304-1307.
51. Sudmant PH, Kitzman JO, Antonacci F, Alkan C, Malig M, et al. (2010) Diversity of Human Copy Number Variation and Multicopy Genes. Science 330: 641-646.
52. Turkheimer E, Haley A, Waldron M, D'Onofrio B, Gottesman II (2003) Socioeconomic status modifies heritability of IQ in young children. Psychological Science 14: 623-628.
53. Harden KP, Turkheimer E, Loehlin JC (2007) Genotype by environment interaction in adolescents' cognitive aptitude. Behavior Genetics 37: 273-283.
54. Sullivan JT, Sykora K, Schneiderman J, Naranjo CA, Sellers EM (1989) Assessment of Alcohol Withdrawal - the Revised Clinical Institute Withdrawal Assessment for Alcohol Scale (Ciwa-Ar). British Journal of Addiction 84: 1353-1357.
55. Skinner HA, Allen BA (1982) Alcohol Dependence Syndrome - Measurement and Validation. Journal of Abnormal Psychology 91: 199-209.
56. Chen J, Liu J, Calhoun VD (under review) A pipeline for copy number variation detection based on principal components analysis. Proceedings IEEE Bioinformatics and Biomedicine.
57. Need AC, Ge DL, Weale ME, Maia J, Feng S, et al. (2009) A Genome-Wide Investigation of SNPs and CNVs in Schizophrenia. Plos Genetics 5: -.
58. Wang K, Li MY, Hadley D, Liu R, Glessner J, et al. (2007) PennCNV: An integrated hidden Markov model designed for high-resolution copy number variation detection in whole-genome SNP genotyping data. Genome Research 17: 1665-1674.
59. Psychological C (2002) Wais-III, Wechsler Adult Intelligence Scale, third edition: WMS-III, Wechsler Memory Scale, third edition: technical manual. [San Antonio, Tex.?]: Psychological Corp.
60. Tukey JW (1977) Exploratory Data Analysis. Reading MA: Addison Wesley.
61. Waldron M, Heath AC, Turkheimer E, Emery R, Bucholz KK, et al. (2007) Age at first sexual intercourse and teenage pregnancy in Australian female twins. Twin Research and Human Genetics 10: 440-449.
62. Finn PR, Hall J (2004) Cognitive ability and risk for alcoholism: Short-term memory capacity and intelligence moderate personality risk for alcohol problems. Journal of Abnormal Psychology 113: 569-581.
63. Koenen KC, Caspi A, Moffitt TE, Rijsdijk F, Taylor A (2006) Genetic influences on the overlap between low IQ and antisocial behavior in young children. Journal of Abnormal Psychology 115: 787-797.
64. Snowdon DA, Kemper SJ, Mortimer JA, Greiner LH, Wekstein DR, et al. (1996) Linguistic ability in early life and cognitive function and Alzheimer's disease in late life - Findings from the Nun Study. Jama-Journal of the American Medical Association 275: 528-532.
65. Whalley LJ, Starr JM, Athawes R, Hunter D, Pattie A, et al. (2000) Childhood mental ability and dementia. Neurology 55: 1455-1459.
66. Yeo R, Arden R, Jung RE. Alzheimers disease and intelligence. Current Alzheimers Research. In press.
67. Kim PM, Lam HYK, Urban AE, Korbel JO, Affourtit J, et al. (2008) Analysis of copy number variants and segmental duplications in the human genome: Evidence for a change in the process of formation in recent evolutionary history. Genome Research 18: 1865-1874.
68. Miller GF (2000) Sexual selection for indicators of intelligence. In: Bock G, Goode J, Webb K, eds. The nature of intelligence (Novartis Foundation Symposium 233). New York: John Wiley. pp 260-275.
69. Gangestad SW, Thornhill R, Garver-Apgar CE. Men's facial masculinity predicts change in their female partner's sexual interest across the cycle, whereas men's intelligence does not. Evolution and Human Behavior. In press.
70. Grant MD, Kremen WS, Jacobson KC, Franz C, Xian H, et al. (2010) Does Parental Education have a Moderating Effect on the Genetic and Environmental Influences of General Cognitive Ability in Early Adulthood? Behavior Genetics 40: 438-446.
71. Cantor-Graae E, Selten JP (2005) Schizophrenia and migration: A meta-analysis and review. American Journal of Psychiatry 162: 12-24.
72. Bourque E, van der Ven E, Malla A (2010) A meta-analysis of the risk for psychotic disorders among first- and second-generation immigrants. Psychological Medicine in press.
73. Houlihan LM, Harris SE, Luciano M, Gow AJ, Starr JM, et al. (2009) Replication study of candidate genes for cognitive abilities: the Lothian Birth Cohort 1936. Genes Brain and Behavior 8: 238-247.