메뉴 건너뛰기




Volumn 40, Issue 2, 2013, Pages 186-197

PET hypoxia imaging with FAZA: Reproducibility at baseline and during fractionated radiotherapy in tumour-bearing mice

Author keywords

Hypoxia; Hypoxia targeting; PET; Radiotherapy; Reproducibility

Indexed keywords

FLUOROAZOMYCIN ARABINOSIDE; TRACER; UNCLASSIFIED DRUG;

EID: 84874108264     PISSN: 16197070     EISSN: 16197089     Source Type: Journal    
DOI: 10.1007/s00259-012-2258-x     Document Type: Article
Times cited : (51)

References (39)
  • 1
    • 10644270846 scopus 로고    scopus 로고
    • Tumor hypoxia: Causative factors, compensatory mechanisms, and cellular response
    • 15591417 10.1634/theoncologist.9-90005-4
    • Vaupel P, Harrison L. Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response. Oncologist. 2004;9 Suppl 5:4-9.
    • (2004) Oncologist , vol.9 , Issue.SUPPL. 5 , pp. 4-9
    • Vaupel, P.1    Harrison, L.2
  • 2
    • 0027935568 scopus 로고
    • Radiation-induced reoxygenation in the SCCVII murine tumour: Evidence for a decrease in oxygen consumption and an increase in tumour perfusion
    • 7938677 10.1016/0167-8140(94)90447-2 1:STN:280:DyaK2M%2FisVyltQ%3D%3D
    • Olive PL. Radiation-induced reoxygenation in the SCCVII murine tumour: evidence for a decrease in oxygen consumption and an increase in tumour perfusion. Radiother Oncol. 1994;32:37-46.
    • (1994) Radiother Oncol , vol.32 , pp. 37-46
    • Olive, P.L.1
  • 3
    • 25844477587 scopus 로고    scopus 로고
    • Early reoxygenation in tumors after irradiation: Determining factors and consequences for radiotherapy regimens using daily multiple fractions
    • 16199320 10.1016/j.ijrobp.2005.02.038 1:CAS:528:DC%2BD2MXhtVKjs7fJ
    • Crokart N, Jordan BF, Baudelet C, et al. Early reoxygenation in tumors after irradiation: determining factors and consequences for radiotherapy regimens using daily multiple fractions. Int J Radiat Oncol Biol Phys. 2005;63:901-10.
    • (2005) Int J Radiat Oncol Biol Phys , vol.63 , pp. 901-910
    • Crokart, N.1    Jordan, B.F.2    Baudelet, C.3
  • 4
    • 0033556540 scopus 로고    scopus 로고
    • Oxygenation of cervical cancers during radiotherapy and radiotherapy + cis-retinoic acid/interferon
    • 10030263 10.1016/S0360-3016(98)00361-7 1:CAS:528:DyaK1MXhsFCntLc%3D
    • Dunst J, Hansgen G, Lautenschlager C, Fuchsel G, Becker A. Oxygenation of cervical cancers during radiotherapy and radiotherapy + cis-retinoic acid/interferon. Int J Radiat Oncol Biol Phys. 1999;43:367-73.
    • (1999) Int J Radiat Oncol Biol Phys , vol.43 , pp. 367-373
    • Dunst, J.1    Hansgen, G.2    Lautenschlager, C.3    Fuchsel, G.4    Becker, A.5
  • 5
    • 78149465786 scopus 로고    scopus 로고
    • Measurement of reoxygenation during fractionated radiotherapy in head and neck squamous cell carcinoma xenografts
    • 20878297 10.1007/s13246-010-0032-6
    • Harriss W, Bezak E, Yeoh E, Hermans M. Measurement of reoxygenation during fractionated radiotherapy in head and neck squamous cell carcinoma xenografts. Australas Phys Eng Sci Med. 2010;33:251-63.
    • (2010) Australas Phys Eng Sci Med , vol.33 , pp. 251-263
    • Harriss, W.1    Bezak, E.2    Yeoh, E.3    Hermans, M.4
  • 6
    • 0031696089 scopus 로고    scopus 로고
    • Changes in tumor oxygenation during combined treatment with split-course radiotherapy and chemotherapy in patients with head and neck cancer
    • 9783887 10.1016/S0167-8140(98)00032-2 1:CAS:528:DyaK1cXltlCjs7c%3D
    • Stadler P, Feldmann HJ, Creighton C, Kau R, Molls M. Changes in tumor oxygenation during combined treatment with split-course radiotherapy and chemotherapy in patients with head and neck cancer. Radiother Oncol. 1998;48:157-64.
    • (1998) Radiother Oncol , vol.48 , pp. 157-164
    • Stadler, P.1    Feldmann, H.J.2    Creighton, C.3    Kau, R.4    Molls, M.5
  • 7
    • 78149360444 scopus 로고    scopus 로고
    • Effect of cetuximab and fractionated irradiation on tumour micro-environment
    • 20667608 10.1016/j.radonc.2010.07.007 1:CAS:528:DC%2BC3cXhtlykt7nF
    • Santiago A, Eicheler W, Bussink J, et al. Effect of cetuximab and fractionated irradiation on tumour micro-environment. Radiother Oncol. 2010;97:322-9.
    • (2010) Radiother Oncol , vol.97 , pp. 322-329
    • Santiago, A.1    Eicheler, W.2    Bussink, J.3
  • 8
    • 79955729281 scopus 로고    scopus 로고
    • Exploratory study of the prognostic value of microenvironmental parameters during fractionated irradiation in human squamous cell carcinoma xenografts
    • 21489709 10.1016/j.ijrobp.2011.02.015
    • Yaromina A, Kroeber T, Meinzer A, et al. Exploratory study of the prognostic value of microenvironmental parameters during fractionated irradiation in human squamous cell carcinoma xenografts. Int J Radiat Oncol Biol Phys. 2011;80:1205-13.
    • (2011) Int J Radiat Oncol Biol Phys , vol.80 , pp. 1205-1213
    • Yaromina, A.1    Kroeber, T.2    Meinzer, A.3
  • 9
    • 34250334707 scopus 로고    scopus 로고
    • Hypoxia-imaging with (18)F-misonidazole and PET: Changes of kinetics during radiotherapy of head-and-neck cancer
    • 17543402 10.1016/j.radonc.2007.05.014 1:CAS:528:DC%2BD2sXmsFKhtr8%3D
    • Eschmann SM, Paulsen F, Bedeshem C, et al. Hypoxia-imaging with (18)F-misonidazole and PET: changes of kinetics during radiotherapy of head-and-neck cancer. Radiother Oncol. 2007;83:406-10.
    • (2007) Radiother Oncol , vol.83 , pp. 406-410
    • Eschmann, S.M.1    Paulsen, F.2    Bedeshem, C.3
  • 10
    • 2442674088 scopus 로고    scopus 로고
    • Oxygenation of spontaneous canine tumors during fractionated radiation therapy
    • 15127160 10.1007/s00066-004-1193-6
    • Achermann RE, Ohlerth SM, Rohrer BC, et al. Oxygenation of spontaneous canine tumors during fractionated radiation therapy. Strahlenther Onkol. 2004;180:297-305.
    • (2004) Strahlenther Onkol , vol.180 , pp. 297-305
    • Achermann, R.E.1    Ohlerth, S.M.2    Rohrer, B.C.3
  • 11
    • 0020539440 scopus 로고
    • Accelerated fractionation vs hyperfractionation: Rationales for several treatments per day
    • 6833014 10.1016/0360-3016(83)90089-5
    • Thames Jr HD, Peters LJ, Withers HR, Fletcher GH. Accelerated fractionation vs hyperfractionation: rationales for several treatments per day. Int J Radiat Oncol Biol Phys. 1983;9:127-38.
    • (1983) Int J Radiat Oncol Biol Phys , vol.9 , pp. 127-138
    • Thames, Jr.H.D.1    Peters, L.J.2    Withers, H.R.3    Fletcher, G.H.4
  • 12
    • 1942439092 scopus 로고    scopus 로고
    • Preclinical studies on how to deal with patient intolerance to nicotinamide and carbogen
    • 15064017 10.1016/j.radonc.2004.01.017 1:CAS:528:DC%2BD2cXivVWltr0%3D
    • Horsman MR, Overgaard J. Preclinical studies on how to deal with patient intolerance to nicotinamide and carbogen. Radiother Oncol. 2004;70:301-9.
    • (2004) Radiother Oncol , vol.70 , pp. 301-309
    • Horsman, M.R.1    Overgaard, J.2
  • 13
    • 84864003904 scopus 로고    scopus 로고
    • Accelerated radiotherapy with carbogen and nicotinamide for laryngeal cancer: Results of a phase III randomized trial
    • 22508814 10.1200/JCO.2011.35.9315 1:CAS:528:DC%2BC38XhtVansbbF
    • Janssens GO, Rademakers SE, Terhaard CH, et al. Accelerated radiotherapy with carbogen and nicotinamide for laryngeal cancer: results of a phase III randomized trial. J Clin Oncol. 2012;30:1777-83.
    • (2012) J Clin Oncol , vol.30 , pp. 1777-1783
    • Janssens, G.O.1    Rademakers, S.E.2    Terhaard, C.H.3
  • 14
    • 0030069889 scopus 로고    scopus 로고
    • Modification of hypoxia-induced radioresistance in tumors by the use of oxygen and sensitizers
    • 10717158 10.1016/S1053-4296(96)80032-4
    • Overgaard J, Horsman MR. Modification of hypoxia-induced radioresistance in tumors by the use of oxygen and sensitizers. Semin Radiat Oncol. 1996;6:10-21.
    • (1996) Semin Radiat Oncol , vol.6 , pp. 10-21
    • Overgaard, J.1    Horsman, M.R.2
  • 15
    • 34748860952 scopus 로고    scopus 로고
    • Hypoxic radiosensitization: Adored and ignored
    • 17827455 10.1200/JCO.2007.12.7878
    • Overgaard J. Hypoxic radiosensitization: adored and ignored. J Clin Oncol. 2007;25:4066-74.
    • (2007) J Clin Oncol , vol.25 , pp. 4066-4074
    • Overgaard, J.1
  • 16
    • 34250326197 scopus 로고    scopus 로고
    • Pretreatment 18F-FAZA PET predicts success of hypoxia-directed radiochemotherapy using tirapazamine
    • 17536108 10.2967/jnumed.106.038570 1:CAS:528:DC%2BD2sXhtVert7fJ
    • Beck R, Roper B, Carlsen JM, et al. Pretreatment 18F-FAZA PET predicts success of hypoxia-directed radiochemotherapy using tirapazamine. J Nucl Med. 2007;48:973-80.
    • (2007) J Nucl Med , vol.48 , pp. 973-980
    • Beck, R.1    Roper, B.2    Carlsen, J.M.3
  • 17
    • 67649380881 scopus 로고    scopus 로고
    • Tirapazamine: A novel agent targeting hypoxic tumor cells
    • 19053884 10.1517/13543780802567250 1:CAS:528:DC%2BD1cXhsVGhtbrF
    • Reddy SB, Williamson SK. Tirapazamine: a novel agent targeting hypoxic tumor cells. Expert Opin Investig Drugs. 2009;18:77-87.
    • (2009) Expert Opin Investig Drugs , vol.18 , pp. 77-87
    • Reddy, S.B.1    Williamson, S.K.2
  • 19
    • 80051794223 scopus 로고    scopus 로고
    • Development of a hypoxia gene expression classifier with predictive impact for hypoxic modification of radiotherapy in head and neck cancer
    • 21846821 10.1158/0008-5472.CAN-11-1182 1:CAS:528:DC%2BC3MXhtFSmtbjO
    • Toustrup K, Sorensen BS, Nordsmark M, et al. Development of a hypoxia gene expression classifier with predictive impact for hypoxic modification of radiotherapy in head and neck cancer. Cancer Res. 2011;71:5923-31.
    • (2011) Cancer Res , vol.71 , pp. 5923-5931
    • Toustrup, K.1    Sorensen, B.S.2    Nordsmark, M.3
  • 20
    • 37049004518 scopus 로고    scopus 로고
    • Reproducibility of intratumor distribution of (18)F-fluoromisonidazole in head and neck cancer
    • 18086391 10.1016/j.ijrobp.2007.08.036 1:CAS:528:DC%2BD2sXhsVentrzK
    • Nehmeh SA, Lee NY, Schroder H, et al. Reproducibility of intratumor distribution of (18)F-fluoromisonidazole in head and neck cancer. Int J Radiat Oncol Biol Phys. 2008;70:235-42.
    • (2008) Int J Radiat Oncol Biol Phys , vol.70 , pp. 235-242
    • Nehmeh, S.A.1    Lee, N.Y.2    Schroder, H.3
  • 21
    • 39749194493 scopus 로고    scopus 로고
    • The influence of changes in tumor hypoxia on dose-painting treatment plans based on 18F-FMISO positron emission tomography
    • 18313529 10.1016/j.ijrobp.2007.09.050
    • Lin Z, Mechalakos J, Nehmeh S, et al. The influence of changes in tumor hypoxia on dose-painting treatment plans based on 18F-FMISO positron emission tomography. Int J Radiat Oncol Biol Phys. 2008;70:1219-28.
    • (2008) Int J Radiat Oncol Biol Phys , vol.70 , pp. 1219-1228
    • Lin, Z.1    Mechalakos, J.2    Nehmeh, S.3
  • 22
    • 79960370596 scopus 로고    scopus 로고
    • Accessing radiation response using hypoxia PET imaging and oxygen sensitive electrodes: A preclinical study
    • 21723634 10.1016/j.radonc.2011.06.034 1:CAS:528:DC%2BC3MXovFOltbY%3D
    • Mortensen LS, Busk M, Nordsmark M, et al. Accessing radiation response using hypoxia PET imaging and oxygen sensitive electrodes: a preclinical study. Radiother Oncol. 2011;99:418-23.
    • (2011) Radiother Oncol , vol.99 , pp. 418-423
    • Mortensen, L.S.1    Busk, M.2    Nordsmark, M.3
  • 23
    • 39749202442 scopus 로고    scopus 로고
    • Imaging hypoxia in xenografted and murine tumors with 18F-fluoroazomycin arabinoside: A comparative study involving microPET, autoradiography, PO2-polarography, and fluorescence microscopy
    • 18313528 10.1016/j.ijrobp.2007.11.034 1:CAS:528:DC%2BD1cXislWlu7c%3D
    • Busk M, Horsman MR, Jakobsen S, et al. Imaging hypoxia in xenografted and murine tumors with 18F-fluoroazomycin arabinoside: a comparative study involving microPET, autoradiography, PO2-polarography, and fluorescence microscopy. Int J Radiat Oncol Biol Phys. 2008;70:1202-12.
    • (2008) Int J Radiat Oncol Biol Phys , vol.70 , pp. 1202-1212
    • Busk, M.1    Horsman, M.R.2    Jakobsen, S.3
  • 24
    • 79960376334 scopus 로고    scopus 로고
    • Inhibition of tumor lactate oxidation: Consequences for the tumor microenvironment
    • 21704401 10.1016/j.radonc.2011.05.053 1:CAS:528:DC%2BC3MXovFOltbo%3D
    • Busk M, Walenta S, Mueller-Klieser W, et al. Inhibition of tumor lactate oxidation: consequences for the tumor microenvironment. Radiother Oncol. 2011;99:404-11.
    • (2011) Radiother Oncol , vol.99 , pp. 404-411
    • Busk, M.1    Walenta, S.2    Mueller-Klieser, W.3
  • 25
    • 0029948108 scopus 로고    scopus 로고
    • Microvascular studies on the origins of perfusion-limited hypoxia
    • 8763890 1:STN:280:DyaK283osFajtw%3D%3D
    • Dewhirst MW, Kimura H, Rehmus SW, et al. Microvascular studies on the origins of perfusion-limited hypoxia. Br J Cancer Suppl. 1996;27:S247-51.
    • (1996) Br J Cancer Suppl , vol.27
    • Dewhirst, M.W.1    Kimura, H.2    Rehmus, S.W.3
  • 26
    • 33644506104 scopus 로고    scopus 로고
    • Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor
    • 16489024 10.1158/0008-5472.CAN-03-2958 1:CAS:528:DC%2BD28XhsFals70%3D
    • Lanzen J, Braun RD, Klitzman B, Brizel D, Secomb TW, Dewhirst MW. Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor. Cancer Res. 2006;66:2219-23.
    • (2006) Cancer Res , vol.66 , pp. 2219-2223
    • Lanzen, J.1    Braun, R.D.2    Klitzman, B.3    Brizel, D.4    Secomb, T.W.5    Dewhirst, M.W.6
  • 27
    • 4444292601 scopus 로고    scopus 로고
    • Physiological noise in murine solid tumours using T2*-weighted gradient-echo imaging: A marker of tumour acute hypoxia?
    • 15379021 10.1088/0031-9155/49/15/006
    • Baudelet C, Ansiaux R, Jordan BF, Havaux X, Macq B, Gallez B. Physiological noise in murine solid tumours using T2*-weighted gradient-echo imaging: a marker of tumour acute hypoxia? Phys Med Biol. 2004;49:3389-411.
    • (2004) Phys Med Biol , vol.49 , pp. 3389-3411
    • Baudelet, C.1    Ansiaux, R.2    Jordan, B.F.3    Havaux, X.4    MacQ, B.5    Gallez, B.6
  • 28
    • 32844470756 scopus 로고    scopus 로고
    • The role of vessel maturation and vessel functionality in spontaneous fluctuations of T2*-weighted GRE signal within tumors
    • 16411170 10.1002/nbm.1002
    • Baudelet C, Cron GO, Ansiaux R, et al. The role of vessel maturation and vessel functionality in spontaneous fluctuations of T2*-weighted GRE signal within tumors. NMR Biomed. 2006;19:69-76.
    • (2006) NMR Biomed , vol.19 , pp. 69-76
    • Baudelet, C.1    Cron, G.O.2    Ansiaux, R.3
  • 29
    • 35148853125 scopus 로고    scopus 로고
    • Fluctuations in tumor blood perfusion assessed by dynamic contrast-enhanced MRI
    • 17763357 10.1002/mrm.21367
    • Brurberg KG, Benjaminsen IC, Dorum LM, Rofstad EK. Fluctuations in tumor blood perfusion assessed by dynamic contrast-enhanced MRI. Magn Reson Med. 2007;58:473-81.
    • (2007) Magn Reson Med , vol.58 , pp. 473-481
    • Brurberg, K.G.1    Benjaminsen, I.C.2    Dorum, L.M.3    Rofstad, E.K.4
  • 30
    • 77957717869 scopus 로고    scopus 로고
    • Noninvasive mapping of spontaneous fluctuations in tumor oxygenation using 19F MRI
    • 21089779 10.1118/1.3484056 1:CAS:528:DC%2BC3cXht1ajtb%2FL
    • Magat J, Jordan BF, Cron GO, Gallez B. Noninvasive mapping of spontaneous fluctuations in tumor oxygenation using 19F MRI. Med Phys. 2010;37:5434-41.
    • (2010) Med Phys , vol.37 , pp. 5434-5441
    • Magat, J.1    Jordan, B.F.2    Cron, G.O.3    Gallez, B.4
  • 31
    • 84865709437 scopus 로고    scopus 로고
    • 18F-HX4 hypoxia imaging with PET/CT in head and neck cancer: A comparison with 18F-FMISO
    • 22836736 10.1097/MNM.0b013e3283571016 1:CAS:528:DC%2BC38Xht1KitL%2FI
    • Chen L, Zhang Z, Kolb HC, Walsh JC, Zhang J, Guan Y. 18F-HX4 hypoxia imaging with PET/CT in head and neck cancer: a comparison with 18F-FMISO. Nucl Med Commun. 2012;33:1096-1102.
    • (2012) Nucl Med Commun , vol.33 , pp. 1096-1102
    • Chen, L.1    Zhang, Z.2    Kolb, H.C.3    Walsh, J.C.4    Zhang, J.5    Guan, Y.6
  • 32
    • 69949180403 scopus 로고    scopus 로고
    • Can hypoxia-PET map hypoxic cell density heterogeneity accurately in an animal tumor model at a clinically obtainable image contrast?
    • 19729214 10.1016/j.radonc.2009.08.026 1:CAS:528:DC%2BD1MXhtFajtL%2FF
    • Busk M, Horsman MR, Jakobsen S, et al. Can hypoxia-PET map hypoxic cell density heterogeneity accurately in an animal tumor model at a clinically obtainable image contrast? Radiother Oncol. 2009;92:429-36.
    • (2009) Radiother Oncol , vol.92 , pp. 429-436
    • Busk, M.1    Horsman, M.R.2    Jakobsen, S.3
  • 33
    • 77956566350 scopus 로고    scopus 로고
    • Assessing hypoxia in animal tumor models based on pharmacokinetic analysis of dynamic FAZA PET
    • 20831479 10.3109/0284186X.2010.503970 1:CAS:528:DC%2BC3cXhtFCru7zK
    • Busk M, Munk OL, Jakobsen S, et al. Assessing hypoxia in animal tumor models based on pharmacokinetic analysis of dynamic FAZA PET. Acta Oncol. 2010;49:922-33.
    • (2010) Acta Oncol , vol.49 , pp. 922-933
    • Busk, M.1    Munk, O.L.2    Jakobsen, S.3
  • 34
    • 84868348070 scopus 로고    scopus 로고
    • Hypoxia imaging with the nitroimidazole (18)F-FAZA PET tracer: A comparison with OxyLite, EPR oximetry and (19)F-MRI relaxometry
    • doi: 10.1016/j.radonc.2012.04.011
    • Tran LB, Bol A, Labar D, et al. Hypoxia imaging with the nitroimidazole (18)F-FAZA PET tracer: a comparison with OxyLite, EPR oximetry and (19)F-MRI relaxometry. Radiother Oncol 2012. doi: 10.1016/j.radonc.2012.04.011
    • (2012) Radiother Oncol
    • Tran, L.B.1    Bol, A.2    Labar, D.3
  • 35
    • 33644831835 scopus 로고    scopus 로고
    • Reproducibility of 3′-deoxy-3′-(18)F-fluorothymidine microPET studies in tumor xenografts in mice
    • 16269599 1:CAS:528:DC%2BD28XitVGltL0%3D
    • Tseng JR, Dandekar M, Subbarayan M, et al. Reproducibility of 3′-deoxy-3′-(18)F-fluorothymidine microPET studies in tumor xenografts in mice. J Nucl Med. 2005;46:1851-7.
    • (2005) J Nucl Med , vol.46 , pp. 1851-1857
    • Tseng, J.R.1    Dandekar, M.2    Subbarayan, M.3
  • 36
    • 34248594167 scopus 로고    scopus 로고
    • Reproducibility of 18F-FDG microPET studies in mouse tumor xenografts
    • 17401098 10.2967/jnumed.106.036608
    • Dandekar M, Tseng JR, Gambhir SS. Reproducibility of 18F-FDG microPET studies in mouse tumor xenografts. J Nucl Med. 2007;48:602-7.
    • (2007) J Nucl Med , vol.48 , pp. 602-607
    • Dandekar, M.1    Tseng, J.R.2    Gambhir, S.S.3
  • 37
    • 0025059322 scopus 로고
    • Modification of tumour radiation response in vivo by the benzamide analogue pyrazinamide
    • 2145963 10.1038/bjc.1990.330 1:CAS:528:DyaK3MXnslyqtw%3D%3D
    • Chaplin DJ, Trotter MJ, Skov KA, Horsman MR. Modification of tumour radiation response in vivo by the benzamide analogue pyrazinamide. Br J Cancer. 1990;62:561-6.
    • (1990) Br J Cancer , vol.62 , pp. 561-566
    • Chaplin, D.J.1    Trotter, M.J.2    Skov, K.A.3    Horsman, M.R.4
  • 38
    • 0025685602 scopus 로고
    • Combination of nicotinamide and hyperthermia to eliminate radioresistant chronically and acutely hypoxic tumor cells
    • 2147577 1:CAS:528:DyaK3MXlvVWqtw%3D%3D
    • Horsman MR, Chaplin DJ, Overgaard J. Combination of nicotinamide and hyperthermia to eliminate radioresistant chronically and acutely hypoxic tumor cells. Cancer Res. 1990;50:7430-6.
    • (1990) Cancer Res , vol.50 , pp. 7430-7436
    • Horsman, M.R.1    Chaplin, D.J.2    Overgaard, J.3
  • 39
    • 70349655722 scopus 로고    scopus 로고
    • Modeling acute and chronic hypoxia using serial images of 18F-FMISO PET
    • 19928070 10.1118/1.3213092
    • Wang K, Yorke E, Nehmeh SA, Humm JL, Ling CC. Modeling acute and chronic hypoxia using serial images of 18F-FMISO PET. Med Phys. 2009;36:4400-8.
    • (2009) Med Phys , vol.36 , pp. 4400-4408
    • Wang, K.1    Yorke, E.2    Nehmeh, S.A.3    Humm, J.L.4    Ling, C.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.