Monoamine-dependent, opioid-independent antihypersensitivity effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a postoperative pain model in rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 334, Issue 3, 2010, Pages 1059-1065

  Obata, Hideaki ^a   Kimura, Masafumi ^a   Nakajima, Kunie ^a   Tobe, Masaru ^a   Nishikawa, Koichi ^a   Saito, Shigeru ^a  

^a GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINOCICEPTIVE AGENT; ATROPINE; IDAZOXAN; METHYSERGIDE; MILNACIPRAN; MORPHINE; NALOXONE; NORADRENALIN; SEROTONIN; SEROTONIN NORADRENALIN REUPTAKE INHIBITOR; ADRENERGIC RECEPTOR AFFECTING AGENT; BIOGENIC AMINE; CYCLOPROPANE DERIVATIVE; MU OPIATE RECEPTOR; NARCOTIC ANALGESIC AGENT; OPIATE RECEPTOR;

ABNORMAL BEHAVIOR; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG POTENTIATION; HYPERALGESIA; MALE; MICRODIALYSIS; NONHUMAN; POSTOPERATIVE PAIN; PRIORITY JOURNAL; RAT; SPINAL CORD; SPINAL CORD DORSAL HORN; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; COMPLICATION; DRUG EFFECTS; DRUG INTERACTION; FOOT INJURY; METABOLISM; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ADRENERGIC UPTAKE INHIBITORS; ANALGESICS, OPIOID; ANIMALS; BEHAVIOR, ANIMAL; BIOGENIC MONOAMINES; CYCLOPROPANES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FOOT INJURIES; HYPERALGESIA; MALE; MICRODIALYSIS; MORPHINE; NOREPINEPHRINE; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID; RECEPTORS, OPIOID, MU; SEROTONIN; SPINAL CORD;

EID: 77956259081     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.110.168336     Document Type: Article

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