Identification of Sensitive Serum microRNA Biomarkers for Radiation Biodosimetry

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Jacob, Naduparambil Korah ^a   Cooley, James V ^a   Yee, Tamara N ^a   Jacob, Jidhin ^a   Alder, Hansjuerg ^b   Wickramasinghe, Priyankara ^c   Maclean, Kirsteen H ^d   Chakravarti, Arnab ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c WISTAR INSTITUTE   (United States)

^d NANOSTRING TECHNOLOGIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; MICRORNA; MICRORNA 106B; MICRORNA 150; MICRORNA 16; MICRORNA 200B; MICRORNA 20A; MICRORNA 23A; MICRORNA 25; MICRORNA 451; MICRORNA 762; MICRORNA 93; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSIMETER; DOSIMETRY; MALE; MOUSE; NON INVASIVE MEASUREMENT; NONHUMAN; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RADIATION DOSE; RADIATION DOSE FRACTIONATION; RADIATION EXPOSURE; RNA HYBRIDIZATION; TIME;

ANIMALS; BIOLOGICAL ASSAY; BIOLOGICAL MARKERS; ENVIRONMENTAL EXPOSURE; HUMANS; LYMPHOCYTES; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICRORNAS; RADIATION DOSAGE; RADIATION, IONIZING; RADIOACTIVE HAZARD RELEASE; RADIOMETRY; SERUM;

EID: 84874345725     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0057603     Document Type: Article

References (46)

1. Waselenko JK, MacVittie TJ, Blakely WF, Pesik N, Wiley AL, et al. (2004) Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group. Ann Intern Med 140: 1037-1051.
2. MacNaughton WK, (2000) Review article: new insights into the pathogenesis of radiation-induced intestinal dysfunction. Aliment Pharmacol Ther 14: 523-528.
3. Hall EJ, Giaccia AJ (2012) Radiobiology for the Radiologist. Seventh Edition: 193-200.
4. Singh VK, Brown DS, Kao TC, Seed TM, (2009) Preclinical development of a bridging therapy for radiation casualties. Exp Hematol 38: 61-70.
5. Hanson WR, Crouse DA, Fry RJ, Ainsworth EJ, (1984) Relative biological effectiveness measurements using murine lethality and survival of intestinal and hematopoietic stem cells after fermilab neutrons compared to JANUS reactor neutrons and 60Co gamma rays. Radiat Res 100: 290-297.
6. Shimizu Y, Kodama K, Nishi N, Kasagi F, Suyama A, et al. (2010) Radiation exposure and circulatory disease risk: Hiroshima and Nagasaki atomic bomb survivor data, 1950-2003. BMJ 340: b5349.
7. Preston DL, Shimizu Y, Pierce DA, Suyama A, Mabuchi K, (2003) Studies of mortality of atomic bomb survivors. Report 13: Solid cancer and noncancer disease mortality: 1950-1997. Radiat Res 160: 381-407.
8. UNSCEAR (2000) SOURCES AND EFFECTS OF IONIZING RADIATION. United Nations Scientific Committee on the Effects of Atomic Radiation Volumes I and II.
9. Blakely WF, Madrid JP, Sandgren DJ, (2010) Biodosimetry medical recording-use of the Biodosimetry Assessment Tool. Health Phys 99Suppl 5: S184-191.
10. Ossetrova NI, Sandgren DJ, Gallego S, Blakely WF, (2010) Combined approach of hematological biomarkers and plasma protein SAA for improvement of radiation dose assessment triage in biodosimetry applications. Health Phys 98: 204-208.
11. Blakely WF, Ossetrova NI, Whitnall MH, Sandgren DJ, Krivokrysenko VI, et al. (2010) Multiple parameter radiation injury assessment using a nonhuman primate radiation model-biodosimetry applications. Health Phys 98: 153-159.
12. Chng WJ, Tan GB, Kuperan P, (2004) Establishment of adult peripheral blood lymphocyte subset reference range for an Asian population by single-platform flow cytometry: influence of age, sex, and race and comparison with other published studies. Clin Diagn Lab Immunol 11: 168-173.
13. Bartel DP, (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297.
14. Iorio MV, Croce CM, (2012) MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review. EMBO Mol Med 4: 143-159.
15. Cui W, Ma J, Wang Y, Biswal S, (2011) Plasma miRNA as biomarkers for assessment of total-body radiation exposure dosimetry. PLoS ONE 6: e22988.
16. Scholl V, Hassan R, Zalcberg IR, (2012) miRNA-451: A putative predictor marker of Imatinib therapy response in chronic myeloid leukemia. Leuk Res 36: 119-121.
17. Qi P, Cheng SQ, Wang H, Li N, Chen YF, et al. (2011) Serum microRNAs as biomarkers for hepatocellular carcinoma in Chinese patients with chronic hepatitis B virus infection. PLoS ONE 6: e28486.
18. Weiland M, Gao XH, Zhou L, Mi QS, (2012) Small RNAs have a large impact: circulating microRNAs as biomarkers for human diseases. RNA Biol 9: 850-859.
19. Cortez MA, Bueso-Ramos C, Ferdin J, Lopez-Berestein G, Sood AK, et al. (2011) MicroRNAs in body fluids-the mix of hormones and biomarkers. Nat Rev Clin Oncol 8: 467-477.
20. Russo F, Di Bella S, Nigita G, Macca V, Lagana A, et al. (2012) miRandola: extracellular circulating microRNAs database. PLoS ONE 7: e47786.
21. Hunter MP, Ismail N, Zhang X, Aguda BD, Lee EJ, et al. (2008) Detection of microRNA expression in human peripheral blood microvesicles. PLoS ONE 3: e3694.
22. Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, et al. (2007) Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 9: 654-659.
23. Etheridge A, Lee I, Hood L, Galas D, Wang K, (2011) Extracellular microRNA: a new source of biomarkers. Mutat Res 717: 85-90.
24. Geiss GK, Bumgarner RE, Birditt B, Dahl T, Dowidar N, et al. (2008) Direct multiplexed measurement of gene expression with color-coded probe pairs. Nat Biotechnol 26: 317-325.
25. Wang B, Hsu SH, Frankel W, Ghoshal K, Jacob ST, (2012) Stat3-mediated activation of microRNA-23a suppresses gluconeogenesis in hepatocellular carcinoma by down-regulating glucose-6-phosphatase and peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. Hepatology 56: 186-197.
26. Thum T, Gross C, Fiedler J, Fischer T, Kissler S, et al. (2008) MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 456: 980-984.
27. Teichler S, Illmer T, Roemhild J, Ovcharenko D, Stiewe T, et al. (2011) MicroRNA29a regulates the expression of the nuclear oncogene Ski. Blood 118: 1899-1902.
28. Vasilescu C, Rossi S, Shimizu M, Tudor S, Veronese A, et al. (2009) MicroRNA fingerprints identify miR-150 as a plasma prognostic marker in patients with sepsis. PLoS ONE 4: e7405.
29. Zhou B, Wang S, Mayr C, Bartel DP, Lodish HF, (2007) miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely. Proc Natl Acad Sci U S A 104: 7080-7085.
30. Adams BD, Guo S, Bai H, Guo Y, Megyola CM, et al. (2012) An in vivo functional screen uncovers miR-150-mediated regulation of hematopoietic injury response. Cell Rep 2: 1048-1060.
31. Xiao C, Calado DP, Galler G, Thai TH, Patterson HC, et al. (2007) MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell 131: 146-159.
32. Goans RE, Holloway EC, Berger ME, Ricks RC, (1997) Early dose assessment following severe radiation accidents. Health Phys 72: 513-518.
33. Venugopal SK, Jiang J, Kim TH, Li Y, Wang SS, et al. (2010) Liver fibrosis causes downregulation of miRNA-150 and miRNA-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation. Am J Physiol Gastrointest Liver Physiol 298: G101-106.
34. Li C, Pei F, Zhu X, Duan DD, Zeng C, (2012) Circulating microRNAs as novel and sensitive biomarkers of acute myocardial Infarction. Clin Biochem 45: 727-732.
35. Pritchard CC, Kroh E, Wood B, Arroyo JD, Dougherty KJ, et al. (2011) Blood cell origin of circulating microRNAs: a cautionary note for cancer biomarker studies. Cancer Prev Res (Phila) 5: 492-497.
36. Liu Z, Zhou C, Liu Y, Wang S, Ye P, et al. (2012) The expression levels of plasma micoRNAs in atrial fibrillation patients. PLoS ONE 7: e44906.
37. Skog J, Wurdinger T, van Rijn S, Meijer DH, Gainche L, et al. (2008) Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 10: 1470-1476.
38. Kosaka N, Iguchi H, Yoshioka Y, Takeshita F, Matsuki Y, et al. (2010) Secretory mechanisms and intercellular transfer of microRNAs in living cells. J Biol Chem 285: 17442-17452.
39. Ji X, Takahashi R, Hiura Y, Hirokawa G, Fukushima Y, et al. (2009) Plasma miR-208 as a biomarker of myocardial injury. Clin Chem 55: 1944-1949.
40. Zernecke A, Bidzhekov K, Noels H, Shagdarsuren E, Gan L, et al. (2009) Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection. Sci Signal 2: ra81.
41. Barcellos-Hoff MH, (1998) How do tissues respond to damage at the cellular level? The role of cytokines in irradiated tissues. Radiat Res 150: S109-120.
42. Zhu Y, Yu X, Fu H, Wang H, Wang P, et al. (2010) MicroRNA-21 is involved in ionizing radiation-promoted liver carcinogenesis. Int J Clin Exp Med 3: 211-222.
43. Davis BN, Hilyard AC, Lagna G, Hata A, (2008) SMAD proteins control DROSHA-mediated microRNA maturation. Nature 454: 56-61.
44. Fevrier B, Raposo G, (2004) Exosomes: endosomal-derived vesicles shipping extracellular messages. Curr Opin Cell Biol 16: 415-421.
45. Arroyo JD, Chevillet JR, Kroh EM, Ruf IK, Pritchard CC, et al. (2011) Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc Natl Acad Sci U S A 108: 5003-5008.
46. Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, et al. (2008) Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci U S A 105: 10513-10518.