Genes, economics, and happiness

Journal of Neuroscience, Psychology, and Economics

Volumn 5, Issue 4, 2012, Pages 193-211

  De Neve, Jan Emmanuel ^a,b   Christakis, Nicholas A ^c   Fowler, James H ^d   Frey, Bruno S ^e,f  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b LONDON SCHOOL OF ECONOMICS   (United Kingdom)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^e UNIVERSITY OF WARWICK   (United Kingdom)

^f ZEPPELIN UNIVERSITY   (Germany)

Author keywords

5 HTTLPR; Genetic association; Life satisfaction; Rs2020933; Serotonin transporter gene; Socioeconomic factors; Twin study; Well being

Indexed keywords

5 HTTLPR GENE; ADULT; ARTICLE; CONTROLLED STUDY; ECONOMICS; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC VARIABILITY; GENOTYPE; HAPPINESS; HERITABILITY; HUMAN; LIFE SATISFACTION; MALE; PRIORITY JOURNAL; TWINS; WELLBEING;

EID: 84874489429     PISSN: 1937321X     EISSN: 2151318X     Source Type: Journal    
DOI: 10.1037/a0030292     Document Type: Article

References (91)

1. Add Health Biomarker Team. (2007). Biomarkers in Wave iii of the Add Health Study. Retrieved from http://www.cpc.unc.edu/projects/addhealth/files/biomark.pdf
2. Alcott, H., Karlan, D., Mobius, M., Rosenblat, T., & Szeidl, A. (2007). Community size and network closure. American Economic Review, 97, 80-85.
3. Ashenfelter, O., & Krueger, A. B. (1994). Estimates of the economic return to schooling from a new sample of twins. American Economic Review, 84, 1157-1173.
4. Baron, R., & Kenny, D. (1986). The moderatormediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations. Journal of Personality and Social Psychology, 51, 1173-1182.
5. Bartels, M., & Boomsma, D. I. (2009). Born to be happy? The etiology of subjective well-being. Behavior Genetics, 39, 605-615.
6. Beauchamp, J., Cesarini, D., Johannesson, M., van der Loos, M., Koellinger, P., Groenen, P.,... Christakis, N. (2011). Molecular genetics and economics. Journal of Economic Perspectives, 25, 57-82.
7. Benjamin, D. J., Cesarini, D., Chabris, C. F., Glaeser, E. L., Laibson, D. I., Gunason, V.,...Lichtenstein, P. (2012). The promises and pitfalls of genoeconomics. Annual Review of Economics, 4(September).
8. Benjamin, D. J., Chabris, C. F., Glaeser, E. L., Gudnason, V., Harris, T. B., Laibson, D. I.,...Purcell, S. (2007). Genoeconomics. In M. Weinstein, J. W. Vaupel, & K. W. Wachter (Eds.), Biosocial surveys. Washington, DC: The National Academies Press.
9. Bertolino, A., Arciero, G., Rubino, V., Latorre, V., Candia, M. D., & Mazzola, V. (2005). Variation of human amygdala response during threatening stimuli as a function of 5httlpr genotype and personality style. Biological Psychiatry, 57, 1517-1525.
10. Bouchard, T. (1998). Genetic and environmental influences on adult intelligence and special mental abilities. Human Biology, 70, 257-279.
11. Can, A., Coe, B. P., & Eichler, E. E. (2011). Genome structural variation discovery and genotyping. Nature Reviews Genetics, 12, 363-376.
12. Canli, T., & Lesch, K. (2007). Long story short: The serotonin transporter in emotion regulation and social cognition. Nature Neuroscience, 10, 1103-1109.
13. Canli, T., Omura, K., Haas, B. W., Fallgatter, A., & Constable, R. T. (2005). Beyond affect: A role for genetic variation of the serotonin transporter in neural activation during a cognitive attention task. Proceedings of the National Academy of Sciences, USA, 102, 12224-12229.
14. Caplin, A., & Dean, M. (2008). Dopamine, reward prediction error, and economics. Quarterly Journal of Economics, 123, 663-701.
15. Caspi, A., Sugden, K., Moffitt, T., Taylor, A., Craig, I., Harrington, H.,...Poulton, R. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-htt gene. Science, 301, 386-389.
16. Cesarini, D., Dawes, C. T., Johannesson, M., Lichtenstein, P., & Wallace, B. (2009). Genetic variation in preferences for giving and risk-taking. Quarterly Journal of Economics, 124, 809-842.
17. Clark, A. E., Frijters, P., & Shields, M. A. (2008). Relative income, happiness, and utility: An explanation for the Easterlin paradox and other puzzles. Journal of Economic Literature, 46, 95-144.
18. Clark, A. E., & Oswald, A. J. (1996). Satisfaction and comparison income. Journal of Public Economics, 61, 359-381.
19. Cupples, L., & D'Agnostino, R. (1988). Survival following initial cardiovascular events: 30 year follow-up. In W. B. Kannel, P. A. Wolf, & R. J. Garrison (Eds.), The Framingham Study: An epidemiological investigation of cardiovascular disease (pp. 88-2969). Bethesda, MD: National Heart, Lung and Blood Institute.
20. Damberg, M., Garpenstrand, H., Hallman, J., & Oreland, L. (2001). Genetic mechanisms of behavior: Don't forget about the transcription factors. Molecular Psychiatry, 6, 503-510.
21. De Bakker, P. (2008). Imputation in the Framingham Heart Study. Cambridge, MA: Harvard Medical School.
22. De Neve, J.-E. (2011). Functional polymorphism (5- HTTLPR) in the serotonin transporter gene is associated with subjective well-being: Evidence from a U.S. nationally representative sample. Journal of Human Genetics, 56, 456-459.
23. Diener, E., & Diener, C. (1996). Most people are happy. Psychological Science, 7, 181-185.
24. Diener, E., & Lucas, R. (1999). Personality and subjective well-being. In D. Kahneman, E. Diener, & N. Schwarz (Eds.), Well-being: The foundations of hedonic psychology. New York, NY: Sage.
25. Di Tella, R., & MacCulloch, R. (2006). Some uses of happiness data in economics. Journal of Economic Perspectives, 20, 25-46.
26. Di Tella, R., MacCulloch, R., & Oswald, A. J. (2001). Preferences over inflation and unemployment: Evidence from surveys of happiness. American Economic Review, 91, 335-341.
27. Di Tella, R., MacCulloch, R., & Oswald, A. J. (2003). The macroeconomics of happiness. Review of Economics and Statistics, 85, 809-827.
28. Dolan, P., Peasgood, T., & White, M. (2008). Do we really know what makes us happy? a review of the economic literature on the factors associated with subjective well-being. Journal of Economic Psychology, 29, 94-122.
29. Easterlin, R. (1974). Does economic growth improve the human lot? some empirical evidence. In P. David & M. Reder (Eds.), Nations and households in economic growth: Essays in honour of Moses Abramowitz. New York, NY: Academic Press.
30. Echenique, F., & Fryer, R. G. (2007). A measure of segregation based on social interactions. Quarterly Journal of Economics, 122, 441-485.
31. Echenique, F., Fryer, R. G., & Kaufman, A. (2006). Is school segregation good or bad? American Economic Review, 96, 265-269.
32. Fahad, A. R., Vasiliou, S. A., Haddley, K., Paredes, U. M., Roberts, J. C., Miyajima, F.,...Quinn, J. (2010). Combinatorial interaction between two human serotonin transporter gene variable number tandem repeats and their regulation by ctcf. Journal of Neurochemistry, 112, 296-306.
33. Ferrer-i-Carbonell, A., & Frijters, P. (2004). How important is methodology for the estimates of the determinants of happiness. The Economic Journal, 114, 641-659.
34. Fitzpatrick, M., Ben-Shahar, Y., Smid, H., Vet, L., Robinson, G., & Sokolowski, M. (2005). Candidate genes for behavioural ecology. Trends in Ecology and Evolution, 20, 96-104.
35. Fletcher, J., & Lehrer, S. (2011). Genetic lotteries within families. Journal of Health Economics, 30, 647-659.
36. Fowler, J. H., Baker, L. A., & Dawes, C. T. (2008). Genetic variation in political participation. American Political Science Review, 101, 233-248.
37. Fowler, J. H., & Christakis, N. A. (2008). Dynamic spread of happiness in a large social network: Longitudinal analysis over 20 years in the Framingham Heart Study. British Medical Journal, 337, 1-9.
38. Fowler, J. H., Dawes, C. T., & Christakis, N. A. (2009). Model of genetic variation in human social networks. Proceedings of the National Academy of Sciences, USA, 106, 1720-1724.
39. Fox, E., Ridgewell, A., & Ashwin, C. (2009). Looking on the bright side: Biased attention and the human serotonin transporter gene. Proceedings of the Royal Society B, 276, 1747-1751.
40. Frey, B. S. (2008). Happiness: A revolution in economics. Cambridge, MA: MIT Press.
41. Frey, B. S., & Stutzer, A. (2002a). Happiness and economics: How the economy and institutions affect well-being. Princeton, NJ: Princeton University Press.
42. Frey, B. S., & Stutzer, A. (2002b). What can economists learn from happiness research? Journal of Economic Literature, 40, 402-435.
43. Glatz, K., Mössner, R., Heils, A., & Lesch, K. (2003). Glucocorticoid-regulated human serotonin transporter (5-HTT) expression is modulated by the 5-HTT gene promotor-linked polymorphic region. Journal of Neurochemistry, 85, 1072-1078.
44. Graham, C. (2008). Economics of happiness. In S. N. Durlauf, & L. E. Blume (Eds.), The New Palgrave Dictionary of Economics. New York, NY: Palgrave Macmillan.
45. Graham, C., & Pettinato, S. (2002). Happiness and hardship: Opportunity and insecurity in new market economics. Washington, DC: Brookings Institution Press.
46. Hariri, A., & Holmes, A. (2006). Genetics of emotional regulation: The role of the serotonin transporter in neural function. Trends Cognitive Science, 10, 182-191.
47. Hariri, A., Mattay, V., Tessitore, A., Kolachana, B., Fera, F., & Goldman, D. (2002). Serotonin transporter genetic variation and the response of the human amygdala. Science, 297, 400-403.
48. Harris, K. M., Halpern, C. T., Smolen, A., & Haberstick, B. C. (2006). The national longitudinal study of adolescent health (Add Health) twin data. Twin Research and Human Genetics, 9, 988-997.
49. Heils, A., Teufel, A., Petri, S., Stober, G., Riederer, P., Bengel, D., & Lesch, K. (1996). Allelic variation of human serotonin transporter gene expression. Journal of Neurochemistry, 66, 2621-2624.
50. Heinz, A., Braus, D., Smolka, M., Wrase, J., Puls, I., Hermann, D.,... Büchel, C. (2005). Amygdalaprefrontal coupling depends on a genetic variation of the serotonin transporter. Nature Neuroscience, 8, 20-21.
51. Huezo-Diaz, P., Rietschel, M., Henigsberg, N., Marusic, A., Mors, O., Maier, W.,...McGuffin, P. (2009). Moderation of antidepressant response by the serotonin transporter gene. British Journal of Psychiatry, 195, 30-38.
52. Jacobson, K., & Rowe, D. (1998). Genetic and shared environmental influences on adolescent bmi: Interactions with race and sex. Behavior Genetics, 28, 265-278.
53. Kahneman, D., Diener, E., & Schwarz, N. (1999). Well-being: The foundations of hedonic psychology. New York, NY: Russel Sage.
54. Kahneman, D., & Krueger, A. B. (2006). Developments in the measurement of subjective wellbeing. Journal of Economic Perspectives, 20, 3-24.
55. Kahneman, D., Krueger, A. B., Schkade, D., Schwarz, N., & Stone, A. A. (2006). Would you be happier if you were richer? A focusing illusion. Science, 312, 1908-1910.
56. Kannel, W., Feinleib, M., McNamara, P., Garrison, R., & Castelli, W. (1979). An investigation of coronary heart disease in families. American Journal of Epidemiology, 110, 281-290.
57. Kendler, K. S., Neale, M. C., Kessler, R. C., Heath, A. C., & Eaves, L. J. (1993). A test of the equalenvironment assumption in twin studies of psychiatric illness. Behavior Genetics, 23, 21-27.
58. Layard, R. (2005). Happiness: Lessons from a new science. New York, NY: Penguin.
59. Lesch, K., Bengel, D., Heils, A., Sabol, S., Greenberg, B., Petri, S.,...Murphy, D. L. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274, 1527-1531.
60. Lipsky, R. H., Hu, X.-Z., & Goldman, D. (2009). Additional functional variation at the slc6a4 gene. American Journal of Medical Genetics B Neuropsychiatric Genetics, 150B, 153.
61. Little, K., McLaughlin, D., Zhang, L., Livermore, C., Dalack, G., & McFinton, P. (1998). Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels. American Journal of Psychiatry, 155, 207-213.
62. Luttmer, E. F. (2005). Neighbors as negatives: Relative earnings and well-being. Quarterly Journal of Economics, 120, 963-1002.
63. Lykken, D., & Tellegen, A. (1996). Happiness is a stochastic phenomenon. Psychological Science, 7, 186-189.
64. Mackay, T. (2001). The genetic architecture of quantitative traits. Annual Review of Genetics, 35, 303-339.
65. Martin, J., Cleak, J., Willis-Owen, S., Flint, J., & Shifman, S. (2007). Mapping regulatory variants for the serotonin transporter gene based on allelic expression imbalance. Molecular Psychiatry, 12, 421-422.
66. McGreal, R., & Stephen, J. (1993). The depressionhappiness scale. Psychological Reports, 3, 1279-1282.
67. Munafò, M. R., Brown, S. M., & Hariri, A. R. (2008). Serotonin transporter (5HTTLPR) genotype and amygdala activation: A meta-analysis. Biological Psychiatry, 63, 852-857.
68. Munafò, M. R., Clark, T., & Flint, J. (2005). Does measurement instrument moderate the association between the serotonin transporter gene and anxiety-related personality traits? a meta-analysis. Molecular Psychiatry, 10, 415-419.
69. Neale, M., Boker, S., Xie, G., & Maes, H. (2010). OpenMx: Advanced structural equation modeling. Retrieved from http://openmx.psyc.virginia.edu/
70. Nes, R. B., Roysamb, E., Tambs, K., Harris, J. R., & Reichborn-Kjennerud, T. (2006). Subjective wellbeing: Genetic and environmental contributions to stability and change. Psychological Medicine, 36, 1033-1042.
71. Norton, E., & Han, E. (2008). Genetic information, obesity, and labor market outcomes. Health Economics, 17, 1089-1104.
72. O'Malley, A., Rosenquist, J., Zaslavsky, A., & Christakis, N. (2010). Estimation of peer effects in longitudinal models using genetic alleles as instrumental variables. Cambridge, MA: Harvard University.
73. Oswald, A. J., & Wu, S. (2010). Objective confirmation of subjective measures of human well-being: Evidence from the U.S.A. Science, 327, 576-579.
74. Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S.,... Weinberger, D. R. (2005). 5-httlpr polymorphism impacts human cingulate-amygdala interactions: A genetic susceptibility mechanism for depression. Nature Neuroscience, 8, 828-834.
75. Plomin, R., DeFries, J. C., McClearn, G. E., & McGuffin, P. (2008). Behavioral genetics (5th ed.). New York, NY: Worth Publishers.
76. Price, A. L., Patterson, N. J., Plenge, R. M., Weinblatt, M. E., Shadick, N. A., & Reich, D. (2006). Principal components analysis corrects for stratification in genome-wide association studies. Nature Genetics, 38, 904-909.
77. Rayo, L., & Becker, G. S. (2007). Habits, peers, and happiness: An evolutionary perspective. American Economic Review, 97, 487-491.
78. Redon, R., Ishikawa, S., Fitch, K. R., Feuk, L., Perry, G. H., Andrews, T. D., Fiegler, H.,... Hurles, M. E. (2006). Global variation in copy number in the human genome. Nature, 444, 444-544.
79. Risch, N., Herrell, R., Lehner, T., Liang, K., Eaves, L., Hoh, J., Griem...Merikangas, K. (2009). Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: A meta-analysis. Journal of the American Medical Association, 301, 2462-2471.
80. Scarr, S., & Carter-Saltzman, L. (1979). Twin method: Defense of a critical assumption. Behavior Genetics, 9, 527-542.
81. Sen, S., Burmeister, M. L., & Ghosh, D. (2004). Metaanalysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety related personality traits. American Journal of Medicine Genet B, 127, 85-89.
82. Stevenson, B., & Wolfers, J. (2008). Economic growth and subjective well-being: Reassessing the Easterlin paradox. Brookings Papers on Economic Activity, 2, 1-87.
83. Stubbe, J., Posthuma, D., Boomsma, D., & De Geus, E. (2005). Heritability of life satisfaction in adults: A twin-family study. Psychological Medicine, 35, 1581-1588.
84. Taubman, P. (1976). The determinants of earnings: Genetics, family, and other environments: A study of white male twins. American Economic Review, 66, 858-870.
85. Urry, H. L., Nitschke, J. B., Dolski, I., Jackson, D. C., Dalton, K. M., Mueller, C. J.,...Davidson, R. J. (2004). Making a life worth living: Neural correlates of well-being. Psychological Science, 15, 367-372.
86. Van Praag, B., & Ferrer-I-Carbonell, A. (2004). Happiness quantified: A satisfaction calculus approach. Oxford, United Kingdom: Oxford University Press.
87. Visscher, P., Medland, S., Ferreira, M., Morley, K., Zhu, G., Cornes, B., MTgomery, G., & Martin, N. (2006). Assumption-free estimation of heritability from genome-wide identity-by-descent sharing between full siblings. PLoS Genetics, 2, e41.
88. von Hinke Kessler Scholder, S., Smith, G. D., Lawlor, D. A., Propper, C., & Windmeijer, F. (2010). Genetic markers as instrumental variables: An application to child fat mass and academic achievement. Bristol, United Kingdom: University of Bristol, Centre for Market and Public Organisation Working Paper 10/229.
89. Wendland, J., Martin, B., Kruse, M., Lesch, K., & Murphy, D. (2006). Simultaneous genotyping of four functional loci of human slc6a4, with a reappraisal of 5-HTTLPR and rs25531. Molecular Psychiatry, 11, 224-226.
90. Xian, H., Scherrer, J. F., Eisen, S. A., True, W. R., Heath, A. C., Goldberg, J.,...Tsuang, M. T. (2000). Self-reported zygosity and the equal environments assumption for psychiatric disorders in the Vietnam era twin registry. Behavior Genetics, 30, 303-310.
91. Xu, H., & Shete, S. (2006). Mixed-effects logistic approach for association following linkage scan for complex disorders. Annals of Human Genetics, 71, 230-237.