-
1
-
-
34247481994
-
The CXCR4 chemokine receptor in acute and chronic leukaemia: a marrow homing receptor and potential therapeutic target
-
Burger JA, Burkle A, (2007) The CXCR4 chemokine receptor in acute and chronic leukaemia: a marrow homing receptor and potential therapeutic target. Br J Haematol 137: 288-296.
-
(2007)
Br J Haematol
, vol.137
, pp. 288-296
-
-
Burger, J.A.1
Burkle, A.2
-
2
-
-
70350734809
-
The microenvironment in mature B-cell malignancies: a target for new treatment strategies
-
Burger JA, Ghia P, Rosenwald A, Caligaris-Cappio F, (2009) The microenvironment in mature B-cell malignancies: a target for new treatment strategies. Blood 114: 3367-3375.
-
(2009)
Blood
, vol.114
, pp. 3367-3375
-
-
Burger, J.A.1
Ghia, P.2
Rosenwald, A.3
Caligaris-Cappio, F.4
-
3
-
-
58149332686
-
Translating an Antagonist of Chemokine Receptor CXCR4: from bench to bedside
-
Wong D, Korz W, (2008) Translating an Antagonist of Chemokine Receptor CXCR4: from bench to bedside. Clin Cancer Res 14: 7975-7980.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 7975-7980
-
-
Wong, D.1
Korz, W.2
-
4
-
-
77953090345
-
CXCL12 (SDF-1)/CXCR4 pathway in cancer
-
Teicher BA, Fricker SP, (2010) CXCL12 (SDF-1)/CXCR4 pathway in cancer. Clin Cancer Res 16: 2927-2931.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 2927-2931
-
-
Teicher, B.A.1
Fricker, S.P.2
-
5
-
-
70349735988
-
Therapeutic targeting of microenvironmental interactions in leukemia: mechanisms and approaches
-
Konopleva M, Tabe Y, Zeng Z, Andreeff M, (2009) Therapeutic targeting of microenvironmental interactions in leukemia: mechanisms and approaches. Drug Resist Updat 12: 103-113.
-
(2009)
Drug Resist Updat
, vol.12
, pp. 103-113
-
-
Konopleva, M.1
Tabe, Y.2
Zeng, Z.3
Andreeff, M.4
-
6
-
-
67049137382
-
Isoform-selective phosphoinositide 3′-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach
-
Niedermeier M, Hennessy BT, Knight ZA, Henneberg M, Hu J, et al. (2009) Isoform-selective phosphoinositide 3′-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach. Blood 113: 5549-5557.
-
(2009)
Blood
, vol.113
, pp. 5549-5557
-
-
Niedermeier, M.1
Hennessy, B.T.2
Knight, Z.A.3
Henneberg, M.4
Hu, J.5
-
7
-
-
0038784379
-
CD40 induces human multiple myeloma cell migration via phosphatidylinositol 3-kinase/AKT/NF-kappa B signaling
-
Tai YT, Podar K, Mitsiades N, Lin B, Mitsiades C, et al. (2003) CD40 induces human multiple myeloma cell migration via phosphatidylinositol 3-kinase/AKT/NF-kappa B signaling. Blood 101: 2762-2769.
-
(2003)
Blood
, vol.101
, pp. 2762-2769
-
-
Tai, Y.T.1
Podar, K.2
Mitsiades, N.3
Lin, B.4
Mitsiades, C.5
-
8
-
-
69549096143
-
Cell biology of the movement of breast cancer cells: intracellular signalling and the actin cytoskeleton
-
Jiang P, Enomoto A, Takahashi M, (2009) Cell biology of the movement of breast cancer cells: intracellular signalling and the actin cytoskeleton. Cancer Lett 284: 122-130.
-
(2009)
Cancer Lett
, vol.284
, pp. 122-130
-
-
Jiang, P.1
Enomoto, A.2
Takahashi, M.3
-
9
-
-
84874196138
-
The phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions
-
Pauls SD, Lafarge ST, Landego I, Zhang T, Marshall AJ, (2012) The phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions. Front Immunol 3: 224.
-
(2012)
Front Immunol
, vol.3
, pp. 224
-
-
Pauls, S.D.1
Lafarge, S.T.2
Landego, I.3
Zhang, T.4
Marshall, A.J.5
-
10
-
-
58149395054
-
Phosphoinositide 3-kinases in cell migration
-
Cain RJ, Ridley AJ, (2009) Phosphoinositide 3-kinases in cell migration. Biol Cell 101: 13-29.
-
(2009)
Biol Cell
, vol.101
, pp. 13-29
-
-
Cain, R.J.1
Ridley, A.J.2
-
11
-
-
0842346270
-
Do phosphoinositide 3-kinases direct lymphocyte navigation?
-
Ward SG, (2004) Do phosphoinositide 3-kinases direct lymphocyte navigation? Trends Immunol 25: 67-74.
-
(2004)
Trends Immunol
, vol.25
, pp. 67-74
-
-
Ward, S.G.1
-
12
-
-
77952911072
-
Eukaryotic chemotaxis: a network of signaling pathways controls motility, directional sensing, and polarity
-
Swaney KF, Huang CH, Devreotes PN, (2010) Eukaryotic chemotaxis: a network of signaling pathways controls motility, directional sensing, and polarity. Annu Rev Biophys 39: 265-289.
-
(2010)
Annu Rev Biophys
, vol.39
, pp. 265-289
-
-
Swaney, K.F.1
Huang, C.H.2
Devreotes, P.N.3
-
13
-
-
70350405643
-
Phosphoinositide 3-kinase-regulated adapters in lymphocyte activation
-
Zhang TT, Li H, Cheung SM, Costantini JL, Hou S, et al. (2009) Phosphoinositide 3-kinase-regulated adapters in lymphocyte activation. Immunol Rev 232: 255-272.
-
(2009)
Immunol Rev
, vol.232
, pp. 255-272
-
-
Zhang, T.T.1
Li, H.2
Cheung, S.M.3
Costantini, J.L.4
Hou, S.5
-
14
-
-
84867214110
-
Interaction of TAPP adapter proteins with phosphatidylinositol (3,4)-bisphosphate regulates B-cell activation and autoantibody production
-
Landego I, Jayachandran N, Wullschleger S, Zhang TT, Gibson IW, et al. (2012) Interaction of TAPP adapter proteins with phosphatidylinositol (3,4)-bisphosphate regulates B-cell activation and autoantibody production. Eur J Immunol.
-
(2012)
Eur J Immunol.
-
-
Landego, I.1
Jayachandran, N.2
Wullschleger, S.3
Zhang, T.T.4
Gibson, I.W.5
-
15
-
-
0034306455
-
Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities
-
Dowler S, Currie RA, Campbell DG, Deak M, Kular G, et al. (2000) Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. Biochem J 351: 19-31.
-
(2000)
Biochem J
, vol.351
, pp. 19-31
-
-
Dowler, S.1
Currie, R.A.2
Campbell, D.G.3
Deak, M.4
Kular, G.5
-
16
-
-
0036310638
-
TAPP1 and TAPP2 are targets of phosphatidylinositol 3-kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptor
-
Marshall AJ, Krahn AK, Ma K, Duronio V, Hou S, (2002) TAPP1 and TAPP2 are targets of phosphatidylinositol 3-kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptor. Mol Cell Biol 22: 5479-5491.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 5479-5491
-
-
Marshall, A.J.1
Krahn, A.K.2
Ma, K.3
Duronio, V.4
Hou, S.5
-
17
-
-
73949099919
-
TAPP2 links phosphoinositide 3-kinase signaling to B cell adhesion through interaction with the cytoskeletal protein utrophin: expression of a novel cell adhesion-promoting complex in B cell leukemia
-
Costantini JL, Cheung SM, Hou S, Li H, Kung SK, et al. (2009) TAPP2 links phosphoinositide 3-kinase signaling to B cell adhesion through interaction with the cytoskeletal protein utrophin: expression of a novel cell adhesion-promoting complex in B cell leukemia. Blood.
-
(2009)
Blood
-
-
Costantini, J.L.1
Cheung, S.M.2
Hou, S.3
Li, H.4
Kung, S.K.5
-
18
-
-
33746589459
-
Clinical significance of ZAP-70 protein expression in B-cell chronic lymphocytic leukemia
-
Del Principe MI, Del Poeta G, Buccisano F, Maurillo L, Venditti A, et al. (2006) Clinical significance of ZAP-70 protein expression in B-cell chronic lymphocytic leukemia. Blood 108: 853-861.
-
(2006)
Blood
, vol.108
, pp. 853-861
-
-
Del Principe, M.I.1
Del Poeta, G.2
Buccisano, F.3
Maurillo, L.4
Venditti, A.5
-
19
-
-
33646433940
-
ZAP-70 expression is associated with enhanced ability to respond to migratory and survival signals in B-cell chronic lymphocytic leukemia (B-CLL)
-
Richardson SJ, Matthews C, Catherwood MA, Alexander HD, Carey BS, et al. (2006) ZAP-70 expression is associated with enhanced ability to respond to migratory and survival signals in B-cell chronic lymphocytic leukemia (B-CLL). Blood 107: 3584-3592.
-
(2006)
Blood
, vol.107
, pp. 3584-3592
-
-
Richardson, S.J.1
Matthews, C.2
Catherwood, M.A.3
Alexander, H.D.4
Carey, B.S.5
-
20
-
-
14844343641
-
Dystroglycan is involved in laminin-1-stimulated motility of Muller glial cells: combined velocity and directionality analysis
-
Mehes E, Czirok A, Hegedus B, Szabo B, Vicsek T, et al. (2005) Dystroglycan is involved in laminin-1-stimulated motility of Muller glial cells: combined velocity and directionality analysis. Glia 49: 492-500.
-
(2005)
Glia
, vol.49
, pp. 492-500
-
-
Mehes, E.1
Czirok, A.2
Hegedus, B.3
Szabo, B.4
Vicsek, T.5
-
21
-
-
76249109093
-
Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafish
-
Yoo SK, Deng Q, Cavnar PJ, Wu YI, Hahn KM, et al. (2010) Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafish. Dev Cell 18: 226-236.
-
(2010)
Dev Cell
, vol.18
, pp. 226-236
-
-
Yoo, S.K.1
Deng, Q.2
Cavnar, P.J.3
Wu, Y.I.4
Hahn, K.M.5
-
22
-
-
33745308103
-
PI3K and RAC signalling in leukocyte and cancer cell migration
-
Barber MA, Welch HC, (2006) PI3K and RAC signalling in leukocyte and cancer cell migration. Bull Cancer 93: E44-52.
-
(2006)
Bull Cancer
, vol.93
-
-
Barber, M.A.1
Welch, H.C.2
-
23
-
-
0025143240
-
Functional characterization of two stromal cell lines that support B lymphopoiesis
-
Henderson AJ, Johnson A, Dorshkind K, (1990) Functional characterization of two stromal cell lines that support B lymphopoiesis. J Immunol 145: 423-428.
-
(1990)
J Immunol
, vol.145
, pp. 423-428
-
-
Henderson, A.J.1
Johnson, A.2
Dorshkind, K.3
-
24
-
-
73949091167
-
The pleckstrin homology domain adaptor protein Bam32/DAPP1 is required for germinal center progression
-
Zhang TT, Al-Alwan M, Marshall AJ, (2010) The pleckstrin homology domain adaptor protein Bam32/DAPP1 is required for germinal center progression. J Immunol 184: 164-172.
-
(2010)
J Immunol
, vol.184
, pp. 164-172
-
-
Zhang, T.T.1
Al-Alwan, M.2
Marshall, A.J.3
-
25
-
-
0033485625
-
Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells
-
Burger JA, Burger M, Kipps TJ, (1999) Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells. Blood 94: 3658-3667.
-
(1999)
Blood
, vol.94
, pp. 3658-3667
-
-
Burger, J.A.1
Burger, M.2
Kipps, T.J.3
-
26
-
-
33750476278
-
T cell chemotaxis in a simple microfluidic device
-
Lin F, Butcher EC, (2006) T cell chemotaxis in a simple microfluidic device. Lab Chip 6: 1462-1469.
-
(2006)
Lab Chip
, vol.6
, pp. 1462-1469
-
-
Lin, F.1
Butcher, E.C.2
-
27
-
-
33947288392
-
Regulation of phosphoinositide 3-kinase signaling by oxidants: hydrogen peroxide selectively enhances immunoreceptor-induced recruitment of phosphatidylinositol (3,4) bisphosphate-binding PH domain proteins
-
Cheung SM, Kornelson JC, Al-Alwan M, Marshall AJ, (2007) Regulation of phosphoinositide 3-kinase signaling by oxidants: hydrogen peroxide selectively enhances immunoreceptor-induced recruitment of phosphatidylinositol (3,4) bisphosphate-binding PH domain proteins. Cell Signal 19: 902-912.
-
(2007)
Cell Signal
, vol.19
, pp. 902-912
-
-
Cheung, S.M.1
Kornelson, J.C.2
Al-Alwan, M.3
Marshall, A.J.4
-
28
-
-
4544261701
-
The adaptor protein Bam32 regulates Rac1 activation and actin remodeling through a phosphorylation-dependent mechanism
-
Allam A, Niiro H, Clark EA, Marshall AJ, (2004) The adaptor protein Bam32 regulates Rac1 activation and actin remodeling through a phosphorylation-dependent mechanism. J Biol Chem 279: 39775-39782.
-
(2004)
J Biol Chem
, vol.279
, pp. 39775-39782
-
-
Allam, A.1
Niiro, H.2
Clark, E.A.3
Marshall, A.J.4
-
29
-
-
35649027944
-
Versatile fluorescent probes for actin filaments based on the actin-binding domain of utrophin
-
Burkel BM, von Dassow G, Bement WM, (2007) Versatile fluorescent probes for actin filaments based on the actin-binding domain of utrophin. Cell Motil Cytoskeleton 64: 822-832.
-
(2007)
Cell Motil Cytoskeleton
, vol.64
, pp. 822-832
-
-
Burkel, B.M.1
von Dassow, G.2
Bement, W.M.3
-
30
-
-
11144234519
-
The phosphoinositol 3,4-bisphosphate-binding protein TAPP1 interacts with syntrophins and regulates actin cytoskeletal organization
-
Hogan A, Yakubchyk Y, Chabot J, Obagi C, Daher E, et al. (2004) The phosphoinositol 3,4-bisphosphate-binding protein TAPP1 interacts with syntrophins and regulates actin cytoskeletal organization. J Biol Chem 279: 53717-53724.
-
(2004)
J Biol Chem
, vol.279
, pp. 53717-53724
-
-
Hogan, A.1
Yakubchyk, Y.2
Chabot, J.3
Obagi, C.4
Daher, E.5
-
31
-
-
54249122300
-
The PCH family member proline-serine-threonine phosphatase-interacting protein 1 targets to the leukocyte uropod and regulates directed cell migration
-
Cooper KM, Bennin DA, Huttenlocher A, (2008) The PCH family member proline-serine-threonine phosphatase-interacting protein 1 targets to the leukocyte uropod and regulates directed cell migration. Mol Biol Cell 19: 3180-3191.
-
(2008)
Mol Biol Cell
, vol.19
, pp. 3180-3191
-
-
Cooper, K.M.1
Bennin, D.A.2
Huttenlocher, A.3
-
32
-
-
24644441368
-
The comings and goings of actin: coupling protrusion and retraction in cell motility
-
Small JV, Resch GP, (2005) The comings and goings of actin: coupling protrusion and retraction in cell motility. Curr Opin Cell Biol 17: 517-523.
-
(2005)
Curr Opin Cell Biol
, vol.17
, pp. 517-523
-
-
Small, J.V.1
Resch, G.P.2
-
33
-
-
0027299745
-
On the crawling of animal cells
-
Stossel TP, (1993) On the crawling of animal cells. Science 260: 1086-1094.
-
(1993)
Science
, vol.260
, pp. 1086-1094
-
-
Stossel, T.P.1
-
34
-
-
0034093830
-
Effects of the chemokine stromal cell-derived factor-1 on the migration and localization of precursor-B acute lymphoblastic leukemia cells within bone marrow stromal layers
-
Bradstock KF, Makrynikola V, Bianchi A, Shen W, Hewson J, et al. (2000) Effects of the chemokine stromal cell-derived factor-1 on the migration and localization of precursor-B acute lymphoblastic leukemia cells within bone marrow stromal layers. Leukemia 14: 882-888.
-
(2000)
Leukemia
, vol.14
, pp. 882-888
-
-
Bradstock, K.F.1
Makrynikola, V.2
Bianchi, A.3
Shen, W.4
Hewson, J.5
-
35
-
-
57349126275
-
Rapid turnover rate of phosphoinositides at the front of migrating MDCK cells
-
Nishioka T, Aoki K, Hikake K, Yoshizaki H, Kiyokawa E, et al. (2008) Rapid turnover rate of phosphoinositides at the front of migrating MDCK cells. Mol Biol Cell 19: 4213-4223.
-
(2008)
Mol Biol Cell
, vol.19
, pp. 4213-4223
-
-
Nishioka, T.1
Aoki, K.2
Hikake, K.3
Yoshizaki, H.4
Kiyokawa, E.5
-
36
-
-
0042354714
-
Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils
-
Xu J, Wang F, Van Keymeulen A, Herzmark P, Straight A, et al. (2003) Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils. Cell 114: 201-214.
-
(2003)
Cell
, vol.114
, pp. 201-214
-
-
Xu, J.1
Wang, F.2
Van Keymeulen, A.3
Herzmark, P.4
Straight, A.5
-
37
-
-
33646764616
-
Spontaneous polarization in eukaryotic gradient sensing: a mathematical model based on mutual inhibition of frontness and backness pathways
-
Narang A, (2006) Spontaneous polarization in eukaryotic gradient sensing: a mathematical model based on mutual inhibition of frontness and backness pathways. J Theor Biol 240: 538-553.
-
(2006)
J Theor Biol
, vol.240
, pp. 538-553
-
-
Narang, A.1
-
38
-
-
77957863006
-
Rac activation by the T-cell receptor inhibits T cell migration
-
Cernuda-Morollon E, Millan J, Shipman M, Marelli-Berg FM, Ridley AJ, (2010) Rac activation by the T-cell receptor inhibits T cell migration. PLoS One 5: e12393.
-
(2010)
PLoS One
, vol.5
-
-
Cernuda-Morollon, E.1
Millan, J.2
Shipman, M.3
Marelli-Berg, F.M.4
Ridley, A.J.5
-
39
-
-
33747383933
-
Role of dystrophin and utrophin for assembly and function of the dystrophin glycoprotein complex in non-muscle tissue
-
Haenggi T, Fritschy JM, (2006) Role of dystrophin and utrophin for assembly and function of the dystrophin glycoprotein complex in non-muscle tissue. Cell Mol Life Sci 63: 1614-1631.
-
(2006)
Cell Mol Life Sci
, vol.63
, pp. 1614-1631
-
-
Haenggi, T.1
Fritschy, J.M.2
-
40
-
-
34247507672
-
Processing and assembly of the dystrophin glycoprotein complex
-
Allikian MJ, McNally EM, (2007) Processing and assembly of the dystrophin glycoprotein complex. Traffic 8: 177-183.
-
(2007)
Traffic
, vol.8
, pp. 177-183
-
-
Allikian, M.J.1
McNally, E.M.2
-
41
-
-
79955516270
-
Myosin IIA/IIB restrict adhesive and protrusive signaling to generate front-back polarity in migrating cells
-
Vicente-Manzanares M, Newell-Litwa K, Bachir AI, Whitmore LA, Horwitz AR, (2011) Myosin IIA/IIB restrict adhesive and protrusive signaling to generate front-back polarity in migrating cells. J Cell Biol 193: 381-396.
-
(2011)
J Cell Biol
, vol.193
, pp. 381-396
-
-
Vicente-Manzanares, M.1
Newell-Litwa, K.2
Bachir, A.I.3
Whitmore, L.A.4
Horwitz, A.R.5
-
42
-
-
0032475863
-
G protein signaling events are activated at the leading edge of chemotactic cells
-
Parent CA, Blacklock BJ, Froehlich WM, Murphy DB, Devreotes PN, (1998) G protein signaling events are activated at the leading edge of chemotactic cells. Cell 95: 81-91.
-
(1998)
Cell
, vol.95
, pp. 81-91
-
-
Parent, C.A.1
Blacklock, B.J.2
Froehlich, W.M.3
Murphy, D.B.4
Devreotes, P.N.5
-
43
-
-
13544249968
-
In vivo analysis of 3-phosphoinositide dynamics during Dictyostelium phagocytosis and chemotaxis
-
Dormann D, Weijer G, Dowler S, Weijer CJ, (2004) In vivo analysis of 3-phosphoinositide dynamics during Dictyostelium phagocytosis and chemotaxis. J Cell Sci 117: 6497-6509.
-
(2004)
J Cell Sci
, vol.117
, pp. 6497-6509
-
-
Dormann, D.1
Weijer, G.2
Dowler, S.3
Weijer, C.J.4
-
44
-
-
79955366131
-
PI3K and chemotaxis: a priming issue?
-
Afonso PV, Parent CA, (2011) PI3K and chemotaxis: a priming issue? Sci Signal 4: pe22.
-
(2011)
Sci Signal
, vol.4
-
-
Afonso, P.V.1
Parent, C.A.2
|