Competition of zinc ion for the [2Fe-2S] cluster binding site in the diabetes drug target protein mitoNEET

BioMetals

Volumn 25, Issue 6, 2012, Pages 1177-1184

  Tan, Guoqiang ^a   Landry, Aaron P ^b   Dai, Ruili ^a   Wang, Li ^a   Lu, Jianxin ^a   Ding, Huangen ^b  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b LOUISIANA STATE UNIVERSITY   (United States)

Author keywords

Human mitoNEET; Iron sulfur cluster; Type II diabetes drug pioglitazone; Zinc binding

Indexed keywords

IRON SULFUR PROTEIN; MITOCHONDRIAL PROTEIN; PROTEIN MITONEET; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; ZINC ION;

ARTICLE; BACTERIAL CELL; CLUSTER ANALYSIS; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PURIFICATION;

BINDING, COMPETITIVE; DIABETES MELLITUS, TYPE 2; HUMANS; IONS; IRON-SULFUR PROTEINS; MITOCHONDRIAL PROTEINS; MOLECULAR TARGETED THERAPY; THIAZOLIDINEDIONES; ZINC;

ESCHERICHIA COLI;

EID: 84874112249     PISSN: 09660844     EISSN: 15728773     Source Type: Journal    
DOI: 10.1007/s10534-012-9580-4     Document Type: Article

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