Tetraspanins in mast cells

Frontiers in Immunology

Volumn 3, Issue MAY, 2012, Pages

  Köberle, Martin ^a   Kaesler, Susanne ^a   Kempf, Wolfgang ^a   Wölbing, Florian ^a   Biedermann, Tilo ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

CD151; CD63; CD81; CD9; Mast cell; Tetraspanin

Indexed keywords

EID: 84874132525     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2012.00106     Document Type: Review

References (107)

1. Abraham, S. N., St John, A. L. (2010). Mast cell-orchestrated immunity to pathogens. Nat. Rev. 10, 440-452.
2. Akahoshi,M.,Song,C. H.,Piliponsky,A. M., Metz, M., Guzzetta, A., Abrink, M., Schlenner, S. M., Feyerabend, T. B., Rodewald, H. R., Pejler, G., Tsai, M., and Galli, S. J. (2011). Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypep- tide in mice. J. Clin. Invest. 121, 4180-4191.
3. Amin, K. (2012). The role of mast cells in allergic inflam- mation. Respir. Med. 106, 9-14.
4. Arduise,C.,Abache,T.,Li,L.,Billard,M., Chabanon, A., Ludwig, A., Mauduit, P., Boucheix, C., Rubinstein, E., and Le Naour, F. (2008). Tetraspanins regulate ADAM10-mediated cleav- age of TNF-alpha and epidermal growth factor. J. Immunol. 181, 7002-7013.
5. Ashman, L. K., Aylett, G. W., Mehra- bani, P. A., Bendall, L. J., Niutta, S., Cambareri, A. C., Cole, S. R., and Berndt, M. C. (1991). The murine monoclonal antibody, 14A2.H1, identifies a novel platelet surface antigen. Br. J. Haematol. 79, 263-270.
6. Baghestanian, M., Bankl, H., Sillaber, C., Beil, W. J., Radaszkiewicz, T., Fureder, W., Preiser, J., Vesely, M., Schernthaner, G., Lechner, K., and Valent, P. (1996). A case of malig- nant mastocytosis with circulat- ing mast cell precursors: biologic and phenotypic characterization of the malignant clone. Leukemia 10, 159-166.
7. Beghdadi, W., Madjene, L. C., Ben- hamou, M., Charles, N., Gau- tier, G., Launay, P., and Blank, U. (2011). Mast cells as cellu- lar sensors in inflammation and immunity. Front. Immun. 2:37. doi:10.3389/fimmu.2011.00037
8. Beil, W. J., Fureder, W., Wiener, H., Grossschmidt, K., Maier, U., Schedle, A., Bankl, H. C., Lechner, K., and Valent, P. (1998). Pheno- typic and functional characteriza- tion of mast cells derived from renal tumor tissues. Exp. Hematol. 26, 158-169.
9. Benhamou, M., and Blank, U. (2010). Stimulus-secretion coupling by high-affinity IgE receptor: new developments. FEBS Lett. 584, 4941-4948.
10. Berditchevski, F. (2001). Complexes of tetraspanins with integrins: more than meets the eye. J. Cell. Sci. 114, 4143-4151.
11. Biedermann, T., Kneilling, M., Mail- hammer, R., Maier, K., Sander, C. A., Kollias, G., Kunkel, S. L., Hultner, L., and Rocken, M. (2000). Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reac- tions through tumor necrosis fac- tor and macrophage inflamma- tory protein 2. J. Exp. Med. 192, 1441-1452.
12. Bradding, P., Roberts, J. A., Britten, K. M., Montefort, S., Djukanovic, R., Mueller,R.,Heusser,C. H.,Howarth, P. H., and Holgate, S. T. (1994). Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. Am. J. Respir. Cell Mol. Biol. 10, 471-480.
13. Chen, M. S., Tung, K. S., Coonrod, S. A., Takahashi, Y., Bigler, D., Chang, A., Yamashita, Y., Kincade, P. W., Herr, J. C., and White, J. M. (1999). Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin alpha6beta1: implications for murine fertilization. Proc. Natl. Acad. Sci. U.S.A. 96, 11830-11835.
14. Collington, S. J., Williams, T. J., and Weller, C. L. (2011). Mechanisms underlying the localisation of mast cells in tissues. Trends Immunol. 32, 478-485.
15. Crivellato, E., and Ribatti, D. (2010). The mast cell: an evo- lutionary perspective. Biol. Rev. Camb. Philos. Soc. 85, 347-360.
16. Deng, J., Yeung, V. P., Tsitoura, D., Dekruyff, R. H., Umetsu, D. T., and Levy, S. (2000). Allergen- induced airway hyperreactivity is diminished in CD81- deficient mice. J. Immunol. 165, 5054-5061.
17. Doyle, E. L., Ridger, V., Ferraro, F., Tur- maine, M., Saftig, P., and Cutler, D. F. (2011). CD63 is an essential cofactor to leukocyte recruitment by endothelial P-selectin. Blood 118, 4265-4273.
18. Draber, P., Halova, I., Levi-Schaffer, F., and Draberova, L. (2012). Transmembrane adaptor proteins in the high-affinity IgE recep- tor signaling. Front. Immun. 2:95. doi:10.3389/fimmu.2011.00095
19. Dudeck, A., Dudeck, J., Scholten, J., Petzold, A., Surianarayanan, S., Kohler, A., Peschke, K., Vohringer, D., Waskow, C., Krieg, T., Muller, W., Waisman, A., Hartmann, K., Gunzer, M., and Roers, A. (2011). Mast cellsarekeypromotersofcontact allergy that mediate the adjuvant effects of haptens. Immunity 34, 973-984.
20. Duffield, A., Kamsteeg, E. J., Brown, A. N., Pagel, P., and Caplan, M. J. (2003). The tetraspanin CD63 enhances the internalization of the H,K-ATPase beta-subunit. Proc. Natl. Acad. Sci. U.S.A. 100, 15560-15565.
21. Echtenacher, B., Mannel, D. N., and Hultner, L. (1996). Critical protec- tive role of mast cells in a model of acute septic peritonitis. Nature 381, 75-77.
22. Escribano, L., Orfao, A., Diaz Agustin, B., Cervero, C., Herrero, S., Villarrubia, J., Bravo, P., Torrelo, A., Montero, T.,Valdemoro, M.,Velasco, J. L., Navarro, J. L., and San Miguel, J. F. (1998). Human bone marrow mast cells from indolent systemic mast cell disease constitutively express increased amounts of the CD63 pro- tein on their surface. Cytometry 34, 223-228.
23. Feyerabend, T. B., Weiser, A., Tietz, A., Stassen, M., Harris, N., Kopf, M., Radermacher, P., Moller, P., Benoist, C., Mathis, D., Fehling, H. J., and Rodewald, H. R. (2011). Cremediated cell ablation con- tests mast cell contribution in models of antibody- and T cell- mediated autoimmunity. Immunity 35, 832-844.
24. Fleming, T. J., Donnadieu, E., Song, C. H., Laethem, F. V., Galli, S. J., and Kinet, J. P. (1997). Negative regulation of Fc epsilon RI-mediated degranulation by CD81. J. Exp. Med. 186, 1307-1314.
25. Fureder, W., Bankl, H. C., Toth, J., Walchshofer, S., Sperr, W., Agis, H., Semper, H., Sillaber, C., Lechner, K., and Valent, P. (1997). Immunophenotypic and functional characterization of human tonsil- lar mast cells. J. Leukoc. Biol. 61, 592-599.
26. Ghannadan, M., Baghestanian, M., Wimazal, F., Eisenmenger, M., Latal, D., Kargul, G., Walchshofer, S., Sillaber, C., Lechner, K., and Valent, P. (1998). Phenotypic characteriza- tion of human skin mast cells by combined staining with toluidine blue and CD antibodies. J. Invest. Dermatol. 111, 689-695.
27. Guo, C. B., Kagey-Sobotka, A., Licht- enstein, L. M., and Bochner, B. S. (1992). Immunophenotyping and functional analysis of purified human uterine mast cells. Blood 79, 708-712.
28. Gutierrez-Lopez, M. D., Ovalle, S., Yanez-Mo, M., Sanchez-Sanchez, N., Rubinstein, E., Olmo, N., Lizarbe, M. A., Sanchez-Madrid, F., and Cabanas, C. (2003). A function- ally relevant conformational epitope on the CD9 tetraspanin depends on the association with activated beta1 integrin. J. Biol. Chem. 278, 208-218.
29. Hallgren, J., and Gurish, M. F. (2007). Pathways of murine mast cell devel- opment and trafficking: tracking the roots and routes of the mast cell. Immunol. Rev. 217, 8-18.
30. Hemler, M. E. (2005). Tetraspanin functions and associated microdomains. Nat. Rev. Mol. Cell Biol. 6, 801-811.
31. Hennersdorf, F., Florian, S., Jakob, A., Baumgartner,K.,Sonneck,K.,Nord- heim, A., Biedermann, T., Valent, P., and Buhring,H. J. (2005). Identifica- tion of CD13, CD107a, and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of IgE- dependent upregulation. Cell Res. 15, 325-335.
32. Higginbottom, A., Wilkinson, I., Mccul- lough, B., Lanza, F., Azorsa, D. O., Partridge, L. J., and Monk, P. N. (2000). Antibody crosslinking of human CD9 and the highaffinity immunoglobulin E recep- tor stimulates secretion from transfected rat basophilic leukaemia cells. Immunology 99, 546-552.
33. Hotta, H., Ross, A. H., Huebner, K., Isobe, M., Wendeborn, S., Chao, M. V., Ricciardi, R. P., Tsujimoto, Y., Croce, C. M., and Koprowski, H. (1988). Molecular cloning and char- acterization of an antigen associ- ated with early stages of melanoma tumor progression. Cancer Res. 48, 2955-2962.
34. Huang, M. M., Indik, Z., Brass, L. F., Hoxie, J. A., Schreiber, A. D., and Brugge, J. S. (1992). Activation of Fc gamma RII induces tyrosine phosphorylation of multiple pro- teins including Fc gamma RII. J. Biol. Chem. 267, 5467-5473.
35. Iizuka, S., Kudo, Y., Yoshida, M., Tsunematsu, T., Yoshiko, Y., Uchida, T., Ogawa, I., Miyauchi, M., and Takata, T. (2011). Ameloblastin regulates osteogenic differentiation by inhibiting Src kinase via cross talk between integrin beta1 and CD63. Mol. Cell. Biol. 31, 783-792.
36. Ikeyama, S., Koyama, M., Yamaoko, M., Sasada, R., and Miyake, M. (1993). Suppression of cell motil- ity and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNA. J. Exp. Med. 177, 1231-1237.
37. Ishibashi, T., Ding, L., Ikenaka, K., Inoue, Y., Miyado, K., Mekada, E., and Baba, H. (2004). Tetraspanin protein CD9 is a novel paran- odal component regulating paran- odal junctional formation. J. Neu- rosci. 24, 96-102.
38. Ishibashi, K., Suzuki, M., Sasaki, S., and Imai, M. (2001). Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor. Gene 264, 87-93.
39. Jin, C., Shelburne, C. P., Li, G., Potts, E. N., Riebe, K. J., Sem- powski, G. D., Foster, W. M., and Abraham, S. N. (2011). Particulate allergens potentiate allergic asthma in mice through sustained IgE- mediated mast cell activation. J. Clin. Invest. 121, 941-955.
40. Jost, E., Michaux, L.,Vanden Abeele, M., Boland, B., Latinne, D., Godfraind, C., Scheiff, J. M., Vaerman, J. L., Lecouvet, F., and Ferrant, A. (2001). Complex karyotype and absence of mutation in the c-kit receptor in aggressive mastocytosis presenting with pelvic osteolysis, eosinophilia and brain damage. Ann. Hematol. 80, 302-307.
41. Kaji, K., Oda, S., Shikano, T., Ohnuki, T., Uematsu, Y., Sakagami, J., Tada, N., Miyazaki, S., and Kudo, A. (2000). The gamete fusion process is defec- tive in eggs of Cd9-deficient mice. Nat. Genet. 24, 279-282.
42. Kambayashi,T.,Allenspach,E. J.,Chang, J. T., Zou, T., Shoag, J. E., Reiner, S. L., Caton, A. J., and Koretzky, G. A. (2009). Inducible MHC class II expression by mast cells supports effector and regulatory T cell acti- vation. J. Immunol. 182, 4686-4695.
43. Kersey, J. H., Lebien, T. W., Abramson, C. S., Newman, R., Suther- land, R., and Greaves, M. (1981). P-24: a human leukemia-associated and lymphohemopoietic progenitor cell surface structure identified with monoclonal antibody. J. Exp. Med. 153, 726-731.
44. Kirshenbaum, A. S., Akin, C., Wu, Y., Rottem, M., Goff, J. P., Beaven, M. A., Rao, V. K., and Metcalfe, D. D. (2003). Characterization of novelstemcellfactorresponsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activa- tion following aggregation of Fcep- silonRI or FcgammaRI. Leuk. Res. 27, 677-682.
45. Kitani, S., Berenstein, E., Mergenhagen, S., Tempst, P., and Siraganian, R. P. (1991). A cell surface glyco- protein of rat basophilic leukemia cells close to the high affinity IgE receptor (Fc epsilon RI). Similarity to human melanoma differentiation antigen ME491. J. Biol. Chem. 266, 1903-1909.
46. Kneilling, M., Hultner, L., Pichler, B. J., Mailhammer, R., Morawietz, L., Solomon, S., Eichner, M., Sabatino, J., Biedermann, T., Krenn, V., Weber, W. A., Illges, H., Haubner, R., and Rocken, M. (2007). Targeted mast cell silencing protects against joint destruction and angiogenesis in experimental arthritis in mice. Arthritis Rheum. 56, 1806-1816.
47. Kneilling, M., Mailhammer, R., Hult- ner, L., Schonberger, T., Fuchs, K., Schaller, M., Bukala, D., Massberg, S., Sander, C. A., Braumuller, H., Eichner, M., Maier, K. L., Hall- mann, R., Pichler, B. J., Haubner, R., Gawaz, M., Pfeffer, K., Biedermann, T., and Rocken, M. (2009). Direct crosstalk between mast cell-TNF and TNFR1-expressing endothelia medi- ates local tissue inflammation. Blood 114, 1696-1706.
48. Knol, E. F., Mul, F. P., Jansen, H., Calafat, J., and Roos, D. (1991). Monitoring human basophil activation via CD63 monoclonal antibody 435. J. Allergy Clin. Immunol. 88, 328-338.
49. Kobayashi, T.,Vischer, U. M., Rosnoblet, C., Lebrand, C., Lindsay, M., Par- ton, R. G., Kruithof, E. K., and Gruenberg, J. (2000). The tetraspanin CD63/lamp3 cycles between endo- cytic and secretory compartments in human endothelial cells. Mol. Biol. Cell 11, 1829-1843.
50. Kraft, S., Fleming, T., Billingsley, J. M., Lin, S. Y., Jouvin, M. H., Storz, P., and Kinet, J. P. (2005). Anti-CD63 antibodies suppress IgE-dependent allergic reactions in vitro and in vivo. J. Exp. Med. 201, 385-396.
51. Krauth, M. T., Majlesi, Y., Florian, S., Bohm, A., Hauswirth, A. W., Ghan- nadan, M., Wimazal, F., Raderer, M., Wrba, F., and Valent, P. (2005). Cell surface membrane antigen pheno- type of human gastrointestinal mast cells. Int. Arch. Allergy Immunol. 138, 111-120.
52. Lammerding, J., Kazarov, A. R., Huang, H., Lee, R. T., and Hemler, M. E. (2003). Tetraspanin CD151 regu- lates alpha6beta1 integrin adhesion strengthening. Proc. Natl. Acad. Sci. U.S.A. 100, 7616-7621.
53. Lau, L. M., Wee, J. L., Wright, M. D., Moseley, G. W., Hogarth, P. M., Ashman, L. K., and Jackson, D. E. (2004). The tetraspanin superfamily member CD151 regulates outside- in integrin alphaIIbbeta3 signaling and platelet function. Blood 104, 2368-2375.
54. Lee, D. M., Friend, D. S., Gurish, M. F., Benoist, C., Mathis, D., and Brenner, M. B. (2002). Mast cells: a cellu- lar link between autoantibodies and inflammatory arthritis. Science 297, 1689-1692.
55. Levy, S., and Shoham, T. (2005). Protein-protein interactions in the tetraspanin web. Physiology (Bethesda) 20, 218-224.
56. Levy, S., Todd, S. C., and Maecker, H. T. (1998). CD81 (TAPA-1): a mole- cule involved in signal transduction and cell adhesion in the immune system. Annu. Rev. Immunol. 16, 89-109.
57. Liu, L., He, B., Liu, W. M., Zhou, D., Cox, J. V., and Zhang, X. A. (2007). Tetraspanin CD151 pro- motes cell migration by regulating integrin trafficking. J. Biol. Chem. 282, 31631-31642.
58. Loffler, S., Lottspeich, F., Lanza, F., Azorsa, D. O., Ter Meulen, V., and Schneider-Schaulies, J. (1997). CD9, a tetraspan transmembrane protein, renders cells susceptible to canine distemper virus. J. Virol. 71, 42-49.
59. Mandal, A. K., Jones, P. B., Bair, A. M., Christmas, P., Miller, D., Yamin, T. T., Wisniewski, D., Menke, J., Evans, J. F., Hyman, B. T., Bac- skai, B., Chen, M., Lee, D. M., Nikolic, B., and Soberman, R. J. (2008). The nuclear membrane organization of leukotriene synthe- sis. Proc. Natl. Acad. Sci. U.S.A. 105, 20434-20439.
60. Metz, M., Piliponsky, A. M., Chen, C. C.,Lammel,V.,Abrink,M.,Pejler,G., Tsai, M., and Galli, S. J. (2006). Mast cells can enhance resistance to snake and honeybee venoms. Science 313, 526-530.
61. Metzelaar, M. J., Wijngaard, P. L., Peters, P. J., Sixma, J. J., Nieuwenhuis, H. K., and Clevers, H. C. (1991). CD63 antigen. A novel lysosomal mem- brane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells. J. Biol. Chem. 266, 3239-3245.
62. Miyake, M., Koyama, M., Seno, M., and Ikeyama, S. (1991). Identifi- cation of the motility-related pro- tein (MRP-1), recognized by mon- oclonal antibody M31-15, which inhibits cell motility. J. Exp. Med. 174, 1347-1354.
63. Moseley, G. W. (2005). Tetraspanin-Fc receptor interactions. Platelets 16, 3-12.
64. Nishibori, M., Cham, B., Mcnicol, A., Shalev, A., Jain, N., and Gerrard, J. M. (1993). The protein CD63 is in platelet dense granules, is deficient in a patient with Hermansky-Pudlak syndrome, and appears identical to granulophysin. J. Clin. Invest. 91, 1775-1782.
65. Oren, R., Takahashi, S., Doss, C., Levy, R., and Levy, S. (1990). TAPA-1, the target of an antiproliferative anti- body, defines a new family of trans- membrane proteins. Mol. Cell. Biol. 10, 4007-4015.
66. Otsuka, A., Kubo, M., Honda, T., Egawa, G., Nakajima, S., Tanizaki, H., Kim, B., Matsuoka, S., Watan- abe, T., Nakae, S., Miyachi, Y., and Kabashima, K. (2011). Requirement of interaction between mast cells and skin dendritic cells to estab- lish contact hypersensitivity. PLoS ONE 6, e25538. doi:10.1371/jour- nal.pone.0025538
67. Parada, N. A., Center, D. M., Kornfeld, H., Rodriguez,W. L., Cook, J.,Vallen, M., and Cruikshank, W. W. (1998). Synergistic activation of CD4 + T cells by IL-16 and IL-2. J. Immunol. 160, 2115-2120.
68. Peng,W. M.,Yu, C. F., Kolanus,W., Maz- zocca, A., Bieber, T., Kraft, S., and Novak, N. (2011). Tetraspanins CD9 and CD81 are molecular partners of trimeric FcvarepsilonRI on human antigen-presenting cells. Allergy 66, 605-611.
69. Pennock, J. L., and Grencis, R. K. (2004). In vivo exit of c- kit+/CD49d(hi)/beta7+ mucosal mast cell precursors from the bone marrow following infection with the intestinal nematode Trichinella spiralis. Blood 103, 2655-2660.
70. Peters, P. J., Borst, J., Oorschot, V., Fukuda, M., Krahenbuhl, O., Tschopp, J., Slot, J. W., and Geuze, H. J. (1991). Cytotoxic T lympho- cyte granules are secretory lyso- somes, containing both perforin and granzymes. J. Exp. Med. 173, 1099-1109.
71. Pileri, P., Uematsu, Y., Campagnoli, S., Galli, G., Falugi, F., Petracca, R., Weiner, A. J., Houghton, M., Rosa, D., Grandi, G., and Abrignani, S. (1998). Binding of hepatitis C virus to CD81. Science 282, 938-941.
72. Puri, N., Kruhlak, M. J., Whiteheart, S. W., and Roche, P. A. (2003). Mast cell degranulation requires N-ethylmaleimide-sensitive factor- mediated SNARE disassembly. J. Immunol. 171, 5345-5352.
73. Qi, J. C., Wang, J., Mandadi, S., Tanaka, K., Roufogalis, B. D., Madigan, M. C., Lai, K., Yan, F., Chong, B. H., Stevens,R. L.,and Krilis,S.A. (2006). Human and mouse mast cells use the tetraspanin CD9 as an alternate interleukin-16 receptor. Blood 107, 135-142.
74. Quast, T., Eppler, F., Semmling, V., Schild, C., Homsi, Y., Levy, S., Lang, T., Kurts, C., and Kolanus,W. (2011). CD81 is essential for the formation of membrane protrusions and reg- ulates Rac1-activation in adhesion- dependent immune cell migration. Blood 118, 1818-1827.
75. Radford, K. J., Thorne, R. F., and Hersey, P. (1997). Regulation of tumor cell motility and migration by CD63 in a human melanoma cell line. J. Immunol. 158, 3353-3358.
76. Rous, B. A., Reaves, B. J., Ihrke, G., Briggs, J. A., Gray, S. R., Stephens, D. J., Banting, G., and Luzio, J. P. (2002). Role of adaptor complex AP- 3 in targeting wild-type and mutated CD63 to lysosomes. Mol. Biol. Cell 13, 1071-1082.
77. Sachs, N., Claessen, N., Aten, J., Kreft, M., Teske, G. J., Koeman, A., Zuur- bier, C. J., Janssen, H., and Sonnenberg, A. (2012). Blood pressure influences end-stage renal disease of Cd151 knockout mice. J. Clin. Invest. 122, 348-358.
78. Sagi, Y., Landrigan, A., Levy, R., and Levy,S. (2012). Complementary cos- timulation of human T-cell sub- populations by cluster of differ- entiation 28 (CD28) and CD81. Proc. Natl. Acad. Sci. U.S.A. 109, 1613-1618.
79. Sayed, B. A., Christy, A., Quirion, M. R., and Brown, M. A. (2008). The mas- ter switch: the role of mast cells in autoimmunity and tolerance. Annu. Rev. Immunol. 26, 705-739.
80. Schafer, T., Starkl, P., Allard, C., Wolf, R. M., and Schweighoffer, T. (2010). A granular variant of CD63 is a regulator of repeated human mast cell degranulation. Allergy 65, 1242-1255.
81. Schernthaner, G. H., Hauswirth, A. W., Baghestanian, M., Agis, H., Ghan- nadan, M., Worda, C., Krauth, M. T., Printz, D., Fritsch, G., Sperr, W. R., and Valent, P. (2005). Detection of differentiation- and activation- linked cell surface antigens on cul- tured mast cell progenitors. Allergy 60, 1248-1255.
82. Secor, V. H., Secor, W. E., Gutekunst, C. A., and Brown, M. A. (2000). Mast cells are essential for early onset and severe disease in a murine model of multiple sclerosis. J. Exp. Med. 191, 813-822.
83. Seigneuret, M., Delaguillaumie, A., Lagaudriere-Gesbert, C., and Con- jeaud, H. (2001). Structure of the tetraspanin main extracellu- lar domain. A partially conserved fold with a structurally variable domain insertion. J. Biol. Chem. 276, 40055-40064.
84. Shumilina, E., Lam, R. S., Wolbing, F., Matzner, N., Zemtsova, I. M., Sobiesiak, M., Mahmud, H., Saus- bier, U., Biedermann, T., Ruth, P., Sausbier, M., and Lang, F. (2008). Blunted IgE-mediated acti- vation of mast cells in mice lack- ing the Ca2+-activated K+ chan- nel KCa3.1. J. Immunol. 180, 8040-8047.
85. Silvie, O., Rubinstein, E., Franetich, J. F., Prenant, M., Belnoue, E., Renia, L., Hannoun, L., Eling, W., Levy, S., Boucheix, C., and Mazier, D. (2003). Hepatocyte CD81 is required for Plasmodium falciparum and Plas- modium yoelii sporozoite infectivity. Nat. Med. 9, 93-96.
86. Sincock, P. M., Mayrhofer, G., and Ashman, L. K. (1997). Localization of the transmembrane 4 super- family (TM4SF) member PETA-3 (CD151) in normal human tissues: comparison with CD9, CD63, and alpha5beta1 integrin. J. Histochem. Cytochem. 45, 515-525.
87. Skokos, D., Goubran-Botros, H., Roa, M., and Mecheri, S. (2002). Immunoregulatory properties of mast cell-derived exosomes. Mol. Immunol. 38, 1359-1362.
88. Skubitz, K. M., Campbell, K. D., Iida, J., and Skubitz, A. P. (1996). CD63 associates with tyrosine kinase activity and CD11/CD18, and transmits an activation signal in neutrophils. J. Immunol. 157, 3617-3626.
89. Smith, D. A., Monk, P. N., and Partridge, L. J. (1995). Antibod- ies against human CD63 activate transfected rat basophilic leukemia (RBL-2H3) cells. Mol. Immunol. 32, 1339-1344.
90. Sobiesiak, M., Shumilina, E., Lam, R. S., Wolbing, F., Matzner, N., Kaesler, S., Zemtsova, I. M., Lupescu, A., Zahir, N., Kuhl, D., Schaller, M., Biedermann, T., and Lang, F. (2009). Impaired mast cell activa- tion in gene-targeted mice lack- ing the serum- and glucocorticoidinducible kinase SGK1. J. Immunol. 183, 4395-4402.
91. Sperr,W. R.,Bankl,H. C.,Mundigler,G., Klappacher, G., Grossschmidt, K., Agis, H., Simon, P., Laufer, P., Imhof, M., Radaszkiewicz, T., Glogar, D., Lechner, K., and Valent, P. (1994). The human cardiac mast cell: local- ization, isolation, phenotype, and functional characterization. Blood 84, 3876-3884.
92. Stelekati, E., Bahri, R., D'Orlando, O., Orinska, Z., Mittrucker, H. W., Lan- genhaun, R., Glatzel, M., Bollinger, A., Paus, R., and Bulfone-Paus, S. (2009). Mast cell-mediated antigen presentation regulates CD8+ T cell effector functions. Immunity 31, 665-676.
93. Tachibana, I., and Hemler, M. E. (1999). Role of transmembrane 4 super- family (TM4SF) proteins CD9 and CD81 in muscle cell fusion and myotube maintenance. J. Cell Biol. 146, 893-904.
94. Takeda, Y., Tachibana, I., Miyado, K., Kobayashi, M., Miyazaki, T., Funakoshi, T., Kimura, H., Yamane, H., Saito, Y., Goto, H., Yoneda, T., Yoshida, M., Kumagai, T., Osaki, T., Hayashi, S., Kawase, I., and Mekada, E. (2003). Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes. J. Cell Biol. 161, 945-956.
95. Todd, S. C., Lipps, S. G., Crisa, L., Salomon, D. R., and Tsoukas, C. D. (1996). CD81 expressed on human thymocytes mediates integrin acti- vation and interleukin 2-dependent proliferation. J. Exp. Med. 184, 2055-2060.
96. Unternaehrer, J. J., Chow, A., Pypaert, M., Inaba, K., and Mellman, I. (2007). The tetraspanin CD9 medi- ates lateral association of MHC class II molecules on the dendritic cell surface. Proc. Natl. Acad. Sci. U.S.A. 104, 234-239.
97. Ushio, H., Ueno, T., Kojima, Y., Komatsu, M., Tanaka, S., Yamamoto, A., Ichimura, Y., Ezaki, J., Nishida, K., Komazawa-Sakon, S., Niyonsaba, F., Ishii, T., Yanagawa, T., Kominami, E., Ogawa, H., Okumura, K., and Nakano, H. (2011). Crucial role for autophagy in degranulation of mast cells. J. Allergy Clin. Immunol. 127, 1267-1276 e1266.
98. Valadi, H., Ekstrom, K., Bossios, A., Sjostrand, M., Lee, J. J., and Lotvall, J. O. (2007). Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat. Cell Biol. 9, 654-659.
99. Valent, P., Schernthaner, G. H., Sperr, W. R., Fritsch, G., Agis, H., Will- heim, M., Buhring, H. J., Orfao, A., and Escribano, L. (2001). Variable expression of activation-linked sur- face antigens on human mast cells in health and disease. Immunol. Rev. 179, 74-81.
100. van Niel, G., Charrin, S., Simoes, S., Romao, M., Rochin, L., Saftig, P., Marks, M. S., Rubinstein, E., and Raposo, G. (2011). The tetraspanin CD63 regu- lates ESCRT-independent and -dependent endosomal sorting during melanogenesis. Dev. Cell 21, 708-721.
101. van Zelm, M. C., Smet, J., Adams, B., Mascart, F., Schandene, L., Janssen, F., Ferster, A., Kuo, C. C., Levy, S., Van Dongen, J. J., and Van Der Burg, M. (2010). CD81 gene defect in humans disrupts CD19 com- plex formation and leads to anti- body deficiency. J. Clin. Invest. 120, 1265-1274.
102. Vischer, U. M., and Wagner, D. D. (1993). CD63 is a compo- nent of Weibel-Palade bodies of human endothelial cells. Blood 82, 1184-1191.
103. Wimazal, F., Ghannadan, M., Muller, M. R., End, A., Willheim, M., Meidlinger, P., Schernthaner, G. H., Jordan, J. H., Hagen, W., Agis, H., Sperr, W. R., Czerwenka, K., Lechner, K., and Valent, P. (1999). Expression of homing recep- tors and related molecules on human mast cells and basophils: a comparative analysis using multi- color flow cytometry and toluidine blue/immunofluorescence staining techniques. Tissue Antigens 54, 499-507.
104. Wright, M. D., Geary, S. M., Fitter, S., Moseley, G. W., Lau, L. M., Sheng, K. C., Apostolopoulos, V., Stanley, E. G., Jackson, D. E., and Ashman, L. K. (2004). Characterization of mice lacking the tetraspanin superfamily member CD151. Mol. Cell. Biol. 24, 5978-5988.
105. Wu, M., Baumgart, T., Hammond, S., Holowka, D., and Baird, B. (2007). Differential targeting of secretory lysosomes and recycling endosomes in mast cells revealed by patterned antigen arrays. J. Cell. Sci. 120, 3147-3154.
106. Yanez-Mo, M., Barreiro, O., Gordon-Alonso, M., Sala-Valdes, M., and Sanchez-Madrid, F. (2009). Tetraspanin-enriched microdomains: a functional unit in cell plasma membranes. Trends Cell Biol. 19, 434-446.
107. Zhou, J. S., Xing, W., Friend, D. S., Austen, K. F., and Katz, H. R. (2007). Mast cell deficiency in Kit(W-sh) mice does not impair antibody- mediated arthritis. J. Exp. Med. 204, 2797-2802.