메뉴 건너뛰기




Volumn 57, Issue 3, 2013, Pages 1262-1269

Cellular pharmacology and potency of HIV-1 nucleoside analogs in primary human macrophages

Author keywords

[No Author keywords available]

Indexed keywords

ABACAVIR; ATAZANAVIR; CARBOVIR; COLONY STIMULATING FACTOR 1; LAMIVUDINE; NUCLEOSIDE ANALOG; RALTEGRAVIR; TENOFOVIR; TENOFOVIR DISOPROXIL;

EID: 84874097081     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.02012-12     Document Type: Article
Times cited : (32)

References (44)
  • 1
    • 70449345986 scopus 로고    scopus 로고
    • Antiretroviral therapy in macrophages: Implication for HIV eradication
    • Gavegnano C, Fromentin E, Schinazi RF. 2009. Antiretroviral therapy in macrophages: implication for HIV eradication. Antivir. Chem. Chemother. 20:63-78.
    • (2009) Antivir. Chem. Chemother. , vol.20 , pp. 63-78
    • Gavegnano, C.1    Fromentin, E.2    Schinazi, R.F.3
  • 5
    • 80355131976 scopus 로고    scopus 로고
    • Protective and pathogenic functions of macrophage subsets
    • Murray PJ, Wynn TA. 2011. Protective and pathogenic functions of macrophage subsets. Nat. Rev. Immunol. 11:723-737.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 723-737
    • Murray, P.J.1    Wynn, T.A.2
  • 6
    • 0032889037 scopus 로고    scopus 로고
    • Microglia express CCR5, CXCR4, and CCR3, but of these, CCR5 is the principal coreceptor for human immunodeficiency virus type 1 dementia isolates
    • Albright AV, Shieh JT, Itoh T, Lee B, Pleasure D, O'Connor MJ, Doms RW, Gonzalez-Scarano F. 1999. Microglia express CCR5, CXCR4, and CCR3, but of these, CCR5 is the principal coreceptor for human immunodeficiency virus type 1 dementia isolates. J. Virol. 73:205-213.
    • (1999) J. Virol. , vol.73 , pp. 205-213
    • Albright, A.V.1    Shieh, J.T.2    Itoh, T.3    Lee, B.4    Pleasure, D.5    O'Connor, M.J.6    Doms, R.W.7    Gonzalez-Scarano, F.8
  • 7
  • 10
    • 0031848314 scopus 로고    scopus 로고
    • Relative potency of protease inhibitors in monocytes/macrophages acutely and chronically infected with human immunodeficiency virus
    • Perno CF, Newcomb FM, Davis DA, Aquaro S, Humphrey RW, Calio R, Yarchoan R. 1998. Relative potency of protease inhibitors in monocytes/macrophages acutely and chronically infected with human immunodeficiency virus. J. Infect. Dis. 178:413- 422.
    • (1998) J. Infect. Dis. , vol.178 , pp. 413-422
    • Perno, C.F.1    Newcomb, F.M.2    Davis, D.A.3    Aquaro, S.4    Humphrey, R.W.5    Calio, R.6    Yarchoan, R.7
  • 12
    • 84860471834 scopus 로고    scopus 로고
    • The intracellular virus-containing compartments in primary human macrophages are largely inaccessible to antibodies and small molecules
    • doi:10.1371/journal.pone.0035297
    • Chu H, Wang JJ, Qi M, Yoon JJ, Wen X, Chen X, Ding L, Spearman P. 2012. The intracellular virus-containing compartments in primary human macrophages are largely inaccessible to antibodies and small molecules. PLoS One 7:e35297. doi:10.1371/journal.pone.0035297.
    • (2012) PLoS One , vol.7
    • Chu, H.1    Wang, J.J.2    Qi, M.3    Yoon, J.J.4    Wen, X.5    Chen, X.6    Ding, L.7    Spearman, P.8
  • 13
    • 0026057767 scopus 로고
    • Effects of thymidine and uridine on the phosphorylation of 3'-azido-3'- deoxythymidine (zidovudine) in human mononuclear cells
    • Szebeni J, Patel SS, Hung K, Wahl LM, Weinstein JN. 1991. Effects of thymidine and uridine on the phosphorylation of 3'-azido-3'- deoxythymidine (zidovudine) in human mononuclear cells. Antimicrob. Agents Chemother. 35:198 -200.
    • (1991) Antimicrob. Agents Chemother. , vol.35 , pp. 198-200
    • Szebeni, J.1    Patel, S.S.2    Hung, K.3    Wahl, L.M.4    Weinstein, J.N.5
  • 14
    • 77749305065 scopus 로고    scopus 로고
    • Simultaneous quantification of intracellular natural and antiretroviral nucleosides and nucleotides by liquid chromatography-tandem mass spectrometry
    • Fromentin E, Gavegnano C, Obikhod A, Schinazi RF. 2010. Simultaneous quantification of intracellular natural and antiretroviral nucleosides and nucleotides by liquid chromatography-tandem mass spectrometry. Anal. Chem. 82:1982-1989.
    • (2010) Anal. Chem. , vol.82 , pp. 1982-1989
    • Fromentin, E.1    Gavegnano, C.2    Obikhod, A.3    Schinazi, R.F.4
  • 16
    • 0025563317 scopus 로고
    • Synergistic drug combinations in AIDS therapy
    • Dipyridamole/3'-azido-3'-deoxythymidine in particular and principles of analysis in general
    • Weinstein JN, Bunow B, Weislow OS, Schinazi RF, Wahl SM, Wahl LM, Szebeni J. 1990. Synergistic drug combinations in AIDS therapy. Dipyridamole/3'-azido- 3'-deoxythymidine in particular and principles of analysis in general. Ann. N. Y. Acad. Sci. 616:367-384.
    • (1990) Ann. N. Y. Acad. Sci. , vol.616 , pp. 367-384
    • Weinstein, J.N.1    Bunow, B.2    Weislow, O.S.3    Schinazi, R.F.4    Wahl, S.M.5    Wahl, L.M.6    Szebeni, J.7
  • 19
    • 0032875534 scopus 로고    scopus 로고
    • Cerebrospinal fluid human immunodeficiency virus type 1 (HIV-1) suppression and efavirenz drug concentrations in HIV-1-infected patients receiving combination therapy
    • Tashima KT, Caliendo AM, Ahmad M, Gormley JM, Fiske WD, Brennan JM, Flanigan TP. 1999. Cerebrospinal fluid human immunodeficiency virus type 1 (HIV-1) suppression and efavirenz drug concentrations in HIV-1-infected patients receiving combination therapy. J. Infect. Dis. 180:862- 864.
    • (1999) J. Infect. Dis. , vol.180 , pp. 862-864
    • Tashima, K.T.1    Caliendo, A.M.2    Ahmad, M.3    Gormley, J.M.4    Fiske, W.D.5    Brennan, J.M.6    Flanigan, T.P.7
  • 22
    • 84857159899 scopus 로고    scopus 로고
    • A plasma biomarker signature of immune activation in HIV patients on antiretroviral therapy
    • doi:10.1371/journal.pone.0030881
    • Kamat A, Misra V, Cassol E, Ancuta P, Yan Z, Li C, Morgello S, Gabuzda D. 2012. A plasma biomarker signature of immune activation in HIV patients on antiretroviral therapy. PLoS One 7:e30881. doi:10.1371/journal.pone.0030881.
    • (2012) PLoS One , vol.7
    • Kamat, A.1    Misra, V.2    Cassol, E.3    Ancuta, P.4    Yan, Z.5    Li, C.6    Morgello, S.7    Gabuzda, D.8
  • 25
    • 84874052451 scopus 로고    scopus 로고
    • Raltegravir is a substrate for the influx transporters OAT1 and PEPT1 and the efflux transporter Pgp but is not transported by OATP1A2, OATP1B1, OATP1B3, OCT1, NTCP, or PEPT2, abstr. 613
    • February 16-19, 2010, Moscone Center West, San Francisco, CA, U. S. A.
    • Moss D, Kwan WS, Liptrott N, Siccardi M, Anstee D, Khoo S, Back D, Owen A. 2010. Raltegravir is a substrate for the influx transporters OAT1 and PEPT1 and the efflux transporter Pgp but is not transported by OATP1A2, OATP1B1, OATP1B3, OCT1, NTCP, or PEPT2, abstr. 613. 17th Conf. Retrovir. Opportunistic Infect.: Progr. Abstr., February 16-19, 2010, Moscone Center West, San Francisco, CA, U. S. A.
    • (2010) 17th Conf. Retrovir. Opportunistic Infect.: Progr. Abstr.
    • Moss, D.1    Kwan, W.S.2    Liptrott, N.3    Siccardi, M.4    Anstee, D.5    Khoo, S.6    Back, D.7    Owen, A.8
  • 26
    • 33644840984 scopus 로고    scopus 로고
    • The power of the pump: Mechanisms of action of P-glycoprotein (ABCB1)
    • Ambudkar SV, Kim IW, Sauna ZE. 2006. The power of the pump: mechanisms of action of P-glycoprotein (ABCB1). Eur. J. Pharm. Sci. 27:392- 400.
    • (2006) Eur. J. Pharm. Sci. , vol.27 , pp. 392-400
    • Ambudkar, S.V.1    Kim, I.W.2    Sauna, Z.E.3
  • 27
    • 31844448665 scopus 로고    scopus 로고
    • The translocation mechanism of P-glycoprotein
    • Callaghan R, Ford RC, Kerr ID. 2006. The translocation mechanism of P-glycoprotein. FEBS Lett. 580:1056 -1063.
    • (2006) FEBS Lett. , vol.580 , pp. 1056-1063
    • Callaghan, R.1    Ford, R.C.2    Kerr, I.D.3
  • 29
    • 84869877833 scopus 로고    scopus 로고
    • The impact of macrophage nucleotide pools on HIV-1 reverse transcription, viral replication, and the development of novel antiviral agents
    • doi:10.1155/2012/625983
    • Gavegnano C, Kennedy EM, Kim B, Schinazi RF. 2012. The impact of macrophage nucleotide pools on HIV-1 reverse transcription, viral replication, and the development of novel antiviral agents. Mol. Biol. Int. 2012: 625983. doi:10.1155/2012/625983.
    • (2012) Mol. Biol. Int. , vol.2012 , pp. 625983
    • Gavegnano, C.1    Kennedy, E.M.2    Kim, B.3    Schinazi, R.F.4
  • 30
    • 78649858731 scopus 로고    scopus 로고
    • Ribonucleoside triphosphates as substrate of human immunodeficiency virus type 1 reverse transcriptase in human macrophages
    • Kennedy EM, Gavegnano C, Nguyen L, Slater R, Lucas A, Fromentin F, Schinazi RF, Kim B. 2010. Ribonucleoside triphosphates as substrate of human immunodeficiency virus type 1 reverse transcriptase in human macrophages. J. Biol. Chem. 285:39380 -39391.
    • (2010) J. Biol. Chem. , vol.285 , pp. 39380-39391
    • Kennedy, E.M.1    Gavegnano, C.2    Nguyen, L.3    Slater, R.4    Lucas, A.5    Fromentin, F.6    Schinazi, R.F.7    Kim, B.8
  • 31
    • 0742286767 scopus 로고    scopus 로고
    • The changes in the T helper 1 (Th1) and T helper 2 (Th2) cytokine balance during HIV-1 infection are indicative of an allergic response to viral proteins that may be reversed by Th2 cytokine inhibitors and immune response modifiers-A review and hypothesis
    • Becker Y. 2004. The changes in the T helper 1 (Th1) and T helper 2 (Th2) cytokine balance during HIV-1 infection are indicative of an allergic response to viral proteins that may be reversed by Th2 cytokine inhibitors and immune response modifiers-a review and hypothesis. Virus Genes 28:5-18.
    • (2004) Virus Genes , vol.28 , pp. 5-18
    • Becker, Y.1
  • 32
    • 0037238708 scopus 로고    scopus 로고
    • The influence of cytokines, chemokines and their receptors on HIV-1 replication in monocytes and macrophages
    • Kedzierska K, Crowe SM, Turville S, Cunningham AL. 2003. The influence of cytokines, chemokines and their receptors on HIV-1 replication in monocytes and macrophages. Rev. Med. Virol. 13:39 -56.
    • (2003) Rev. Med. Virol. , vol.13 , pp. 39-56
    • Kedzierska, K.1    Crowe, S.M.2    Turville, S.3    Cunningham, A.L.4
  • 33
    • 0029023744 scopus 로고
    • Decreased thymidine kinase levels in peripheral blood cells from HIV-seropositive individuals: Implications for zidovudine metabolism
    • Jacobsson B, Britton S, He Q, Karlsson A, Eriksson S. 1995. Decreased thymidine kinase levels in peripheral blood cells from HIV-seropositive individuals: implications for zidovudine metabolism. AIDS Res. Hum. Retroviruses 11:805- 811.
    • (1995) AIDS Res. Hum. Retroviruses , vol.11 , pp. 805-811
    • Jacobsson, B.1    Britton, S.2    He, Q.3    Karlsson, A.4    Eriksson, S.5
  • 34
    • 0031713503 scopus 로고    scopus 로고
    • Decrease in thymidylate kinase activity in peripheral blood mononuclear cells from HIV-infected individuals
    • Jacobsson B, Britton S, Tornevik Y, Eriksson S. 1998. Decrease in thymidylate kinase activity in peripheral blood mononuclear cells from HIV-infected individuals. Biochem. Pharmacol. 56:389 -395.
    • (1998) Biochem. Pharmacol. , vol.56 , pp. 389-395
    • Jacobsson, B.1    Britton, S.2    Tornevik, Y.3    Eriksson, S.4
  • 35
    • 27744562116 scopus 로고    scopus 로고
    • Effect of cell cycle arrest on the activity of nucleoside analogues against human immunodeficiency virus type 1
    • Wurtzer S, Compain S, Benech H, Hance AJ, Clavel F. 2005. Effect of cell cycle arrest on the activity of nucleoside analogues against human immunodeficiency virus type 1. J. Virol. 79:14815-14821.
    • (2005) J. Virol. , vol.79 , pp. 14815-14821
    • Wurtzer, S.1    Compain, S.2    Benech, H.3    Hance, A.J.4    Clavel, F.5
  • 36
    • 0031467604 scopus 로고    scopus 로고
    • Interference with cell cycle progression and induction of apoptosis by dideoxynucleoside analogs
    • Viora M, Di Genova G, Rivabene R, Malorni W, Fattorossi A. 1997. Interference with cell cycle progression and induction of apoptosis by dideoxynucleoside analogs. Int. J. Immunopharmacol. 19:311-321.
    • (1997) Int. J. Immunopharmacol. , vol.19 , pp. 311-321
    • Viora, M.1    Di Genova, G.2    Rivabene, R.3    Malorni, W.4    Fattorossi, A.5
  • 39
    • 33747100570 scopus 로고    scopus 로고
    • Pharmacology of current and promising nucleosides for the treatment of human immunodeficiency viruses
    • Schinazi RF, Hernandez-Santiago BI, Hurwitz SJ. 2006. Pharmacology of current and promising nucleosides for the treatment of human immunodeficiency viruses. Antiviral Res. 71:322-334.
    • (2006) Antiviral Res. , vol.71 , pp. 322-334
    • Schinazi, R.F.1    Hernandez-Santiago, B.I.2    Hurwitz, S.J.3
  • 42
    • 77950666839 scopus 로고    scopus 로고
    • Antiviral activity and tolerability of amdoxovir with zidovudine in a randomized double-blind placebo-controlled study in HIV- 1-infected individuals
    • Murphy RL, Kivel NM, Zala C, Ochoa C, Tharnish P, Mathew J, Pascual ML, Schinazi RF. 2010. Antiviral activity and tolerability of amdoxovir with zidovudine in a randomized double-blind placebo-controlled study in HIV- 1-infected individuals. Antivir. Ther. 15:185-192.
    • (2010) Antivir. Ther. , vol.15 , pp. 185-192
    • Murphy, R.L.1    Kivel, N.M.2    Zala, C.3    Ochoa, C.4    Tharnish, P.5    Mathew, J.6    Pascual, M.L.7    Schinazi, R.F.8
  • 43
    • 77149177021 scopus 로고    scopus 로고
    • Lack of pharmacokinetic interaction between amdoxovir and reduced- and standard-dose zidovudine in HIV-1-infected individuals
    • Hurwitz SJ, Asif G, Fromentin E, Tharnish PM, Schinazi RF. 2010. Lack of pharmacokinetic interaction between amdoxovir and reduced- and standard-dose zidovudine in HIV-1-infected individuals. Antimicrob. Agents Chemother. 54:1248 -1255.
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 1248-1255
    • Hurwitz, S.J.1    Asif, G.2    Fromentin, E.3    Tharnish, P.M.4    Schinazi, R.F.5
  • 44
    • 41349096516 scopus 로고    scopus 로고
    • Short communication cellular pharmacology of 9-(beta-D-1, 3- dioxolan-4-yl) guanine and its lack of drug interactions with zidovudine in primary human lymphocytes
    • Hernandez-Santiago BI, Obikhod A, Fromentin E, Hurwitz SJ, Schinazi RF. 2007. Short communication cellular pharmacology of 9-(beta-D-1, 3- dioxolan-4-yl) guanine and its lack of drug interactions with zidovudine in primary human lymphocytes. Antivir. Chem. Chemother. 18:343-346.
    • (2007) Antivir. Chem. Chemother. , vol.18 , pp. 343-346
    • Hernandez-Santiago, B.I.1    Obikhod, A.2    Fromentin, E.3    Hurwitz, S.J.4    Schinazi, R.F.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.