Molecular modelling studies on Arylthioindoles as potent inhibitors of tubulin polymerization

European Journal of Medicinal Chemistry

Volumn 46, Issue 8, 2011, Pages 3519-3525

  Coluccia, Antonio ^a   Sabbadin, Davide ^b   Brancale, Andrea ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Arylthioindole; Colchicine; Docking; Molecular dynamics; Tubulin

Indexed keywords

ANTINEOPLASTIC AGENT; ARYLTHIOINDOLE DERIVATIVE; COLCHICINE; COMBRETASTATIN A4; TUBULIN; TUBULIN MODULATOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG STRUCTURE; MICROTUBULE ASSEMBLY; MOLECULAR DYNAMICS; POLYMERIZATION;

ANTINEOPLASTIC AGENTS; BINDING SITES; COLCHICINE; HUMANS; INDOLES; MICROTUBULES; MODELS, CHEMICAL; MOLECULAR DYNAMICS SIMULATION; NEOPLASMS; POLYMERIZATION; PROTEIN BINDING; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS; TUBULIN; TUBULIN MODULATORS;

EID: 79958256962     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.05.020     Document Type: Article

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