메뉴 건너뛰기




Volumn 4, Issue 2, 2013, Pages 78-91

A MicroRNA196a2* and TP63 Circuit Regulated by Estrogen Receptor-α and ERK2 that Controls Breast Cancer Proliferation and Invasiveness Properties

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; ESTROGEN RECEPTOR ALPHA; MICRORNA; MICRORNA 196A2; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN P63; UNCLASSIFIED DRUG; MAPK1 PROTEIN, HUMAN; MIRN196 MICRORNA, HUMAN; TP63 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN;

EID: 84874439323     PISSN: 18688497     EISSN: 18688500     Source Type: Journal    
DOI: 10.1007/s12672-012-0129-3     Document Type: Article
Times cited : (28)

References (62)
  • 1
    • 69249137029 scopus 로고    scopus 로고
    • Biological determinants of endocrine resistance in breast cancer
    • Musgrove EA, Sutherland RL (2009) Biological determinants of endocrine resistance in breast cancer. Nat Rev Cancer 9: 631-643.
    • (2009) Nat Rev Cancer , vol.9 , pp. 631-643
    • Musgrove, E.A.1    Sutherland, R.L.2
  • 2
    • 79551576468 scopus 로고    scopus 로고
    • Mechanisms of endocrine resistance in breast cancer
    • Osborne CK, Schiff R (2011) Mechanisms of endocrine resistance in breast cancer. Annu Rev Med 62: 233-247.
    • (2011) Annu Rev Med , vol.62 , pp. 233-247
    • Osborne, C.K.1    Schiff, R.2
  • 3
    • 78751683777 scopus 로고    scopus 로고
    • Genomic collaboration of estrogen receptor alpha and extracellular signal-regulated kinase 2 in regulating gene and proliferation programs
    • Madak-Erdogan Z, Lupien M, Stossi F, Brown M, Katzenellenbogen BS (2011) Genomic collaboration of estrogen receptor alpha and extracellular signal-regulated kinase 2 in regulating gene and proliferation programs. Mol Cell Biol 31: 226-236.
    • (2011) Mol Cell Biol , vol.31 , pp. 226-236
    • Madak-Erdogan, Z.1    Lupien, M.2    Stossi, F.3    Brown, M.4    Katzenellenbogen, B.S.5
  • 4
    • 37249069903 scopus 로고    scopus 로고
    • Reversal of the estrogen receptor negative phenotype in breast cancer and restoration of antiestrogen response
    • Bayliss J, Hilger A, Vishnu P, Diehl K, El-Ashry D (2007) Reversal of the estrogen receptor negative phenotype in breast cancer and restoration of antiestrogen response. Clin Cancer Res 13: 7029-7036.
    • (2007) Clin Cancer Res , vol.13 , pp. 7029-7036
    • Bayliss, J.1    Hilger, A.2    Vishnu, P.3    Diehl, K.4    El-Ashry, D.5
  • 5
    • 84855339741 scopus 로고    scopus 로고
    • Tamoxifen downregulation of miR-451 increases 14-3-3zeta and promotes breast cancer cell survival and endocrine resistance
    • Bergamaschi A, Katzenellenbogen BS (2012) Tamoxifen downregulation of miR-451 increases 14-3-3zeta and promotes breast cancer cell survival and endocrine resistance. Oncogene 31: 39-47.
    • (2012) Oncogene , vol.31 , pp. 39-47
    • Bergamaschi, A.1    Katzenellenbogen, B.S.2
  • 6
    • 25844490097 scopus 로고    scopus 로고
    • Endocrinology and hormone therapy in breast cancer: new insight into estrogen receptor-alpha function and its implication for endocrine therapy resistance in breast cancer
    • Schiff R, Osborne CK (2005) Endocrinology and hormone therapy in breast cancer: new insight into estrogen receptor-alpha function and its implication for endocrine therapy resistance in breast cancer. Breast Cancer Res 7: 205-211.
    • (2005) Breast Cancer Res , vol.7 , pp. 205-211
    • Schiff, R.1    Osborne, C.K.2
  • 7
    • 33845755467 scopus 로고    scopus 로고
    • Illuminating the silence: understanding the structure and function of small RNAs
    • Rana TM (2007) Illuminating the silence: understanding the structure and function of small RNAs. Nat Rev Mol Cell Biol 8: 23-36.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 23-36
    • Rana, T.M.1
  • 8
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: target recognition and regulatory functions
    • Bartel DP (2009) MicroRNAs: target recognition and regulatory functions. Cell 136: 215-233.
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 10
    • 1942435249 scopus 로고    scopus 로고
    • Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs
    • Bartel DP, Chen CZ (2004) Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs. Nat Rev Genet 5: 396-400.
    • (2004) Nat Rev Genet , vol.5 , pp. 396-400
    • Bartel, D.P.1    Chen, C.Z.2
  • 11
    • 77955644289 scopus 로고    scopus 로고
    • Mammalian microRNAs predominantly act to decrease target mRNA levels
    • Guo H, Ingolia NT, Weissman JS, Bartel DP (2010) Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature 466: 835-840.
    • (2010) Nature , vol.466 , pp. 835-840
    • Guo, H.1    Ingolia, N.T.2    Weissman, J.S.3    Bartel, D.P.4
  • 12
    • 38349169664 scopus 로고    scopus 로고
    • Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?
    • Filipowicz W, Bhattacharyya SN, Sonenberg N (2008) Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet 9: 102-114.
    • (2008) Nat Rev Genet , vol.9 , pp. 102-114
    • Filipowicz, W.1    Bhattacharyya, S.N.2    Sonenberg, N.3
  • 13
    • 33747876113 scopus 로고    scopus 로고
    • MicroRNA-cancer connection: the beginning of a new tale
    • Calin GA, Croce CM (2006) MicroRNA-cancer connection: the beginning of a new tale. Cancer Res 66: 7390-7394.
    • (2006) Cancer Res , vol.66 , pp. 7390-7394
    • Calin, G.A.1    Croce, C.M.2
  • 14
    • 33645294070 scopus 로고    scopus 로고
    • Oncomirs-microRNAs with a role in cancer
    • Esquela-Kerscher A, Slack FJ (2006) Oncomirs-microRNAs with a role in cancer. Nat Rev Cancer 6: 259-269.
    • (2006) Nat Rev Cancer , vol.6 , pp. 259-269
    • Esquela-Kerscher, A.1    Slack, F.J.2
  • 16
    • 24344494340 scopus 로고    scopus 로고
    • How microRNAs control cell division, differentiation and death
    • Miska EA (2005) How microRNAs control cell division, differentiation and death. Curr Opin Genet Dev 15: 563-568.
    • (2005) Curr Opin Genet Dev , vol.15 , pp. 563-568
    • Miska, E.A.1
  • 17
    • 33846188098 scopus 로고    scopus 로고
    • microRNAs as oncogenes and tumor suppressors
    • Zhang B, Pan X, Cobb GP, Anderson TA (2007) microRNAs as oncogenes and tumor suppressors. Dev Biol 302: 1-12.
    • (2007) Dev Biol , vol.302 , pp. 1-12
    • Zhang, B.1    Pan, X.2    Cobb, G.P.3    Anderson, T.A.4
  • 19
    • 27244433702 scopus 로고    scopus 로고
    • Real-time expression profiling of microRNA precursors in human cancer cell lines
    • Jiang J, Lee EJ, Gusev Y, Schmittgen TD (2005) Real-time expression profiling of microRNA precursors in human cancer cell lines. Nucleic Acids Res 33: 5394-5403.
    • (2005) Nucleic Acids Res , vol.33 , pp. 5394-5403
    • Jiang, J.1    Lee, E.J.2    Gusev, Y.3    Schmittgen, T.D.4
  • 23
    • 57649174634 scopus 로고    scopus 로고
    • MicroRNA-221/222 negatively regulates estrogen receptor alpha and is associated with tamoxifen resistance in breast cancer
    • Zhao JJ, Lin J, Yang H, Kong W, He L, Ma X, Coppola D, Cheng JQ (2008) MicroRNA-221/222 negatively regulates estrogen receptor alpha and is associated with tamoxifen resistance in breast cancer. J Biol Chem 283: 31079-31086.
    • (2008) J Biol Chem , vol.283 , pp. 31079-31086
    • Zhao, J.J.1    Lin, J.2    Yang, H.3    Kong, W.4    He, L.5    Ma, X.6    Coppola, D.7    Cheng, J.Q.8
  • 26
    • 65849267719 scopus 로고    scopus 로고
    • Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells
    • Wickramasinghe NS, Manavalan TT, Dougherty SM, Riggs KA, Li Y, Klinge CM (2009) Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells. Nucleic Acids Res 37: 2584-2595.
    • (2009) Nucleic Acids Res , vol.37 , pp. 2584-2595
    • Wickramasinghe, N.S.1    Manavalan, T.T.2    Dougherty, S.M.3    Riggs, K.A.4    Li, Y.5    Klinge, C.M.6
  • 27
    • 34547753615 scopus 로고    scopus 로고
    • p63 and p73 in human cancer: defining the network
    • Deyoung MP, Ellisen LW (2007) p63 and p73 in human cancer: defining the network. Oncogene 26: 5169-5183.
    • (2007) Oncogene , vol.26 , pp. 5169-5183
    • Deyoung, M.P.1    Ellisen, L.W.2
  • 28
    • 73949139019 scopus 로고    scopus 로고
    • Triple-negative breast cancer: clinicopathological characteristics and relationship with basal-like breast cancer
    • Thike AA, Cheok PY, Jara-Lazaro AR, Tan B, Tan P, Tan PH (2010) Triple-negative breast cancer: clinicopathological characteristics and relationship with basal-like breast cancer. Mod Pathol 23: 123-133.
    • (2010) Mod Pathol , vol.23 , pp. 123-133
    • Thike, A.A.1    Cheok, P.Y.2    Jara-Lazaro, A.R.3    Tan, B.4    Tan, P.5    Tan, P.H.6
  • 30
    • 30644474977 scopus 로고    scopus 로고
    • p63: oncogene or tumor suppressor?
    • Mills AA (2006) p63: oncogene or tumor suppressor? Curr Opin Genet Dev 16: 38-44.
    • (2006) Curr Opin Genet Dev , vol.16 , pp. 38-44
    • Mills, A.A.1
  • 33
    • 1642377359 scopus 로고    scopus 로고
    • p63 and the epithelial stem cell: more than status quo?
    • McKeon F (2004) p63 and the epithelial stem cell: more than status quo? Genes Dev 18: 465-469.
    • (2004) Genes Dev , vol.18 , pp. 465-469
    • McKeon, F.1
  • 36
    • 27644567107 scopus 로고    scopus 로고
    • p63, cytokeratin 5, and P-cadherin: three molecular markers to distinguish basal phenotype in breast carcinomas
    • Matos I, Dufloth R, Alvarenga M, Zeferino LC, Schmitt F (2005) p63, cytokeratin 5, and P-cadherin: three molecular markers to distinguish basal phenotype in breast carcinomas. Virchows Arch 447: 688-694.
    • (2005) Virchows Arch , vol.447 , pp. 688-694
    • Matos, I.1    Dufloth, R.2    Alvarenga, M.3    Zeferino, L.C.4    Schmitt, F.5
  • 38
    • 16844386318 scopus 로고    scopus 로고
    • IGFBP-3 is a direct target of transcriptional regulation by DeltaNp63alpha in squamous epithelium
    • Barbieri CE, Perez CA, Johnson KN, Ely KA, Billheimer D, Pietenpol JA (2005) IGFBP-3 is a direct target of transcriptional regulation by DeltaNp63alpha in squamous epithelium. Cancer Res 65: 2314-2320.
    • (2005) Cancer Res , vol.65 , pp. 2314-2320
    • Barbieri, C.E.1    Perez, C.A.2    Johnson, K.N.3    Ely, K.A.4    Billheimer, D.5    Pietenpol, J.A.6
  • 39
    • 80051789515 scopus 로고    scopus 로고
    • p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53
    • Melino G (2011) p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53. Cell Death Differ 18: 1487-1499.
    • (2011) Cell Death Differ , vol.18 , pp. 1487-1499
    • Melino, G.1
  • 41
    • 0032161624 scopus 로고    scopus 로고
    • p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities
    • Yang A, Kaghad M, Wang Y, Gillett E, Fleming MD, Dotsch V, Andrews NC, Caput D, McKeon F (1998) p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell 2: 305-316.
    • (1998) Mol Cell , vol.2 , pp. 305-316
    • Yang, A.1    Kaghad, M.2    Wang, Y.3    Gillett, E.4    Fleming, M.D.5    Dotsch, V.6    Andrews, N.C.7    Caput, D.8    McKeon, F.9
  • 42
    • 34548336347 scopus 로고    scopus 로고
    • Estrogen-regulated gene networks in human breast cancer cells: involvement of E2F1 in the regulation of cell proliferation
    • Stender JD, Frasor J, Komm B, Chang KC, Kraus WL, Katzenellenbogen BS (2007) Estrogen-regulated gene networks in human breast cancer cells: involvement of E2F1 in the regulation of cell proliferation. Mol Endocrinol 21: 2112-2123.
    • (2007) Mol Endocrinol , vol.21 , pp. 2112-2123
    • Stender, J.D.1    Frasor, J.2    Komm, B.3    Chang, K.C.4    Kraus, W.L.5    Katzenellenbogen, B.S.6
  • 43
    • 63049112988 scopus 로고    scopus 로고
    • Estrogen receptor alpha represses transcription of early target genes via p300 and CtBP1
    • Stossi F, Madak-Erdogan Z, Katzenellenbogen BS (2009) Estrogen receptor alpha represses transcription of early target genes via p300 and CtBP1. Mol Cell Biol 29: 1749-1759.
    • (2009) Mol Cell Biol , vol.29 , pp. 1749-1759
    • Stossi, F.1    Madak-Erdogan, Z.2    Katzenellenbogen, B.S.3
  • 45
    • 79959672853 scopus 로고    scopus 로고
    • Reversal of endocrine resistance in breast cancer: interrelationships among 14-3-3zeta, FOXM1, and a gene signature associated with mitosis
    • Bergamaschi A, Christensen BL, Katzenellenbogen BS (2011) Reversal of endocrine resistance in breast cancer: interrelationships among 14-3-3zeta, FOXM1, and a gene signature associated with mitosis. Breast Cancer Res 13: R70.
    • (2011) Breast Cancer Res , vol.13
    • Bergamaschi, A.1    Christensen, B.L.2    Katzenellenbogen, B.S.3
  • 48
    • 77955629953 scopus 로고    scopus 로고
    • Genome-wide analysis of estrogen receptor alpha DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation
    • Stender JD, Kim K, Charn TH, Komm B, Chang KC, Kraus WL, Benner C, Glass CK, Katzenellenbogen BS (2010) Genome-wide analysis of estrogen receptor alpha DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation. Mol Cell Biol 30: 3943-3955.
    • (2010) Mol Cell Biol , vol.30 , pp. 3943-3955
    • Stender, J.D.1    Kim, K.2    Charn, T.H.3    Komm, B.4    Chang, K.C.5    Kraus, W.L.6    Benner, C.7    Glass, C.K.8    Katzenellenbogen, B.S.9
  • 49
    • 33747872417 scopus 로고    scopus 로고
    • Loss of p63 leads to increased cell migration and up-regulation of genes involved in invasion and metastasis
    • Barbieri CE, Tang LJ, Brown KA, Pietenpol JA (2006) Loss of p63 leads to increased cell migration and up-regulation of genes involved in invasion and metastasis. Cancer Res 66: 7589-7597.
    • (2006) Cancer Res , vol.66 , pp. 7589-7597
    • Barbieri, C.E.1    Tang, L.J.2    Brown, K.A.3    Pietenpol, J.A.4
  • 50
    • 70449562133 scopus 로고    scopus 로고
    • One billion years of p53/p63/p73 evolution
    • Belyi VA, Levine AJ (2009) One billion years of p53/p63/p73 evolution. Proc Natl Acad Sci U S A 106: 17609-17610.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 17609-17610
    • Belyi, V.A.1    Levine, A.J.2
  • 53
    • 0141785350 scopus 로고    scopus 로고
    • Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype
    • Frasor J, Danes JM, Komm B, Chang KC, Lyttle CR, Katzenellenbogen BS (2003) Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype. Endocrinology 144: 4562-4574.
    • (2003) Endocrinology , vol.144 , pp. 4562-4574
    • Frasor, J.1    Danes, J.M.2    Komm, B.3    Chang, K.C.4    Lyttle, C.R.5    Katzenellenbogen, B.S.6
  • 54
    • 1242338758 scopus 로고    scopus 로고
    • Selective estrogen receptor modulators: discrimination of agonistic versus antagonistic activities by gene expression profiling in breast cancer cells
    • Frasor J, Stossi F, Danes JM, Komm B, Lyttle CR, Katzenellenbogen BS (2004) Selective estrogen receptor modulators: discrimination of agonistic versus antagonistic activities by gene expression profiling in breast cancer cells. Cancer Res 64: 1522-1533.
    • (2004) Cancer Res , vol.64 , pp. 1522-1533
    • Frasor, J.1    Stossi, F.2    Danes, J.M.3    Komm, B.4    Lyttle, C.R.5    Katzenellenbogen, B.S.6
  • 55
    • 58249119436 scopus 로고    scopus 로고
    • GEMS (gene expression metasignatures), a web resource for querying meta-analysis of expression microarray datasets: 17β-estradiol in MCF-7 cells
    • Ochsner SA, Steffen DL, Hilsenbeck SG, Chen ES, Watkins C, McKenna NJ (2009) GEMS (gene expression metasignatures), a web resource for querying meta-analysis of expression microarray datasets: 17β-estradiol in MCF-7 cells. Cancer Res 69: 23-26.
    • (2009) Cancer Res , vol.69 , pp. 23-26
    • Ochsner, S.A.1    Steffen, D.L.2    Hilsenbeck, S.G.3    Chen, E.S.4    Watkins, C.5    McKenna, N.J.6
  • 56
    • 77956901498 scopus 로고    scopus 로고
    • The promise of microRNA replacement therapy
    • Bader AG, Brown D, Winkler M (2010) The promise of microRNA replacement therapy. Cancer Res 70: 7027-7030.
    • (2010) Cancer Res , vol.70 , pp. 7027-7030
    • Bader, A.G.1    Brown, D.2    Winkler, M.3
  • 57
    • 38949111440 scopus 로고    scopus 로고
    • MicroRNAs as prognostic indicators and therapeutic targets: potential effect on breast cancer management
    • Lowery AJ, Miller N, McNeill RE, Kerin MJ (2008) MicroRNAs as prognostic indicators and therapeutic targets: potential effect on breast cancer management. Clin Cancer Res 14: 360-365.
    • (2008) Clin Cancer Res , vol.14 , pp. 360-365
    • Lowery, A.J.1    Miller, N.2    McNeill, R.E.3    Kerin, M.J.4
  • 59
    • 77950470765 scopus 로고    scopus 로고
    • IKKepsilon phosphorylation of estrogen receptor alpha Ser-167 and contribution to tamoxifen resistance in breast cancer
    • Guo JP, Shu SK, Esposito NN, Coppola D, Koomen JM, Cheng JQ (2010) IKKepsilon phosphorylation of estrogen receptor alpha Ser-167 and contribution to tamoxifen resistance in breast cancer. J Biol Chem 285: 3676-3684.
    • (2010) J Biol Chem , vol.285 , pp. 3676-3684
    • Guo, J.P.1    Shu, S.K.2    Esposito, N.N.3    Coppola, D.4    Koomen, J.M.5    Cheng, J.Q.6
  • 60
    • 77958556047 scopus 로고    scopus 로고
    • Overexpression of DeltaNp63alpha induces a stem cell phenotype in MCF7 breast carcinoma cell line through the Notch pathway
    • Du Z, Li J, Wang L, Bian C, Wang Q, Liao L, Dou X, Bian X, Zhao RC (2010) Overexpression of DeltaNp63alpha induces a stem cell phenotype in MCF7 breast carcinoma cell line through the Notch pathway. Cancer Sci 101: 2417-2424.
    • (2010) Cancer Sci , vol.101 , pp. 2417-2424
    • Du, Z.1    Li, J.2    Wang, L.3    Bian, C.4    Wang, Q.5    Liao, L.6    Dou, X.7    Bian, X.8    Zhao, R.C.9
  • 61
    • 34250843675 scopus 로고    scopus 로고
    • The micro-ribonucleic acid (miRNA) miR-206 targets the human estrogen receptor-alpha (ERalpha) and represses ERalpha messenger RNA and protein expression in breast cancer cell lines
    • Adams BD, Furneaux H, White BA (2007) The micro-ribonucleic acid (miRNA) miR-206 targets the human estrogen receptor-alpha (ERalpha) and represses ERalpha messenger RNA and protein expression in breast cancer cell lines. Mol Endocrinol 21: 1132-1147.
    • (2007) Mol Endocrinol , vol.21 , pp. 1132-1147
    • Adams, B.D.1    Furneaux, H.2    White, B.A.3
  • 62
    • 48549099077 scopus 로고    scopus 로고
    • miR-206 Expression is down-regulated in estrogen receptor alpha-positive human breast cancer
    • Kondo N, Toyama T, Sugiura H, Fujii Y, Yamashita H (2008) miR-206 Expression is down-regulated in estrogen receptor alpha-positive human breast cancer. Cancer Res 68: 5004-5008.
    • (2008) Cancer Res , vol.68 , pp. 5004-5008
    • Kondo, N.1    Toyama, T.2    Sugiura, H.3    Fujii, Y.4    Yamashita, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.