Binding of reduced nicotinamide adenine dinucleotide phosphate destabilizes the iron-sulfur clusters of human MitoNEET

Biochemistry

Volumn 49, Issue 44, 2010, Pages 9604-9612

  Zhou, Tao ^a   Lin, Jinzhong ^a   Feng, Yingang ^a   Wang, Jinfeng ^a  

^a INSTITUTE OF BIOPHYSICS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC DRUG; CELLULAR TARGETS; CIRCULAR DICHROISM; DESTABILIZATION EFFECTS; DESTABILIZING EFFECT; IRON-SULFUR CLUSTERS; ISOTHERMAL TITRATION CALORIMETRY; LOOP REGIONS; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATES; OUTER MITOCHONDRIAL MEMBRANES; PIOGLITAZONE; SOLUBLE DOMAINS; THREE-DIMENSIONAL STRUCTURE; VISIBLE-UV;

AMIDES; BIOLOGICAL MEMBRANES; CELL MEMBRANES; DICHROISM; PROTEINS; RESONANCE; SULFUR;

NUCLEAR MAGNETIC RESONANCE;

2,4 THIAZOLIDINEDIONE DERIVATIVE; IRON SULFUR PROTEIN; MITONEET; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL INTERACTION; CLUSTER ANALYSIS; HUMAN; ISOTHERMAL TITRATION CALORIMETRY; LIGHT ABSORPTION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING;

HUMANS; IRON; IRON-SULFUR PROTEINS; MITOCHONDRIAL PROTEINS; NADP; OXIDATION-REDUCTION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN SUBUNITS; SULFUR;

EID: 78149308097     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi101168c     Document Type: Article

References (23)

1. Colca, J. R., McDonald, W. G., Waldon, D. J., Leone, J. W., Lull, J. M., Bannow, C. A., Lund, E. T., and Mathews, W. R. (2004) Identification of a novel mitochondrial protein ("mitoNEET") cross-linked specifically by a thiazolidinedione photoprobe Am. J. Physiol. 286, E252-E260
2. Nolte, R. T., Wisely, G. B., Westin, S., Cobb, J. E., Lambert, M. H., Kurokawa, R., Rosenfeld, M. G., Willson, T. M., Glass, C. K., and Milburn, M. V. (1998) Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ Nature 395, 137-143
3. Wiley, S. E., Paddock, M. L., Abresch, E. C., Gross, L., van der Geer, P., Nechushtai, R., Murphy, A. N., Jennings, P. A., and Dixon, J. E. (2007) The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster J. Biol. Chem. 282, 23745-23749 (Pubitemid 47327996)
4. Wiley, S. E., Murphy, A. N., Ross, S. A., van der Geer, P., and Dixon, J. E. (2007) MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity Proc. Natl. Acad. Sci. U.S.A. 104, 5318-5323
5. Paddock, M. L., Wiley, S. E., Axelrod, H. L., Cohen, A. E., Roy, M., Abresch, E. C., Capraro, D., Murphy, A. N., Nechushtai, R., Dixon, J. E., and Jennings, P. A. (2007) MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone Proc. Natl. Acad. Sci. U.S.A. 104, 14342-14347
6. Lin, J., Zhou, T., Ye, K., and Wang, J. (2007) Crystal structure of human mitoNEET reveals distinct groups of iron sulfur proteins Proc. Natl. Acad. Sci. U.S.A. 104, 14640-14645
7. Hou, X., Liu, R., Ross, S., Smart, E. J., Zhu, H., and Gong, W. (2007) Crystallographic studies of human MitoNEET J. Biol. Chem. 282, 33242-33246
8. Conlan, A. R., Axelrod, H. L., Cohen, A. E., Abresch, E. C., Nechushtai, R., Paddock, M. L., and Jennings, P. A. (2009) Structural Comparison of a Diabetes Drug Target, Mitoneet, a 2Fe-2S Cluster Protein to Its More Stable Mutant, H87C Biophys. J. 96 (Suppl. 1) 67a
9. 4 mutant and implications of the effects of pH on the labile metal center Biochemistry 48, 4747-4752
10. Zuris, J. A., Paddock, M. L., Abresch, E. C., Conlan, A. R., Nechushtai, R., and Jennings, P. A. (2009) Redox Potential of the Outer-Mitochondrial Membrane 2Fe-2S Protein MitoNEET Biophys. J. 96 (Suppl. 1) 240a
11. Homer, C., Yee, D., Axelrod, H. L., Cohen, A. E., Abresch, E. C., Chang, C., Nechushtai, R., Jennings, P. A., and Paddock, M. L. (2009) Structural Basis for Phosphate Stabilization of the Uniquely Coordinated 2Fe-2S Cluster of the Outer Mitochondrial Membrane Protein MitoNEET Biophys. J. 96 (Suppl. 1) 442a-443a
12. Ho, S. N., Hunt, H. D., Horton, R. M., Pullen, J. K., and Pease, L. R. (1989) Site-directed mutagenesis by overlap extension using the polymerase chain reaction Gene 77, 51-59
13. Markley, J. L., Bax, A., Arata, Y., Hilbers, C. W., Kaptein, R., Sykes, B. D., Wright, P. E., and Wüthrich, K. (1998) Recommendations for the Presentation of NMR Structures of Proteins and Nucleic Acids (IUPAC Recommendations 1998) Pure Appl. Chem. 70, 117-142 (Pubitemid 128484457)
14. Pitcher, W. H., III, DeRose, E. F., Mueller, G. A., Howell, E. E., and London, R. E. (2003) NMR studies of the interaction of a type II dihydrofolate reductase with pyridine nucleotides reveal unexpected phosphatase and reductase activity Biochemistry 42, 11150-11160
15. Gupte, S. A., Kaminski, P. M., Floyd, B., Agarwal, R., Ali, N., Ahmad, M., Edwards, J., and Wolin, M. S. (2005) Cytosolic NADPH may regulate differences in basal Nox oxidase-derived superoxide generation in bovine coronary and pulmonary arteries Am. J. Physiol. 288, H13-H21
16. Lassegue, B. and Clempus, R. E. (2003) Vascular NAD(P)H oxidases: Specific features, expression, and regulation Am. J. Physiol. 285, R277-R297
17. Hernandez, C., Genesca, J., Ignasi Esteban, J., Garcia, L., and Simo, R. (2000) [Relationship between iron stores and diabetes mellitus in patients infected by hepatitis C virus: A case-control study] Med. Clin. (Barcelona) 115, 21-22
18. Jiang, R., Manson, J. E., Meigs, J. B., Ma, J., Rifai, N., and Hu, F. B. (2004) Body iron stores in relation to risk of type 2 diabetes in apparently healthy women JAMA, J. Am. Med. Assoc. 291, 711-717
19. Opara, E. C. (2004) Role of oxidative stress in the etiology of type 2 diabetes and the effect of antioxidant supplementation on glycemic control J. Invest. Med. 52, 19-23
20. Valko, M., Morris, H., and Cronin, M. T. (2005) Metals, toxicity and oxidative stress Curr. Med. Chem. 12, 1161-1208
21. Wolff, S. P. (1993) Diabetes mellitus and free radicals. Free radicals, transition metals and oxidative stress in the aetiology of diabetes mellitus and complications Br. Med. Bull. 49, 642-652
22. Colca, J. R. (2006) Insulin sensitizers may prevent metabolic inflammation Biochem. Pharmacol. 72, 125-131
23. Yki-Jarvinen, H. (2004) Thiazolidinediones N. Engl. J. Med. 351, 1106-1118