A selective inhibitor of heme biosynthesis in endosymbiotic bacteria elicits antifilarial activity in vitro

Chemistry and Biology

Volumn 20, Issue 2, 2013, Pages 177-187

  Lentz, Christian S ^a   Halls, Victoria ^b   Hannam, Jeffrey S ^b   Niebel, Björn ^b   Strübing, Uta ^a   Mayer, Günter ^b   Hoerauf, Achim ^a   Famulok, Michael ^b   Pfarr, Kenneth M ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFILARIAL AGENT; BENZIMIDAZOLE DERIVATIVE; HEME; PORPHOBILINOGEN SYNTHASE; UNCLASSIFIED DRUG; WALADIN 1; ZINC ION;

ANTHELMINTIC ACTIVITY; ARTICLE; BIOSYNTHESIS; COMPETITIVE INHIBITION; CONTROLLED STUDY; ENDOSYMBIONT; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; WOLBACHIA;

ANIMALS; ANTIPROTOZOAL AGENTS; BENZIMIDAZOLES; DRUG DESIGN; ELEPHANTIASIS, FILARIAL; FILARIOIDEA; HEME; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; KINETICS; MAGNESIUM; PORPHOBILINOGEN SYNTHASE; SYMBIOSIS; THIOPHENES; WOLBACHIA;

EID: 84874336861     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2012.11.009     Document Type: Article

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