Mapping pharmacokinetic and tissue distribution profile of [6]-shogaol from ginger oleoresin

International Journal of Pharmacy and Pharmaceutical Sciences

Volumn 5, Issue 1, 2013, Pages 185-189

  Nikam, Ajinkya R ^a   Sathiyanarayanan, Lohidasan ^a   Mahadik, Kakasaheb R ^a  

^a BHARATI VIDYAPEETH DEEMED UNIVERSITY   (India)

Author keywords

6 shogaol; Ginger oleoresin; Pharmacokinetics; RP HPLC; Tissue distribution

Indexed keywords

ACETONITRILE; GINGER EXTRACT; GINGER OLEORESIN; PHOSPHORIC ACID; SHOGAOL; UNCLASSIFIED DRUG;

ACCURACY; ANALYTICAL PARAMETERS; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; BRAIN; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG HALF LIFE; ENTEROHEPATIC CIRCULATION; GASTROINTESTINAL TRACT; HEART; KIDNEY; LIVER; LUNG; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SINGLE DRUG DOSE; SPLEEN; TIME TO MAXIMUM PLASMA CONCENTRATION; TISSUE DISTRIBUTION;

EID: 84874519906     PISSN: None     EISSN: 09751491     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Chrubasik S, Roufogalis B, Pittler M. Zingiberis rhizoma: A comprehensive review on the ginger effect and efficacy profiles. Phytomedicine 2005; 12: 684-701.
2. Badreldin H, Gerald B, Musbah O, Nemmar A. Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research. Food Chem Toxicol 2008; 46: 409-420.
3. Bailey-Shaw Y, Williams L, Junor G, Green C, Hibbert S, Salmon C et al. Changes in the contents of oleoresin and pungent bioactive principles of Jamaican Ginger (Zingiber officinale Roscoe) during maturation. J Agric Food Chem 2008; 56: 5564-5571.
4. Mishra N, Behal K. Antimicrobial activity of some spices against selected microbes. International Journal of Pharmacy and Pharmaceutical Sciences 2010; 2: 187-196.
5. Patwardhan S, Bodas K, Gundewar S. Coping with arthritis using safer herbal options. International Journal of Pharmacy and Pharmaceutical Sciences 2010; 2 (1): 1-11.
6. Ushimaru P, Barbosa L, Fernandes A, DiStasi L, Fernandes Jr A. In vitro antibacterial activity of medicinal plant extracts against Escherichia coli strains from human clinical specimens and interactions with antimicrobial drugs. Nat Prod Res 2012; 26(16): 1553-1557.
7. Rhode J, Fogoros S, Zick S, Wahl H, Griffith K, Huang J et al. Ginger inhibits cell growth and modulates angiogenic factors in ovarian cancer cells. BMC Complement Altern Med 2007; 7: 44.
8. Hung J, Hsu Y, Li C, Ko Y, Ni W, Huang M et al. [6]-shogaol, an active constituent of dietary ginger, induces autophagy by inhibiting the AKT/mTOR pathway in human non-small cell lung cancer A549 cells. J Agric Food Chem 2009; 57(20): 9809-9816.
9. Vaiyapuri M, Namasivayam N. Chemopreventive efficacy of ginger, a naturally occurring anticarcinogen during the initiation, post-initiation stages of 1, 2 dimethylhydrazine-induced colon cancer. Clin Chim Acta 2005; 358: 60-67.
10. Ishiguro K, Ando T, Maeda O, Ohmiya N, Niwa Y, Kadomatsu K et al. Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms. Biochem Biophys Res Commun 2007; 362: 218-223.
11. Chen H, Lv L, Soroka D, Warin R, Parks T, Hu Y et al. Metabolism of [6]-shogaol in Mice and in Cancer Cells. Drug Metab Dispos 2012; 40(4): 742-753.
12. Winek C, Wahba W, Winek Jr C, Balzer T. Drug and chemical blood-level data 2001. Forensic Sci Int 2001; 122, 107-123.
13. Zick S, Djuric Z, Ruffin M, Litzinger A, Normolle D, Alrawi S et al. Pharmacokinetics of 6-Gingerol, 8-Gingerol, 10-Gingerol, and 6-Shogaol and Conjugate Metabolites in Healthy Human Subjects. Cancer Epidemiol Biomarkers Prev 2008; 17: 1930-1936.
14. Wang W, Li C, Wen X, Li P, Qi L. Simultaneous determination of 6-gingerol, 8-gingerol, 10-gingerol and 6-shogaol in rat plasma by liquid chromatography-mass spectrometry: Application to pharmacokinetics. J Chromatogr B 2009; 877: 671-679.
15. Asami A, Shimada T, Mizuhara Y, Asano T, Takeda S, Aburada T et al. Pharmacokinetics of [6]-shogaol, a pungent ingredient of Zingiber officinale Roscoe (Part I). J Nat Med 2010; 64: 281-287.
16. Surh Y, Lee S. Enzymatic reduction of shogaol: a novel biotransformation pathway for the alpha, beta-unsaturated ketone system. Biochem Int 1992; 27: 179-187.
17. Surh Y, Lee S. Enzymatic reduction of xenobiotic alpha, beta-unsaturated ketones: formation of allyl alcohol metabolites from shogaol and dehydroparadol. Res Commun Chem Pathol Pharmacol 1994; 84: 53-61.
18. Yin Q, Sun H, Zhang A, Wang X. Pharmacokinetics and tissue distribution study of scoparone in rats by ultraperformance liquid-chromatography with tandem high-definition mass spectrometry. Fitoterapia 2012; 83(4): 795-800.
19. Guidance For Industry: Bioanalytical Method Validation. US Food and Drug Administration 2001; 1-22.
20. Crosby W. Normal functions of the spleen raltive to Red Blood Cells: Review. Blood 1959; 14: 399-408.
21. Murata P, Kase Y, Ishige A, Sasaki H, Kurosawa S, Nakamura T. The herbal medicine Dai-kenchu-to and one of its active components [6]-shogaol increase intestinal blood flow in rats. Life Sci 2002; 70: 2061-2070.