(-)-Norpseudoephedrine, a metabolite of cathinone with amphetamine-like stimulus properties, enhances the analgesic and rate decreasing effects of morphine, but inhibits its discriminative properties

Behavioural Brain Research

Volumn 92, Issue 1, 1998, Pages 11-20

  Nencini, Paolo ^a   Fraioli, Sabina ^a   Pascucci, Tiziana ^a   Vania Nucerito, C ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

( ) Norpseudoephedrine; Amphetamine; Analgesia; Drug discrimination; Morphine; Rats

Indexed keywords

AMPHETAMINE; CATHINONE; DRUG METABOLITE; FORMALDEHYDE; MORPHINE; MU OPIATE RECEPTOR; NORPSEUDOEPHEDRINE; PHENYLPROPANOLAMINE; SOLVENT; WATER;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DISCRIMINATION; DRUG POTENTIATION; FEMALE; HOT PLATE TEST; INSTRUMENTAL CONDITIONING; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; REINFORCEMENT;

ALKALOIDS; AMPHETAMINE; ANALGESICS, OPIOID; ANIMALS; CENTRAL NERVOUS SYSTEM STIMULANTS; DISCRIMINATION (PSYCHOLOGY); DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; FEMALE; FORMALDEHYDE; MALE; MICE; MORPHINE; PAIN MEASUREMENT; PHENYLPROPANOLAMINE; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME;

EID: 0031916773     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-4328(97)00123-X     Document Type: Article

References (51)

1. Abbott F.V., Franklin K.B.J., Westbrook R.F. The formalin test: scoring properties of the first and second phases of the pain response in rats. Pain. 60:1995;91-102.
2. Arch J.R.S., Ainsworth A.T., Cawthorne M.A. Thermogenic and anorectic effects of ephedrine and congeners in mice and rats. Life Sci. 30:1982;1817-1826.
3. Blosser J.C., Barrantes M., Parker R.B. Correlation between anorectic potency and affinity for hypothalamic (+)-amphetamine binding sites of phenylethylamines. Eur J Pharmacol. 134:1987;97-103.
4. Basbaum A.I., Fields H.L. Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Ann Rev Neurosci. 7:1984;309-338.
5. Clarke P.B.S., Franklin K.B.J. Infusion of 6-hydroxydopamine into nucleus accumbens abolish the analgesic effect of amphetamine but not of MOR in the formalin test. Brain Res. 580:1992;106-110.
6. Dambisya Y.M., Chan K., Wong C.L. Role of adrenoceptors in the potentiation of opioid antinociception by ephedrine and phenylpropanolamine in mice. Psychopharmacology. 105:1991;563-567.
7. Della Bella D., Carenzi A., Frigeni V., Reggiani A., Zambon A. Involvement of monoaminergic and peptidergic components in cathinone-induced analgesia. Eur J Pharmacol. 114:1985;231-234.
8. Druhan J.P., Fibiger H.C., Phillips A.G. Influence of some drugs of abuse on the stimulus properties of amphetamine. Behav Pharmacol. 2:1991;391-403.
9. Druhan J.P., Deschamps S.-E., Stewart J. D-amphetamine stimulus properties are produced by morphine injections into the ventral tegmental area but not into the nucleus accumbens. Behav Brain Res. 59:1993;41-51.
10. Fairchild M.D., Alles G.A. The central locomotor stimulatory activity and acute toxicity of the ephedrine and norephedrine isomers in mice. J Pharmacol Exp Ther. 158:1967;135-139.
11. Fields H.L., Heinricher M.M., Mason P. Neurotransmitters in nociceptive modulatory circuits. Ann Rev Neurosci. 14:1991;219-245.
12. Forrest W.H. Jr., Brown B.W. Jr., Brown C.R., Defalque R., Gold M., Gordon H.E., James K.E., Katz J., Mahler D.L., Schroff P., Teutsch G. Dextroamphetamine with morphine for the treatment of postoperative pain. New Engl J Med. 296:1977;712-715.
13. Gauvin D.V., Young A.M. Evidence for perceptual masking of the discriminative morphine stimulus. Psychopharmacology. 98:1989;212-221.
14. Gauvin D.V., Moore K.R., Youngblood B.D., Holloway F.A. The discriminative stimulus properties of legal, over-the-counter stimulants administered singly and in binary and ternary combinations. Psychopharmacology. 110:1993;309-319.
15. Gauvin D.V., Peirce J.M., Holloway F.A. Perceptual masking of the chlordiazepoxide discriminative cue by both caffeine and buspirone. Pharmacol Biochem Behav. 47:1994;153-159.
16. Görlitz B.-D., Frey H.-H. Central monoamines and antinociceptive drug action. Eur J Pharmacol. 20:1972;171-180.
17. Hale White W. Text-Book of Pharmacology and Therapeutics. London: Frowde, Hodder and Stoughton, 1901:255.
18. Hammond DL. Pharmacology of central pain-modulating networks (biogenic amines and nonopioid analgesics). In: Fields HL, Dubner R, Cervero F, editors. Advances In Pain Research and Therapy, vol. 9. New York: Raven Press, 1985:499-511.
19. Izenwasser S., Kornetsky C. Potentiation of morphine analgesia by D-amphetamine is mediated by norepinephrine and not dopamine. Pain. 33:1988;363-368.
20. Jett M.F., Michelson S. The formalin test in rat: validation of an automated system. Pain. 64:1996;19-25.
21. Jones C.N., Hill H.F., Harris R.T. Discriminative response control by D-amphetamine and related compounds in the rats. Psychopharmacology. 36:1974;347-356.
22. Kalix P. The pharmacological of psychoactive alkaloids from Ephedra and Catha. J Ethnopharmacol. 32:1991;201-208.
23. Kiritsy-Roy J.A., Shyu B.C., Danneman P.J., Morrow T.J., Belczynski C., Casey K.L. Spinal antinociception mediated by a cocaine-sensitive dopaminergic supraspinal mechanism. Brain Res. 644:1994;109-116.
24. Kubota K., Matsuoka Y., Sakuma M., Satoh S., Uruno T., Sunagane N. Characteristic of analgesia induced by noncatecholic phenylethylamines in mice. Life Sci. 31:1982;1221-1224.
25. Lee F., Stafford I., Hoebel B.G. Similarities between the stimulus properties of phenylpropanolamine and amphetamine. Psychopharmacology. 97:1989;410-412.
26. Manning B.H., Morgan M.J., Franklin K.B.J. Morphine analgesia in the formalin test: evidence for forebrain and midbrain sites of action. Neuroscience. 63:1994;289-294.
27. McMillan D.E., Snodgrass S.H. Incomplete stimulus generalization from a mixture of D-amphetamine and morphine to different doses of the component drugs. Behav Pharmacol. 4:1993;279-281.
28. Melzack R., Ofiesh J.G., Mount B.M. The Brompton mixture: effects on pain in cancer patients. Can Med Assoc J. 115:1976;125-129.
29. Miksic S., Shearman G., Lal H. Differential enhancement of narcotic discrimination and analgesia by amphetamine and haloperidol: an evidence for distinct mechanisms underlying analgesia and euphoria. Subst Alcohol Actions Misuse. 1:1980;281-285.
30. Misra A.L., Pontani R.B., Vadlamani N.L. Stereospecific potentiation of opiate analgesia by cocaine: predominant role of noradrenaline. Pain. 28(1):1987;29-138.
31. Mount B.J., Ajemian I., Scott J.F. Use of the Brompton mixture in treating chronic pain of malignant disease. Can Med Assoc J. 115:1976;122-124.
32. Negus S.S., Picker M.J., Dykstra L.A. Interactions between μ and κ opioid agonists in the rat drug discrimination procedure. Psychopharmacology. 102:1990;465-473.
33. Nencini P., Abullahi M.A. Naloxone-reversible antinociceptive activity of cathinone, the active principle of khat, in the mouse and rat. Pharmacol Res Commun. 14:1982;759-770.
34. Nencini P., Abdullahi M.A. Khat consumption: a pharmacological review. Drug Alcohol Depend. 23:1989;19-29.
35. Nencini P., Abdullahi M.A., Anania M.C., Moscucci M., Paroli E. Prolonged analgesia induced by cathinone. The role of stress and opioid and nonopioid mechanisms. Pharmacology. 29:1984;269-281.
36. Nencini P., Woolverton W.L. Effects of nimodipine, a calcium channel blocker, on the discriminative stimulus properties of D-amphetamine in rats. Psychopharmacology. 96:1988;40-44.
37. Nencini P., Fraioli S. Environment specific reinstatment of amphetamine-mediated hyperdipsia by morphine and (-)-norpseudoephedrine. Pharmacol Biochem Behav. 47:1994;339-343.
38. Nencini P., Valeri P. (-)-Norpseudoephedrine, but not (±)-amphetamine, prevents the increase in fluid intake associated with ethanol presentation in rats. Pharmacol Res. 24:1991;83-91.
39. Nencini P., Fraioli S., Perrella D. Tolerance does not develop to the suppressant effects of (-)-norpseudoephedrine on ingestive behavior in the rat. Pharmacol Biochem Behav. 53:1996;297-301.
40. Sasson S., Unterwald E.M., Kornetsky C. Potentiation of morphine analgesia by D-amphetamine. Psychopharmacology. 90:1986;163-165.
41. Shannon H.E., Holtzman S.G. Morphine training dose: a determinant of stimulus generalization to narcotic antagonists in the rat. Psychopharmacology. 61:1979;239-244.
42. Schechter M.D. Rats become acutely tolerant to cathine after amphetamine or cathinone administration. Psychopharmacology. 101:1990;126-131.
43. Schuelke G.S., Terry L.C., Powers R.H., Rice J., Madden J.A. Cocaine analgesia: an in vivo structure-activity study. Pharmacol Biochem Behav. 53:1996;133-140.
44. Snow H. Opium and cocaine in the treatment of cancerous disease. Br Med J 1896:718-719.
45. Swedberg MDB, Järbe TUC. Morphine cue saliency; limits of discriminability and third state perception by pigeons. In: Colpaert FC, Slangen JL, editors. Drug Discrimination: Applications in CNS Pharmacology. Amsterdam: Elsevier Bimedical Press, 1982:147-164.
46. Tallarida RJ, Murray RB. Manual of Pharmacologic Calculations with Computer Programs. 2nd edn. New York: Springer-Verlag, 1986.
47. Tocco D.R., Maickel R.P. Analgesic activities of amphetamine isomers. Arch Int Pharmacodyn Ther. 268:1984;25-31.
48. Ushijima I., Horita A. Cocaine: evidence for NMDA- and opioid-mediated antinociception in the tail-flick test. Pharmacol Biochem Behav. 44:1993;365-370.
49. Wheeler-Aceto H., Cowan A. Standardization of the rat paw formalin test for the evaluation of analgesics. Psychopharmacology. 104:1991;35-44.
50. Wellman P.J. A review of the physiological bases of the anorectic action of phenylpropanolamine (D,L-norephedrine). Neurosci Biobehav Rev. 14:1990;339-355.
51. Widler P., Mathys K., Brenneis R., Kalix P., Fisch H.-U. Pharmacodynamics and pharmacokinetics of khat: a controlled study. Clin Pharmacol Ther. 55:1994;556-562.