Rescue of paclitaxel sensitivity by repression of Prohibitin1 in drug-resistant cancer cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 6, 2010, Pages 2503-2508

  Patel, Nish ^a   Chatterjee, Sabarni K ^a,b   Vrbanac, Vladimir ^a   Chung, Ivy ^a   Mu, Chunyao Jenny ^a   Olsen, Rachelle R ^a   Waghorne, Carol ^a,c   Zetter, Bruce R ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c ARQULE INC   (United States)

Author keywords

Apoptosis; Glutathione S transferase Pi; Mitochondria; Plasma membrane; Protein translocation

Indexed keywords

CAMPTOTHECIN; CASPASE 3; CASPASE 7; DOCETAXEL; DOXORUBICIN; ETOPOSIDE; GLUTATHIONE TRANSFERASE P1; PACLITAXEL; PROHIBITIN; PROHIBITIN 1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL; CANCER RESISTANCE; CELL MEMBRANE; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; GENE OVEREXPRESSION; GENE REPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; MALE; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEOMICS;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; CELL MEMBRANE; DRUG RESISTANCE, NEOPLASM; GLUTATHIONE TRANSFERASE; HUMANS; IMMUNOBLOTTING; MALE; MICE; MICE, NUDE; MICROSCOPY, CONFOCAL; MITOCHONDRIA; NEOPLASMS; PACLITAXEL; PROTEOMICS; REPRESSOR PROTEINS; RNA INTERFERENCE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 77249134537     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0910649107     Document Type: Article

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