Cholera toxin inhibits IL-12 production and CD8α+ dendritic cell differentiation by cAMP-mediated inhibition of IRF8 function

Journal of Experimental Medicine

Volumn 206, Issue 6, 2009, Pages 1227-1235

  La Sala, Andrea ^a   He, Jianping ^b   Laricchia Robbio, Leopoldo ^c   Gorini, Stefania ^a   Iwasaki, Akiko ^d   Braun, Michael ^e   Yap, George S ^f   Sher, Alan ^b   Ozato, Keiko ^c   Kelsall, Brian ^b  

^a IRCCS SAN RAFFAELE PISANA   (Italy)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^f The State University of New Jersey   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUCLADESINE; CD135 ANTIGEN; CHOLERA TOXIN; CYCLIC AMP; FORSKOLIN; GAMMA INTERFERON; INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 12; INTERLEUKIN 12P35; INTERLEUKIN 12P40; LIPOPOLYSACCHARIDE; PROTEIN P40;

ANIMAL CELL; ARTICLE; BLEACHING; BONE MARROW CELL; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CHROMATIN; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LYMPHOID ORGAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; SPLEEN CELL; TH1 CELL; TOXOPLASMOSIS;

ANIMALS; ANTIGENS, CD8; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELLS, CULTURED; CHOLERA TOXIN; CYCLIC AMP; DENDRITIC CELLS; FEMALE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HUMANS; INTERFERON REGULATORY FACTOR-1; INTERFERON REGULATORY FACTORS; INTERFERON-GAMMA; INTERLEUKIN-12; INTERLEUKIN-12 SUBUNIT P40; MICE; MICE, INBRED BALB C; SPLEEN; TOXOPLASMOSIS;

EID: 67449124387     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20080912     Document Type: Article

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