Targeted drug delivery to renal proximal tubule epithelial cells mediated by 2-glucosamine

Journal of Controlled Release

Volumn 167, Issue 2, 2013, Pages 148-156

  Lin, Yan ^a   Li, Yanping ^a   Wang, Xiaohong ^a   Gong, Tao ^a   Zhang, Ling ^b   Sun, Xun ^a  

^a SICHUAN UNIVERSITY   (China)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Glucosamine; Kidney targeting; Megalin; Prednisolone; Uptake

Indexed keywords

INTRAVENOUS INJECTIONS; ISCHEMIA REPERFUSION; KIDNEY-TARGETING; MEGALIN; PREDNISOLONE; TARGETED DRUG DELIVERY; TARGETING EFFICACIES; UPTAKE;

DRUG DELIVERY; LIGANDS;

GLUCOSAMINE;

2 GLUCOSAMINE; CARBAMIC ACID; GLUCOSAMINE DERIVATIVE; MEGALIN; PREDNISOLONE; PREDNISOLONE CARBAMATE GLUCOSAMINE CONJUGATE; PREDNISOLONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; CONJUGATE; CONTROLLED STUDY; DISEASE COURSE; DISEASE MODEL; DRUG DELIVERY SYSTEM; DRUG UPTAKE; EPITHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; KIDNEY PROXIMAL TUBULE; MALE; MOUSE; NONHUMAN; OSTEOPOROSIS; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SINGLE DRUG DOSE;

ACUTE KIDNEY INJURY; ANIMALS; ANTI-INFLAMMATORY AGENTS; BONE DENSITY; CARBAMATES; CELL LINE; EPITHELIAL CELLS; GLUCOSAMINE; HUMANS; KIDNEY TUBULES, PROXIMAL; MALE; PREDNISOLONE; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; TISSUE DISTRIBUTION;

EID: 84874397955     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.02.001     Document Type: Article

References (28)

1. L.X. Zhang, F. Wang, L. Wang, W.K. Wang, and B.C. Liu Prevalence of chronic kidney disease in china a cross-sectional survey Lancet 379 2012 815 822
2. K.H. Choi, S.K. Kim, J.I. Moon, Y.S. Kim, H.Y. Lee, D.S. Han, and K. Park Renal replacement therapies in the elderly: renal transplantation and continuous ambulatory peritoneal dialysis Transplant. Proc. 32 2000 1814
3. M.E.M. Dolman, S. Harmsen, G. Storm, W.E. Hennink, and R.J. Kok Drug targeting to the kidney: advances in the active targeting of therapeutics to proximal tubular cells Adv. Drug Deliv. Rev. 62 2010 1344 1357
4. H. Kodaira, Y. Tsutsumi, Y. Yoshioka, H. Kamada, Y. Kaneda, Y. Yamamoto, S. Tsunoda, T. Okamoto, Y. Mukai, H. Shibata, S. Nakagawa, and T. Mayumi The targeting of anionized polyvinylpyrrolidone to the renal system Biomaterials 25 2004 4309 4315
5. T. Okamoto, S. Nakagawa, and Y. Tsutsumi The optimal molecular design of poly meric drug carriers and its application for renal drug targeting Gene Ther. Mol. Biol. 8 2004 221 230
6. R.F. Haverdings, M. Haas, A.R. Greupink, P.A. de Vries, F. Moolenaar, D. de Zeeuw, and D.K. Meijer Potentials and limitations of the low-molecular-weight protein lysozyme as a carrier for renal drug targeting Ren. Fail. 23 2001 397 409
7. Z.R. Zhang, Q. Zheng, J. Han, G. Gao, J. Liu, T. Gong, Y. Huang, X. Sun, and Q. He The targeting of 14-succinate triptolide-lysozyme conjugate to proximal renal tubular epithelial cells Biomaterials 30 2009 1372 1381
8. E.J. Franssen, J. Koiter, C.A. Kuipers, A.P. Bruins, F. Moolenaar, D. de Zeeuw, W.H. Kruizing, R.M. Kellogg, and D.K. Meijer Low molecular weight proteins as carriers for renal drug targeting. Preparation of drug-protein conjugates and drug-spacer derivatives and their catabolism in renal cortex homogenates and lysosomal lysates J. Med. Chem. 35 1992 1246 1259
9. H. Kamada, Y. Tsutsumi, K. Sato-Kamada, Y. Yamamoto, Y. Yoshioka, T. Okamoto, S. Nakagawa, S. Nagata, and T. Mayumi Synthesis of a poly (vinylpyrrolidone-co-dimethyl maleic anhydride) copolymer and its application as renal targeting carrier Nat. Biotechnol. 21 2003 399 404
10. Z.X. Yuan, X. Sun, T. Gong, H. Ding, Y. Fu, and Z.R. Zhang Randomly 50% N-acetylated low molecular weight chitosan as a novel renal targeting carrier J. Drug Target. 15 2007 269 278
11. J.W. Anderson, R.J. Nicolosi, and J.F. Borzelleca Glucosamine effects in humans: a review of effects on glucose metabolism, side effects, safety considerations and efficacy Food Chem. Toxicol. 43 2005 187 201
12. J.D. Adachi Glucocorticoid-induced osteoporosis Osteoporos. Int. 20 2009 239 240
13. R.S. Weinstein Glucocorticoid-induced osteoporosis Rev. Endocr. Metab. Disord. 2 2001 65 73
14. A. Medgyes, E. Farkas, A. Lipták, and V. Pozsgay Synthesis of the monosaccharide units of the O-specific polysaccharide of Shigella sonnei Tetrahedron 53 1997 4159 4178
15. D. Wulf, C. Julio, P. Castro, and M. Leonardo N-Trichloroethoxy-carbonyl- glucosamine derivatives as glycosyl donors Carbohydr. Res. 296 1996 135 147
16. S.K. Moestrup, S. Cui, H. Vorum, C. Bregengård, S.E. Bjørn, K. Norris, J. Gliemann, and E.I. Christensen Evidence that epithelial glycoprotein 330/megalin dediates uptake of polybasic drugs J. Clin. Invest. 96 1995 1404 1413
17. A.D. Kirk Location, location, location: regional immune mechanisms critically influence rejection Nat. Med. 8 2002 553 555
18. G. Castellano, V. Cappiello, N. Fiore, P. Pontrelli, L. Gesualdo, F.P. Schena, and V. Montinaro CD40 ligand increases complement C3 secretion by proximal tubular epithelial cells J. Am. Soc. Nephrol. 16 2005 2003 2011
19. K. Li, H. Patel, C.A. Farrar, R.E.G. Hargreaves, S.H. Sacks, and W.D. Zhou Complement activation regulates the capacity of proximal tubular epithelial cell to stimulate alloreactive T cell response J. Am. Soc. Nephrol. 15 2004 2414 2422
20. Z.X. Yuan, Z.R. Zhang, D. Zhu, X. Sun, T. Gong, J. Liu, and C.T. Luan Specific renal uptake of randomly 50% N-acetylated low molecular weight chitosan Mol. Pharmaceutics 6 2009 305 314
21. J. Nagai, H. Tanaka, N. Nakanishi, T. Murakami, and M. Takano Role of megalin in renal handling of aminoglycosides Am. J. Physiol. Renal Physiol. 281 2001 F337 F344
22. C. Schmitz, J. Hilpert, C. Jacobsen, C. Boensch, E.I. Christensen, F.C. Luft, and T.E. Willnow Megalin deficiency offers protection from renal aminoglycoside accumulation J. Biol. Chem. 27 2002 618 622
23. J. Rautio, H. Kumpulainen, T. Heimbach, and R. Oliyai Prodrugs: design and clinical applications Nat. Rev. Drug Discov. 7 2008 255 270
24. J. Prakash, M.H. de Borst, M. Lacombe, F. Opdam, P.A. Klok, H. van Goor, D.K. Meijer, F. Moolenaar, K. Poelstra, and R.J. Kok Inhibition of renal Rho kinase attenuates ischemia/reperfusion-induced injury J. Am. Soc. Nephrol. 19 2008 2086 2097
25. D.D.H. Koo, and S.V. Fuggle Impact of ischemia/reperfusion injury and early inflammatory responses in kidney transplantation Transplant. Rev. 14 2000 210 224
26. J.M. Thurman, P.A. Royer, D. Ljubanovic, B. Dursun, A.M. Lenderink, C.L. Edelstein, and V.M. Holers Treatment with an inhibitory monoclonal antibody to mouse factor B protects mice from induction of apoptosis and renal ischemia/reperfusion injury J. Am. Soc. Nephrol. 17 2006 707 715
27. Y. Hideki, H. Fumitoshi, K. Makoto, A. Hidetoshi, and U. Kaneto Colon-specific delivery of prednisolone-appended α-cyclodextrin conjugate: alleviation of systemic side effect after oral administration J. Control Release 79 2002 103 112
28. P. Pennisi, M.A. D'Alcamo, C. Leonetti, A. Clementi, V.M. Cutuli, S. Riccobene, N. Parisi, and C.E. Fiore Supplementation of l-arginine prevents glucocorticoid-induced reduction of bone growth and bone turnover abnormalities in a growing rat model J. Bone Miner. Metab. 23 2005 134 139