Effects of chronic khat use on cardiovascular, adrenocortical, and psychological responses to stress in men and women

American Journal on Addictions

Volumn 22, Issue 2, 2013, Pages 99-107

  Al'Absi, Mustafa ^a   Khalil, Najat Sayem ^b   Al Habori, Molham ^b   Hoffman, Richard ^a   Fujiwara, Koji ^a   Wittmers, Lorentz ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b SANA A UNIVERSITY   (Yemen)

Author keywords

[No Author keywords available]

Indexed keywords

CATHA EDULIS EXTRACT; HYDROCORTISONE; CENTRAL STIMULANT AGENT;

ACUTE STRESS; ADRENAL CORTEX; ADULT; AFFECT; AMBULATORY MONITORING; ARTICLE; CARDIOVASCULAR RESPONSE; CIRCADIAN RHYTHM; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG ABUSE; DRUG EFFECT; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL STRESS; MOOD; SALIVA LEVEL; SELF REPORT; SEX DIFFERENCE; SLEEP PATTERN; SYSTOLIC BLOOD PRESSURE; BLOOD PRESSURE; CATHA; CROSS-SECTIONAL STUDY; DRUG EFFECTS; HEART RATE; METABOLISM; PATHOPHYSIOLOGY; PLANT LEAF; PSYCHOLOGY; SALIVA;

ADULT; AFFECT; BLOOD PRESSURE; CATHA; CENTRAL NERVOUS SYSTEM STIMULANTS; CROSS-SECTIONAL STUDIES; FEMALE; HEART RATE; HUMANS; HYDROCORTISONE; MALE; PLANT LEAVES; SALIVA; STRESS, PSYCHOLOGICAL;

EID: 84874108365     PISSN: 10550496     EISSN: 15210391     Source Type: Journal    
DOI: 10.1111/j.1521-0391.2013.00302.x     Document Type: Article

References (60)

1. UNODC. World Drug Report 2010. Washington, DC: National Press Club; 2010.
2. World Health Organization. WHO Tobacco or Health: A Global Status Report. Geneva: World Health Organization; 1997.
3. Anderson P., Global use of alcohol, drugs and tobacco. Drug Alcohol Rev. 2006; 25: 489-502.
4. Krikorian AD., Kat and its use: An historical perspective. J Ethnopharmacol. 1984; 12: 115-178.
5. Gebissa E., Khat in the Horn of Africa: Historical perspectives and current trends. J Ethnopharmacol. 2010; 132: 607-614.
6. Kennedy JG., The Flower of Paradise. The Institutionalized Use of the Drug Qat in North Yemen. Dordrecht: D. Reidel Publishing Co; 1988.
7. Griffiths P, Lopez D, Sedefov R, et al. Khat use and monitoring drug use in Europe: The current situation and issues for the future. J Ethnopharmacol. 2010; 132: 578-583.
8. Odenwald M, Warfa N, Bhui K, et al. The stimulant khat-another door in the wall? A call for overcoming the barriers. J Ethnopharmacol. 2010; 132: 615-619.
9. Kalix P., Catha edulis, a plant that has amphetamine effects. Pharm World Sci. 1996; 18: 69-73.
10. Pantelis C, Hindler CG, Taylor JC., Use and abuse of khat (Catha edulis): A review of the distribution, pharmacology, side effects and a description of psychosis attributed to khat chewing. Psychol Med. 1989; 19: 657-668.
11. Kalix P, Braenden O., Pharmacological aspects of the chewing of khat leaves. Pharmacol Rev. 1985; 37: 149-164.
12. Brenneisen R, Fisch HU, Koelbing U, et al. Amphetamine-like effects in humans of the khat alkaloid cathinone. Br J Clin Pharmacol. 1990; 30: 825-828.
13. Widler P, Mathys K, Brenneisen R, et al. Pharmacodynamics and pharmacokinetics of khat: A controlled study. Clin Pharmacol Ther. 1994; 55: 556-562.
14. Kalix P, Geisshusler S, Brenneisen R, et al. Cathinone, a phenylpropylamine alkaolid from khat leaves that has amphetamine effects in humans. NIDA Res Monogr. 1990; 105: 289-290.
15. Hassan NA, Gunaid AA, Abdo-Rabbo AA, et al. The effect of Qat chewing on blood pressure and heart rate in healthy volunteers. Trop Doct. 2000; 30: 107-108.
16. Al Motarreb A, Al Habori M, Broadley KJ., Khat chewing, cardiovascular diseases and other internal medical problems: The current situation and directions for future research. J Ethnopharmacol. 2010; 132: 540-548.
17. Ali WM, Zubaid M, Al Motarreb A, et al. Association of khat chewing with increased risk of stroke and death in patients presenting with acute coronary syndrome. Mayo Clin Proc. 2010; 85: 974-980.
18. Al Habori M., The potential adverse effects of habitual use of Catha edulis (khat). Expert Opin Drug Saf. 2005; 4: 1145-1154.
19. Manghi RA, Broers B, Khan R, et al. Khat use: Lifestyle or addiction ? J Psychoactive Drugs. 2009; 41: 1-10.
20. Hassan NA, Gunaid AA, Murray-Lyon IM., Khat (Catha edulis): Health aspects of khat chewing. East Mediterr Health J. 2007; 13: 706-718.
21. Lam S, Dickerson SS, Zoccola PM, et al. Emotion regulation and cortisol reactivity to a social-evaluative speech task. Psychoneuroendocrinology. 2009; 34: 1355-1362.
22. Laurent H, Powers S., Emotion regulation in emerging adult couples: Temperament, attachment, and HPA response to conflict. Biol Psychol. 2007; 76: 61-71.
23. Hoffman R, al'Absi M., Khat use and neurobehavioral functions: Suggestions for future studies. J Ethnopharmacol. 2010; 132: 554-563.
24. al'Absi M, Hatsukami D, Davis GL., Attenuated adrenocorticotropic responses to psychological stress are associated with early smoking relapse. Psychopharmacology (Berl). 2005; 181: 107-117.
25. al'Absi M, Wittmers LE, Erickson J, et al. Attenuated adrenocortical and blood pressure responses to psychological stress in ad libitum and abstinent smokers. Pharmacol Biochem Behav. 2003; 74: 401-410.
26. al'Absi M, Bongard S, Buchanan T, et al. Cardiovascular and neuroendocrine adjustment to public speaking and mental arithmetic stressors. Psychophysiology. 1997; 34: 266-275.
27. al'Absi M, Lovallo WR, McKey B, et al. Borderline hypertensives produce exaggerated adrenocortical responses to mental stress. Psychosom Med. 1994; 56: 245-250.
28. Lundberg U, Frankenhaeuser M., Pituitary-adrenal and sympathetic-adrenal correlates of distress and effort. J Psychosom Res. 1980; 24: 125-130.
29. Kirschbaum C, Strasburger CJ, Jammers W, et al. Cortisol and behavior: 1. Adaptation of a radioimmunoassay kit for reliable and inexpensive salivary cortisol determination. Pharmacol Biochem Behav. 1989; 34: 747-751.
30. Dressendorfer RA, Kirschbaum C, Rohde W, et al. Synthesis of a cortisol-biotin conjugate and evaluation as a tracer in an immunoassay for salivary cortisol measurement. J Steroid Biochem Mol Biol. 1992; 43: 683-692.
31. Kirschbaum C, Hellhammer DH., Salivary cortisol in psychoneuroendocrine research: Recent developments and applications. Psychoneuroendocrinology. 1994; 19: 313-333.
32. Peters JR, Walker RF, Riad-Fahmy D, et al. Salivary cortisol assays for assessing pituitary-adrenal reserve. Clin Endocrinol (Oxf). 1982; 17: 583-592.
33. Bailey SL, Heitkemper MM., Morningness-eveningness and early-morning salivary cortisol levels. Biol Psychol. 1991; 32: 181-192.
34. Kirschbaum C, Strasburger CJ, Langkrar J., Attenuated cortisol response to psychological stress but not to CRH or ergometry in young habitual smokers. Pharmacol Biochem Behav. 1993; 44: 527-531.
35. Errico AL, Parsons OA, King AC, et al. Attenuated cortisol response to biobehavioral stressors in sober alcoholics. J Stud Alcohol. 1993; 54: 393-398.
36. Huizink AC, Ferdinand RF, Ormel J, et al. Hypothalamic-pituitary-adrenal axis activity and early onset of cannabis use. Addiction. 2006; 101: 1581-1588.
37. Weissbecker I, Floyd A, Dedert E, et al. Childhood trauma and diurnal cortisol disruption in fibromyalgia syndrome. Psychoneuroendocrinology. 2006; 31: 312-324.
38. van der Vegt EJ, van der EJ, Kirschbaum C, et al. Early neglect and abuse predict diurnal cortisol patterns in adults A study of international adoptees. Psychoneuroendocrinology. 2009; 34: 660-669.
39. McEwen BS., Protection and damage from acute and chronic stress: Allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders. Ann N Y Acad Sci. 2004; 1032: 1-7.
40. Yehuda R, Halligan SL, Grossman R., Childhood trauma and risk for PTSD: Relationship to intergenerational effects of trauma, parental PTSD, and cortisol excretion. Dev Psychopathol. 2001; 13: 733-753.
41. Roy A., Urinary free cortisol and childhood trauma in cocaine dependent adults. J Psychiatr Res. 2002; 36: 173-177.
42. Mereu GP, Pacitti C, Argiolas A., Effect of (-)-cathinone, a khat leaf constituent, on dopaminergic firing and dopamine metabolism in the rat brain. Life Sci. 1983; 32: 1383-1389.
43. Connor JD, Rostom A, Makonnen E., Comparison of effects of khat extract and amphetamine on motor behaviors in mice. J Ethnopharmacol. 2002; 81: 65-71.
44. Geracioti TD Jr, West SA, Baker DG, et al. Low CSF concentration of a dopamine metabolite in tobacco smokers. Am J Psychiatry. 1999; 156: 130-132.
45. Aceto MD, Scates SM, Ji Z, et al. Nicotine's opioid and anti-opioid interactions: Proposed role in smoking behavior. Eur J Pharmacol. 1993; 248: 333-335.
46. Nencini P, Ahmed AM., Khat consumption: A pharmacological review. Drug Alcohol Depend. 1989; 23: 19-29.
47. Nencini P, Fraioli S, Pascucci T, et al. (-)-Norpseudoephedrine, a metabolite of cathinone with amphetamine-like stimulus properties, enhances the analgesic and rate decreasing effects of morphine, but inhibits its discriminative properties. Behav Brain Res. 1998; 92: 11-20.
48. Patel NB., Mechanism of action of cathinone: The active ingredient of khat (Catha edulis). East Afr Med J. 2000; 77: 329-332.
49. Calcagnetti DJ, Schechter MD., Increases in the locomotor activity of rats after intracerebral administration of cathinone. Brain Res Bull. 1992; 29: 843-846.
50. Edwards S, Evans P, Hucklebridge F, et al. Association between time of awakening and diurnal cortisol secretory activity. Psychoneuroendocrinology. 2001; 26: 613-622.
51. Born J, Hansen K, Marshall L, et al. Timing the end of nocturnal sleep. Nature. 1999; 397: 29-30.
52. Lovallo WR, Farag NH, Vincent AS., Use of a resting control day in measuring the cortisol response to mental stress: Diurnal patterns, time of day, and gender effects. Psychoneuroendocrinology. 2010; 35: 1253-1258.
53. Shaw D, al'Absi M., Attenuated beta endorphin response to acute stress is associated with smoking relapse. Pharmacol Biochem Behav. 2008; 90: 357-362.
54. Koob GF, Le Moal M., Drug abuse: Hedonic homeostatic dysregulation. Science. 1997; 278: 52-57.
55. Kreek MJ, Koob GF., Drug dependence: Stress and dysregulation of brain reward pathways. Drug Alcohol Depend. 1998; 51: 23-47.
56. Hassan NA, Gunaid AA, El Khally FM, et al. The effect of chewing Khat leaves on human mood. Saudi Med J. 2002; 23: 850-853.
57. Bhui K, Warfa N., Trauma, khat and common psychotic symptoms: A quantitative study. J Ethnopharmacol. 2010; 131: 459-463.
58. Yousef G, Huq Z, Lambert T., Khat chewing as a cause of psychosis. Br J Hosp Med. 1995; 54: 322-326.
59. Odenwald M, Hinkel H, Schauer E, et al. The consumption of khat and other drugs in Somali combatants: A cross-sectional study. PLoS Med. 2007; 4: e341.
60. Khawaja M, Al Nsour M, Saad G., Khat (Catha edulis) chewing during pregnancy in Yemen: Findings from a national population survey. Matern Child Health J. 2008; 12: 308-312.