Precancerous Lesions Upon Sporadic Activation of β-Catenin in Mice

Gastroenterology

Volumn 132, Issue 4, 2007, Pages 1299-1308

  Coste, Isabelle ^a   Freund, Jean Noël ^b   Spaderna, Simone ^c   Brabletz, Thomas ^c   Renno, Toufic ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b INSERM   (France)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; SONIC HEDGEHOG PROTEIN;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; BREAST PAPILLOMA; CANCER GROWTH; CARCINOGENESIS; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; DIGESTIVE SYSTEM CANCER; ENVIRONMENTAL FACTOR; FEMALE; GENE ACTIVATION; HEREDITY; MALE; MOUSE; NONHUMAN; ONCOGENE; PRECANCER; PRIORITY JOURNAL; SENSITIZATION;

EID: 34247200970     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2007.01.029     Document Type: Article

References (37)

1. Nusse R. Wnt signaling in disease and in development. Cell Res 15 (2005) 28-32
2. Reya T., and Clevers H. Wnt signalling in stem cells and cancer. Nature 434 (2005) 843-850
3. Sieber O.M., Tomlinson I.P., and Lamlum H. The adenomatous polyposis coli (APC) tumour suppressor-genetics, function and disease. Mol Med Today 6 (2000) 462-469
4. de La Coste A., Romagnolo B., Billuart P., Renard C.A., Buendia M.A., Soubrane O., Fabre M., Chelly J., Beldjord C., Kahn A., and Perret C. Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas. Proc Natl Acad Sci U S A 95 (1998) 8847-8851
5. Clements W.M., Wang J., Sarnaik A., Kim O.J., MacDonald J., Fenoglio-Preiser C., Groden J., and Lowy A.M. beta-Catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer. Cancer Res 62 (2002) 3503-3506
6. Cheng X.X., Wang Z.C., Chen X.Y., Sun Y., Kong Q.Y., Liu J., and Li H. Correlation of Wnt-2 expression and beta-catenin intracellular accumulation in Chinese gastric cancers: relevance with tumour dissemination. Cancer Lett 223 (2005) 339-347
7. Koppert L.B., van der Velden A.W., van de W.M., Abbou M., van den Ouweland A.M., Tilanus H.W., Wijnhoven B.P., and Dinjens W.N. Frequent loss of the AXIN1 locus but absence of AXIN1 gene mutations in adenocarcinomas of the gastro-oesophageal junction with nuclear beta-catenin expression. Br J Cancer 90 (2004) 892-899
8. Fodde R., Edelmann W., Yang K., van Leeuwen C., Carlson C., Renault B., Breukel C., Alt E., Lipkin M., and Khan P.M. A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors. Proc Natl Acad Sci U S A 91 (1994) 8969-8973
9. Oshima M., Oshima H., Kitagawa K., Kobayashi M., Itakura C., and Taketo M. Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene. Proc Natl Acad Sci U S A 92 (1995) 4482-4486
10. Colnot S., Decaens T., Niwa-Kawakita M., Godard C., Hamard G., Kahn A., Giovannini M., and Perret C. Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas. Proc Natl Acad Sci U S A 101 (2004) 17216-17221
11. Romagnolo B., Berrebi D., Saadi-Keddoucci S., Porteu A., Pichard A.L., Peuchmaur M., Vandewalle A., Kahn A., and Perret C. Intestinal dysplasia and adenoma in transgenic mice after overexpression of an activated beta-catenin. Cancer Res 59 (1999) 3875-3879
12. Harada N., Tamai Y., Ishikawa T., Sauer B., Takaku K., Oshima M., and Taketo M.M. Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene. EMBO J 18 (1999) 5931-5942
13. Gat U., DasGupta R., Degenstein L., and Fuchs E. De novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin. Cell 95 (1998) 605-614
14. Imbert A., Eelkema R., Jordan S., Feiner H., and Cowin P. Delta N89 beta-catenin induces precocious development, differentiation, and neoplasia in mammary gland. J Cell Biol 153 (2001) 555-568
15. Kwan H., Pecenka V., Tsukamoto A., Parslow T.G., Guzman R., Lin T.P., Muller W.J., Lee F.S., Leder P., and Varmus H.E. Transgenes expressing the Wnt-1 and int-2 proto-oncogenes cooperate during mammary carcinogenesis in doubly transgenic mice. Mol Cell Biol 12 (1992) 147-154
16. Garcia S.B., Park H.S., Novelli M., and Wright N.A. Field cancerization, clonality, and epithelial stem cells: the spread of mutated clones in epithelial sheets. J Pathol 187 (1999) 61-81
17. Brigid H., Costantini F., Beddington R., and Elizabeth L. Manipulating the mouse embryo (1994), Cold Spring Harbor Laboratory, New York
18. Bonhomm C., Duluc I., Martin E., Chawengsaksophak K., Chenard M.P., Kedinger M., Beck F., Freund J.N., and Domon-Dell C. The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development. Gut 52 (2003) 1465-1471
19. Dimmler A., Brabletz T., Hlubek F., Hafner M., Rau T., Kirchner T., and Faller G. Transcription of sonic hedgehog, a potential factor for gastric morphogenesis and gastric mucosa maintenance, is up-regulated in acidic conditions. Lab Invest 83 (2003) 1829-1837
20. Haegel H., Larue L., Ohsugi M., Fedorov L., Herrenknecht K., and Kemler R. Lack of beta-catenin affects mouse development at gastrulation. Development 121 (1995) 3529-3537
21. Beck F., Chawengsaksophak K., Waring P., Playford R.J., and Furness J.B. Reprogramming of intestinal differentiation and intercalary regeneration in cdx2 mutant mice. Proc Natl Acad Sci U S A 96 (1999) 7318-7323
22. Tamai Y., Nakajima R., Ishikawa T., Takaku K., Seldin M.F., and Taketo M.M. Colonic hamartoma development by anomalous duplication in Cdx2 knockout mice. Cancer Res 59 (1999) 2965-2970
23. Mizoshita T., Inada K.I., Tsukamoto T., Nozaki K., Joh T., Itoh M., Yamamura Y., Ushijima T., Nakamura S., and Tatematsu M. Expression of the intestine-specific transcription factors, Cdx1 and Cdx2, correlates shift to an intestinal phenotype in gastric cancer cells. J Cancer Res Clin Oncol 130 (2004) 29-36
24. Mutoh H., Hakamata Y., Sato K., Eda A., Yanaka I., Honda S., Osawa H., Kaneko Y., and Sugano K. Conversion of gastric mucosa to intestinal metaplasia in Cdx2-expressing transgenic mice. Biochem Biophys Res Commun 294 (2002) 470-479
25. Ramalho-Santos M., Melton D.A., and McMahon A.P. Hedgehog signals regulate multiple aspects of gastrointestinal development. Development 127 (2000) 2763-2772
26. van den Brink G.R., Hardwick J.C., Tytgat G.N., Brink M.A., Ten Kate F.J., van Deventer S.J., and Peppelenbosch M.P. Sonic hedgehog regulates gastric gland morphogenesis in man and mouse. Gastroenterology 121 (2001) 317-328
27. Dimmler A., Brabletz T., Hlubek F., Hafner M., Rau T., Kirchner T., and Faller G. Transcription of sonic hedgehog, a potential factor for gastric morphogenesis and gastric mucosa maintenance, is up-regulated in acidic conditions. Lab Invest 83 (2003) 1829-1837
28. Hlubek F., Spaderna S., Jung A., Kirchner T., and Brabletz T. Beta-catenin activates a coordinated expression of the proinvasive factors laminin-5 gamma2 chain and MT1-MMP in colorectal carcinomas. Int J Cancer 108 (2004) 321-326
29. Anderson C.B., Neufeld K.L., and White R.L. Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon. Proc Natl Acad Sci U S A 99 (2002) 8683-8688
30. Hayashi S.M., Ton T.V., Hong H.H., Irwin R.D., Haseman J.K., Devereux T.R., and Sills R.C. Genetic alterations in the Catnb gene but not the H-ras gene in hepatocellular neoplasms and hepatoblastomas of B6C3F(1) mice following exposure to diethanolamine for 2 years. Chem Biol Interact 146 (2003) 251-261
31. Athar M., Tang X., Lee J.L., Kopelovich L., and Kim A.L. Hedgehog signalling in skin development and cancer. Exp Dermatol 15 (2006) 667-677
32. Johnson L., Mercer K., Greenbaum D., Bronson R.T., Crowley D., Tuveson D.A., and Jacks T. Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature 410 (2001) 1111-1116
33. Shiotani A., Iishi H., Uedo N., Ishiguro S., Tatsuta M., Nakae Y., Kumamoto M., and Merchant J.L. Evidence that loss of sonic hedgehog is an indicator of Helicobater pylori-induced atrophic gastritis progressing to gastric cancer. Am J Gastroenterol 100 (2005) 581-587
34. van den Brink G.R., Hardwick J.C., Nielsen C., Xu C., Ten Kate F.J., Glickman J., van Deventer S.J., Roberts D.J., and Peppelenbosch M.P. Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract. Gut 51 (2002) 628-633
35. Wong M.H., Rubinfeld B., and Gordon J.I. Effects of forced expression of an NH2-terminal truncated beta-Catenin on mouse intestinal epithelial homeostasis. J Cell Biol 141 (1998) 765-777
36. Kim K., Pang K.M., Evans M., and Hay E.D. Overexpression of beta-catenin induces apoptosis independent of its transactivation function with LEF-1 or the involvement of major G1 cell cycle regulators. Mol Biol Cell 11 (2000) 3509-3523
37. Smits R., van der Houven van Oordt, Luz A., Zurcher C., Jagmohan-Changur S., Breukel C., Khan P.M., and Fodde R. Apc1638N: a mouse model for familial adenomatous polyposis-associated desmoid tumors and cutaneous cysts. Gastroenterology 114 (1998) 275-283