An efficient approach to bioconversion kinetic model generation based on automated microscale experimentation integrated with model driven experimental design

Chemical Engineering Science

Volumn 64, Issue 2, 2009, Pages 403-409

  Chen, B H ^a   Micheletti, M ^a   Baganz, F ^a   Woodley, J M ^b   Lye, G J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

Automation; Biocatalysis; Biochemical engineering; Kinetics; Mathematical modelling; Microscale bioprocessing; Transketolase

Indexed keywords

AUTOMATION; BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; BIOCONVERSION; DESIGN; DISPERSIONS; ENZYME KINETICS; ENZYMES; EXPERIMENTS; KINETIC PARAMETERS; KINETIC THEORY; MICROCHANNELS; PROCESS ENGINEERING; REACTION RATES; STATISTICS; SYNTHESIS (CHEMICAL);

ASYMMETRIC SYNTHESES; BIOCATALYSIS; BIOCONVERSION PROCESSES; CHIRAL INTERMEDIATES; ERYTHRULOSE; EXPERIMENTAL DATUMS; EXPERIMENTAL DESIGNS; KINETIC EXPRESSIONS; KINETIC MODELS; MATERIAL REQUIREMENTS; MATHEMATICAL MODELLING; MICROSCALE BIOPROCESSING; MODEL DRIVEN; MODEL PREDICTIONS; PHARMACEUTICAL SYNTHESES; RELIABLE MODELS; TIME CONSUMING; TRANSKETOLASE;

MATHEMATICAL MODELS;

EID: 57649233931     PISSN: 00092509     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ces.2008.09.030     Document Type: Article

References (27)

1. Blackmond D.G. Reaction progress kinetic analysis: a powerful methodology for mechanistic studies of complex catalytic reactions. Angewandte Chemie-International Edition 44 (2005) 4302-4320
2. Blanch H.W., and Clark D.S. Biochemical Engineering (1997), M. Dekker, New York
3. Chen B.H., Baganz F., and Woodley J.M. Modelling and optimisation of a transketolase mediated carbon-carbon bond formation reaction. Chemical Engineering Science 62 (2007) 3178-3184
4. Chen B.H., Hibbert E.G., Dalby P.A., and Woodley J.M. A new approach to bioconversion reaction kinetic parameter identification. American Institution of Chemical Engineers Journal 54 (2008) 2155-2163
5. Doig S.D., Pickering S.C.R., Lye G.J., and Baganz F. Modelling surface aeration rates in shaken microtitre plates using dimensionless groups. Chemical Engineering Science 60 10 (2005) 2741-2750
6. Duetz W.A., Ruedi L., Hermann R., O'Connor K., Buchs J., and Witholt B. Methods for intense aeration, growth, storage, and replication of bacterial strains in microtiter plates. Applied and Environmental Microbiology 66 6 (2000) 2641-2646
7. Ferreira-Torres C., Micheletti M., and Lye G.J. Microscale process evaluation of recombinant biocatalyst libraries: application to Baeyer-Villiger monooxygenase catalysed lactone synthesis. Bioprocess Biosystems Engineering 28 (2005) 83-93
8. Gyamerah M., and Willetts A.J. Kinetics of overexpressed transketolase from Escherichia coli JM 107/pQR 700. Enzyme and Microbial Technology 20 (1997) 127-134
9. Hermann R., Lehmann M., and Buchs J. Characterization of gas-liquid mass transfer phenomena in microtiter plates. Biotechnology and Bioengineering 81 2 (2003) 178-186
10. Hibbert E.G., Senussi T., Costelloe S.J., Lei W., Smith M.E.B., Ward J.M., Hailes H.C., and Dalby P.A. Directed evolution of transketolase activity on non-phosphorylated substrates. Journal of Biotechnology 131 (2007) 425-432
11. Hobbs, G., 1994. The production and use of transketolase as a catalyst for carbon-carbon bond formation. Ph.D. Thesis, University College London, London, UK.
12. Islam R.S., Tisi D., Levy M.S., and Lye G.J. Framework for the rapid optimization of soluble protein expression in Escherichia coli combining microscale experiments and statistical experimental design. Biotechnology Progress 23 (2007) 785-793
13. La. Biotechnology and Bioengineering 99 (2008) 1128-1139
14. John G.T., and Heinzle E. Quantitative screening method for hydrolases in microplates using pH indicators: determination of kinetic parameters by dynamic pH monitoring. Biotechnology and Bioengineering 72 6 (2001) 620-627
15. Law H.E.M., Baldwin C.V.F., Chen B.H., and Woodley J.M. Process limitations in a whole-cell catalysed oxidation: sensitivity analysis. Chemical Engineering Science 61 (2006) 6646-6652
16. Lye G.J., Dalby P.A., and Woodley J.M. Better biocatalytic processes faster: new tools for the implementation of biocatalysis in organic synthesis. Organic Process Research and Development 6 (2002) 434-440
17. Lye G.J., Shamlou P.A., Baganz F., Dalby P.A., and Woodley J.M. Accelerated design of bioconversion processes using automated microscale processing techniques. Trends in Biotechnology 21 (2003) 29-37
18. Micheletti M., Barrett T., Doig S.D., Baganz F., Levy M.S., Woodley J.M., and Lye G.J. Fluid mixing in shaken bioreactors: implications for scale-up predictions from microlitre scale microbial and mammalian cell cultures. Chemical Engineering Science 61 (2006) 2939-2949
19. Micheletti M., and Lye G.J. Microscale bioprocess optimisation. Current Opinion in Biotechnology 17 (2006) 611-618
20. Miller O.J., Hibbert E.G., Ingram C.U., Lye G.J., and Dalby P.A. Optimisation and statistical evaluation of a generic high-throughput screen for transketolase. Biotechnology Letters 29 (2007) 1759-1770
21. Nealon A.J., Willson K.E., Pickering S.C.R., Clayton T.M., O'Kennedy R., Titchener-Hooker N.J., and Lye G.J. Use of operating windows in the assessment of integrated robotic systems for the measurement of bioprocess kinetics. Biotechnology Progress 21 (2005) 283-291
22. Pollard D.J., and Woodley J.M. Biocatalysis for pharmaceutical intermediates: the future is now. Trends in Biotechnology 25 (2007) 66-73
23. Rozzell J.D. Commercial scale biocatalysis: myths and realities. Bioorganic & Medicinal Chemistry 7 10 (1999) 2253-2261
24. Vasic-Racki D., Bongs J., Schorken U., Sprenger G.A., and Liese A. Modeling of reaction kinetics for reactor selection in the case of L-erythrulose synthesis. Bioprocess and Biosystems Engineering 25 (2003) 285-290
25. Weiss S., John G.T., Klimant I., and Heinzle E. Modeling of mixing in 96-well microplates observed with fluorescence indicators. Biotechnology Progress 18 4 (2002) 821-830
26. Yazbeck D.R., Martinez C.A., Hu S.H., and Tao J.H. Challenges in the development of an efficient enzymatic process in the pharmaceutical industry. Tetrahedron-Asymmetry 15 18 (2004) 2757-2763
27. Zhang H., Lamping S.R., Pickering S.C.R., Lye G.J., and Shamlou P.A. Engineering characterisation of a single well from 24- and 96-well microtitre plates. Biochemical Engineering Journal 40 (2008) 138-149