Invasive colon cancer, but not non-invasive adenomas induce a gradient effect of Wnt pathway receptor frizzled 1 (Fz1) expression in the tumor microenvironment

Journal of Translational Medicine

Volumn 11, Issue 1, 2013, Pages

  Planutis, Kestutis ^a   Planutiene, Marina ^a   Nguyen, Anthony V ^b   Moyer, Mary Pat ^c   Holcombe, Randall F ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c INCELL Corporation ^*  (United States)

Author keywords

Colon cancer; Fz receptors; Tumor microenvironment; Wnt signaling; Wnt3a

Indexed keywords

FRIZZLED PROTEIN; FRIZZLED RECEPTOR 1; FRIZZLED RECEPTOR 2; UNCLASSIFIED DRUG; WNT3A PROTEIN;

ANIMAL CELL; ARTICLE; AUTOCRINE EFFECT; CANCER INVASION; COLON ADENOMA; COLON CANCER; COLON POLYPOSIS; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; NONHUMAN; PARACRINE SIGNALING; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR MICROENVIRONMENT; VILLOUS ADENOMA;

ADENOMA; CELL LINE, TUMOR; COLONIC NEOPLASMS; CULTURE MEDIA, CONDITIONED; FRIZZLED RECEPTORS; HUMANS; IMMUNOHISTOCHEMISTRY; REAL-TIME POLYMERASE CHAIN REACTION; TUMOR MICROENVIRONMENT;

EID: 84874195014     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-11-50     Document Type: Article

References (29)

1. Witz IP. Yin-yang activities and vicious cycles in the tumor microenvironment. Cancer Res 2008, 68:9-13. 10.1158/0008-5472.CAN-07-2917, 18172289.
2. Miyaki M, Konishi M, Kikuchi-Yanoshita R, Enomoto M, Igari T, Tanaka K, Muraoka M, Takahashi H, Amada Y, Fukayama M, Maeda Y, Iwama T, Mishima Y, Mori T, Koike M. Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors. Cancer Res 1994, 54:3011-3020.
3. Naji R, Holcombe RF, Waterman ML. Wnt signaling and colon carcinogenesis: Beyond APC. J Carcinogenesis 2011, 10:5-13.
4. Lau W, Barker N, Clevers H. Wnt signaling in the normal intestine and colorectal cancer. Front Biosci 2007, 12:471-491. 10.2741/2076, 17127311.
5. Vermeulen L, DeSousa EMF, van der Heijden M, Cameron K, de Jong JH, Borovski R, Tuynman JB, Todaro M, Merz C, Rodermond H, Sprick MR, Kemper K, Richel DJ, Stassi G, Medema JP. Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nat Cell Bio 2010, 12:468-476.
6. Le NH, Franken P, Fodde R. Tumour-stroma interactions in colorectal cancer: converging on beta-catenin activation and cancer stemness. Br J Cancer 2008, 98:1886-1893. 10.1038/sj.bjc.6604401, 2441948, 18506144.
7. Bandapalli OR, Dihlmann S, Helwa R, Macher-Geoppinger S, Weitz J, Schirmacher P, Brand K. Transcriptional activation of the beta-catenin gene at the invasion front of colorectal liver metastases. J Pathol 2009, 218:370-379. 10.1002/path.2539, 19347947.
8. Bafico A, Liu G, Goldin L, Harris V, Aaronson SA. An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells. Cancer Cell 2004, 6:497-506. 10.1016/j.ccr.2004.09.032, 15542433.
9. Holcombe RF, Marsh JL, Waterman ML, Milovanovic T, Truong T. Expression of Wnt ligands and frizzled receptors in colonic mucosa and in colon carcinoma. Mol Pathol 2002, 55:220-226. 10.1136/mp.55.4.220, 1187182, 12147710.
10. Jung A, Schrauder M, Oswald U, Knoll C, Sellberg P, Palmqvist R, Niedobitek G, Brabletz T, Kirchner T. The Invasion Front of Human Colorectal Adenocarcinomas Shows Co-Localization of Nuclear β-Catenin, Cyclin D1, and p16INK4A and Is a Region of Low Proliferation. Am J Pathol 2001, 159:1613-1617. 10.1016/S0002-9440(10)63007-6, 1867079, 11696421.
11. Macheda ML, Stacker SA. Importance of Wnt signaling in the tumor stroma microenvironment. Curr Cancer Drug Targets 2008, 8:454-465. 10.2174/156800908785699324, 18781892.
12. Van Amerongen R, Nusse R. Toward an integrated view of Wnt signaling in development. Development 2009, 36:3205-3214.
13. Vincan E, Flanagan DJ, Pouliot N, BRabletz R, Spaderna S. Variable FZD7 expression in colorectal cancers indicates regulation by the tumor microenvironment. Dev Dyn 2010, 239:311-317.
14. Ueno K, Hazama S, Mitormori S, Nishioka M, Suehiro Y, Hirata H, Oka M, Imai K, Dahiya R, Hinoda Y. Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells. Br J Cancer 2009, 101:1374-1381. 10.1038/sj.bjc.6605307, 2768449, 19773752.
15. Nguyen AV, Albers CG, Holcombe RF. Differentiation of tubular and villous adenomas based on Wnt pathway-related gene expression profiles. Int J Mol Med 2010, 26:121-5.
16. Moyer MP, Stauffer JS, Manzano LA, Tanzer LR, Merriman RL. NCM460, A normal human colon mucosal epithelial cell Line. In Vitro Cell Dev Biol Anim 1996, 32:315-317. 10.1007/BF02722955, 8842743.
17. Willert K, Brown JD, Danenberg E, Duncan AW, Weissman IL, Reya T, Yates JR, Nusse R. Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 2003, 423:448-452. 10.1038/nature01611, 12717451.
18. Milovanovic T, Planutis K, Nguyen A, Marsh L, Lin F, Hope C, Holcombe RF. Expression of Wnt genes and frizzled 1 and 2 receptors in normal breast epithelium and infiltrating breast carcinoma. Int J Oncol 2004, 25:1337-1342.
19. Flahaut M, Meier R, Coulon A, Nardou KA, Niggli FK, Martinet D, Bechmann JS, Joseph JM, Muehlethaler-Mottet A, Gross N. The Wnt receptor FZD1 mediates chemoresistance in neuroblastoma through activation of the Wnt/beta-catenin pathway. Oncogene 2009, 28:2245-2256. 10.1038/onc.2009.80, 19421142.
20. Neumann J, Schaale K, Farhat K, Endermann T, Ulmer AJ, Ehlers S, Reiling N. Frizzled 1 is a marker of inflammatory macrophages and its ligand Wnt3a is involved in reprogramming Mycobacterium tuberculosis-infected macrophages. FASEB J 2010, 24:4599-4612. 10.1096/fj.10-160994, 20667980.
21. Chacon MA, Varela-Nallar L, Inestrosa NC. Frizzled-1 is involved in the neuroprotective effect of Wnt3a against Abeta oligomers. J Cell Physiol 2008, 217:215-227. 10.1002/jcp.21497, 18521822.
22. Roman-Roman S, Shi E-L, Stiot V, Hay E, Vayssiere B, Garcia R, Baron R, Rawadi G. Murine frizzled-1 behaves as an antogaonist of the canonical Wnt/β-catinin signaling. J Biol Chem 2004, 279:5725-5733.
23. Sato A, Yamamoto H, Sakane H, Koyama H, Kikuchi A. Wnt5a regulates distinct signaling pathways by binding to frizzled 2. EMBO J 2010, 29:41-54. 10.1038/emboj.2009.322, 2808370, 19910923.
24. Brabletz T, Jung A, Hermann K, Guenther K, Hohenberger W, Kirchner T. Nuclear overexpression of the oncoprotein β-catenin in colorectal cancer is localized predominantly at the invasion front. Pathol Res Pract 1998, 194:701-704. 10.1016/S0344-0338(98)80129-5, 9820866.
25. Suzuki H, Watkins DN, Jair K-W, Schuebel KE, Markowitz SD, Chen WD, Pretlow TP, Yang B, Akiyama Y, van Engeland M, Toyota M, Tokino T, Hinoda Y, Imai K, Herman JG, Baylin SB. Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet 2004, 36:417-422. 10.1038/ng1330, 15034581.
26. Kobayashi M, Honma T, Matsuda Y, Suzuki Y, Narisawa R, Ajioka Y, Asakura H. Nuclear translocation of beta-catenin in colorectal cancer. Br J Cancer 2000, 82:1689-1693. 2374509, 10817505.
27. Kolben T, Perobner I, Fernsebner K, Lechner F, Geissler C, Ruiz-Heinrich L, Capovilla S, Jochum M, Neth P. Dissecting the impact of frizzled receptors in Wnt/β-catenin signaling of human mesenchymal stem cells. Biol Chem 2012, 393:1433-1447.
28. Wels J, Kaplan RN, Rafii S, Lyden D. Migratory neighbors and distant invaders: tumor -associated niche cells. Genes Dev 2008, 22:559-574. 10.1101/gad.1636908, 2731657, 18316475.
29. Lieberman DA, Smith FW. Screening for colon malignancy with colonoscopy. Am J Gastroenterol 1991, 86:946-951.