Holothurian Glycosaminoglycan Inhibits Metastasis and Thrombosis via Targeting of Nuclear Factor-κB/Tissue Factor/Factor Xa Pathway in Melanoma B16F10 Cells

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Zhao, Yang ^a   Zhang, Daohai ^b   Wang, Sheng ^a   Tao, Li ^a   Wang, Aiyun ^a   Chen, Wenxing ^a   Zhu, Zhijie ^a   Zheng, Shizhong ^a   Gao, Xiang ^c   Lu, Yin ^a  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b UNIVERSITY OF SYDNEY   (Australia)

^c NANJING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; ANTIMETASTATIC AGENT; BLOOD CLOTTING FACTOR 10A; HOLOTHURIAN GLYCOSAMINOGLYCAN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; THROMBOPLASTIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICOAGULATION; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVATION; ENZYME REPRESSION; FIBRIN FORMATION; IN VITRO STUDY; IN VIVO STUDY; LUNG METASTASIS; METASTASIS INHIBITION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; THROMBOSIS;

ANIMALS; CALCIUM; FACTOR XA; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOSAMINOGLYCANS; HOLOTHURIN; HUMANS; MELANOMA; MELANOMA, EXPERIMENTAL; MICE; NEOPLASM METASTASIS; NF-KAPPA B; PHOSPHORYLATION; SIGNAL TRANSDUCTION; THROMBOPLASTIN; THROMBOSIS;

EID: 84874330932     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0056557     Document Type: Article

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