-
1
-
-
77953666101
-
The VEGF family in cancer and antibody-based strategies for their inhibition
-
Sullivan LA, Brekken RA. The VEGF family in cancer and antibody-based strategies for their inhibition. MAbs 2(2), 165-175 (2010).
-
(2010)
MAbs
, vol.2
, Issue.2
, pp. 165-175
-
-
Sullivan, L.A.1
Brekken, R.A.2
-
2
-
-
33645095226
-
Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease
-
Ng EW, Shima DT, Calias P et al. Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease. Nat. Rev. Drug Discov. 5(2), 123-132 (2006).
-
(2006)
Nat. Rev. Drug Discov.
, vol.5
, Issue.2
, pp. 123-132
-
-
Ng, E.W.1
Shima, D.T.2
Calias, P.3
-
3
-
-
84860186303
-
Neovascular age-related macular degeneration
-
Veritti D, Sarao V, Lanzetta P. Neovascular age-related macular degeneration. Ophthalmologica 227(Suppl. 1), 11-20 (2012).
-
(2012)
Ophthalmologica
, vol.227
, Issue.SUPPL. 1
, pp. 11-20
-
-
Veritti, D.1
Sarao, V.2
Lanzetta, P.3
-
4
-
-
0029831672
-
Subfoveal fibrovascular membranes in age-related macular degeneration express vascular endothelial growth factor
-
Kvanta A, Algvere PV, Berglin L, Seregard S. Subfoveal fibrovascular membranes in age-related macular degeneration express vascular endothelial growth factor. Invest. Ophthalmol. Vis. Sci. 37(9), 1929-1934 (1996).
-
(1996)
Invest. Ophthalmol. Vis. Sci.
, vol.37
, Issue.9
, pp. 1929-1934
-
-
Kvanta, A.1
Algvere, P.V.2
Berglin, L.3
Seregard, S.4
-
5
-
-
0029739620
-
Vascular endothelial growth factor is sufficient to produce iris neovascularization and neovascular glaucoma in a nonhuman primate
-
Tolentino MJ, Miller JW, Gragoudas ES et al. Vascular endothelial growth factor is sufficient to produce iris neovascularization and neovascular glaucoma in a nonhuman primate. Arch. Ophthalmol. 114(8), 964-970 (1996).
-
(1996)
Arch. Ophthalmol.
, vol.114
, Issue.8
, pp. 964-970
-
-
Tolentino, M.J.1
Miller, J.W.2
Gragoudas, E.S.3
-
6
-
-
0031050126
-
Increased expression of angiogenic growth factors in age-related maculopathy
-
Kliffen M, Sharma HS, Mooy CM, Kerkvliet S, de Jong PT. Increased expression of angiogenic growth factors in age-related maculopathy. Br. J. Ophthalmol. 81(2), 154-162 (1997).
-
(1997)
Br. J. Ophthalmol.
, vol.81
, Issue.2
, pp. 154-162
-
-
Kliffen, M.1
Sharma, H.S.2
Mooy, C.M.3
Kerkvliet, S.4
De Jong, P.T.5
-
7
-
-
0037900481
-
Placental growth factor, a member of the VEGF family, contributes to the development of choroidal neovascularization
-
Rakic JM, Lambert V, Devy L et al. Placental growth factor, a member of the VEGF family, contributes to the development of choroidal neovascularization. Invest. Ophthalmol. Vis. Sci. 44(7), 3186-3193 (2003).
-
(2003)
Invest. Ophthalmol. Vis. Sci.
, vol.44
, Issue.7
, pp. 3186-3193
-
-
Rakic, J.M.1
Lambert, V.2
Devy, L.3
-
8
-
-
0036129304
-
Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment
-
Krzystolik MG, Afshari MA, Adamis AP et al. Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment. Arch. Ophthalmol. 120(3), 338-346 (2002).
-
(2002)
Arch. Ophthalmol.
, vol.120
, Issue.3
, pp. 338-346
-
-
Krzystolik, M.G.1
Afshari, M.A.2
Adamis, A.P.3
-
9
-
-
53449095951
-
Comparison of bevacizumab, ranibizumab, and pegaptanib in vitro: Efficiency and possible additional pathways
-
Klettner A, Roider J. Comparison of bevacizumab, ranibizumab, and pegaptanib in vitro: efficiency and possible additional pathways. Invest. Ophthalmol. Vis. Sci. 49(10), 4523-4527 (2010).
-
(2010)
Invest. Ophthalmol. Vis. Sci.
, vol.49
, Issue.10
, pp. 4523-4527
-
-
Klettner, A.1
Roider, J.2
-
10
-
-
33746591262
-
Tyrosine kinase inhibitors of vascular endothelial growth factor receptors in clinical trials: Current status and future directions
-
Morabito A, De Maio E, Di Maio M, Normanno N, Perrone F. Tyrosine kinase inhibitors of vascular endothelial growth factor receptors in clinical trials: current status and future directions. Oncologist 11(7), 753-764 (2006).
-
(2006)
Oncologist
, vol.11
, Issue.7
, pp. 753-764
-
-
Morabito, A.1
De Maio, E.2
Di Maio, M.3
Normanno, N.4
Perrone, F.5
-
11
-
-
77957756488
-
Phase II study of Aflibercept (VEGF-Trap) in patients with recurrent or metastatic urothelial cancer, a California Cancer Consortium Trial
-
Twardowski P, Stadler WM, Frankel P et al. Phase II study of Aflibercept (VEGF-Trap) in patients with recurrent or metastatic urothelial cancer, a California Cancer Consortium Trial. Urology 76(4), 923-926 (2010).
-
(2010)
Urology
, vol.76
, Issue.4
, pp. 923-926
-
-
Twardowski, P.1
Stadler, W.M.2
Frankel, P.3
-
12
-
-
84868588283
-
A Phase II evaluation of aflibercept in the treatment of recurrent or persistent endometrial cancer: A Gynecologic Oncology Group study
-
Coleman RL, Sill MW, Lankes HA et al. A Phase II evaluation of aflibercept in the treatment of recurrent or persistent endometrial cancer: A Gynecologic Oncology Group study. Gynecol. Oncol. 127(3), 538-543 (2012).
-
(2012)
Gynecol. Oncol.
, vol.127
, Issue.3
, pp. 538-543
-
-
Coleman, R.L.1
Sill, M.W.2
Lankes, H.A.3
-
13
-
-
84856509199
-
Intravenous aflibercept for treatment of recurrent symptomatic malignant ascites in patients with advanced ovarian cancer: A Phase 2, randomised, double-blind, placebo-controlled study
-
Gotlieb WH, Amant F, Advani S et al. Intravenous aflibercept for treatment of recurrent symptomatic malignant ascites in patients with advanced ovarian cancer: A Phase 2, randomised, double-blind, placebo-controlled study. Lancet Oncol. 13(2), 154-162 (2012).
-
(2012)
Lancet Oncol.
, vol.13
, Issue.2
, pp. 154-162
-
-
Gotlieb, W.H.1
Amant, F.2
Advani, S.3
-
14
-
-
84867047384
-
Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a Phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen
-
Van Cutsem E, Tabernero J, Lakomy R et al. Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a Phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen. J. Clin. Oncol. 30(28), 3499-3506 (2012).
-
(2012)
J. Clin. Oncol.
, vol.30
, Issue.28
, pp. 3499-3506
-
-
Van Cutsem, E.1
Tabernero, J.2
Lakomy, R.3
-
15
-
-
80054097652
-
Aflibercept (VEGF Trap) in inoperable stage III or stage IV melanoma of cutaneous or uveal origin
-
Tarhini AA, Frankel P, Margolin KA et al. Aflibercept (VEGF Trap) in inoperable stage III or stage IV melanoma of cutaneous or uveal origin. Clin. Cancer Res. 17(20), 6574-6581 (2011).
-
(2011)
Clin. Cancer Res.
, vol.17
, Issue.20
, pp. 6574-6581
-
-
Tarhini, A.A.1
Frankel, P.2
Margolin, K.A.3
-
18
-
-
11144354339
-
Prevalence of age-related macular degeneration in the United States
-
Friedman DS, O'Colmain BJ, Muñoz B et al. Prevalence of age-related macular degeneration in the United States. Arch. Ophthalmol. 122(4), 564-572 (2004).
-
(2004)
Arch. Ophthalmol.
, vol.122
, Issue.4
, pp. 564-572
-
-
Friedman, D.S.1
O'colmain, B.J.2
Muñoz, B.3
-
19
-
-
27744516278
-
A simplified severity scale for age-related macular degeneration: AREDS Report No 18
-
Ferris FL, Davis MD, Clemons TE et al. A simplified severity scale for age-related macular degeneration: AREDS Report No. 18. Arch. Ophthalmol. 123(11), 1570-1574 (2005).
-
(2005)
Arch. Ophthalmol.
, vol.123
, Issue.11
, pp. 1570-1574
-
-
Ferris, F.L.1
Davis, M.D.2
Clemons, T.E.3
-
20
-
-
0037388460
-
The risk and natural course of age-related maculopathy: Follow-up at 6 1/2 years in the Rotterdam study
-
van Leeuwen R, Klaver CC, Vingerling JR, Hofman A, de Jong PT. The risk and natural course of age-related maculopathy: follow-up at 6 1/2 years in the Rotterdam study. Arch. Ophthalmol. 121(4), 519-526 (2003).
-
(2003)
Arch. Ophthalmol.
, vol.121
, Issue.4
, pp. 519-526
-
-
Van Leeuwen, R.1
Klaver, C.C.2
Vingerling, J.R.3
Hofman, A.4
De Jong, P.T.5
-
21
-
-
0028859859
-
The relationship of age-related maculopathy, cataract, and glaucoma to visual acuity
-
Klein R, Wang Q, Klein BE, Moss SE, Meuer SM. The relationship of age-related maculopathy, cataract, and glaucoma to visual acuity. Invest. Ophthalmol. Vis. Sci. 36(1), 182-191 (1995).
-
(1995)
Invest. Ophthalmol. Vis. Sci.
, vol.36
, Issue.1
, pp. 182-191
-
-
Klein, R.1
Wang, Q.2
Klein, B.E.3
Moss, S.E.4
Meuer, S.M.5
-
22
-
-
79957604976
-
Genetics of age-related macular degeneration: Current concepts, future directions
-
Deangelis MM, Silveira AC, Carr EA, Kim IK. Genetics of age-related macular degeneration: current concepts, future directions. Semin. Ophthalmol. 26(3), 77-93 (2011).
-
(2011)
Semin. Ophthalmol.
, vol.26
, Issue.3
, pp. 77-93
-
-
Deangelis, M.M.1
Silveira, A.C.2
Carr, E.A.3
Kim, I.K.4
-
23
-
-
0033795036
-
The role of oxidative stress in the pathogenesis of age-related macular degeneration
-
Beatty S, Koh H, Phil M, Henson D, Boulton M. The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv. Ophthalmol. 45(2), 115-134 (2000).
-
(2000)
Surv. Ophthalmol.
, vol.45
, Issue.2
, pp. 115-134
-
-
Beatty, S.1
Koh, H.2
Phil, M.3
Henson, D.4
Boulton, M.5
-
24
-
-
79957619481
-
Inflammation and age-related macular degeneration (AMD)
-
Telander DG. Inflammation and age-related macular degeneration (AMD). Semin. Ophthalmol. 26(3), 192-197 (2011).
-
(2011)
Semin. Ophthalmol.
, vol.26
, Issue.3
, pp. 192-197
-
-
Telander, D.G.1
-
25
-
-
1842478123
-
Current concepts in the pathogenesis of age-related macular degeneration
-
Zarbin MA. Current concepts in the pathogenesis of age-related macular degeneration. Arch. Ophthalmol. 122(4), 598-614 (2004).
-
(2004)
Arch. Ophthalmol.
, vol.122
, Issue.4
, pp. 598-614
-
-
Zarbin, M.A.1
-
26
-
-
0026409933
-
Argon laser photocoagulation for neovascular maculopathy Five-year results from randomized clinical trials
-
Macular Photocoagulation Study Group
-
Macular Photocoagulation Study Group. Argon laser photocoagulation for neovascular maculopathy. Five-year results from randomized clinical trials. Arch. Ophthalmol. 109(8), 1109-1114 (1991).
-
(1991)
Arch. Ophthalmol.
, vol.109
, Issue.8
, pp. 1109-1114
-
-
-
27
-
-
0342632445
-
Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: One-year results of 2 randomized clinical trials-TAP report
-
TAP Study Group. Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: one-year results of 2 randomized clinical trials-TAP report. Arch. Ophthalmol. 117(10), 1329-1345 (1999).
-
(1999)
Arch. Ophthalmol.
, vol.117
, Issue.10
, pp. 1329-1345
-
-
Study Group, T.1
-
28
-
-
30044436689
-
A therapeutic aptamer inhibits angiogenesis by specifically targeting the heparin binding domain of VEGF165
-
Lee JH, Canny MD, De Erkenez A et al. A therapeutic aptamer inhibits angiogenesis by specifically targeting the heparin binding domain of VEGF165. Proc. Natl Acad. Sci. USA 102(52), 18902-18907 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, Issue.52
, pp. 18902-18907
-
-
Lee, J.H.1
Canny, M.D.2
De Erkenez, A.3
-
29
-
-
11144239923
-
Pegaptanib for neovascular age-related macular degeneration
-
Gragoudas ES, Adamis AP, Cunningham ET, Feinsod M, Guyer DR. Pegaptanib for neovascular age-related macular degeneration. N. Engl. J. Med. 351(27), 2805-2816 (2004).
-
(2004)
N. Engl. J. Med.
, vol.351
, Issue.27
, pp. 2805-2816
-
-
Gragoudas, E.S.1
Adamis, A.P.2
Cunningham, E.T.3
Feinsod, M.4
Guyer, D.R.5
-
30
-
-
33747891752
-
Year 2 efficacy results of 2 randomized controlled clinical trials of pegaptanib for neovascular age-related macular degeneration
-
Chakravarthy U, Adamis AP, Cunningham ET Jr et al. Year 2 efficacy results of 2 randomized controlled clinical trials of pegaptanib for neovascular age-related macular degeneration. Ophthalmology 113(9), 1508.e1-1508.e25 (2006).
-
(2006)
Ophthalmology
, vol.113
, Issue.9
-
-
Chakravarthy, U.1
Adamis, A.P.2
Cunningham Jr., E.T.3
-
31
-
-
0030856731
-
Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders
-
Presta LG, Chen H, O'Connor SJ et al. Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res. 57(20), 4593-4599 (1997).
-
(1997)
Cancer Res.
, vol.57
, Issue.20
, pp. 4593-4599
-
-
Presta, L.G.1
Chen, H.2
O'connor, S.J.3
-
32
-
-
20144372969
-
Systemic bevacizumab (Avastin) therapy for neovascular age-related macular degeneration twelve-week results of an uncontrolled open-label clinical study
-
Michels S, Rosenfeld PJ, Puliafito CA, Marcus EN, Venkatraman AS. Systemic bevacizumab (Avastin) therapy for neovascular age-related macular degeneration twelve-week results of an uncontrolled open-label clinical study. Ophthalmology 112(6), 1035-1047 (2005).
-
(2005)
Ophthalmology
, vol.112
, Issue.6
, pp. 1035-1047
-
-
Michels, S.1
Rosenfeld, P.J.2
Puliafito, C.A.3
Marcus, E.N.4
Venkatraman, A.S.5
-
33
-
-
33750305221
-
Systemic bevacizumab (Avastin) therapy for neovascular age-related macular degeneration: Twenty-four-week results of an uncontrolled open-label clinical study
-
Moshfeghi AA, Rosenfeld PJ, Puliafito CA et al. Systemic bevacizumab (Avastin) therapy for neovascular age-related macular degeneration: twenty-four-week results of an uncontrolled open-label clinical study. Ophthalmology 113(11), 2002.e1-2002.e12 (2006).
-
(2006)
Ophthalmology
, vol.113
, Issue.11
-
-
Moshfeghi, A.A.1
Rosenfeld, P.J.2
Puliafito, C.A.3
-
34
-
-
36448993366
-
Twelve-month safety of intravitreal injections of bevacizumab (avastin): Results of the Pan-American Collaborative Retina Study Group (PACORES)
-
Wu L, Martínez-Castellanos MA, Quiroz-Mercado H et al. Twelve-month safety of intravitreal injections of bevacizumab (avastin): results of the Pan-American Collaborative Retina Study Group (PACORES). Graefes Arch. Clin. Exp. Ophthalmol. 246(1), 81-87 (2008).
-
(2008)
Graefes Arch. Clin. Exp. Ophthalmol.
, vol.246
, Issue.1
, pp. 81-87
-
-
Wu, L.1
Martínez-Castellanos, M.A.2
Quiroz-Mercado, H.3
-
35
-
-
77954106891
-
Bevacizumab for neovascular age related macular degeneration (ABC trial): Multicentre randomised double masked study
-
Tufail A, Patel PJ, Egan C et al. Bevacizumab for neovascular age related macular degeneration (ABC trial): multicentre randomised double masked study. BMJ 340, c2459 (2010).
-
(2010)
BMJ
, vol.340
-
-
Tufail, A.1
Patel, P.J.2
Egan, C.3
-
36
-
-
33745782355
-
Short-term safety and efficacy of intravitreal bevacizumab (avastin) for neovascular age-related macular degeneration
-
Rich RM, Rosenfeld PJ, Puliafito CA et al. Short-term safety and efficacy of intravitreal bevacizumab (avastin) for neovascular age-related macular degeneration. Retina (Phil.) 26(5), 495-511 (2006).
-
(2006)
Retina (Phil.)
, vol.26
, Issue.5
, pp. 495-511
-
-
Rich, R.M.1
Rosenfeld, P.J.2
Puliafito, C.A.3
-
37
-
-
33644502828
-
Intravitreal bevacizumab (avastin) for neovascular age-related macular degeneration
-
Avery RL, Pieramici DJ, Rabena MD et al. Intravitreal bevacizumab (avastin) for neovascular age-related macular degeneration. Ophthalmology 113(3), 363.e5-372.e5 (2006).
-
(2006)
Ophthalmology
, vol.113
, Issue.3
-
-
Avery, R.L.1
Pieramici, D.J.2
Rabena, M.D.3
-
38
-
-
33745091547
-
Intravitreal bevacizumab treatment of choroidal neovascularization secondary to age-related macular degeneration
-
Spaide RF, Laud K, Fine HF et al. Intravitreal bevacizumab treatment of choroidal neovascularization secondary to age-related macular degeneration. Retina (Phil.) 26(4), 383-390 (2006).
-
(2006)
Retina (Phil.)
, vol.26
, Issue.4
, pp. 383-390
-
-
Spaide, R.F.1
Laud, K.2
Fine, H.F.3
-
39
-
-
79955085045
-
Pharmacotherapy for neovascular age-related macular degeneration: An analysis of the 100% 2008 medicare fee-for-service part B claims file
-
Brechner RJ, Rosenfeld PJ, Babish JD, Caplan S. Pharmacotherapy for neovascular age-related macular degeneration: an analysis of the 100% 2008 medicare fee-for-service part B claims file. Am. J. Ophthalmol. 151(5), 887.e1-895.e1 (2011).
-
(2011)
Am. J. Ophthalmol.
, vol.151
, Issue.5
-
-
Brechner, R.J.1
Rosenfeld, P.J.2
Babish, J.D.3
Caplan, S.4
-
40
-
-
84857302077
-
Ranibizumab for age-related macular degeneration
-
Dhoot DS, Kaiser PK. Ranibizumab for age-related macular degeneration. Expert Opin Biol Ther. 12(3), 371-381 (2012).
-
(2012)
Expert Opin Biol Ther.
, vol.12
, Issue.3
, pp. 371-381
-
-
Dhoot, D.S.1
Kaiser, P.K.2
-
41
-
-
33749445317
-
Ranibizumab for neovascular age-related macular degeneration
-
Rosenfeld PJ, Brown DM, Heier JS et al. Ranibizumab for neovascular age-related macular degeneration. N. Engl. J. Med. 355(14), 1419-1431 (2006).
-
(2006)
N. Engl. J. Med.
, vol.355
, Issue.14
, pp. 1419-1431
-
-
Rosenfeld, P.J.1
Brown, D.M.2
Heier, J.S.3
-
42
-
-
33749451356
-
Ranibizumab versus verteporfin for neovascular age-related macular degeneration
-
Brown DM, Kaiser PK, Michels M et al. Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N. Engl. J. Med. 355(14), 1432-1444 (2006).
-
(2006)
N. Engl. J. Med.
, vol.355
, Issue.14
, pp. 1432-1444
-
-
Brown, D.M.1
Kaiser, P.K.2
Michels, M.3
-
43
-
-
57949094834
-
Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: Two-year results of the ANCHOR study
-
Brown DM, Michels M, Kaiser PK et al. Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: two-year results of the ANCHOR study. Ophthalmology 116(1), 57.e5-65.e5 (2009).
-
(2009)
Ophthalmology
, vol.116
, Issue.1
-
-
Brown, D.M.1
Michels, M.2
Kaiser, P.K.3
-
44
-
-
77956056292
-
Randomized, double-masked, sham-controlled trial of ranibizumab for neovascular age-related macular degeneration: PIER study year 2
-
Abraham P, Yue H, Wilson L. Randomized, double-masked, sham-controlled trial of ranibizumab for neovascular age-related macular degeneration: PIER study year 2. Am. J. Ophthalmol. 150(3), 315.e1-324.e1 (2010).
-
(2010)
Am. J. Ophthalmol.
, vol.150
, Issue.3
-
-
Abraham, P.1
Yue, H.2
Wilson, L.3
-
45
-
-
67149101784
-
A variable-dosing regimen with intravitreal ranibizumab for neovascular age-related macular degeneration: Year 2 of the PrONTO study
-
Lalwani GA, Rosenfeld PJ, Fung AE et al. A variable-dosing regimen with intravitreal ranibizumab for neovascular age-related macular degeneration: year 2 of the PrONTO study. Am. J. Ophthalmol. 148(1), 43.e1-58.e1 (2009).
-
(2009)
Am. J. Ophthalmol.
, vol.148
, Issue.1
-
-
Lalwani, G.A.1
Rosenfeld, P.J.2
Fung, A.E.3
-
46
-
-
79955631484
-
Efficacy and safety of monthly versus quarterly ranibizumab treatment in neovascular age-related macular degeneration: The EXCITE study
-
Schmidt-Erfurth U, Eldem B, Guymer R et al. Efficacy and safety of monthly versus quarterly ranibizumab treatment in neovascular age-related macular degeneration: the EXCITE study. Ophthalmology 118(5), 831-839 (2011).
-
(2011)
Ophthalmology
, vol.118
, Issue.5
, pp. 831-839
-
-
Schmidt-Erfurth, U.1
Eldem, B.2
Guymer, R.3
-
47
-
-
79953295148
-
Safety and efficacy of a flexible dosing regimen of ranibizumab in neovascular age-related macular degeneration: The SUSTAIN study
-
Holz FG, Amoaku W, Donate J et al. Safety and efficacy of a flexible dosing regimen of ranibizumab in neovascular age-related macular degeneration: the SUSTAIN study. Ophthalmology 118(4), 663-671 (2011).
-
(2011)
Ophthalmology
, vol.118
, Issue.4
, pp. 663-671
-
-
Holz, F.G.1
Amoaku, W.2
Donate, J.3
-
48
-
-
84859400504
-
HORIZON: An open-label extension trial of ranibizumab for choroidal neovascularization secondary to age-related macular degeneration
-
Singer MA, Awh CC, Sadda S et al. HORIZON: an open-label extension trial of ranibizumab for choroidal neovascularization secondary to age-related macular degeneration. Ophthalmology 119(6), 1175-1183 (2012).
-
(2012)
Ophthalmology
, vol.119
, Issue.6
, pp. 1175-1183
-
-
Singer, M.A.1
Awh, C.C.2
Sadda, S.3
-
49
-
-
74349104001
-
Clinical safety of ranibizumab in age-related macular degeneration
-
Schmidt-Erfurth U. Clinical safety of ranibizumab in age-related macular degeneration. Expert Opin Drug Saf. 9(1), 149-165 (2010).
-
(2010)
Expert Opin Drug Saf.
, vol.9
, Issue.1
, pp. 149-165
-
-
Schmidt-Erfurth, U.1
-
50
-
-
79956218863
-
Ranibizumab and bevacizumab for neovascular age-related macular degeneration
-
Martin DF, Maguire MG, Ying G et al. Ranibizumab and bevacizumab for neovascular age-related macular degeneration. N. Engl. J. Med. 364(20), 1897-1908 (2011).
-
(2011)
N. Engl. J. Med.
, vol.364
, Issue.20
, pp. 1897-1908
-
-
Martin, D.F.1
Maguire, M.G.2
Ying, G.3
-
51
-
-
84863320414
-
Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration: Two-year results
-
Martin DF, Maguire MG, Fine SL et al. Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration: two-year results. Ophthalmology 119(7), 1388-1398 (2012).
-
(2012)
Ophthalmology
, vol.119
, Issue.7
, pp. 1388-1398
-
-
Martin, D.F.1
Maguire, M.G.2
Fine, S.L.3
-
52
-
-
84863327423
-
Ranibizumab versus bevacizumab to treat neovascular age-related macular degeneration: One-year findings from the IVAN randomized trial
-
Chakravarthy U, Harding SP, Rogers CA et al. Ranibizumab versus bevacizumab to treat neovascular age-related macular degeneration: one-year findings from the IVAN randomized trial. Ophthalmology 119(7), 1399-1411 (2012).
-
(2012)
Ophthalmology
, vol.119
, Issue.7
, pp. 1399-1411
-
-
Chakravarthy, U.1
Harding, S.P.2
Rogers, C.A.3
-
53
-
-
0028786651
-
Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins
-
Aiello LP, Pierce EA, Foley ED et al. Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. Proc. Natl Acad. Sci. USA 92(23), 10457-10461 (1995).
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, Issue.23
, pp. 10457-10461
-
-
Aiello, L.P.1
Pierce, E.A.2
Foley, E.D.3
-
54
-
-
0029790466
-
The second immunoglobulin-like domain of the VEGF tyrosine kinase receptor Flt-1 determines ligand binding and may initiate a signal transduction cascade
-
Davis-Smyth T, Chen H, Park J, Presta LG, Ferrara N. The second immunoglobulin-like domain of the VEGF tyrosine kinase receptor Flt-1 determines ligand binding and may initiate a signal transduction cascade. EMBO J. 15(18), 4919-4927 (1996).
-
(1996)
EMBO J.
, vol.15
, Issue.18
, pp. 4919-4927
-
-
Davis-Smyth, T.1
Chen, H.2
Park, J.3
Presta, L.G.4
Ferrara, N.5
-
55
-
-
0034920084
-
Luteal angiogenesis: Prevention and intervention by treatment with vascular endothelial growth factor trap (A40)
-
Wulff C, Wilson H, Rudge JS et al. Luteal angiogenesis: prevention and intervention by treatment with vascular endothelial growth factor trap (A40). J. Clin. Endocrinol. Metab. 86(7), 3377-3386 (2001).
-
(2001)
J. Clin. Endocrinol. Metab.
, vol.86
, Issue.7
, pp. 3377-3386
-
-
Wulff, C.1
Wilson, H.2
Rudge, J.S.3
-
56
-
-
0034987872
-
Angiogenesis during follicular development in the primate and its inhibition by treatment with truncated Flt-1-Fc (vascular endothelial growth factor Trap(A40))
-
Wulff C, Wiegand SJ, Saunders PT, Scobie GA, Fraser HM. Angiogenesis during follicular development in the primate and its inhibition by treatment with truncated Flt-1-Fc (vascular endothelial growth factor Trap(A40)). Endocrinology 142(7), 3244-3254 (2001).
-
(2001)
Endocrinology
, vol.142
, Issue.7
, pp. 3244-3254
-
-
Wulff, C.1
Wiegand, S.J.2
Saunders, P.T.3
Scobie, G.A.4
Fraser, H.M.5
-
57
-
-
0037143764
-
VEGF-Trap: A VEGF blocker with potent antitumor effects
-
Holash J, Davis S, Papadopoulos N et al. VEGF-Trap: A VEGF blocker with potent antitumor effects. Proc. Natl Acad. Sci. USA 99(17), 11393-11398 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, Issue.17
, pp. 11393-11398
-
-
Holash, J.1
Davis, S.2
Papadopoulos, N.3
-
58
-
-
0037143739
-
Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma
-
Kim ES, Serur A, Huang J et al. Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma. Proc. Natl Acad. Sci. USA 99(17), 11399-11404 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, Issue.17
, pp. 11399-11404
-
-
Kim, E.S.1
Serur, A.2
Huang, J.3
-
59
-
-
79955661504
-
Comparing protein VEGF inhibitors: In vitro biological studies
-
Yu L, Liang XH, Ferrara N. Comparing protein VEGF inhibitors: in vitro biological studies. Biochem. Biophys. Res. Commun. 408(2), 276-281 (2011).
-
(2011)
Biochem. Biophys. Res. Commun.
, vol.408
, Issue.2
, pp. 276-281
-
-
Yu, L.1
Liang, X.H.2
Ferrara, N.3
-
60
-
-
0037934449
-
Regression of established tumors and metastases by potent vascular endothelial growth factor blockade
-
Huang J, Frischer JS, Serur A et al. Regression of established tumors and metastases by potent vascular endothelial growth factor blockade. Proc. Natl Acad. Sci. USA 100(13), 7785-7790 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, Issue.13
, pp. 7785-7790
-
-
Huang, J.1
Frischer, J.S.2
Serur, A.3
-
61
-
-
0345060442
-
Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model
-
Byrne AT, Ross L, Holash J et al. Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model. Clin. Cancer Res. 9(15), 5721-5728 (2003).
-
(2003)
Clin. Cancer Res.
, vol.9
, Issue.15
, pp. 5721-5728
-
-
Byrne, A.T.1
Ross, L.2
Holash, J.3
-
62
-
-
79951911015
-
A subretinal matrigel rat choroidal neovascularization (CNV) model and inhibition of CNV and associated inflammation and fibrosis by VEGF trap
-
Cao J, Zhao L, Li Y et al. A subretinal matrigel rat choroidal neovascularization (CNV) model and inhibition of CNV and associated inflammation and fibrosis by VEGF trap. Invest. Ophthalmol. Vis. Sci. 51(11), 6009-6017 (2010).
-
(2010)
Invest. Ophthalmol. Vis. Sci.
, vol.51
, Issue.11
, pp. 6009-6017
-
-
Cao, J.1
Zhao, L.2
Li, Y.3
-
63
-
-
0037401890
-
VEGF-TRAP(R1R2) suppresses choroidal neovascularization and VEGF-induced breakdown of the blood-retinal barrier
-
Saishin Y, Saishin Y, Takahashi K et al. VEGF-TRAP(R1R2) suppresses choroidal neovascularization and VEGF-induced breakdown of the blood-retinal barrier. J. Cell. Physiol. 195(2), 241-248 (2003).
-
(2003)
J. Cell. Physiol.
, vol.195
, Issue.2
, pp. 241-248
-
-
Saishin, Y.1
Saishin, Y.2
Takahashi, K.3
-
64
-
-
33747874091
-
A Phase i trial of an IV-administered vascular endothelial growth factor trap for treatment in patients with choroidal neovascularization due to age-related macular degeneration
-
Nguyen QD, Shah SM, Hafiz G et al. A Phase I trial of an IV-administered vascular endothelial growth factor trap for treatment in patients with choroidal neovascularization due to age-related macular degeneration. Ophthalmology 113(9), 1522.e1-1522.e14 (2006).
-
(2006)
Ophthalmology
, vol.113
, Issue.9
-
-
Nguyen, Q.D.1
Shah, S.M.2
Hafiz, G.3
-
65
-
-
70350757650
-
A Phase i study of intravitreal vascular endothelial growth factor trap-eye in patients with neovascular age-related macular degeneration
-
Nguyen QD, Shah SM, Browning DJ et al. A Phase I study of intravitreal vascular endothelial growth factor trap-eye in patients with neovascular age-related macular degeneration. Ophthalmology 116(11), 2141.e1-2148.e1 (2009).
-
(2009)
Ophthalmology
, vol.116
, Issue.11
-
-
Nguyen, Q.D.1
Shah, S.M.2
Browning, D.J.3
-
66
-
-
79957986348
-
Primary endpoint results of a Phase II study of vascular endothelial growth factor trap-eye in wet age-related macular degeneration
-
Brown DM, Heier JS, Ciulla T et al. Primary endpoint results of a Phase II study of vascular endothelial growth factor trap-eye in wet age-related macular degeneration. Ophthalmology 118(6), 1089-1097 (2011).
-
(2011)
Ophthalmology
, vol.118
, Issue.6
, pp. 1089-1097
-
-
Brown, D.M.1
Heier, J.S.2
Ciulla, T.3
-
67
-
-
79957990661
-
The 1-year results of CLEAR-IT 2, a Phase 2 study of vascular endothelial growth factor trap-eye dosed as-needed after 12-week fixed dosing
-
Heier JS, Boyer D, Nguyen QD et al. The 1-year results of CLEAR-IT 2, a Phase 2 study of vascular endothelial growth factor trap-eye dosed as-needed after 12-week fixed dosing. Ophthalmology 118(6), 1098-1106 (2011).
-
(2011)
Ophthalmology
, vol.118
, Issue.6
, pp. 1098-1106
-
-
Heier, J.S.1
Boyer, D.2
Nguyen, Q.D.3
-
68
-
-
84870723704
-
Intravitreal aflibercept (VEGF Trap-Eye) in wet age-related macular degeneration
-
Heier JS, Brown DM, Chong V et al. Intravitreal aflibercept (VEGF Trap-Eye) in wet age-related macular degeneration. Ophthalmology 119(12), 2537-2548 (2012).
-
(2012)
Ophthalmology
, vol.119
, Issue.12
, pp. 2537-2548
-
-
Heier, J.S.1
Brown, D.M.2
Chong, V.3
-
69
-
-
43649083100
-
Predicted biological activity of intravitreal VEGF Trap
-
Stewart MW, Rosenfeld PJ. Predicted biological activity of intravitreal VEGF Trap. Br. J. Ophthalmol. 92(5), 667-668 (2008).
-
(2008)
Br. J. Ophthalmol.
, vol.92
, Issue.5
, pp. 667-668
-
-
Stewart, M.W.1
Rosenfeld, P.J.2
-
70
-
-
84865129521
-
Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab
-
Papadopoulos N, Martin J, Ruan Q et al. Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab. Angiogenesis 15(2), 171-185 (2012).
-
(2012)
Angiogenesis
, vol.15
, Issue.2
, pp. 171-185
-
-
Papadopoulos, N.1
Martin, J.2
Ruan, Q.3
-
72
-
-
84874099519
-
The Superdose Anti-VEGF (SAVE) trial: 2.0-mg intravitreal ranibizumab for recalcitrant neovascular AMD
-
Orlando FL, USA, 22-25 October Poster
-
Benz MS. The Superdose Anti-VEGF (SAVE) trial: 2.0-mg intravitreal ranibizumab for recalcitrant neovascular AMD. American Academy of Opthalmology 2011 Annual Meeting. Orlando, FL, USA, 22-25 October (Poster 493).
-
American Academy of Opthalmology 2011 Annual Meeting
, pp. 493
-
-
Benz, M.S.1
-
73
-
-
84874044074
-
Pigment epithelial detachment improvement in non-naive neovascular AMD patients after intravitreal aflibercept
-
Las Vegas, NY, USA 27 August
-
Major J. Pigment epithelial detachment improvement in non-naive neovascular AMD patients after intravitreal aflibercept. Presented at: American Society of Retina Specialists. Las Vegas, NY, USA, 27 August 2012.
-
(2012)
American Society of Retina Specialists
-
-
Major, J.1
-
74
-
-
84874078827
-
Resolution of persistent macular edema SRF and/or RPE detachment after single injection of aflibercept in patients with neovascular AMD
-
Las Vegas, NY, USA, 27 August
-
Sharma A. Resolution of persistent macular edema, SRF and/or RPE detachment after single injection of aflibercept in patients with neovascular AMD. Presented at: American Society of Retina Specialists. Las Vegas, NY, USA, 27 August 2012.
-
(2012)
American Society of Retina Specialists
-
-
Sharma, A.1
-
75
-
-
84862779327
-
Vascular endothelial growth factor Trap-Eye for macular edema secondary to central retinal vein occlusion: Six-month results of the Phase 3 COPERNICUS study
-
Boyer D, Heier J, Brown DM et al. Vascular endothelial growth factor Trap-Eye for macular edema secondary to central retinal vein occlusion: six-month results of the Phase 3 COPERNICUS study. Ophthalmology 119(5), 1024-1032 (2012).
-
(2012)
Ophthalmology
, vol.119
, Issue.5
, pp. 1024-1032
-
-
Boyer, D.1
Heier, J.2
Brown, D.M.3
-
76
-
-
84864444516
-
One-year outcomes of the da VINCI study of VEGF Trap-Eye in eyes with diabetic macular edema
-
Do DV, Nguyen QD, Schmidt-Erfurth U et al. One-year outcomes of the DA VINCI study of VEGF Trap-Eye in eyes with diabetic macular edema. Ophthalmology 119(8), 1658-1665 (2012).
-
(2012)
Ophthalmology
, vol.119
, Issue.8
, pp. 1658-1665
-
-
Do, D.V.1
Nguyen, Q.D.2
Schmidt-Erfurth, U.3
|