The X-ray structure of yeast 5-aminolaevulinic acid dehydratase complexed with substrate and three inhibitors

Journal of Molecular Biology

Volumn 312, Issue 1, 2001, Pages 133-141

  Erskine, P T ^a   Newbold, R ^b   Brindley, A A ^b   Wood, S P ^a   Shoolingin Jordan, P M ^a   Warren, M J ^b   Cooper, J B ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

5 aminolaevulinate dehydratase; 5 aminolaevulinic acid; Laevulinic acid; Succinylacetone; Type I tyrosinaemia

Indexed keywords

4 KETO 5 AMINOHEXANOIC ACID; 4 KETO 5 AMINOLAEVULINIC ACID; AMINOCAPROIC ACID; AMINOLEVULINIC ACID; ENZYME INHIBITOR; LEVULINIC ACID; LYSINE; METHANOLAMINE; PORPHOBILINOGEN SYNTHASE; PORPHOBILINOGEN SYNTHASE INHIBITOR; SCHIFF BASE; SUCCINYLACETONE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; COVALENT BOND; ENZYME ACTIVE SITE; ENZYME DEFICIENCY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; GENETIC DISORDER; LIGAND BINDING; MOLECULAR INTERACTION; MOLECULAR STABILITY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; STRUCTURE ANALYSIS; TYROSINEMIA; X RAY ANALYSIS; YEAST;

EID: 0035823060     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.4947     Document Type: Article

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