Non-linear kinetic modelling of reversible bioconversions: Application to the transaminase catalyzed synthesis of chiral amino-alcohols

Biochemical Engineering Journal

Volumn 73, Issue , 2013, Pages 38-48

  Rios Solis, L ^a   Bayir, N ^a   Halim, M ^a   Du, C ^a   Ward, J M ^a   Baganz, F ^a   Lye, G J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Amino alcohols; Microscale high throughput; Nonlinear kinetic modelling; Reaction mechanism selection; Reversible bioconversions; Transaminase

Indexed keywords

AMINO DONORS; APPARENT KINETIC PARAMETERS; ASYMMETRIC SYNTHESIS; BI-BI MECHANISMS; BIOCONVERSION PROCESS; CATALYZED SYNTHESIS; CHROMOBACTERIUM VIOLACEUM; COFACTORS; DEAD-END COMPLEX; DESIGN AND OPTIMIZATION; E. COLI; ENZYME COMPLEXES; EXPERIMENTAL PLATFORM; GLOBAL MINIMA; HALF REACTIONS; HIGH-THROUGHPUT; HYBRID METHODOLOGIES; INHIBITION EFFECT; INITIAL RATE; KINETIC MODELS; METHYLBENZYLAMINE; MICHAELIS CONSTANTS; MICRO-SCALES; NON-LINEAR REGRESSION METHOD; NONLINEAR KINETICS; PING PONG; REACTION CONDITIONS; REACTION MECHANISM; STATISTICAL EVALUATION; SYSTEMATIC METHODOLOGY; TRANSAMINASE; WHOLE CELL; WHOLE CELL BIOCATALYSTS;

AMINO ALCOHOLS; EQUILIBRIUM CONSTANTS; ESCHERICHIA COLI; EXPERIMENTS; KINETIC PARAMETERS; KINETIC THEORY; PARAMETER ESTIMATION; RATE CONSTANTS; REGRESSION ANALYSIS; SUBSTRATES; TOXICITY;

BIOCONVERSION;

ALPHA METHYLBENZYLAMINE; AMINOALCOHOL; AMINOTRANSFERASE;

ARTICLE; BIOCATALYST; BIOTRANSFORMATION; CATALYSIS; CHEMICAL STRUCTURE; CHIRALITY; CHROMOBACTERIUM VIOLACEUM; ENZYME KINETICS; ENZYME STABILITY; EQUILIBRIUM CONSTANT; ESCHERICHIA COLI; HYBRID; NONLINEAR SYSTEM; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SYNTHESIS;

EID: 84874428634     PISSN: 1369703X     EISSN: 1873295X     Source Type: Journal    
DOI: 10.1016/j.bej.2013.01.010     Document Type: Article

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