Noggin attenuates cerulein-induced acute pancreatitis and impaired autophagy

Pancreas

Volumn 42, Issue 2, 2013, Pages 301-307

  Cao, Yanna ^a   Yang, Wenli ^a   Tyler, Matthew A ^a   Gao, Xuxia ^a   Duan, Chaojun ^a   Kim, Sung O ^a   Aronson, Judith F ^b   Popov, Vsevolod ^b   Takahashi, Hitoshi ^a   Saito, Hiroshi ^c   Evers, Bernard Mark ^c   Chao, Celia ^a   Hellmich, Mark R ^a   Ko, Tien C ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

acute pancreatitis; autophagy; cerulein; noggin

Indexed keywords

AMYLASE; BECLIN 1; BONE MORPHOGENETIC PROTEIN 2; CERULETIDE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; NOGGIN; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN;

ACINAR CELL; ACUTE PANCREATITIS; AMYLASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENUATION; AUTOPHAGY; CELL SWELLING; CELL VACUOLE; CONTROLLED STUDY; HISTOPATHOLOGY; IN VIVO STUDY; ISOLATED ORGAN; MOUSE; NONHUMAN; PANCREAS INJURY; PANCREAS NECROSIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ACUTE DISEASE; ANIMALS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; BONE MORPHOGENETIC PROTEIN 2; CAERULEIN; CARRIER PROTEINS; CELL LINE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; INJECTIONS, INTRAPERITONEAL; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 2; MALE; MICE; MICE, INBRED C57BL; MICROTUBULE-ASSOCIATED PROTEINS; PANCREAS; PANCREATITIS; PHOSPHORYLATION; RATS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; TIME FACTORS;

EID: 84874113882     PISSN: 08853177     EISSN: 15364828     Source Type: Journal    
DOI: 10.1097/MPA.0b013e31825b9f2c     Document Type: Article

References (28)

1. Lees C, Howie S, Sartor RB, et al. The hedgehog signalling pathway in the gastrointestinal tract: Implications for development, homeostasis, and disease. Gastroenterology. 2005;129:1696-1710.
2. Ye L, Lewis-Russell JM, Kyanaston HG, et al. Bone morphogenetic proteins and their receptor signaling in prostate cancer. Histol Histopathol. 2007;22:1129-1147.
3. Groppe J, Greenwald J, Wiater E, et al. Structural basis of BMP signalling inhibition by the cystine knot protein Noggin. Nature. 2002;420:636-642.
4. Yanagita M. BMP antagonists: Their roles in development and involvement in pathophysiology. Cytokine Growth Factor Rev. 2005;16:309-317.
5. Brunet LJ, McMahon JA, McMahon AP, et al. Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. Science. 1998;280:1455-1457.
6. Gong Y, Krakow D, Marcelino J, et al. Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis. Nat Genet. 1999;21:302-304.
7. Marcelino J, Sciortino CM, Romero MF, et al. Human disease-causing NOG missense mutations: Effects on noggin secretion, dimer formation, and bone morphogenetic protein binding. Proc Natl Acad Sci U S A. 2001;98:11353-11358.
8. Wu XB, Li Y, Schneider A, et al. Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing mice. J Clin Invest. 2003;112:924-934.
9. Lim DA, Tramontin AD, Trevejo JM, et al. Noggin antagonizes BMP signaling to create a niche for adult neurogenesis. Neuron. 2000;28:713-726.
10. Haramis AP, Begthel H, van den Born M, et al. De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine. Science. 2004;303:1684-1686.
11. Rosendahl A, Pardali E, Speletas M, et al. Activation of bone morphogenetic protein/Smad signaling in bronchial epithelial cells during airway inflammation. Am J Respir Cell Mol Biol. 2002;27:160-169.
12. Dhore CR, Cleutjens JP, Lutgens E, et al. Differential expression of bone matrix regulatory proteins in human atherosclerotic plaques. Arterioscler Thromb Vasc Biol. 2001;21:1998-2003.
13. Csiszar A, Ahmad M, Smith KE, et al. Bone morphogenetic protein-2 induces proinflammatory endothelial phenotype. Am J Pathol. 2006;168:629-638.
14. Niederau C, Grendell JH. Intracellular vacuoles in experimental acute pancreatitis in rats and mice are an acidified compartment. J Clin Invest. 1988;81:229-236.
15. Watanabe O, Baccino FM, Steer ML, et al. Supramaximal caerulein stimulation and ultrastructure of rat pancreatic acinar cell: Early morphological changes during development of experimental pancreatitis. Am J Physiol. 1984;246:G457-G467.
16. Koike H, Steer ML, Meldolesi J. Pancreatic effects of ethionine: Blockade of exocytosis and appearance of crinophagy and autophagy precede cellular necrosis. Am J Physiol. 1982;242:G297-G307.
17. Aho HJ, Nevalainen TJ, Havia VT, et al. Human acute pancreatitis: A light and electron microscopic study. Acta Pathol Microbiol Immunol Scand A. 1982;90:367-373.
18. Hashimoto D, Ohmuraya M, Hirota M, et al. Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells. J Cell Biol. 2008;181:1065-1072.
19. Mareninova OA, Hermann K, FrenchSW, et al. Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis. J Clin Invest. 2009;119:3340-3355.
20. Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell. 2008;132:27-42.
21. Fortunato F, Burgers H, Bergmann F, et al. Impaired autolysosome formation correlates with Lamp-2 depletion: role of apoptosis, autophagy, and necrosis in pancreatitis. Gastroenterology. 2009;137:350-360, 360 e351-355.
22. Schmidt J, Lewandrowski K, Fernandez-del Castillo C, et al. Histopathologic correlates of serum amylase activity in acute experimental pancreatitis. Dig Dis Sci. 1992;37:1426-1433.
23. Han B, Ji B, Logsdon CD. CCK independently activates intracellular trypsinogen and NF-kappaB in rat pancreatic acinar cells. Am J Physiol Cell Physiol. 2001;280:C465-C472.
24. Cao Y, Gao X, Zhang W, et al. Dietary fiber enhances TGF-{beta} signaling and growth inhibition in the gut. Am J Physiol Gastrointest Liver Physiol. 2011;301:G156-G164.
25. Niederau C, Ferrell LD, Grendell JH. Caerulein-induced acute necrotizing pancreatitis in mice: Protective effects of proglumide, benzotript, and secretin. Gastroenterology. 1985;88:1192-1204.
26. Bhatia M, Saluja AK, Hofbauer B, et al. Role of substance P and the neurokinin 1 receptor in acute pancreatitis and pancreatitis-associated lung injury. Proc Natl Acad Sci U S A. 1998;95:4760-4765.
27. Canalis E, Economides AN, Gazzerro E. Bone morphogenetic proteins, their antagonists, and the skeleton. Endocr Rev. 2003;24:218-235.
28. Barth S, Glick D, Macleod KF. Autophagy: Assays and artifacts. J Pathol. 2010;221(2):117-124.