-
1
-
-
33947732977
-
Angiogenesis: An organizing principle for drug discovery?
-
Folkman, J. (2007) Angiogenesis: An organizing principle for drug discovery? Nat. Rev. Drug Discov. 6, 273-286
-
(2007)
Nat. Rev. Drug Discov
, vol.6
, pp. 273-286
-
-
Folkman, J.1
-
2
-
-
2942657615
-
Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
-
Johnson, D.H., Fehrenbacher, L., Novotny, W.F., Herbst, R.S., Nemunaitis, J.J., Jablons, D.M., Langer, C.J., DeVore, R.F., Gaudreault, J., Damico, L.A., Holmgren, E., and Kabbinavar, F. (2004) Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J. Clin. Oncol. 22, 2184-2191
-
(2004)
J. Clin. Oncol
, vol.22
, pp. 2184-2191
-
-
Johnson, D.H.1
Fehrenbacher, L.2
Novotny, W.F.3
Herbst, R.S.4
Nemunaitis, J.J.5
Jablons, D.M.6
Langer, C.J.7
DeVore, R.F.8
Gaudreault, J.9
Damico, L.A.10
Holmgren, E.11
Kabbinavar, F.12
-
3
-
-
85013312416
-
Tumor angiogenesis: Therapeutic implications
-
Folkman, J. (1971) Tumor angiogenesis: Therapeutic implications. N. Engl. J. Med. 285, 1182-1186
-
(1971)
N. Engl. J. Med
, vol.285
, pp. 1182-1186
-
-
Folkman, J.1
-
4
-
-
30944446883
-
Lessons from phase III clinical trials on anti-VEGF therapy for cancer
-
Jain, R.K., Duda, D.G., Clark, J.W., and Loeffler, J.S. (2006) Lessons from phase III clinical trials on anti-VEGF therapy for cancer. Nat. Clin. Pract. Oncol. 3, 24-40
-
(2006)
Nat. Clin. Pract. Oncol
, vol.3
, pp. 24-40
-
-
Jain, R.K.1
Duda, D.G.2
Clark, J.W.3
Loeffler, J.S.4
-
5
-
-
70349782389
-
An overview of small-molecule inhibitors of VEGFR signaling
-
Ivy, S.P., Wick, J.Y., and Kaufman, B.M. (2009) An overview of small-molecule inhibitors of VEGFR signaling. Nat. Rev. Clin. Oncol. 6, 569-579
-
(2009)
Nat. Rev. Clin. Oncol
, vol.6
, pp. 569-579
-
-
Ivy, S.P.1
Wick, J.Y.2
Kaufman, B.M.3
-
6
-
-
2942615257
-
The anti-angiogenic basis of metronomic chemotherapy
-
Kerbel, R.S. and Kamen, B.A. (2004) The anti-angiogenic basis of metronomic chemotherapy. Nat. Rev. Cancer 4, 423-436
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 423-436
-
-
Kerbel, R.S.1
Kamen, B.A.2
-
7
-
-
0035214416
-
Metronomic scheduling: The future of chemotherapy?
-
Gasparini, G (2001) Metronomic scheduling: The future of chemotherapy? Lancet Oncol. 2, 733-740
-
(2001)
Lancet Oncol
, vol.2
, pp. 733-740
-
-
Gasparini, G.1
-
8
-
-
34547617338
-
Antiangiogenic strategies on defense: On the possibility of blocking rebounds by the tumor vasculature after chemotherapy
-
Shaked, Y. and Kerbel, R.S. (2007) Antiangiogenic strategies on defense: On the possibility of blocking rebounds by the tumor vasculature after chemotherapy. Cancer Res. 67, 7055-7058
-
(2007)
Cancer Res
, vol.67
, pp. 7055-7058
-
-
Shaked, Y.1
Kerbel, R.S.2
-
9
-
-
0034087691
-
Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity
-
Klement, G., Baruchel, S., Rak, J., Man, S., Clark, K., Hicklin, D.J., Bohlen, P., and Kerbel, R.S. (2000) Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity. J. Clin. Invest. 105, R15-R24
-
(2000)
J. Clin. Invest
, vol.105
-
-
Klement, G.1
Baruchel, S.2
Rak, J.3
Man, S.4
Clark, K.5
Hicklin, D.J.6
Bohlen, P.7
Kerbel, R.S.8
-
10
-
-
0025717523
-
Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents
-
Kerbel, R.S. (1991) Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents. Bioessays 13, 31-36
-
(1991)
Bioessays
, vol.13
, pp. 31-36
-
-
Kerbel, R.S.1
-
11
-
-
77955172181
-
Metronomic chemotherapy: New rationale for
-
new directions
-
Pasquier, E., Kavallaris, M., and Andre, N. (2010) Metronomic chemotherapy: New rationale for new directions. Nat. Rev. Clin. Oncol. 7, 455-465
-
(2010)
Nat. Rev. Clin. Oncol
, vol.7
, pp. 45-465
-
-
Pasquier, E.1
Kavallaris, M.2
Andre, N.3
-
12
-
-
16544369867
-
A randomized trial of adjuvant chemotherapy with uracil-tegafur for adenocarcinoma of the lung
-
Kato, H., Ichinose, Y., Ohta, M., Hata, E., Tsubota, N., Tada, H., Watanabe, Y., Wada, H., Tsuboi, M., and Hamajima, N. (2004) A randomized trial of adjuvant chemotherapy with uracil-tegafur for adenocarcinoma of the lung. N. Engl. J. Med. 350, 1713-1721
-
(2004)
N. Engl. J. Med
, vol.350
, pp. 1713-1721
-
-
Kato, H.1
Ichinose, Y.2
Ohta, M.3
Hata, E.4
Tsubota, N.5
Tada, H.6
Watanabe, Y.7
Wada, H.8
Tsuboi, M.9
Hamajima, N.10
-
13
-
-
67649995780
-
Metronomic schedule of paclitaxel is effective in hormone receptor-positive and hormone receptor-negative breast cancer
-
Mehta, R.S., Jackson, D., and Schubbert, T. (2009) Metronomic schedule of paclitaxel is effective in hormone receptor-positive and hormone receptor-negative breast cancer. J. Clin. Oncol. 27, 3067-3068
-
(2009)
J. Clin. Oncol
, vol.27
, pp. 3067-3068
-
-
Mehta, R.S.1
Jackson, D.2
Schubbert, T.3
-
14
-
-
0034528854
-
Angiogenesis assays: Problems and pitfalls
-
Auerbach, R., Akhtar, N., Lewis, R.L., and Shinners, B.L. (2000) Angiogenesis assays: Problems and pitfalls. Cancer Metastasis Rev. 19, 167-172
-
(2000)
Cancer Metastasis Rev
, vol.19
, pp. 167-172
-
-
Auerbach, R.1
Akhtar, N.2
Lewis, R.L.3
Shinners, B.L.4
-
15
-
-
0035692285
-
Possible mechanisms of acquired resistance to anti-angiogenic drugs: Implications for the use of combination therapy approaches
-
Kerbel, R.S., Yu, J., Tran, J., Man, S., Viloria-Petit, A., Klement, G., Coomber, B.L., and Rak, J. (2001) Possible mechanisms of acquired resistance to anti-angiogenic drugs: Implications for the use of combination therapy approaches. Cancer Metastasis Rev. 20, 79-86
-
(2001)
Cancer Metastasis Rev
, vol.20
, pp. 79-86
-
-
Kerbel, R.S.1
Yu, J.2
Tran, J.3
Man, S.4
Viloria-Petit, A.5
Klement, G.6
Coomber, B.L.7
Rak, J.8
-
16
-
-
34547486126
-
Phase II study of metronomic chemotherapy for recurrent malignant gliomas in adults
-
Kesari, S., Schiff, D., Doherty, L., Gigas, D.C., Batchelor, T.T., Muzikansky, A., O'Neill, A., Drappatz, J., Chen-Plotkin, A.S., Ramakrishna, N., Weiss, S.E., Levy, B., Bradshaw, J., Kracher, J., Laforme, A., Black, P.M., Folkman, J., Kieran, M., and Wen, P.Y. (2007) Phase II study of metronomic chemotherapy for recurrent malignant gliomas in adults. Neuro Oncol. 9, 354-363
-
(2007)
Neuro Oncol
, vol.9
, pp. 354-363
-
-
Kesari, S.1
Schiff, D.2
Doherty, L.3
Gigas, D.C.4
Batchelor, T.T.5
Muzikansky, A.6
O'Neill, A.7
Drappatz, J.8
Chen-Plotkin, A.S.9
Ramakrishna, N.10
Weiss, S.E.11
Levy, B.12
Bradshaw, J.13
Kracher, J.14
Laforme, A.15
Black, P.M.16
Folkman, J.17
Kieran, M.18
Wen, P.Y.19
-
17
-
-
34247383919
-
A phase II trial of continuous low-dose oral cyclophosphamide and celecoxib in patients with renal cell carcinoma
-
Krzyzanowska, M.K., Tannock, I.F., Lockwood, G., Knox, J., Moore, M., and Bjarnason, G.A. (2007) A phase II trial of continuous low-dose oral cyclophosphamide and celecoxib in patients with renal cell carcinoma. Cancer Chemother. Pharmacol. 60, 135-141
-
(2007)
Cancer Chemother. Pharmacol
, vol.60
, pp. 135-141
-
-
Krzyzanowska, M.K.1
Tannock, I.F.2
Lockwood, G.3
Knox, J.4
Moore, M.5
Bjarnason, G.A.6
-
18
-
-
26644471951
-
Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
-
Casanovas, O., Hicklin, D.J., Bergers, G., and Hanahan, D. (2005) Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 8, 299-309
-
(2005)
Cancer Cell
, vol.8
, pp. 299-309
-
-
Casanovas, O.1
Hicklin, D.J.2
Bergers, G.3
Hanahan, D.4
-
19
-
-
36749052895
-
Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy
-
Ebos, J.M., Lee, C.R., Christensen, J.G., Mutsaers, A.J., and Kerbel, R.S. (2007) Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy. Proc. Natl Acad. Sci. U S A 104, 17069-17074
-
(2007)
Proc. Natl Acad. Sci. U S A
, vol.104
, pp. 17069-17074
-
-
Ebos, J.M.1
Lee, C.R.2
Christensen, J.G.3
Mutsaers, A.J.4
Kerbel, R.S.5
-
20
-
-
28644432204
-
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
-
Kaplan, R.N., Riba, R.D., Zacharoulis, S., Bramley, A.H., Vincent, L., Costa, C., MacDonald, D.D., Jin, D.K., Shido, K., Kerns, S.A., Zhu, Z., Hicklin, D., Wu, Y., Port, J.L., Altorki, N., Port, E.R., Ruggero, D., Shmelkov, S.V., Jensen, K.K., Rafii, S., and Lyden, D. (2005) VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 438, 820-827
-
(2005)
Nature
, vol.438
, pp. 820-827
-
-
Kaplan, R.N.1
Riba, R.D.2
Zacharoulis, S.3
Bramley, A.H.4
Vincent, L.5
Costa, C.6
MacDonald, D.D.7
Jin, D.K.8
Shido, K.9
Kerns, S.A.10
Zhu, Z.11
Hicklin, D.12
Wu, Y.13
Port, J.L.14
Altorki, N.15
Port, E.R.16
Ruggero, D.17
Shmelkov, S.V.18
Jensen, K.K.19
Rafii, S.20
Lyden, D.21
more..
-
21
-
-
60649087564
-
Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
-
Ebos, J.M., Lee, C.R., Cruz-Munoz, W., Bjarnason, G.A., Christensen, J.G., and Kerbel, R.S. (2009) Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 232-239
-
(2009)
Cancer Cell
, pp. 232-239
-
-
Ebos, J.M.1
Lee, C.R.2
Cruz-Munoz, W.3
Bjarnason, G.A.4
Christensen, J.G.5
Kerbel, R.S.6
-
22
-
-
60649106195
-
Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
-
Paez-Ribes, M., Allen, E., Hudock, J., Takeda, T., Okuyama, H., Vinals, F., Inoue, M., Bergers, G., Hanahan, D., and Casanovas, O. (2009) Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 15, 220-231
-
(2009)
Cancer Cell
, vol.15
, pp. 220-231
-
-
Paez-Ribes, M.1
Allen, E.2
Hudock, J.3
Takeda, T.4
Okuyama, H.5
Vinals, F.6
Inoue, M.7
Bergers, G.8
Hanahan, D.9
Casanovas, O.10
-
23
-
-
70549102293
-
Drug resistance associated with antiangiogenesis therapy
-
Eikesdal, H.P. and Kalluri, R. (2009) Drug resistance associated with antiangiogenesis therapy. Semin. Cancer Biol. 19, 310-317
-
(2009)
Semin. Cancer Biol
, vol.19
, pp. 310-317
-
-
Eikesdal, H.P.1
Kalluri, R.2
-
24
-
-
0033822622
-
Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption
-
Rubenstein, J.L., Kim, J., Ozawa, T., Zhang, M., Westphal, M., Deen, D.F., and Shuman, M.A. (2000) Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption. Neoplasia 2, 306-314
-
(2000)
Neoplasia
, vol.2
, pp. 306-314
-
-
Rubenstein, J.L.1
Kim, J.2
Ozawa, T.3
Zhang, M.4
Westphal, M.5
Deen, D.F.6
Shuman, M.A.7
-
25
-
-
0036067866
-
Vascularization of cutaneous melanoma involves vessel co-option and has clinical significance
-
Döme, B., Paku, S., Somlai, B., and Tímár, J. (2002) Vascularization of cutaneous melanoma involves vessel co-option and has clinical significance. J. Pathol. 197, 355-362
-
(2002)
J. Pathol
, vol.197
, pp. 355-362
-
-
Döme, B.1
Paku, S.2
Somlai, B.3
Tímár, J.4
-
26
-
-
4644304024
-
Antiangiogenic therapy of cerebral melanoma metastases results in sustained tumor progression via vessel co-option
-
Leenders, W.P., Küsters, B., Verrijp, K., Maass, C., Wesseling, P., Heerschap, A., Ruiter, D., Ryan, A., and de Waal, R. (2004) Antiangiogenic therapy of cerebral melanoma metastases results in sustained tumor progression via vessel co-option. Clin. Cancer Res. 15, 6222-6230
-
(2004)
Clin. Cancer Res
, vol.15
, pp. 6222-6230
-
-
Leenders, W.P.1
Küsters, B.2
Verrijp, K.3
Maass, C.4
Wesseling, P.5
Heerschap, A.6
Ruiter, D.7
Ryan, A.8
De Waal, R.9
-
27
-
-
78650153633
-
Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells
-
Ricci-Vitiani, L., Pallini, R., Biffoni, M., Todaro, M., Invernici, G., Cenci, T., Maira, G., Parati, E.A., Stassi, G., Larocca, L.M., and De Maria, R. (2010) Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells. Nature 468, 824-828
-
(2010)
Nature
, vol.468
, pp. 824-828
-
-
Ricci-Vitiani, L.1
Pallini, R.2
Biffoni, M.3
Todaro, M.4
Invernici, G.5
Cenci, T.6
Maira, G.7
Parati, E.A.8
Stassi, G.9
Larocca, L.M.10
De Maria, R.11
-
28
-
-
78650098659
-
Glioblastoma stem-like cells give rise to tumour endothelium
-
Wang, R., Chadalavada, K., Wilshire, J., Kowalik, U., Hovinga, K.E., Geber, A., Fligelman, B., Leversha, M., Brennan, C., and Tabar, V. (2010) Glioblastoma stem-like cells give rise to tumour endothelium. Nature 468, 829-833
-
(2010)
Nature
, vol.468
, pp. 829-833
-
-
Wang, R.1
Chadalavada, K.2
Wilshire, J.3
Kowalik, U.4
Hovinga, K.E.5
Geber, A.6
Fligelman, B.7
Leversha, M.8
Brennan, C.9
Tabar, V.10
-
29
-
-
79952721477
-
Transdifferentiation of glioblastoma cells into vascular endothelial cells
-
Soda, Y., Marumoto, T., Friedmann-Morvinski, D., Soda, M., Liu, F., Michiue, H., Pastorino, S., Yang, M., Hoffman, R.M., Kesari, S., and Verma, I.M. (2011) Transdifferentiation of glioblastoma cells into vascular endothelial cells. Proc. Natl Acad. Sci. U S A. 108, 4274-4280
-
(2011)
Proc. Natl Acad. Sci. U S A.
, vol.108
, pp. 4274-4280
-
-
Soda, Y.1
Marumoto, T.2
Friedmann-Morvinski, D.3
Soda, M.4
Liu, F.5
Michiue, H.6
Pastorino, S.7
Yang, M.8
Hoffman, R.M.9
Kesari, S.10
Verma, I.M.11
-
30
-
-
34249669336
-
Imatinib mesylate and nilotinib (AMN107) exhibit high-affinity interaction with ABCG2 on primitive hematopoietic stem cells
-
Brendel, C., Scharenberg, C., Dohse, M., Robey, R.W., Bates, S.E., Shukla, S., Ambudkar, S.V., Wang, Y., Wennemuth, G., Burchert, A., Boudriot, U., and Neubauer, A. (2007) Imatinib mesylate and nilotinib (AMN107) exhibit high-affinity interaction with ABCG2 on primitive hematopoietic stem cells. Leukemia 21, 1267-1275
-
(2007)
Leukemia
, vol.21
, pp. 1267-1275
-
-
Brendel, C.1
Scharenberg, C.2
Dohse, M.3
Robey, R.W.4
Bates, S.E.5
Shukla, S.6
Ambudkar, S.V.7
Wang, Y.8
Wennemuth, G.9
Burchert, A.10
Boudriot, U.11
Neubauer, A.12
-
31
-
-
59649129538
-
Sunitinib (Sutent, SU11248), a small-molecule receptor tyrosine kinase inhibitor, blocks function of the ATP-binding cassette (ABC) transporters P-glycoprotein (ABCB1) and ABCG2
-
Shukla, S., Robey, R.W., Bates, S.E., and Ambudkar, S.V. (2009) Sunitinib (Sutent, SU11248), a small-molecule receptor tyrosine kinase inhibitor, blocks function of the ATP-binding cassette (ABC) transporters P-glycoprotein (ABCB1) and ABCG2. Drug Metab. Dispos. 37, 359-365
-
(2009)
Drug Metab. Dispos
, vol.37
, pp. 359-365
-
-
Shukla, S.1
Robey, R.W.2
Bates, S.E.3
Ambudkar, S.V.4
-
32
-
-
33745303045
-
Nature hypoxia signalling in cancer and approaches to enforce tumour regression
-
Pouyssëgur, J., Dayan, F., and Mazure, N.M. (2006) Nature hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 441, 437-443
-
(2006)
Nature
, vol.441
, pp. 437-443
-
-
Pouyssëgur, J.1
Dayan, F.2
Mazure, N.M.3
-
33
-
-
38349155463
-
Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan
-
Sathornsumetee, S., Cao, Y., Marcello, J.E., Herndon, J.E. 2nd, McLendon, R.E., Desjardins, A., Friedman, H.S., Dewhirst, M.W., Vredenburgh, J.J., and Rich, J.N. (2008) Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan. J. Clin. Oncol. 26, 271-278
-
(2008)
J. Clin. Oncol
, vol.26
, pp. 271-278
-
-
Sathornsumetee, S.1
Cao, Y.2
Marcello, J.E.3
Herndon II, J.E.4
McLendon, R.E.5
Desjardins, A.6
Friedman, H.S.7
Dewhirst, M.W.8
Vredenburgh, J.J.9
Rich, J.N.10
-
34
-
-
33644863498
-
Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF
-
Liang, W.C., Wu, X., Peale, F.V., Lee, C.V., Meng, Y.G., Gutierrez, J., Fu, L., Malik, A.K., Gerber, H.P., Ferrara, N., and Fuh, G. (2006) Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF. J. Biol. Chem. 281, 951-961
-
(2006)
J. Biol. Chem
, vol.281
, pp. 951-961
-
-
Liang, W.C.1
Wu, X.2
Peale, F.V.3
Lee, C.V.4
Meng, Y.G.5
Gutierrez, J.6
Fu, L.7
Malik, A.K.8
Gerber, H.P.9
Ferrara, N.10
Fuh, G.11
-
35
-
-
33749005405
-
Therapyinduced acute recruitment of circulating endothelial progenitor cells to tumors
-
Shaked, Y., Ciarrocchi, A., Franco, M., Lee, C.R., Man, S., Cheung, A.M., Hicklin, D.J., Chaplin, D., Foster, F.S., Benezra, R., and Kerbel, R.S. (2006) Therapyinduced acute recruitment of circulating endothelial progenitor cells to tumors. Science 313, 1785-1787
-
(2006)
Science 313, 1785-1787
-
-
Shaked, Y.1
Ciarrocchi, A.2
Franco, M.3
Lee, C.R.4
Man, S.5
Cheung, A.M.6
Hicklin, D.J.7
Chaplin, D.8
Foster, F.S.9
Benezra, R.10
Kerbel, R.S.11
-
36
-
-
31044433663
-
Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis
-
Condeelis, J. and Pollard, J.W. (2006) Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis. Cell 124, 263-266
-
(2006)
Cell 124
, pp. 263-266
-
-
Condeelis, J.1
Pollard, J.W.2
-
37
-
-
33747602354
-
Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis
-
Nozawa, H., Chiu, C., and Hanahan, D. (2006) Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis. Proc. Natl Acad. Sci. U S A. 103, 12493-12498
-
(2006)
Proc. Natl Acad. Sci. U S A.
, vol.103
, pp. 12493-12498
-
-
Nozawa, H.1
Chiu, C.2
Hanahan, D.3
-
38
-
-
54449094358
-
Identification of amino acids essential for the antiangiogenic activity of tumstatin and its use in combination antitumor activity
-
Eikesdal, H.P., Sugimoto, H., Birrane, G., Maeshima, Y., Cooke, V.G., Kieran, M., and Kalluri, R. (2008) Identification of amino acids essential for the antiangiogenic activity of tumstatin and its use in combination antitumor activity. Proc. Natl Acad. Sci. U S A. 105, 15040-15045
-
(2008)
Proc. Natl Acad. Sci. U S A.
, vol.105
, pp. 15040-15045
-
-
Eikesdal, H.P.1
Sugimoto, H.2
Birrane, G.3
Maeshima, Y.4
Cooke, V.G.5
Kieran, M.6
Kalluri, R.7
-
39
-
-
63049104211
-
Microenvironmental regulation of metastasis
-
Joyce, J.A. and Pollard, J.W. (2009) Microenvironmental regulation of metastasis. Nat. Rev. Cancer 9, 239-252
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 239-252
-
-
Joyce, J.A.1
Pollard, J.W.2
-
40
-
-
8544249895
-
Tumor-associated endothelial cells with cytogenetic abnormalities
-
Hida, K., Hida, Y., Amin, D.N., Flint, A.F., Panigrahy, D., Morton, C.C., and Klagsbrun, M. (2004) Tumor-associated endothelial cells with cytogenetic abnormalities. Cancer Res. 64, 8249-8255
-
(2004)
Cancer Res
, vol.64
, pp. 8249-8255
-
-
Hida, K.1
Hida, Y.2
Amin, D.N.3
Flint, A.F.4
Panigrahy, D.5
Morton, C.C.6
Klagsbrun, M.7
-
41
-
-
3142767799
-
Lymphoma-specific genetic aberrations in microvascular endothelial cells in B-cell lymphomas
-
Streubel, B., Chott, A., Huber, D., Exner, M., Jager, U., Wagner, O., and Schwarzinger, I. (2004) Lymphoma-specific genetic aberrations in microvascular endothelial cells in B-cell lymphomas. N. Engl. J. Med. 351, 250-259
-
(2004)
N. Engl. J. Med
, vol.351
, pp. 250-259
-
-
Streubel, B.1
Chott, A.2
Huber, D.3
Exner, M.4
Jager, U.5
Wagner, O.6
Schwarzinger, I.7
-
42
-
-
73549104498
-
Cytogenetic abnormalities of tumor-associated endothelial cells in human malignant tumors
-
Akino, T., Hida, K., Hida, Y., Tsuchiya, K., Freedman, D., Muraki, C., Ohga, N., Matsuda, K., Akiyama, K., Harabayashi, T., Shinohara, N., Nonomura, K., Klagsbrun, M., and Shindoh, M. (2009) Cytogenetic abnormalities of tumor-associated endothelial cells in human malignant tumors. Am. J. Pathol. 175, 2657-2667
-
(2009)
Am. J. Pathol
, vol.175
, pp. 2657-2667
-
-
Akino, T.1
Hida, K.2
Hida, Y.3
Tsuchiya, K.4
Freedman, D.5
Muraki, C.6
Ohga, N.7
Matsuda, K.8
Akiyama, K.9
Harabayashi, T.10
Shinohara, N.11
Nonomura, K.12
Klagsbrun, M.13
Shindoh, M.14
-
43
-
-
0038718703
-
Altered angiogenesis and survival in human tumor-derived endothelial cells
-
Bussolati, B., Deambrosis, I., Russo, S., Deregibus, M.C., and Camussi, G. (2003) Altered angiogenesis and survival in human tumor-derived endothelial cells. FASEB J. 17, 1159-1161
-
(2003)
FASEB J.
, vol.17
, pp. 1159-1161
-
-
Bussolati, B.1
Deambrosis, I.2
Russo, S.3
Deregibus, M.C.4
Camussi, G.5
-
44
-
-
68049139572
-
Human hepatocellular carcinoma tumor-derived endothelial cells manifest increased angiogenesis capability and drug resistance compared with normal endothelial cells
-
Xiong, Y.Q., Sun, H.C., Zhang, W., Zhu, X.D., Zhuang, P.Y., Zhang, J.B., Wang, L., Wu, W.Z., Qin, L.X., and Tang, Z.Y. (2009) Human hepatocellular carcinoma tumor-derived endothelial cells manifest increased angiogenesis capability and drug resistance compared with normal endothelial cells. Clin. Cancer Res. 15, 4838-4846
-
(2009)
Clin. Cancer Res
, vol.15
, pp. 4838-4846
-
-
Xiong, Y.Q.1
Sun, H.C.2
Zhang, W.3
Zhu, X.D.4
Zhuang, P.Y.5
Zhang, J.B.6
Wang, L.7
Wu, W.Z.8
Qin, L.X.9
Tang, Z.Y.10
-
45
-
-
84857197449
-
Tumor endothelial cells acquire drug resistance by MDR1 up-regulation via VEGF signaling in tumor microenvironment
-
Akiyama, K., Ohga, N., Hida, Y., Kawamoto, T., Sadamoto, Y., Ishikawa, S., Maishi, N., Akino, T., Kondoh, M., Matsuda, A., Inoue, N., Shindoh, M., and Hida, K. (2012) Tumor endothelial cells acquire drug resistance by MDR1 up-regulation via VEGF signaling in tumor microenvironment. Am. J. Pathol. 180, 1283-1293
-
(2012)
Am. J. Pathol
, vol.180
, pp. 1283-1293
-
-
Akiyama, K.1
Ohga, N.2
Hida, Y.3
Kawamoto, T.4
Sadamoto, Y.5
Ishikawa, S.6
Maishi, N.7
Akino, T.8
Kondoh, M.9
Matsuda, A.10
Inoue, N.11
Shindoh, M.12
Hida, K.13
-
46
-
-
0034682892
-
Genes expressed in human tumor endothelium
-
St Croix, B., Rago, C., Velculescu, V. et al. (2000) Genes expressed in human tumor endothelium. Science 289, 1197-1202
-
(2000)
Science
, vol.289
, pp. 1197-1202
-
-
St Croix, B.1
Rago, C.2
Velculescu, V.3
-
47
-
-
33847735810
-
Gene alterations identified by expression profiling in tumor-associated endothelial cells from invasive ovarian carcinoma
-
Lu, C., Bonome, T., Li, Y., Kamat, A.A., Han, L.Y., Schmandt, R., Coleman, R.L., Gershenson, D.M., Jaffe, R.B., Birrer, M.J., and Sood, K. (2007) Gene alterations identified by expression profiling in tumor-associated endothelial cells from invasive ovarian carcinoma. Cancer Res 67, 1757-1768
-
(2007)
Cancer Res
, vol.67
, pp. 1757-1768
-
-
Lu, C.1
Bonome, T.2
Li, Y.3
Kamat, A.A.4
Han, L.Y.5
Schmandt, R.6
Coleman, R.L.7
Gershenson, D.M.8
Jaffe, R.B.9
Birrer, M.J.10
Sood, K.11
-
48
-
-
34249822498
-
Genes that distinguish physiological and pathological angiogenesis
-
Seaman, S., Stevens, J., Yang, M.Y., Logsdon, D., Graff-Cherry, C., and St Croix, B. (2007) Genes that distinguish physiological and pathological angiogenesis. Cancer Cell 11, 539-554
-
(2007)
Cancer Cell
, vol.11
, pp. 539-554
-
-
Seaman, S.1
Stevens, J.2
Yang, M.Y.3
Logsdon, D.4
Graff-Cherry, C.5
St Croix, B.6
-
49
-
-
16844381577
-
A new perspective on tumor endothelial cells: Unexpected chromosome and centrosome abnormalities
-
Hida, K. and Klagsbrun, M. (2005) A new perspective on tumor endothelial cells: Unexpected chromosome and centrosome abnormalities. Cancer Res. 65, 2507-2510
-
(2005)
Cancer Res
, vol.65
, pp. 2507-2510
-
-
Hida, K.1
Klagsbrun, M.2
-
50
-
-
33644546368
-
Tumor endothelial cells express epidermal growth factor receptor (EGFR) but not ErbB3 and are responsive to EGF and to EGFR kinase inhibitors
-
Amin, D.N., Hida, K., Bielenberg, D.R., and Klagsbrun, M. (2006) Tumor endothelial cells express epidermal growth factor receptor (EGFR) but not ErbB3 and are responsive to EGF and to EGFR kinase inhibitors. Cancer Res. 66, 2173-2180
-
(2006)
Cancer Res
, vol.66
, pp. 2173-2180
-
-
Amin, D.N.1
Hida, K.2
Bielenberg, D.R.3
Klagsbrun, M.4
-
51
-
-
77951569864
-
Adrenomedullin antagonist suppresses tumor formation in renal cell carcinoma through inhibitory effects on tumor endothelial cells and endothelial progenitor mobilization
-
Tsuchiya, K., Hida, K., Hida, Y., Muraki, C., Ohga, N., Akino, T., Kondo, T., Miseki, T., Nakagawa, K., Shindoh, M., Harabayashi, T., Shinohara, N., Nonomura, K., and Kobayashi, M. (2010) Adrenomedullin antagonist suppresses tumor formation in renal cell carcinoma through inhibitory effects on tumor endothelial cells and endothelial progenitor mobilization. Int. J. Oncol. 36, 1379-1386
-
(2010)
Int. J. Oncol
, vol.36
, pp. 1379-1386
-
-
Tsuchiya, K.1
Hida, K.2
Hida, Y.3
Muraki, C.4
Ohga, N.5
Akino, T.6
Kondo, T.7
Miseki, T.8
Nakagawa, K.9
Shindoh, M.10
Harabayashi, T.11
Shinohara, N.12
Nonomura, K.13
Kobayashi, M.14
-
52
-
-
77950857559
-
Isolated tumor endothelial cells maintain specific character during long-term culture
-
Matsuda, K., Ohga, N., Hida, Y., Muraki, C., Tsuchiya, K., Kurosu, T., Akino, T., Shih, S.C., Totsuka, Y., Klagsbrun, M., Shindoh, M., and Hida, K. (2010) Isolated tumor endothelial cells maintain specific character during long-term culture. Biochem. Biophys. Res. Commun. 394, 947-954
-
(2010)
Biochem. Biophys. Res. Commun
, vol.394
, pp. 947-954
-
-
Matsuda, K.1
Ohga, N.2
Hida, Y.3
Muraki, C.4
Tsuchiya, K.5
Kurosu, T.6
Akino, T.7
Shih, S.C.8
Totsuka, Y.9
Klagsbrun, M.10
Shindoh, M.11
Hida, K.12
-
53
-
-
33744470405
-
Isolation and characterization of human breast tumor-derived endothelial cells
-
Grange, C., Bussolati, B., Bruno, S., Fonsato, V., Sapino, A., and Camussi, G. (2006) Isolation and characterization of human breast tumor-derived endothelial cells. Oncol. Rep. 15, 381-386
-
(2006)
Oncol. Rep
, vol.15
, pp. 381-386
-
-
Grange, C.1
Bussolati, B.2
Bruno, S.3
Fonsato, V.4
Sapino, A.5
Camussi, G.6
-
54
-
-
84863393758
-
Heterogeneity of tumor endothelial cells: Comparison between tumor endothelial cells isolated from high-and low-metastatic tumors
-
Ohga, N., Ishikawa, S., Maishi, N., Akiyama, K., Hida, Y., Kawamoto, T., Sadamoto, Y., Osawa, T., Yamamoto, K., Kondoh, M., Ohmura, H., Shinohara, N., Nonomura, K., Shindoh, M., and Hida, K. (2012) Heterogeneity of tumor endothelial cells: Comparison between tumor endothelial cells isolated from high-and low-metastatic tumors. Am. J. Pathol. 180, 1294-1307
-
(2012)
Am. J. Pathol
, vol.180
, pp. 1294-1307
-
-
Ohga, N.1
Ishikawa, S.2
Maishi, N.3
Akiyama, K.4
Hida, Y.5
Kawamoto, T.6
Sadamoto, Y.7
Osawa, T.8
Yamamoto, K.9
Kondoh, M.10
Ohmura, H.11
Shinohara, N.12
Nonomura, K.13
Shindoh, M.14
Hida, K.15
-
55
-
-
0037137872
-
Y-box factor YB-1 predicts drug resistance and patient outcome in breast cancer independent of clinically relevant tumor biologic factors HER2, uPA and PAI-1
-
Janz, M., Harbeck, N., Dettmar, P., Berger, U., Schmidt, A., Jurchott, K., Schmitt, M., and Royer, H.D. (2002) Y-box factor YB-1 predicts drug resistance and patient outcome in breast cancer independent of clinically relevant tumor biologic factors HER2, uPA and PAI-1. Int. J. Cancer 97, 278-282
-
(2002)
Int. J. Cancer
, vol.97
, pp. 278-282
-
-
Janz, M.1
Harbeck, N.2
Dettmar, P.3
Berger, U.4
Schmidt, A.5
Jurchott, K.6
Schmitt, M.7
Royer, H.D.8
-
56
-
-
1942539331
-
YB-1 is upregulated during prostate cancer tumor progression and increases P-glycoprotein activity
-
Gimenez-Bonafe, P., Fedoruk, M.N., Whitmore, T.G., Akbari, M., Ralph, J.L., Ettinger, S., Gleave, M.E., and Nelson, C.C. (2004) YB-1 is upregulated during prostate cancer tumor progression and increases P-glycoprotein activity. Prostate 59, 337-349
-
(2004)
Prostate
, vol.59
, pp. 337-349
-
-
Gimenez-Bonafe, P.1
Fedoruk, M.N.2
Whitmore, T.G.3
Akbari, M.4
Ralph, J.L.5
Ettinger, S.6
Gleave, M.E.7
Nelson, C.C.8
-
57
-
-
1942477310
-
Co-expression of Y box-binding protein-1 and P-glycoprotein as a prognostic marker for survival in epithelial ovarian cancer
-
Huang, X., Ushijima, K., Komai, K., Takemoto, Y., Motoshima, S., Kamura, T., and Kohno, K. (2004) Co-expression of Y box-binding protein-1 and P-glycoprotein as a prognostic marker for survival in epithelial ovarian cancer. Gynecol. Oncol. 93, 287-291
-
(2004)
Gynecol. Oncol
, vol.93
, pp. 287-291
-
-
Huang, X.1
Ushijima, K.2
Komai, K.3
Takemoto, Y.4
Motoshima, S.5
Kamura, T.6
Kohno, K.7
-
58
-
-
0026669192
-
Functional involvement of P-glycoprotein in blood-brain barrier
-
Tatsuta, T., Naito, M., Oh-hara, T., Sugawara, I., and Tsuruo, T. (1992) Functional involvement of P-glycoprotein in blood-brain barrier. J. Biol. Chem. 267, 20383-20391
-
(1992)
J. Biol. Chem
, vol.267
, pp. 20383-20391
-
-
Tatsuta, T.1
Naito, M.2
Oh-hara, T.3
Sugawara, I.4
Tsuruo, T.5
-
59
-
-
0037648896
-
Molecular targeting therapy of cancer: Drug resistance, apoptosis and survival signal
-
Tsuruo, T., Naito, M., Tomida, A., Fujita, N., Mashima, T., Sakamoto, H., and Haga, N. (2003) Molecular targeting therapy of cancer: Drug resistance, apoptosis and survival signal. Cancer Sci. 94, 15-21
-
(2003)
Cancer Sci
, vol.94
, pp. 15-21
-
-
Tsuruo, T.1
Naito, M.2
Tomida, A.3
Fujita, N.4
Mashima, T.5
Sakamoto, H.6
Haga, N.7
-
60
-
-
84857040086
-
Identification and characterization of a resident vascular stem/progenitor cell population in preexisting blood vessels
-
Naito, H., Kidoya, H., Sakimoto, S., Wakabayashi, T., and Takakura, N. (2011) Identification and characterization of a resident vascular stem/progenitor cell population in preexisting blood vessels. EMBO J. 31, 842-855
-
(2011)
EMBO J.
, vol.31
, pp. 842-855
-
-
Naito, H.1
Kidoya, H.2
Sakimoto, S.3
Wakabayashi, T.4
Takakura, N.5
-
61
-
-
77249134537
-
Rescue of paclitaxel sensitivity by repression of Prohibitin1 in drug-resistant cancer cells
-
Patel, N., Chatterjee, S.K., Vrbanac, V., Chung, I., Mu, C.J., Olsen, R.R., Waghorne, C., and Zetter, B.R. (2010) Rescue of paclitaxel sensitivity by repression of Prohibitin1 in drug-resistant cancer cells. Proc. Natl Acad. Sci. U S A 107, 2503-2508
-
(2010)
Proc. Natl Acad. Sci. U S A
, vol.107
, pp. 2503-2508
-
-
Patel, N.1
Chatterjee, S.K.2
Vrbanac, V.3
Chung, I.4
Mu, C.J.5
Olsen, R.R.6
Waghorne, C.7
Zetter, B.R.8
-
62
-
-
78049281857
-
Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters
-
Mi, Y.J., Liang, Y.J., Huang, H.B., Zhao, H.Y., Wu, C.P., Wang, F., Tao, L.Y., Zhang, C.Z., Dai, C.L., Tiwari, A.K., Ma, X.X., To, K.K., Ambudkar, S.V., Chen, Z.S., and Fu, L.W. (2010) Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters. Cancer Res. 70, 7981-7991
-
(2010)
Cancer Res
, vol.70
, pp. 7981-7991
-
-
Mi, Y.J.1
Liang, Y.J.2
Huang, H.B.3
Zhao, H.Y.4
Wu, C.P.5
Wang, F.6
Tao, L.Y.7
Zhang, C.Z.8
Dai, C.L.9
Tiwari, A.K.10
Ma, X.X.11
To, K.K.12
Ambudkar, S.V.13
Chen, Z.S.14
Fu, L.W.15
-
63
-
-
4043181214
-
Cancer genes and the pathways they control
-
Vogelstein, B. and Kinzler, K.W. (2004) Cancer genes and the pathways they control. Nat. Med. 10, 789-799
-
(2004)
Nat. Med
, vol.10
, pp. 789-799
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
64
-
-
34047245311
-
Chemoresistance of endothelial cells induced by basic fibroblast growth factor depends on Raf-1-mediated inhibition of the proapoptotic kinase, ASK1
-
Alavi, A.S., Acevedo, L., Min, W., and Cheresh, D.A. (2007) Chemoresistance of endothelial cells induced by basic fibroblast growth factor depends on Raf-1-mediated inhibition of the proapoptotic kinase, ASK1. Cancer Res. 67, 2766-2772
-
(2007)
Cancer Res
, vol.67
, pp. 2766-2772
-
-
Alavi, A.S.1
Acevedo, L.2
Min, W.3
Cheresh, D.A.4
-
65
-
-
33750702508
-
LY294002, a specific inhibitor of PI3K/ Akt kinase pathway, antagonizes P-glycoproteinmediated multidrug resistance
-
Barancik, M., Bohacova, V., Sedlak, J., Sulova, Z., and Breier, A. (2006) LY294,002, a specific inhibitor of PI3K/ Akt kinase pathway, antagonizes P-glycoproteinmediated multidrug resistance. Eur. J. Pharm. Sci. 29, 426-434
-
(2006)
Eur. J. Pharm. Sci
, vol.29
, pp. 426-434
-
-
Barancik, M.1
Bohacova, V.2
Sedlak, J.3
Sulova, Z.4
Breier, A.5
-
66
-
-
66849111843
-
Reversal of P-glycoprotein-mediated multi-drug resistance by the E3 ubiquitin ligase Cbl-b in human gastric adenocarcinoma cells
-
Zhang, Y., Qu, X., Hu, X., Yang, X., Hou, K., Teng, Y., Zhang, J., Sada, K., and Liu, Y. (2009) Reversal of P-glycoprotein-mediated multi-drug resistance by the E3 ubiquitin ligase Cbl-b in human gastric adenocarcinoma cells. J. Pathol. 218, 248-255
-
(2009)
J. Pathol
, vol.218
, pp. 248-255
-
-
Zhang, Y.1
Qu, X.2
Hu, X.3
Yang, X.4
Hou, K.5
Teng, Y.6
Zhang, J.7
Sada, K.8
Liu, Y.9
-
67
-
-
20544455061
-
Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells
-
Sutherland, B.W., Kucab, J., Wu, J., Lee, C., Cheang, M.C., Yorida, E., Turbin, D., Dedhar, S., Nelson, C., Pollak, M., Leighton, G.H., Miller, K., Badve, S., Huntsman, D., Blake-Gilks, C., Chen, M., Pallen, C.J., and Dunn, S.E. (2005) Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells. Oncogene 24, 4281-4292
-
(2005)
Oncogene
, vol.24
, pp. 4281-4292
-
-
Sutherland, B.W.1
Kucab, J.2
Wu, J.3
Lee, C.4
Cheang, M.C.5
Yorida, E.6
Turbin, D.7
Dedhar, S.8
Nelson, C.9
Pollak, M.10
Leighton, G.H.11
Miller, K.12
Badve, S.13
Huntsman, D.14
Blake-Gilks, C.15
Chen, M.16
Pallen, C.J.17
Dunn, S.E.18
-
68
-
-
70349609377
-
Inhibitory effects of epigallocatechin-3 gallate, a polyphenol in green tea, on tumor-associated endothelial cells and endothelial progenitor cells
-
Ohga, N., Hida, K., Hida, Y., Muraki, C., Tsuchiya, K., Matsuda, K., Ohiro, Y., Totsuka, Y., and Shindoh, M. (2009) Inhibitory effects of epigallocatechin-3 gallate, a polyphenol in green tea, on tumor-associated endothelial cells and endothelial progenitor cells. Cancer Sci. 100, 1963-1970
-
(2009)
Cancer Sci
, vol.100
, pp. 1963-1970
-
-
Ohga, N.1
Hida, K.2
Hida, Y.3
Muraki, C.4
Tsuchiya, K.5
Matsuda, K.6
Ohiro, Y.7
Totsuka, Y.8
Shindoh, M.9
-
69
-
-
11844254414
-
Normalization of tumor vasculature:an emerging concept in antiangiogenic therapy
-
Jain, R.K. (2005) Normalization of tumor vasculature:an emerging concept in antiangiogenic therapy. Science 58-62
-
(2005)
Science
, pp. 58-62
-
-
Jain, R.K.1
|