MicroRNAs as prognostic indicators and therapeutic targets: Potential effect on breast cancer management

Clinical Cancer Research

Volumn 14, Issue 2, 2008, Pages 360-365

  Lowery, Aoife J ^a   Miller, Nicola ^a   McNeill, Roisin E ^a   Kerin, Michael J ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; SINGLE STRANDED RNA;

BREAST CANCER; BREAST CARCINOGENESIS; CELL FUNCTION; GENE EXPRESSION REGULATION; GENE MUTATION; GENE REPRESSION; GENE TARGETING; HUMAN; ONCOGENE; PRIORITY JOURNAL; PROGNOSIS; REVIEW; RNA CLEAVAGE; RNA TRANSLATION; TUMOR SUPPRESSOR GENE;

BREAST NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MESENCHYMAL STEM CELLS; MICRORNAS; NEOPLASTIC STEM CELLS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROGNOSIS;

EID: 38949111440     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-07-0992     Document Type: Review

References (50)

1. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2006. CA Cancer J Clin 2006;56:106-30.
2. Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993;75:843-54.
3. Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A, Enright AJ. miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res 2006;34:D140-4.
4. Berezikov E, Guryev V, van de Belt J, Wienholds E, Plasterk RH, Cuppen E. Phylogenetic shadowing and computational identification of human microRNA genes. Cell 2005;120:21-4.
5. Kim VN, Nam JW. Genomics of microRNA. Trends Genet 2006;22:165-73.
6. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism and function. Cell 2004;116:281-97.
7. Li SC, Tang P, Lin WC. Intronic microRNA: discovery and biological implications. DNA Cell Biol 2007;26:195-207.
8. Gregory RI, Chendrimada TP, Cooch N, Shiekhattar R. Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. Cell 2005;123:631-40.
9. Niwa R, Slack FJ. The evolution of animal microRNA function. Curr Opin Genet Dev 2007;17:145-50.
10. Jackson RJ, Standart N. How do microRNAs regulate gene expression? Sci STKE 2007;2007:re1.
11. Kloosterman WP, Wienholds E, Ketting RF, Plasterk RH. Substrate requirements for let-7 function in the developingz ebrafish embryo. Nucleic Acids Res 2004;32:6284-91.
12. Tomari Y, Zamore PD. Perspective: machines for RNAi. Genes Dev 2005;19:517-29.
13. Petersen CP, Bordeleau ME, Pelletier J, Sharp PA. Short RNAs repress translation after initiation in mammalian cells. Mol Cell 2006;21:533-42.
14. Humphreys DT, Westman BJ, Martin DI, Preiss T. MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function. Proc Natl Acad Sci U S A 2005;102:16961-6.
15. Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R. MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nat Cell Biol 2005;7:719-23.
16. Giraldez AJ, Mishima Y, Rihel J, et al. Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs. Science 2006;312:75-9.
17. Mattick JS, Makunin IV. Non-coding RNA. Hum Mol Genet 2006;15 Spec No 1:R17-29.
18. Chuang JC, Jones PA. Epigenetics and microRNAs. Pediatr Res 2007;61:24-9R.
19. Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005;120:15-20.
20. Bentwich I, Avniel A, Karov Y, et al. Identification of hundreds of conserved and nonconserved human microRNAs. Nat Genet 2005;37:766-70.
21. Wang X, Wang X. Systematic identification of micro-RNA functions by combining target prediction and expression profiling. Nucleic Acids Res 2006;34:1646-52.
22. Calin GA, Dumitru CD, Shimizu M, et al. Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 2002;99:15524-9.
23. Castoldi M, Schmidt S, Benes V, et al. A sensitive array for microRNA expression profiling (miChip) based on locked nucleic acids (LNA). RNA 2006;12:913-20.
24. Abbott AL, Alvarez-Saavedra E, Miska EA, et al. The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans. Dev Cell 2005;9:403-14.
25. Lu J, Getz G, Miska EA, et al. MicroRNA expression profiles classify human cancers. Nature 2005;435:834-8.
26. Lao K, Xu NL, Yeung V, Chen C, Livak KJ, Straus NA. Multiplexing RT-PCR for the detection of multiple miRNA species in small samples. Biochem Biophys Res Commun 2006;343:85-9.
27. Hutvagner G, Simard MJ, Mello CC, Zamore PD. Sequence-specific inhibition of small RNA function. PLoS Biol 2004;2:E98.
28. Meister G, Landthaler M, Dorsett Y, Tuschl T. Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing. RNA 2004;10:544-50.
29. Boutla A, Delidakis C, Tabler M. Developmental defects by antisense-mediated inactivation of micro-RNAs 2 and 13 in Drosophila and the identification of putative target genes. Nucleic Acids Res 2003;31:4973-80.
30. Orom UA, Kauppinen S, Lund AH. LNA-modified oligonucleotides mediate specific inhibition of micro-RNA function. Gene 2006;372:137-41.
31. Si ML, Zhu S, Wu H, Lu Z, Wu F, Mo YY. miR-21-mediated tumor growth. Oncogene 2007;26:2799-803.
32. Krutzfeldt J, Rajewsky N, Braich R, et al. Silencing of microRNAs in vivo with 'antagomirs'. Nature 2005;438:685-9.
33. Calin GA, Sevignani C, Dumitru CD, et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci U S A 2004;101:2999-3004.
34. Negrini M, Rasio D, Hampton GM, et al. Definition and refinement of chromosome 11 regions of loss of heterozygosity in breast cancer: identification of a new region at 11q23.3. Cancer Res 1995;55:3003-7.
35. Makiyama K, Hamada J, Takada M, et al. Aberrant expression of HOX genes in human invasive breast carcinoma. Oncol Rep 2005;13:673-9.
36. Iorio MV, Ferracin M, Liu CG, et al. MicroRNA gene expression deregulation in human breast cancer. Cancer Res 2005;65:7065-70.
37. Mattie MD, Benz CC, Bowers J, et al. Optimized high-throughput microRNA expression profiling provides novel biomarker assessment of clinical prostate and breast cancer biopsies. Mol Cancer 2006;5:24.
38. Lowery AJ, Miller N, McNeill RE, Kerin MJ. Micro-RNA expression profiling in primary breast tumours [abstract]. Eur J Cancer 2007;5 Suppl 3.
39. Potti A, Dressman HK, Bild A, et al. Genomic signatures to guide the use of chemotherapeutics. Nat Med 2006;12:1294-300.
40. Sorlie T, Perou CM, Tibshirani R, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A 2001;98:10869-74.
41. Hossain A, Kuo MT, Saunders GF. Mir-17-5p regulates breast cancer cell proliferation by inhibiting translation of AIB1 mRNA. Mol Cell Biol 2006;5:24.
42. Adams BD, Furneaux Dagger H, White B. The micro-ribonucleic acid (miRNA) miR-206 targets the human estrogen receptor-α (ERα), and represses ERα messenger RNA and protein expression in breast cancer cell lines. Mol Endocrinol 2007;2:1132-47.
43. Scott GK, Goga A, Bhaumik D, Berger CE, Sullivan CS, Benz CC. Coordinate suppression of ERBB2 and ERBB3 by enforced expression of microRNA miR-125a or miR-125b. J Biol Chem 2007;282:1479-86.
44. Saito Y, Liang G , Egger G, et al. Specific activation of microRNA-127 with downregulation of the protooncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell 2006;9:435-43.
45. Clarke MF, Dick JE, Dirks PB, et al. Cancer stem cells - perspectives on current status and future directions: AACR Workshop on Cancer Stem Cells. Cancer Res 2006;66:9339-44.
46. Suh MR, Lee Y, Kim JY, et al. Human embryonic stem cells express a unique set of microRNAs. Dev Biol 2004;270:488-98.
47. Bernstein E, Kim SY, Carmell MA, et al. Dicer is essential for mouse development. Nat Genet 2003;35:215-7.
48. Kanellopoulou C, Muljo SA, Kung AL, et al. Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev 2005;19:489-501.
49. Hatfield SD, Shcherbata HR, Fischer KA, Nakahara K, Carthew RW, Ruohola-Baker H. Stem cell division is regulated by the microRNA pathway. Nature 2005;435:974-8.
50. Dwyer RM, Potter SM, Harrington KA, et al. Monocyte chemotactic protein-1 (MCP-1) secreted by primary breast tumours stimulates migration of mesenchymal stem cells (MSCs). Clin Cancer Res 2007;13:5020-7.