Amiloride disrupts NaCl versus KCl discrimination performance: Implications for salt taste coding in rats

Journal of Neuroscience

Volumn 16, Issue 24, 1996, Pages 8115-8122

  Spector, Alan C ^a   Guagliardo, Nick A ^a   St John, Steven J ^a  

^a University of Florida ^*  (United States)

Author keywords

amiloride; discrimination learning; gustatory system; KCl; NaCl; psychophysics; salt; sensory coding; taste transduction

Indexed keywords

AMILORIDE; POTASSIUM CHLORIDE; SODIUM CHANNEL AFFECTING AGENT; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DISCRIMINATION LEARNING; GUSTATORY SYSTEM; MALE; NONHUMAN; PRIORITY JOURNAL; PSYCHOPHYSICS; RAT; TASTE DISCRIMINATION;

EID: 0029852337     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.16-24-08115.1996     Document Type: Article

References (29)

1. Avenet P, Lindemann B (1991) Noninvasive recording of receptor cell action potentials and sustained currents from single taste buds maintained in the tongue: the response to mucosal NaCl and amiloride. J Membr Biol 124:33-41.
2. Bernstein IL, Hennessy CJ (1987) Amiloride-sensitive sodium channels and expression of sodium appetite in rats. Am J Physiol 253:R371-R374.
3. Boudreau JC, Hoang NK, Oravec J, Do LT (1983) Rat neurophysiological taste responses to salt solutions. Chem Senses 8:131-150.
4. Brand JG, Teeter JH, Silver WL (1985) Inhibition by amiloride of chorda tympani responses evoked by monovalent salts. Brain Res 334:207-214.
5. Contreras RJ, Studley JL (1994) Amiloride alters lick rate responses to NaCl and KCl in rats. Chem Senses 19:219-229.
6. DeSimone JA, Ferrell F (1985) Analysis of amiloride inhibition of chorda tymapni taste response of rat to NaCl. Am J Physiol 249:R52-R61.
7. Formaker BK, Hill DL (1991) Lack of amiloride sensitivity in SHR and WKY glossopharyngeal taste responses to NaCl. Physiol Behav 50:765-769.
8. Frank ME, Contreras RJ, Hettinger TP (1983) Nerve fibers sensitive to ionic taste stimuli in chorda tympani of the rat. J Neurophysiol 50:941-960.
9. Gilbertson TA, Avenet P, Kinnamon SC, Roper SD (1992) Proton currents through amiloride-sensittve Na channels in hamster taste cells: role in acid transduction. J Gen Physiol 100:803-824.
10. Heck GI, Mierson S, DeSimone JA (1984) Salt taste transduction occurs through an amiloride-sensitive sodium transport pathway. Science 223:403-405.
11. Hellekant G, Dubois GE, Roberts TW, van der Wel H (1988) On the gustatory effect of amiloride in the monkey (Macaca mulatta). Chem Senses 13:89-93.
12. Herness MS (1987) Effect of amiloride on bulk flow and iontophoretic taste stimuli. J Comp Physiol [A] 160:281-288.
13. Hettinger TP, Frank ME (1990) Specificity of amiloride inhibition of hamster taste responses. Brain Res 513:24-34.
14. Hill DL, Formaker BK, White KS (1990) Perceptual characteristics of the amiloride-suppressed sodium chloride taste response in the rat. Behav Neurosci 104:734-741.
15. Markison S, Spector AC (1996) Amiloride is an ineffective conditioned stimulus in taste aversion learning. Chem Senses 20:559-563.
16. McCutcheon NB (1991) Sodium deficient rats are unmotivated by sodium chloride solutions mixed with the sodium channel blocker amiloride. Behav Neurosci 105:764-766.
17. Miller IJ (1977) Gustatory receptors of the palate. In: Food intake and chemical senses (Katsuki Y, Sato M, Takagi S, Oomura T, eds), pp 173-186. Tokyo: University of Tokyo.
18. +-specific channels exist in canine taste receptor membranes? Brain Res 524:42-48.
19. Nejad MS (1986) The neural activities of the greater superficial petrosal nerve of the rat in response to chemical stimulation of the palate. Chem Senses 11:283-293.
20. Ninomiya Y, Funakoshi M (1988) Amiloride inhibition of responses of rat single chorda tympani fibers to chemical and electrical tongue stimulations. Brain Res 451:319-325.
21. Nissenbaum JW, Sclafani A (1987) Qualitative differences in polysaccharide and sugar tastes in the rat: a two-carbohydrate taste model. Neurosci Biobehav Rev 11:187-196.
22. Smith DV, Hanamori T (1991) Organization of gustatory sensitivities in hamster superior laryngeal nerve fibers. J Neurophysiol 65:1098-1113.
23. Smith DV, Ossebaard CA (1995) Amiloride suppression of the taste intensity of sodium chloride: evidence from direct magnitude scaling. Physiol Behav 57:773-777.
24. Spector AC, Grill HJ (1988) Differences in the taste quality of maltose and sucrose in rats: issues involving the generalization of conditioned taste aversions. Chem Senses 13:95-113.
25. Spector AC, Grill HJ (1992) Salt taste discrimination after bilateral section of the chorda tympani or glossopharyngeal nerves. Am J Physiol 263:R169-R176.
26. Spector AC, Andrews-Labenski J, Letterio FC (1990) A new gustometer for psychophysical taste testing in the rat. Physiol Behav 47:795-803.
27. Spector AC, Markison S, St. John SJ, Garcea M (1996) Behavioral discrimination between sucrose and maltose by rats depends on the gustatory input of the seventh cranial nerve. Am J Physiol, in press.
28. St. John SJ, Markison S, Guagliardo NA, Hackenberg TD, Spector AC (1996) Chorda tympani nerve transection and selective desalivation differentially disrupt two-lever salt descrimination performance in rats. Behav Neurosci, in press.
29. Travers SP, Nicklas K (1990) Taste hud distribution in the rat pharynx and larynx. Anat Rec 227:373-379.