Acidic mucopolysaccharide from holothuria leucospilota has antitumor effect by inhibiting angiogenesis and tumor cell invasion in vivo and in vitro

Cancer Biology and Therapy

Volumn 8, Issue 15, 2009, Pages 1489-1499

  Zhang, Weiwei ^a   Lu, Yin ^a,b   Xu, Bo ^a   Wu, Jiaming ^a   Zhang, Lijuan ^a   Gao, Ming ^a   Zheng, Shizhong ^a,b   Wang, Aiyun ^a   Zhang, Changbin ^a   Chen, Lei ^a   Lei, Na ^a  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b Jiangsu Key Laboratory for TCM Formulae Research   (China)

Author keywords

Acidic mucopolysaccharide; Angiogenesis; Invasion; MMP; Regulation; Tumor metastasis; VEGF

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; GELATINASE A; GELATINASE B; GLYCOSAMINOGLYCAN; TUMOR PROTEIN; VASCULAR ENDOTHELIAL GROWTH FACTOR A, MOUSE; VASCULOTROPIN A;

ANIMAL; AORTA; ARTICLE; BIOSYNTHESIS; C57BL MOUSE; CANCER INVASION; CELL LINE; CELL MOTION; CHEMISTRY; CYTOLOGY; DRUG EFFECT; DRUG SCREENING; ENDOTHELIUM CELL; EXPERIMENTAL MELANOMA; GENETICS; HOLOTHURIA; HUMAN; ISOLATION AND PURIFICATION; LUNG TUMOR; METASTASIS; MOUSE; PATHOLOGY; RAT; TUMOR CELL LINE;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTINEOPLASTIC AGENTS; AORTA; CELL LINE; CELL LINE, TUMOR; CELL MOVEMENT; DRUG SCREENING ASSAYS, ANTITUMOR; ENDOTHELIAL CELLS; GLYCOSAMINOGLYCANS; HOLOTHURIA; HUMANS; LUNG NEOPLASMS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; RATS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 85046914977     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.8.15.8948     Document Type: Article

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