메뉴 건너뛰기




Volumn 35, Issue 11, 2012, Pages 1961-1968

Enhanced IL-12p40 production in LPS-stimulated macrophages by inhibiting JNK activation by artemisinin

Author keywords

Anti microbial; Antitumor; Artemisinin; IL 12; JNK; Macrophage

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ARTEMISININ; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12P40; JANUS KINASE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PREGNANCY SPECIFIC BETA1 GLYCOPROTEIN; TRANSCRIPTION FACTOR;

EID: 84874442640     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-012-1113-8     Document Type: Article
Times cited : (14)

References (48)
  • 2
    • 0035089760 scopus 로고    scopus 로고
    • Regulation of interleukin-12 production by G-protein-coupled receptors
    • 11251296 10.1016/S1286-4579(00)01357-5 1:CAS:528:DC%2BD3MXit1CitL8%3D
    • Braun, M. C. and Kelsall, B. L.; Regulation of interleukin-12 production by G-protein-coupled receptors. Microbes Infect.; 3, 99-107 (2001).
    • (2001) Microbes Infect. , vol.3 , pp. 99-107
    • Braun, M.C.1    Kelsall, B.L.2
  • 3
    • 0027239503 scopus 로고
    • Antitumor and antimetastatic activity of interleukin 12 a gainst murine tumors
    • 8104230 10.1084/jem.178.4.1223 1:CAS:528:DyaK3sXlsFyjsL4%3D
    • Brunda, M. J.; Luistro, L.; Warrier, R. R.; Wright, R. B.; Hubbard, B. R.; Murphy, M.; Wolf, S. F.; and Gately, M. K.; Antitumor and antimetastatic activity of interleukin 12 a gainst murine tumors. J. Exp. Med.; 178, 1223-1230 (1993).
    • (1993) J. Exp. Med. , vol.178 , pp. 1223-1230
    • Brunda, M.J.1    Luistro, L.2    Warrier, R.R.3    Wright, R.B.4    Hubbard, B.R.5    Murphy, M.6    Wolf, S.F.7    Gately, M.K.8
  • 4
    • 1642619557 scopus 로고    scopus 로고
    • Inhibitory effects of artesunate on angiogenesis and on expressions of vascular endothelial growth factor and VEGF receptor KDR/flk-1
    • 15051917 10.1159/000076256 1:CAS:528:DC%2BD2cXis1OqsLY%3D
    • Chen, H. H.; Zhou, H. J.; Wu, G. D.; and Lou, X. E.; Inhibitory effects of artesunate on angiogenesis and on expressions of vascular endothelial growth factor and VEGF receptor KDR/flk-1. Pharmacology, 71, 1-9 (2004).
    • (2004) Pharmacology , vol.71 , pp. 1-9
    • Chen, H.H.1    Zhou, H.J.2    Wu, G.D.3    Lou, X.E.4
  • 5
    • 0036005890 scopus 로고    scopus 로고
    • Interleukin-12 in anti-tumor immunity and immunotherapy
    • 11900991 10.1016/S1359-6101(01)00032-6 1:CAS:528:DC%2BD38XitFWhs74%3D
    • Colombo, M. P. and Trinchieri, G.; Interleukin-12 in anti-tumor immunity and immunotherapy. Cytokine Growth Factor Rev.; 13, 155-168 (2002).
    • (2002) Cytokine Growth Factor Rev. , vol.13 , pp. 155-168
    • Colombo, M.P.1    Trinchieri, G.2
  • 6
    • 0036467445 scopus 로고    scopus 로고
    • Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present
    • 11801672 1:CAS:528:DC%2BD38XpsFeksw%3D%3D
    • Cooper, A. M.; Kipnis, A.; Turner, J.; Magram, J.; Ferrante, J.; and Orme, I. M.; Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present. J. Immunol.; 168, 1322-1327 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 1322-1327
    • Cooper, A.M.1    Kipnis, A.2    Turner, J.3    Magram, J.4    Ferrante, J.5    Orme, I.M.6
  • 8
    • 0031707741 scopus 로고    scopus 로고
    • Interleukin-12 is essential for a protective Th1 response in mice infected with Cryptococcus neoformans
    • 9746609 1:CAS:528:DyaK1cXmsV2lsbc%3D
    • Decken, K.; Kohler, G.; Palmer-Lehmann, K.; Wunderlin, A.; Mattner, F.; Magram, J.; Gately, M. K.; and Alber, G.; Interleukin-12 is essential for a protective Th1 response in mice infected with Cryptococcus neoformans. Infect. Immun.; 66, 4994-5000 (1998).
    • (1998) Infect. Immun. , vol.66 , pp. 4994-5000
    • Decken, K.1    Kohler, G.2    Palmer-Lehmann, K.3    Wunderlin, A.4    Mattner, F.5    Magram, J.6    Gately, M.K.7    Alber, G.8
  • 9
    • 0036238927 scopus 로고    scopus 로고
    • Antiviral activity of artesunate towards wild-type, recombinant, and ganciclovir-resistant human cytomegaloviruses
    • 11976732 10.1007/s00109-001-0300-8 1:CAS:528:DC%2BD38XksFGmsro%3D
    • Efferth, T.; Marschall, M.; Wang, X.; Huong, S. M.; Hauber, I.; Olbrich, A.; Kronschnabl, M.; Stamminger, T.; and Huang, E. S.; Antiviral activity of artesunate towards wild-type, recombinant, and ganciclovir-resistant human cytomegaloviruses. J. Mol. Med.; 80, 233-242 (2002).
    • (2002) J. Mol. Med. , vol.80 , pp. 233-242
    • Efferth, T.1    Marschall, M.2    Wang, X.3    Huong, S.M.4    Hauber, I.5    Olbrich, A.6    Kronschnabl, M.7    Stamminger, T.8    Huang, E.S.9
  • 10
    • 0036127059 scopus 로고    scopus 로고
    • In vivo clearance of an intracellular bacterium, Francisella tularensis LVS, is dependent on the p40 subunit of interleukin-12 (IL-12) but not on IL-12 p70
    • 11895957 10.1128/IAI.70.4.1936-1948.2002 1:CAS:528:DC%2BD38Xitl2mu7Y%3D
    • Elkins, K. L.; Cooper, A.; Colombini, S. M.; Cowley, S. C.; and Kieffer, T. L.; In vivo clearance of an intracellular bacterium, Francisella tularensis LVS, is dependent on the p40 subunit of interleukin-12 (IL-12) but not on IL-12 p70. Infect. Immun.; 70, 1936-1948 (2002).
    • (2002) Infect. Immun. , vol.70 , pp. 1936-1948
    • Elkins, K.L.1    Cooper, A.2    Colombini, S.M.3    Cowley, S.C.4    Kieffer, T.L.5
  • 14
    • 33845268199 scopus 로고    scopus 로고
    • In vitro inhibition of Toxoplasma gondii by four new derivatives of artemisinin
    • 17060514 10.1128/AAC.00793-06 1:CAS:528:DC%2BD28XhtlWksrbN
    • Jones-Brando, L.; D'angelo, J.; Posner, G. H.; and Yolken, R.; In vitro inhibition of Toxoplasma gondii by four new derivatives of artemisinin. Antimicrob. Agents Chemother.; 50, 4206-4208 (2006).
    • (2006) Antimicrob. Agents Chemother. , vol.50 , pp. 4206-4208
    • Jones-Brando, L.1    D'Angelo, J.2    Posner, G.H.3    Yolken, R.4
  • 15
    • 44449100233 scopus 로고    scopus 로고
    • Macrophage deletion of p38alpha partially impairs lipopolysaccharide- induced cellular activation
    • 18354233 1:CAS:528:DC%2BD1cXjsVKqtbk%3D
    • Kang, Y. J.; Chen, J.; Otsuka, M.; Mols, J.; Ren, S.; Wang, Y.; and Han, J.; Macrophage deletion of p38alpha partially impairs lipopolysaccharide-induced cellular activation. J. Immunol.; 180, 5075-5082 (2008).
    • (2008) J. Immunol. , vol.180 , pp. 5075-5082
    • Kang, Y.J.1    Chen, J.2    Otsuka, M.3    Mols, J.4    Ren, S.5    Wang, Y.6    Han, J.7
  • 16
    • 67449124387 scopus 로고    scopus 로고
    • Cholera toxin inhibits IL-12 production and CD8alpha+ dendritic cell differentiation by cAMP-mediated inhibition of IRF8 function
    • 19487420 10.1084/jem.20080912
    • La Sala, A.; He, J.; Laricchia-Robbio, L.; Gorini, S.; Iwasaki, A.; Braun, M.; Yap, G. S.; Sher, A.; Ozato, K.; and Kelsall, B.; Cholera toxin inhibits IL-12 production and CD8alpha+ dendritic cell differentiation by cAMP-mediated inhibition of IRF8 function. J. Exp. Med.; 206, 1227-1235 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 1227-1235
    • La Sala, A.1    He, J.2    Laricchia-Robbio, L.3    Gorini, S.4    Iwasaki, A.5    Braun, M.6    Yap, G.S.7    Sher, A.8    Ozato, K.9    Kelsall, B.10
  • 17
    • 0035500298 scopus 로고    scopus 로고
    • IL-12p40-dependent agonistic effects on the development of protective innate and adaptive immunity against Salmonella enteritidis
    • 11673546 1:CAS:528:DC%2BD3MXotVWjsbc%3D
    • Lehmann, J.; Bellmann, S.; Werner, C.; Schroder, R.; Schutze, N.; and Alber, G.; IL-12p40-dependent agonistic effects on the development of protective innate and adaptive immunity against Salmonella enteritidis. J. Immunol.; 167, 5304-5315 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 5304-5315
    • Lehmann, J.1    Bellmann, S.2    Werner, C.3    Schroder, R.4    Schutze, N.5    Alber, G.6
  • 19
    • 0033118982 scopus 로고    scopus 로고
    • Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice
    • 10202148 10.1093/emboj/18.7.1845 1:CAS:528:DyaK1MXivVyksrg%3D
    • Lu, H. T.; Yang, D. D.; Wysk, M.; Gatti, E.; Mellman, I.; Davis, R. J.; and Flavell, R. A.; Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice. EMBO J.; 18, 1845-1857 (1999).
    • (1999) EMBO J. , vol.18 , pp. 1845-1857
    • Lu, H.T.1    Yang, D.D.2    Wysk, M.3    Gatti, E.4    Mellman, I.5    Davis, R.J.6    Flavell, R.A.7
  • 20
    • 0030064148 scopus 로고    scopus 로고
    • The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells
    • 8551218 10.1084/jem.183.1.147 1:CAS:528:DyaK28XjsVCgsA%3D%3D
    • Ma, X.; Chow, J. M.; Gri, G.; Carra, G.; Gerosa, F.; Wolf, S. F.; Dzialo, R.; and Trinchieri, G.; The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells. J. Exp. Med.; 183, 147-157 (1996).
    • (1996) J. Exp. Med. , vol.183 , pp. 147-157
    • Ma, X.1    Chow, J.M.2    Gri, G.3    Carra, G.4    Gerosa, F.5    Wolf, S.F.6    Dzialo, R.7    Trinchieri, G.8
  • 22
    • 0025904817 scopus 로고
    • Susceptibility of Pneumocystis carinii to artemisinin in vitro
    • 1929266 10.1128/AAC.35.6.1225 1:CAS:528:DyaK3MXksVGqt7k%3D
    • Merali, S. and Meshnick, S. R.; Susceptibility of Pneumocystis carinii to artemisinin in vitro. Antimicrob. Agents Chemother.; 35, 1225-1227 (1991).
    • (1991) Antimicrob. Agents Chemother. , vol.35 , pp. 1225-1227
    • Merali, S.1    Meshnick, S.R.2
  • 23
    • 34248229771 scopus 로고    scopus 로고
    • Evidence for the involvement of carbon-centered radicals in the induction of apoptotic cell death by artemisinin compounds
    • 17227762 10.1074/jbc.M610375200 1:CAS:528:DC%2BD2sXjtlCitrw%3D
    • Mercer, A. E.; Maggs, J. L.; Sun, X. M.; Cohen, G. M.; Chadwick, J.; O'neill, P. M.; and Park, B. K.; Evidence for the involvement of carbon-centered radicals in the induction of apoptotic cell death by artemisinin compounds. J. Biol. Chem.; 282, 9372-9382 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 9372-9382
    • Mercer, A.E.1    Maggs, J.L.2    Sun, X.M.3    Cohen, G.M.4    Chadwick, J.5    O'Neill, P.M.6    Park, B.K.7
  • 24
    • 0028865074 scopus 로고
    • Oral administration of dihydroartemisinin and ferrous sulfate retarded implanted fibrosarcoma growth in the rat
    • 8529210 1:CAS:528:DyaK2MXpsV2nu70%3D
    • Moore, J. C.; Lai, H.; Li, J. R.; Ren, R. L.; Mcdougall, J. A.; Singh, N. P.; and Chou, C. K.; Oral administration of dihydroartemisinin and ferrous sulfate retarded implanted fibrosarcoma growth in the rat. Cancer Lett.; 98, 83-87 (1995).
    • (1995) Cancer Lett. , vol.98 , pp. 83-87
    • Moore, J.C.1    Lai, H.2    Li, J.R.3    Ren, R.L.4    McDougall, J.A.5    Singh, N.P.6    Chou, C.K.7
  • 25
    • 0029143632 scopus 로고
    • Regulation of interleukin 12 p40 expression through an NF-kappa B half-site
    • 7565674 1:STN:280:DyaK28%2FgvFGmsg%3D%3D
    • Murphy, T. L.; Cleveland, M. G.; Kulesza, P.; Magram, J.; and Murphy, K. M.; Regulation of interleukin 12 p40 expression through an NF-kappa B half-site. Mol. Cell. Biol.; 15, 5258-5267 (1995).
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 5258-5267
    • Murphy, T.L.1    Cleveland, M.G.2    Kulesza, P.3    Magram, J.4    Murphy, K.M.5
  • 26
    • 10844273239 scopus 로고    scopus 로고
    • Role of c-Jun N-terminal kinase on lipopolysaccharide induced maturation of human monocyte-derived dendritic cells
    • 15477228 10.1093/intimm/dxh171 1:CAS:528:DC%2BD2cXhtVSkt7vF
    • Nakahara, T.; Uchi, H.; Urabe, K.; Chen, Q.; Furue, M.; and Moroi, Y.; Role of c-Jun N-terminal kinase on lipopolysaccharide induced maturation of human monocyte-derived dendritic cells. Int. Immunol.; 16, 1701-1709 (2004).
    • (2004) Int. Immunol. , vol.16 , pp. 1701-1709
    • Nakahara, T.1    Uchi, H.2    Urabe, K.3    Chen, Q.4    Furue, M.5    Moroi, Y.6
  • 27
    • 79952789527 scopus 로고    scopus 로고
    • UNC93B1 is essential for TLR11 activation and IL-12-dependent host resistance to Toxoplasma gondii
    • 21097503 10.1074/jbc.M110.171025 1:CAS:528:DC%2BC3MXhtFKksLk%3D
    • Pifer, R.; Benson, A.; Sturge, C. R.; and Yarovinsky, F.; UNC93B1 is essential for TLR11 activation and IL-12-dependent host resistance to Toxoplasma gondii. J. Biol. Chem.; 286, 3307-3314 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 3307-3314
    • Pifer, R.1    Benson, A.2    Sturge, C.R.3    Yarovinsky, F.4
  • 28
    • 0030872393 scopus 로고    scopus 로고
    • Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: Evidence of functional synergy between C/EBP and Rel proteins
    • 9234715 1:CAS:528:DyaK2sXkvVCjurY%3D
    • Plevy, S. E.; Gemberling, J. H.; Hsu, S.; Dorner, A. J.; and Smale, S. T.; Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins. Mol. Cell. Biol.; 17, 4572-4588 (1997).
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 4572-4588
    • Plevy, S.E.1    Gemberling, J.H.2    Hsu, S.3    Dorner, A.J.4    Smale, S.T.5
  • 29
    • 0032900383 scopus 로고    scopus 로고
    • Immunological effects of interleukin 12 administered by bolus intravenous injection to patients with cancer
    • 9918197 1:CAS:528:DyaK1MXhtVSht7g%3D
    • Robertson, M. J.; Cameron, C.; Atkins, M. B.; Gordon, M. S.; Lotze, M. T.; Sherman, M. L.; and Ritz, J.; Immunological effects of interleukin 12 administered by bolus intravenous injection to patients with cancer. Clin. Cancer Res.; 5, 9-16 (1999).
    • (1999) Clin. Cancer Res. , vol.5 , pp. 9-16
    • Robertson, M.J.1    Cameron, C.2    Atkins, M.B.3    Gordon, M.S.4    Lotze, M.T.5    Sherman, M.L.6    Ritz, J.7
  • 30
    • 27644565158 scopus 로고    scopus 로고
    • Effect of artemisinin/ artesunate as inhibitors of hepatitis B virus production in an "in vitro" replicative system
    • 16122816 10.1016/j.antiviral.2005.07.005 1:CAS:528:DC%2BD2MXhtFOhsb3J
    • Romero, M. R.; Efferth, T.; Serrano, M. A.; Castano, B.; Macias, R. I.; Briz, O.; and Marin, J. J.; Effect of artemisinin/ artesunate as inhibitors of hepatitis B virus production in an "in vitro" replicative system. Antiviral Res.; 68, 75-83 (2005).
    • (2005) Antiviral Res. , vol.68 , pp. 75-83
    • Romero, M.R.1    Efferth, T.2    Serrano, M.A.3    Castano, B.4    MacIas, R.I.5    Briz, O.6    Marin, J.J.7
  • 31
    • 0035184612 scopus 로고    scopus 로고
    • The p38 mitogen-activated protein kinases can have opposing roles in the antigen-dependent or endotoxin-stimulated production of IL-12 and IFN-gamma
    • 11745338 10.1002/1521-4141(200111)31:11<3218: AID-IMMU3218>3.0. CO;2-9 1:CAS:528:DC%2BD3MXosl2qurk%3D
    • Salmon, R. A.; Guo, X.; Teh, H. S.; and Schrader, J. W.; The p38 mitogen-activated protein kinases can have opposing roles in the antigen-dependent or endotoxin-stimulated production of IL-12 and IFN-gamma. Eur. J. Immunol.; 31, 3218-3227 (2001).
    • (2001) Eur. J. Immunol. , vol.31 , pp. 3218-3227
    • Salmon, R.A.1    Guo, X.2    Teh, H.S.3    Schrader, J.W.4
  • 32
    • 0033748023 scopus 로고    scopus 로고
    • Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages
    • 11058167 10.1073/pnas.230436397 1:CAS:528:DC%2BD3cXotFynsLg%3D
    • Sanjabi, S.; Hoffmann, A.; Liou, H. C.; Baltimore, D.; and Smale, S. T.; Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages. Proc. Natl. Acad. Sci. U.S.A.; 97, 12705-12710 (2000).
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 12705-12710
    • Sanjabi, S.1    Hoffmann, A.2    Liou, H.C.3    Baltimore, D.4    Smale, S.T.5
  • 34
    • 0030266857 scopus 로고    scopus 로고
    • Differential roles for IL-12 in the maintenance of immune responses in infectious versus autoimmune disease
    • 8816374 1:CAS:528:DyaK28XlvVWnu7Y%3D
    • Seder, R. A.; Kelsall, B. L.; and Jankovic, D.; Differential roles for IL-12 in the maintenance of immune responses in infectious versus autoimmune disease. J. Immunol.; 157, 2745-2748 (1996).
    • (1996) J. Immunol. , vol.157 , pp. 2745-2748
    • Seder, R.A.1    Kelsall, B.L.2    Jankovic, D.3
  • 35
    • 58849163688 scopus 로고    scopus 로고
    • Functional analysis of a polymorphism in the promoter region of the IL-12/23p40 gene
    • 19134014 10.1111/j.1365-2222.2008.03165.x 1:CAS:528:DC%2BD1MXjtFKit7Y%3D
    • Shimokawa, N.; Nishiyama, C.; Hirota, T.; Tamari, M.; Hara, M.; Ikeda, S.; Okumura, K.; and Ogawa, H.; Functional analysis of a polymorphism in the promoter region of the IL-12/23p40 gene. Clin. Exp. Allergy, 39, 228-235 (2009).
    • (2009) Clin. Exp. Allergy , vol.39 , pp. 228-235
    • Shimokawa, N.1    Nishiyama, C.2    Hirota, T.3    Tamari, M.4    Hara, M.5    Ikeda, S.6    Okumura, K.7    Ogawa, H.8
  • 36
    • 0026693587 scopus 로고
    • Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5
    • 1358798 10.1016/S0888-7543(05)80283-6 1:CAS:528:DyaK3sXhs1ait7o%3D
    • Sieburth, D.; Jabs, E. W.; Warrington, J. A.; Li, X.; Lasota, J.; Laforgia, S.; Kelleher, K.; Huebner, K.; Wasmuth, J. J.; and Wolf, S. F.; Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5. Genomics, 14, 59-62 (1992).
    • (1992) Genomics , vol.14 , pp. 59-62
    • Sieburth, D.1    Jabs, E.W.2    Warrington, J.A.3    Li, X.4    Lasota, J.5    Laforgia, S.6    Kelleher, K.7    Huebner, K.8    Wasmuth, J.J.9    Wolf, S.F.10
  • 37
    • 0028970060 scopus 로고
    • Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
    • 7612223 10.1146/annurev.iy.13.040195.001343 1:CAS:528:DyaK2MXltFamtbg%3D
    • Trinchieri, G.; Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol.; 13, 251-276 (1995).
    • (1995) Annu. Rev. Immunol. , vol.13 , pp. 251-276
    • Trinchieri, G.1
  • 38
    • 0038784487 scopus 로고    scopus 로고
    • C-Jun N-terminal kinase negatively regulates lipopolysaccharide-induced IL-12 production in human macrophages: Role of mitogenactivated protein kinase in glutathione redox regulation of IL-12 production
    • 12847227 1:CAS:528:DC%2BD3sXltFymt7Y%3D
    • Utsugi, M.; Dobashi, K.; Ishizuka, T.; Endou, K.; Hamuro, J.; Murata, Y.; Nakazawa, T.; and Mori, M.; c-Jun N-terminal kinase negatively regulates lipopolysaccharide-induced IL-12 production in human macrophages: role of mitogenactivated protein kinase in glutathione redox regulation of IL-12 production. J. Immunol.; 171, 628-635 (2003).
    • (2003) J. Immunol. , vol.171 , pp. 628-635
    • Utsugi, M.1    Dobashi, K.2    Ishizuka, T.3    Endou, K.4    Hamuro, J.5    Murata, Y.6    Nakazawa, T.7    Mori, M.8
  • 39
    • 0035211343 scopus 로고    scopus 로고
    • Current progress in the development and use of artemether for chemoprophylaxis of major human schistosome parasites
    • 11772354 10.2174/0929867013371581 1:CAS:528:DC%2BD3MXpt1Sls7w%3D
    • Utzinger, J.; Xiao, S.; Keiser, J.; Chen, M.; Zheng, J.; and Tanner, M.; Current progress in the development and use of artemether for chemoprophylaxis of major human schistosome parasites. Curr. Med. Chem.; 8, 1841-1860 (2001a).
    • (2001) Curr. Med. Chem. , vol.8 , pp. 1841-1860
    • Utzinger, J.1    Xiao, S.2    Keiser, J.3    Chen, M.4    Zheng, J.5    Tanner, M.6
  • 40
    • 0035217959 scopus 로고    scopus 로고
    • The potential of artemether for the control of schistosomiasis
    • 11730781 10.1016/S0020-7519(01)00297-1 1:CAS:528:DC%2BD3MXos1GqsLw%3D
    • Utzinger, J.; Xiao, S.; N'goran, E. K.; Bergquist, R.; and Tanner, M.; The potential of artemether for the control of schistosomiasis. Int. J. Parasitol.; 31, 1549-1562 (2001b).
    • (2001) Int. J. Parasitol. , vol.31 , pp. 1549-1562
    • Utzinger, J.1    Xiao, S.2    N'Goran, E.K.3    Bergquist, R.4    Tanner, M.5
  • 41
    • 0025875022 scopus 로고
    • Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells
    • 1673147 1:CAS:528:DyaK38XktVGktLc%3D
    • Wolf, S. F.; Temple, P. A.; Kobayashi, M.; Young, D.; Dicig, M.; Lowe, L.; Dzialo, R.; Fitz, L.; Ferenz, C.; Hewick, R. M.; and Et Al. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J. Immunol.; 146, 3074-3081 (1991).
    • (1991) J. Immunol. , vol.146 , pp. 3074-3081
    • Wolf, S.F.1    Temple, P.A.2    Kobayashi, M.3    Young, D.4    Dicig, M.5    Lowe, L.6    Dzialo, R.7    Fitz, L.8    Ferenz, C.9    Hewick, R.M.10
  • 42
    • 11844281505 scopus 로고    scopus 로고
    • Apoptosis of human umbilical vein endothelial cells induced by artesunate
    • 15653096 10.1016/j.vph.2004.11.001 1:CAS:528:DC%2BD2MXksVaktg%3D%3D
    • Wu, G. D.; Zhou, H. J.; and Wu, X. H.; Apoptosis of human umbilical vein endothelial cells induced by artesunate. Vascul. Pharmacol.; 41, 205-212 (2004).
    • (2004) Vascul. Pharmacol. , vol.41 , pp. 205-212
    • Wu, G.D.1    Zhou, H.J.2    Wu, X.H.3
  • 43
    • 0038346613 scopus 로고    scopus 로고
    • Suppression of interleukin-12 production through endogenously secreted interleukin-10 in activated dendritic cells: Involvement of activation of extracellular signal-regulated protein kinase
    • 12828555 10.1046/j.1365-3083.2003.01268.x 1:CAS:528:DC%2BD3sXmtVajsbY%3D
    • Xia, C. Q. and Kao, K. J.; Suppression of interleukin-12 production through endogenously secreted interleukin-10 in activated dendritic cells: involvement of activation of extracellular signal-regulated protein kinase. Scand. J. Immunol.; 58, 23-32 (2003).
    • (2003) Scand. J. Immunol. , vol.58 , pp. 23-32
    • Xia, C.Q.1    Kao, K.J.2
  • 44
    • 78650656137 scopus 로고    scopus 로고
    • The regulation of Th1 responses by the p38 MAPK
    • 20937847 10.4049/jimmunol.1000243 1:CAS:528:DC%2BC3cXhtlOhsbnM
    • Yang, Z.; Zhang, X.; Darrah, P. A.; and Mosser, D. M.; The regulation of Th1 responses by the p38 MAPK. J. Immunol.; 185, 6205-6213 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 6205-6213
    • Yang, Z.1    Zhang, X.2    Darrah, P.A.3    Mosser, D.M.4
  • 45
    • 0034662258 scopus 로고    scopus 로고
    • Cutting edge: IL-12 is required for the maintenance of IFN-gamma production in T cells mediating chronic resistance to the intracellular pathogen, Toxoplasma gondii
    • 10878333 1:CAS:528:DC%2BD3cXkvFWisrg%3D
    • Yap, G.; Pesin, M.; and Sher, A.; Cutting edge: IL-12 is required for the maintenance of IFN-gamma production in T cells mediating chronic resistance to the intracellular pathogen, Toxoplasma gondii. J. Immunol.; 165, 628-631 (2000).
    • (2000) J. Immunol. , vol.165 , pp. 628-631
    • Yap, G.1    Pesin, M.2    Sher, A.3
  • 46
    • 84861410440 scopus 로고    scopus 로고
    • Interleukin-12: Clinical usage and molecular markers of cancer susceptibility
    • 22515181 10.3109/08977194.2012.678843 1:CAS:528:DC%2BC38Xnt1eqs7Y%3D
    • Yuzhalin, A. E. and Kutikhin, A. G.; Interleukin-12: clinical usage and molecular markers of cancer susceptibility. Growth Factors, 30, 176-191 (2012).
    • (2012) Growth Factors , vol.30 , pp. 176-191
    • Yuzhalin, A.E.1    Kutikhin, A.G.2
  • 47
    • 84861229798 scopus 로고    scopus 로고
    • Evaluation of γ-retroviral vectors that mediate the inducible expression of IL-12 for clinical application
    • 22576348 10.1097/CJI.0b013e31825898e8
    • Zhang, L.; Feldman, S. A.; Zheng, Z.; Chinnasamy, N.; Xu, H.; Nahvi, A. V.; Dudley, M. E.; Rosenberg, S. A.; and Morgan, R. A.; Evaluation of γ-retroviral vectors that mediate the inducible expression of IL-12 for clinical application. J. Immunother.; 35, 430-439 (2012).
    • (2012) J. Immunother. , vol.35 , pp. 430-439
    • Zhang, L.1    Feldman, S.A.2    Zheng, Z.3    Chinnasamy, N.4    Xu, H.5    Nahvi, A.V.6    Dudley, M.E.7    Rosenberg, S.A.8    Morgan, R.A.9
  • 48
    • 0035947732 scopus 로고    scopus 로고
    • Characterization of an activation protein-1-binding site in the murine interleukin-12 p40 promoter. Demonstration of novel functional elements by a reductionist approach
    • 11279072 10.1074/jbc.M100440200 1:CAS:528:DC%2BD3MXktFWmtbo%3D
    • Zhu, C.; Gagnidze, K.; Gemberling, J. H.; and Plevy, S. E.; Characterization of an activation protein-1-binding site in the murine interleukin-12 p40 promoter. Demonstration of novel functional elements by a reductionist approach. J. Biol. Chem.; 276, 18519-18528 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 18519-18528
    • Zhu, C.1    Gagnidze, K.2    Gemberling, J.H.3    Plevy, S.E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.