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Volumn 15, Issue 1, 2013, Pages

Metabolic biomarkers for response to PI3K inhibition in basal-like breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; 8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; BIOLOGICAL MARKER; GLUCOSE; GLYCEROPHOSPHORYLCHOLINE; LACTIC ACID; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHORYLCHOLINE; PROTEIN KINASE B; DACTOLISIB; FUSED HETEROCYCLIC RINGS; IMIDAZOLE DERIVATIVE; QUINOLINE DERIVATIVE; TARGET OF RAPAMYCIN KINASE;

EID: 84874358175     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr3391     Document Type: Article
Times cited : (43)

References (65)
  • 1
    • 57749092800 scopus 로고    scopus 로고
    • Triple-negative/basal-like breast cancer: review
    • Rakha EA, Ellis IO. Triple-negative/basal-like breast cancer: review. Pathology 2009, 41:40-47.
    • (2009) Pathology , vol.41 , pp. 40-47
    • Rakha, E.A.1    Ellis, I.O.2
  • 2
    • 34247569300 scopus 로고    scopus 로고
    • Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: a population-based study from the California cancer Registry
    • 10.1002/cncr.22618, 17387718
    • Bauer KR, Brown M, Cress RD, Parise CA, Caggiano V. Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: a population-based study from the California cancer Registry. Cancer 2007, 109:1721-1728. 10.1002/cncr.22618, 17387718.
    • (2007) Cancer , vol.109 , pp. 1721-1728
    • Bauer, K.R.1    Brown, M.2    Cress, R.D.3    Parise, C.A.4    Caggiano, V.5
  • 3
    • 78149483057 scopus 로고    scopus 로고
    • Triple-negative breast cancer
    • 10.1056/NEJMra1001389, 21067385
    • Foulkes WD, Smith IE, Reis-Filho JS. Triple-negative breast cancer. N Engl J Med 2010, 363:1938-1948. 10.1056/NEJMra1001389, 21067385.
    • (2010) N Engl J Med , vol.363 , pp. 1938-1948
    • Foulkes, W.D.1    Smith, I.E.2    Reis-Filho, J.S.3
  • 7
    • 67749122122 scopus 로고    scopus 로고
    • Targeting PI3K signalling in cancer: opportunities, challenges and limitations
    • 10.1038/nrc2664, 19629070
    • Engelman JA. Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev Cancer 2009, 9:550-562. 10.1038/nrc2664, 19629070.
    • (2009) Nat Rev Cancer , vol.9 , pp. 550-562
    • Engelman, J.A.1
  • 9
    • 80755127903 scopus 로고    scopus 로고
    • Mutations in the phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic implications in breast cancer
    • 10.1186/bcr3039, 3315683, 22114931
    • Miller TW, Rexer BN, Garrett JT, Arteaga CL. Mutations in the phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic implications in breast cancer. Breast Cancer Res 2011, 13:224. 10.1186/bcr3039, 3315683, 22114931.
    • (2011) Breast Cancer Res , vol.13 , pp. 224
    • Miller, T.W.1    Rexer, B.N.2    Garrett, J.T.3    Arteaga, C.L.4
  • 10
    • 84860217431 scopus 로고    scopus 로고
    • The functions and regulation of the PTEN tumour suppressor
    • 10.1038/nrg3199, 22473468
    • Song MS, Salmena L, Pandolfi PP. The functions and regulation of the PTEN tumour suppressor. Nat Rev Mol Cell Biol 2012, 13:283-296. 10.1038/nrg3199, 22473468.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 283-296
    • Song, M.S.1    Salmena, L.2    Pandolfi, P.P.3
  • 11
    • 80052397301 scopus 로고    scopus 로고
    • Exploiting tumor metabolism for non-invasive imaging of the therapeutic activity of molecularly targeted anticancer agents
    • 10.4161/cc.10.17.17192, 21857160
    • Beloueche-Babari M, Workman P, Leach MO. Exploiting tumor metabolism for non-invasive imaging of the therapeutic activity of molecularly targeted anticancer agents. Cell Cycle 2011, 10:2883-2893. 10.4161/cc.10.17.17192, 21857160.
    • (2011) Cell Cycle , vol.10 , pp. 2883-2893
    • Beloueche-Babari, M.1    Workman, P.2    Leach, M.O.3
  • 12
    • 79957527946 scopus 로고    scopus 로고
    • Metabolic effects of signal transduction inhibition in cancer assessed by magnetic resonance spectroscopy
    • 10.1016/j.molonc.2011.04.001, 21536506
    • Moestue S, Engebraaten O, Gribbestad IS. Metabolic effects of signal transduction inhibition in cancer assessed by magnetic resonance spectroscopy. Mol Oncol 2011, 5:224-241. 10.1016/j.molonc.2011.04.001, 21536506.
    • (2011) Mol Oncol , vol.5 , pp. 224-241
    • Moestue, S.1    Engebraaten, O.2    Gribbestad, I.S.3
  • 13
    • 67650165225 scopus 로고    scopus 로고
    • Metabolic transformation in cancer
    • 10.1093/carcin/bgp070, 19321800
    • Tennant DA, Duran RV, Boulahbel H, Gottlieb E. Metabolic transformation in cancer. Carcinogenesis 2009, 30:1269-1280. 10.1093/carcin/bgp070, 19321800.
    • (2009) Carcinogenesis , vol.30 , pp. 1269-1280
    • Tennant, D.A.1    Duran, R.V.2    Boulahbel, H.3    Gottlieb, E.4
  • 14
    • 58149136865 scopus 로고    scopus 로고
    • Roles of p53, MYC and HIF-1 in regulating glycolysis - the seventh hallmark of cancer
    • 10.1007/s00018-008-8224-x, 18766298
    • Yeung SJ, Pan J, Lee MH. Roles of p53, MYC and HIF-1 in regulating glycolysis - the seventh hallmark of cancer. Cell Mol Life Sci 2008, 65:3981-3999. 10.1007/s00018-008-8224-x, 18766298.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 3981-3999
    • Yeung, S.J.1    Pan, J.2    Lee, M.H.3
  • 17
    • 78649717890 scopus 로고    scopus 로고
    • Does the PI3K pathway play a role in basal breast cancer?
    • Moulder SL. Does the PI3K pathway play a role in basal breast cancer?. Clin Breast Cancer 2010, 10:S66.
    • (2010) Clin Breast Cancer , vol.10
    • Moulder, S.L.1
  • 19
    • 77954615408 scopus 로고    scopus 로고
    • MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo
    • 10.1158/1535-7163.MCT-09-1012, 20571069
    • Hirai H, Sootome H, Nakatsuru Y, Miyama K, Taguchi S, Tsujioka K, Ueno Y, Hatch H, Majumder PK, Pan BS, Kotani H. MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo. Mol Cancer Ther 2010, 9:1956-1967. 10.1158/1535-7163.MCT-09-1012, 20571069.
    • (2010) Mol Cancer Ther , vol.9 , pp. 1956-1967
    • Hirai, H.1    Sootome, H.2    Nakatsuru, Y.3    Miyama, K.4    Taguchi, S.5    Tsujioka, K.6    Ueno, Y.7    Hatch, H.8    Majumder, P.K.9    Pan, B.S.10    Kotani, H.11
  • 22
    • 36249024271 scopus 로고    scopus 로고
    • Phosphohistone H3 expression has much stronger prognostic value than classical prognosticators in invasive lymph node-negative breast cancer patients less than 55 years of age
    • 10.1038/modpathol.3800972, 17917671
    • Skaland I, Janssen EA, Gudlaugsson E, Klos J, Kjellevold KH, Soiland H, Baak JP. Phosphohistone H3 expression has much stronger prognostic value than classical prognosticators in invasive lymph node-negative breast cancer patients less than 55 years of age. Mod Pathol 2007, 20:1307-1315. 10.1038/modpathol.3800972, 17917671.
    • (2007) Mod Pathol , vol.20 , pp. 1307-1315
    • Skaland, I.1    Janssen, E.A.2    Gudlaugsson, E.3    Klos, J.4    Kjellevold, K.H.5    Soiland, H.6    Baak, J.P.7
  • 23
    • 32844456226 scopus 로고    scopus 로고
    • Comparison of HR MAS MR spectroscopic profiles of breast cancer tissue with clinical parameters
    • 10.1002/nbm.992, 16229059
    • Sitter B, Lundgren S, Bathen TF, Halgunset J, Fjosne HE, Gribbestad IS. Comparison of HR MAS MR spectroscopic profiles of breast cancer tissue with clinical parameters. NMR Biomed 2006, 19:30-40. 10.1002/nbm.992, 16229059.
    • (2006) NMR Biomed , vol.19 , pp. 30-40
    • Sitter, B.1    Lundgren, S.2    Bathen, T.F.3    Halgunset, J.4    Fjosne, H.E.5    Gribbestad, I.S.6
  • 25
    • 84855319821 scopus 로고    scopus 로고
    • 13C high-resolution-magic angle spinning MRS reveals differences in glucose metabolism between two breast cancer xenograft models with different gene expression patterns
    • 10.1002/nbm.1683, 21462378
    • Grinde MT, Moestue SA, Borgan E, Risa O, Engebraaten O, Gribbestad IS. 13C high-resolution-magic angle spinning MRS reveals differences in glucose metabolism between two breast cancer xenograft models with different gene expression patterns. NMR Biomed 2011, 24:1243-1252. 10.1002/nbm.1683, 21462378.
    • (2011) NMR Biomed , vol.24 , pp. 1243-1252
    • Grinde, M.T.1    Moestue, S.A.2    Borgan, E.3    Risa, O.4    Engebraaten, O.5    Gribbestad, I.S.6
  • 26
    • 77955523425 scopus 로고    scopus 로고
    • Distinct choline metabolic profiles are associated with differences in gene expression for basal-like and luminal-like breast cancer xenograft models
    • 10.1186/1471-2407-10-433, 2931488, 20716336
    • Moestue SA, Borgan E, Huuse EM, Lindholm EM, Sitter B, Borresen-Dale AL, Engebraaten O, Maelandsmo GM, Gribbestad IS. Distinct choline metabolic profiles are associated with differences in gene expression for basal-like and luminal-like breast cancer xenograft models. BMC Cancer 2010, 10:433. 10.1186/1471-2407-10-433, 2931488, 20716336.
    • (2010) BMC Cancer , vol.10 , pp. 433
    • Moestue, S.A.1    Borgan, E.2    Huuse, E.M.3    Lindholm, E.M.4    Sitter, B.5    Borresen-Dale, A.L.6    Engebraaten, O.7    Maelandsmo, G.M.8    Gribbestad, I.S.9
  • 27
    • 34548268026 scopus 로고    scopus 로고
    • Modelling breast cancer: one size does not fit all
    • Vargo-Gogola T, Rosen JM. Modelling breast cancer: one size does not fit all. Nat Rev Cancer 2007, 7:659-672.
    • (2007) Nat Rev Cancer , vol.7 , pp. 659-672
    • Vargo-Gogola, T.1    Rosen, J.M.2
  • 28
    • 65649134770 scopus 로고    scopus 로고
    • Whole-body section fluorescence imaging - a novel method for tissue distribution studies of fluorescent substances
    • 10.1002/cmmi.264, 19142979
    • Moestue S, Nunez P, Healey A, Bjerke R, Indrevoll B, Skotland T, Hustvedt SO. Whole-body section fluorescence imaging - a novel method for tissue distribution studies of fluorescent substances. Contrast Media Mol Imaging 2009, 4:73-80. 10.1002/cmmi.264, 19142979.
    • (2009) Contrast Media Mol Imaging , vol.4 , pp. 73-80
    • Moestue, S.1    Nunez, P.2    Healey, A.3    Bjerke, R.4    Indrevoll, B.5    Skotland, T.6    Hustvedt, S.O.7
  • 29
    • 20444447110 scopus 로고    scopus 로고
    • Stability of phosphoprotein as a biological marker of tumor signaling
    • 10.1158/1078-0432.CCR-05-0422, 15958615
    • Baker AF, Dragovich T, Ihle NT, Williams R, Fenoglio-Preiser C, Powis G. Stability of phosphoprotein as a biological marker of tumor signaling. Clin Cancer Res 2005, 11:4338-4340. 10.1158/1078-0432.CCR-05-0422, 15958615.
    • (2005) Clin Cancer Res , vol.11 , pp. 4338-4340
    • Baker, A.F.1    Dragovich, T.2    Ihle, N.T.3    Williams, R.4    Fenoglio-Preiser, C.5    Powis, G.6
  • 30
    • 84871399634 scopus 로고    scopus 로고
    • US National Institutes of Health
    • US National Institutes of Health. , http://www.clinicaltrials.gov
  • 31
    • 79960732694 scopus 로고    scopus 로고
    • PIK3CA mutation, but not PTEN loss of function, determines the sensitivity of breast cancer cells to mTOR inhibitory drugs
    • 10.1038/onc.2011.42, 21358673
    • Weigelt B, Warne PH, Downward J. PIK3CA mutation, but not PTEN loss of function, determines the sensitivity of breast cancer cells to mTOR inhibitory drugs. Oncogene 2011, 30:3222-3233. 10.1038/onc.2011.42, 21358673.
    • (2011) Oncogene , vol.30 , pp. 3222-3233
    • Weigelt, B.1    Warne, P.H.2    Downward, J.3
  • 32
    • 84869009687 scopus 로고    scopus 로고
    • How cancer metabolism is tuned for proliferation and vulnerable to disruption
    • 10.1038/nature11706, 23151579
    • Schulze A, Harris AL. How cancer metabolism is tuned for proliferation and vulnerable to disruption. Nature 2012, 491:364-373. 10.1038/nature11706, 23151579.
    • (2012) Nature , vol.491 , pp. 364-373
    • Schulze, A.1    Harris, A.L.2
  • 33
    • 0001221508 scopus 로고
    • On respiratory impairment in cancer cells
    • Warburg O. On respiratory impairment in cancer cells. Science 1956, 124:269-270.
    • (1956) Science , vol.124 , pp. 269-270
    • Warburg, O.1
  • 34
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: the metabolic requirements of cell proliferation
    • 10.1126/science.1160809, 2849637, 19460998
    • Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009, 324:1029-1033. 10.1126/science.1160809, 2849637, 19460998.
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 35
    • 0033079597 scopus 로고    scopus 로고
    • Oncogenic alterations of metabolism
    • 10.1016/S0968-0004(98)01344-9, 10098401
    • Dang CV, Semenza GL. Oncogenic alterations of metabolism. Trends Biochem Sci 1999, 24:68-72. 10.1016/S0968-0004(98)01344-9, 10098401.
    • (1999) Trends Biochem Sci , vol.24 , pp. 68-72
    • Dang, C.V.1    Semenza, G.L.2
  • 36
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
    • 10.1016/j.cmet.2007.10.002, 18177721
    • Deberardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 2008, 7:11-20. 10.1016/j.cmet.2007.10.002, 18177721.
    • (2008) Cell Metab , vol.7 , pp. 11-20
    • Deberardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 37
    • 58149136865 scopus 로고    scopus 로고
    • Roles of p53, MYC and HIF-1 in regulating glycolysis - the seventh hallmark of cancer
    • 10.1007/s00018-008-8224-x, 18766298
    • Yeung SJ, Pan J, Lee MH. Roles of p53, MYC and HIF-1 in regulating glycolysis - the seventh hallmark of cancer. Cell Mol Life Sci 2008, 65:3981-3999. 10.1007/s00018-008-8224-x, 18766298.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 3981-3999
    • Yeung, S.J.1    Pan, J.2    Lee, M.H.3
  • 39
    • 27944501189 scopus 로고    scopus 로고
    • Glycolytic glioma cells with active glycogen synthase are sensitive to PTEN and inhibitors of PI3K and gluconeogenesis
    • Beckner ME, Gobbel GT, Abounader R, Burovic F, Agostino NR, Laterra J, Pollack IF. Glycolytic glioma cells with active glycogen synthase are sensitive to PTEN and inhibitors of PI3K and gluconeogenesis. Lab Invest 2005, 85:1457-1470.
    • (2005) Lab Invest , vol.85 , pp. 1457-1470
    • Beckner, M.E.1    Gobbel, G.T.2    Abounader, R.3    Burovic, F.4    Agostino, N.R.5    Laterra, J.6    Pollack, I.F.7
  • 40
    • 33644866627 scopus 로고    scopus 로고
    • Identification of magnetic resonance detectable metabolic changes associated with inhibition of phosphoinositide 3-kinase signaling in human breast cancer cells
    • 10.1158/1535-7163.MCT-03-0220, 16432178
    • Beloueche-Babari M, Jackson LE, Al-Saffar NM, Eccles SA, Raynaud FI, Workman P, Leach MO, Ronen SM. Identification of magnetic resonance detectable metabolic changes associated with inhibition of phosphoinositide 3-kinase signaling in human breast cancer cells. Mol Cancer Ther 2006, 5:187-196. 10.1158/1535-7163.MCT-03-0220, 16432178.
    • (2006) Mol Cancer Ther , vol.5 , pp. 187-196
    • Beloueche-Babari, M.1    Jackson, L.E.2    Al-Saffar, N.M.3    Eccles, S.A.4    Raynaud, F.I.5    Workman, P.6    Leach, M.O.7    Ronen, S.M.8
  • 41
    • 80053496669 scopus 로고    scopus 로고
    • Metabolic imaging: a link between lactate dehydrogenase a, lactate, and tumor phenotype
    • 10.1158/1078-0432.CCR-11-0397, 21844011
    • Serganova I, Rizwan A, Ni X, Thakur SB, Vider J, Russell J, Blasberg R, Koutcher JA. Metabolic imaging: a link between lactate dehydrogenase a, lactate, and tumor phenotype. Clin Cancer Res 2011, 17:6250-6261. 10.1158/1078-0432.CCR-11-0397, 21844011.
    • (2011) Clin Cancer Res , vol.17 , pp. 6250-6261
    • Serganova, I.1    Rizwan, A.2    Ni, X.3    Thakur, S.B.4    Vider, J.5    Russell, J.6    Blasberg, R.7    Koutcher, J.A.8
  • 43
    • 79960821542 scopus 로고    scopus 로고
    • MRS and MRSI guidance in molecular medicine: targeting and monitoring of choline and glucose metabolism in cancer
    • 3146026, 21793073
    • Glunde K, Jiang L, Moestue SA, Gribbestad IS. MRS and MRSI guidance in molecular medicine: targeting and monitoring of choline and glucose metabolism in cancer. NMR Biomed 2011, 24:673-690. 3146026, 21793073.
    • (2011) NMR Biomed , vol.24 , pp. 673-690
    • Glunde, K.1    Jiang, L.2    Moestue, S.A.3    Gribbestad, I.S.4
  • 44
    • 81855226152 scopus 로고    scopus 로고
    • Choline metabolism in malignant transformation
    • Glunde K, Bhujwalla ZM, Ronen SM. Choline metabolism in malignant transformation. Nat Rev Cancer 2011, 11:835-848.
    • (2011) Nat Rev Cancer , vol.11 , pp. 835-848
    • Glunde, K.1    Bhujwalla, Z.M.2    Ronen, S.M.3
  • 45
    • 0032893756 scopus 로고    scopus 로고
    • Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells
    • Aboagye EO, Bhujwalla ZM. Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells. Cancer Res 1999, 59:80-84.
    • (1999) Cancer Res , vol.59 , pp. 80-84
    • Aboagye, E.O.1    Bhujwalla, Z.M.2
  • 46
    • 0028918256 scopus 로고
    • Generation of phosphorylcholine as an essential event in the activation of Raf-1 and MAP-kinases in growth factors-induced mitogenic stimulation
    • 10.1002/jcb.240570114, 7721953
    • Jimenez B, del PL, Montaner S, Esteve P, Lacal JC. Generation of phosphorylcholine as an essential event in the activation of Raf-1 and MAP-kinases in growth factors-induced mitogenic stimulation. J Cell Biochem 1995, 57:141-149. 10.1002/jcb.240570114, 7721953.
    • (1995) J Cell Biochem , vol.57 , pp. 141-149
    • Jimenez, B.1    del, P.L.2    Montaner, S.3    Esteve, P.4    Lacal, J.C.5
  • 47
    • 77949504534 scopus 로고    scopus 로고
    • Lysophosphatidic acid production and action: critical new players in breast cancer initiation and progression
    • 10.1038/sj.bjc.6605588, 2844037, 20234370
    • Panupinthu N, Lee HY, Mills GB. Lysophosphatidic acid production and action: critical new players in breast cancer initiation and progression. Br J Cancer 2010, 102:941-946. 10.1038/sj.bjc.6605588, 2844037, 20234370.
    • (2010) Br J Cancer , vol.102 , pp. 941-946
    • Panupinthu, N.1    Lee, H.Y.2    Mills, G.B.3
  • 51
    • 4644284916 scopus 로고    scopus 로고
    • Choline kinase activation is a critical requirement for the proliferation of primary human mammary epithelial cells and breast tumor progression
    • 10.1158/0008-5472.CAN-04-0489, 15374991
    • Ramirez de MA, Banez-Coronel M, Gutierrez R, Rodriguez-Gonzalez A, Olmeda D, Megias D, Lacal JC. Choline kinase activation is a critical requirement for the proliferation of primary human mammary epithelial cells and breast tumor progression. Cancer Res 2004, 64:6732-6739. 10.1158/0008-5472.CAN-04-0489, 15374991.
    • (2004) Cancer Res , vol.64 , pp. 6732-6739
    • Ramirez de, M.A.1    Banez-Coronel, M.2    Gutierrez, R.3    Rodriguez-Gonzalez, A.4    Olmeda, D.5    Megias, D.6    Lacal, J.C.7
  • 52
  • 54
    • 0032893756 scopus 로고    scopus 로고
    • Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells
    • Aboagye EO, Bhujwalla ZM. Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells. Cancer Res 1999, 59:80-84.
    • (1999) Cancer Res , vol.59 , pp. 80-84
    • Aboagye, E.O.1    Bhujwalla, Z.M.2
  • 55
    • 77952469993 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopy in metabolic and molecular imaging and diagnosis of cancer
    • 10.1021/cr9004007, 2877696, 20384323
    • Glunde K, Artemov D, Penet MF, Jacobs MA, Bhujwalla ZM. Magnetic resonance spectroscopy in metabolic and molecular imaging and diagnosis of cancer. Chem Rev 2010, 110:3043-3059. 10.1021/cr9004007, 2877696, 20384323.
    • (2010) Chem Rev , vol.110 , pp. 3043-3059
    • Glunde, K.1    Artemov, D.2    Penet, M.F.3    Jacobs, M.A.4    Bhujwalla, Z.M.5
  • 56
    • 79960829692 scopus 로고    scopus 로고
    • Correlation of phospholipid metabolites with prostate cancer pathologic grade, proliferative status and surgical stage - impact of tissue environment
    • 10.1002/nbm.1738, 21793074
    • Keshari KR, Tsachres H, Iman R, Delos SL, Tabatabai ZL, Shinohara K, Vigneron DB, Kurhanewicz J. Correlation of phospholipid metabolites with prostate cancer pathologic grade, proliferative status and surgical stage - impact of tissue environment. NMR Biomed 2011, 24:691-699. 10.1002/nbm.1738, 21793074.
    • (2011) NMR Biomed , vol.24 , pp. 691-699
    • Keshari, K.R.1    Tsachres, H.2    Iman, R.3    Delos, S.L.4    Tabatabai, Z.L.5    Shinohara, K.6    Vigneron, D.B.7    Kurhanewicz, J.8
  • 57
    • 84866552299 scopus 로고    scopus 로고
    • Glycerophosphocholine (GPC) is a poorly understood biomarker in breast cancer
    • 10.1073/pnas.1208226109, 22851771
    • Moestue SA, Giskeodegard GF, Cao MD, Bathen TF, Gribbestad IS. Glycerophosphocholine (GPC) is a poorly understood biomarker in breast cancer. Proc Natl Acad Sci USA 2012, 109:E2506. 10.1073/pnas.1208226109, 22851771.
    • (2012) Proc Natl Acad Sci USA , vol.109
    • Moestue, S.A.1    Giskeodegard, G.F.2    Cao, M.D.3    Bathen, T.F.4    Gribbestad, I.S.5
  • 58
    • 79957483893 scopus 로고    scopus 로고
    • Modulation of melanoma cell phospholipid metabolism in response to heat shock protein 90 inhibition
    • 2965833,2965833, 21037799
    • Beloueche-Babari M, Arunan V, Jackson LE, Perusinghe N, Sharp SY, Workman P, Leach MO. Modulation of melanoma cell phospholipid metabolism in response to heat shock protein 90 inhibition. Oncotarget 2010, 1:185-197. 2965833,2965833, 21037799.
    • (2010) Oncotarget , vol.1 , pp. 185-197
    • Beloueche-Babari, M.1    Arunan, V.2    Jackson, L.E.3    Perusinghe, N.4    Sharp, S.Y.5    Workman, P.6    Leach, M.O.7
  • 60
  • 62
    • 77954358936 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase inhibitor PI-103 downregulates choline kinase alpha leading to phosphocholine and total choline decrease detected by magnetic resonance spectroscopy
    • 10.1158/0008-5472.CAN-09-4476, 2896552, 20551061
    • Al-Saffar NM, Jackson LE, Raynaud FI, Clarke PA, Ramirez de MA, Lacal JC, Workman P, Leach MO. The phosphoinositide 3-kinase inhibitor PI-103 downregulates choline kinase alpha leading to phosphocholine and total choline decrease detected by magnetic resonance spectroscopy. Cancer Res 2010, 70:5507-5517. 10.1158/0008-5472.CAN-09-4476, 2896552, 20551061.
    • (2010) Cancer Res , vol.70 , pp. 5507-5517
    • Al-Saffar, N.M.1    Jackson, L.E.2    Raynaud, F.I.3    Clarke, P.A.4    Ramirez de, M.A.5    Lacal, J.C.6    Workman, P.7    Leach, M.O.8
  • 63
    • 77956004085 scopus 로고    scopus 로고
    • Cellular and in vivo activity of a novel PI3K inhibitor, PX-866, against human glioblastoma
    • 10.1093/neuonc/nop058, 2940638, 20156803
    • Koul D, Shen R, Kim YW, Kondo Y, Lu Y, Bankson J, Ronen SM, Kirkpatrick DL, Powis G, Yung WK. Cellular and in vivo activity of a novel PI3K inhibitor, PX-866, against human glioblastoma. Neuro Oncol 2010, 12:559-569. 10.1093/neuonc/nop058, 2940638, 20156803.
    • (2010) Neuro Oncol , vol.12 , pp. 559-569
    • Koul, D.1    Shen, R.2    Kim, Y.W.3    Kondo, Y.4    Lu, Y.5    Bankson, J.6    Ronen, S.M.7    Kirkpatrick, D.L.8    Powis, G.9    Yung, W.K.10
  • 64
    • 78651519725 scopus 로고    scopus 로고
    • 31P magnetic resonance spectroscopic imaging with polarisation transfer of phosphomono- and diesters at 3 T in the human brain: relation with age and spatial differences
    • 10.1002/nbm.1523, 20669234
    • Wijnen JP, Scheenen TW, Klomp DW, Heerschap A. 31P magnetic resonance spectroscopic imaging with polarisation transfer of phosphomono- and diesters at 3 T in the human brain: relation with age and spatial differences. NMR Biomed 2010, 23:968-976. 10.1002/nbm.1523, 20669234.
    • (2010) NMR Biomed , vol.23 , pp. 968-976
    • Wijnen, J.P.1    Scheenen, T.W.2    Klomp, D.W.3    Heerschap, A.4


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