The antinociceptive effect of milnacipran in the monosodium iodoacetate model of osteoarthritis pain and its relation to changes in descending inhibition

Journal of Pharmacology and Experimental Therapeutics

Volumn 344, Issue 3, 2013, Pages 696-707

  Burnham, Liam J ^a   Dickenson, Anthony H ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 [2 [2 (4 METHYL 1 PIPERIDINYL)ETHYL] 1 PYRROLIDINESULFONYL]PHENOL; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR; ATIPAMEZOLE; IODOACETIC ACID; MILNACIPRAN; NALOXONE; OPIATE RECEPTOR; SB 2699670; SEROTONIN 7 RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTHRALGIA; ARTICLE; BRAIN ELECTROPHYSIOLOGY; CELL ACTIVITY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE CONTROL; DISEASE COURSE; DISEASE MODEL; DRUG EFFICACY; DRUG MEGADOSE; EVOKED RESPONSE; IN VIVO STUDY; LOW DRUG DOSE; MALE; MECHANICAL STIMULATION; MONOTHERAPY; NERVE CELL INHIBITION; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SYNTHESIS INHIBITION; RAT; RECEPTOR BLOCKING; SPINAL CORD DORSAL HORN; SPINAL CORD NERVE CELL;

ADRENERGIC ALPHA-2 RECEPTOR ANTAGONISTS; ADRENERGIC NEURONS; ANALGESICS; ANIMALS; BEHAVIOR, ANIMAL; CHRONIC PAIN; CYCLOPROPANES; IMIDAZOLES; MALE; NALOXONE; NOREPINEPHRINE; OSTEOARTHRITIS; POSTERIOR HORN CELLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID; RECEPTORS, SEROTONIN; SEROTONERGIC NEURONS; SEROTONIN; SEROTONIN ANTAGONISTS; SEROTONIN UPTAKE INHIBITORS; SPINAL CORD;

EID: 84874416214     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.112.199489     Document Type: Article

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