메뉴 건너뛰기




Volumn 19, Issue 4, 2013, Pages 785-797

Reciprocal interactions between tumor-associated macrophages and CD44-positive cancer cells via osteopontin/CD44 promote tumorigenicity in colorectal cancer

Author keywords

[No Author keywords available]

Indexed keywords

CD44V6 ANTIGEN; HERMES ANTIGEN; OSTEOPONTIN; STRESS ACTIVATED PROTEIN KINASE;

EID: 84874056227     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-12-2788     Document Type: Article
Times cited : (107)

References (50)
  • 1
    • 0020577072 scopus 로고
    • A cell-surface molecule involved in organ-specific homing of lymphocytes
    • Gallatin WM, Weissman IL, Butcher EC. A cell-surface molecule involved in organ-specific homing of lymphocytes. Nature 1983;304: 30-4.
    • (1983) Nature , vol.304 , pp. 30-34
    • Gallatin, W.M.1    Weissman, I.L.2    Butcher, E.C.3
  • 2
    • 44749091840 scopus 로고    scopus 로고
    • Involvement of CD44, a molecule with a thousand faces, in cancer dissemination
    • Naor D, Wallach-Dayan SB, Zahalka MA, Sionov RV. Involvement of CD44, a molecule with a thousand faces, in cancer dissemination. Semin Cancer Biol 2008;18:260-7.
    • (2008) Semin Cancer Biol , vol.18 , pp. 260-267
    • Naor, D.1    Wallach-Dayan, S.B.2    Zahalka, M.A.3    Sionov, R.V.4
  • 3
    • 0027065573 scopus 로고
    • Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons
    • Screaton GR, Bell MV, Jackson DG, Cornelis FB, Gerth U, Bell JI. Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons. Proc Natl Acad Sci U S A 1992;89:12160-4.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 12160-12164
    • Screaton, G.R.1    Bell, M.V.2    Jackson, D.G.3    Cornelis, F.B.4    Gerth, U.5    Bell, J.I.6
  • 4
    • 80053174609 scopus 로고    scopus 로고
    • CD44 isoforms are heterogeneously expressed in breast cancer and correlate with tumor subtypes and cancer stem cell markers
    • Olsson E, Honeth G, Bendahl PO, Saal LH, Gruvberger-Saal S, Ringner M, et al. CD44 isoforms are heterogeneously expressed in breast cancer and correlate with tumor subtypes and cancer stem cell markers. BMC Cancer 2011;11:418.
    • (2011) BMC Cancer , vol.11 , pp. 418
    • Olsson, E.1    Honeth, G.2    Bendahl, P.O.3    Saal, L.H.4    Gruvberger-Saal, S.5    Ringner, M.6
  • 5
    • 0036093542 scopus 로고    scopus 로고
    • CD44 variant exons in leukemia and lymphoma
    • Akisik E, Bavbek S, Dalay N. CD44 variant exons in leukemia and lymphoma. Pathol Oncol Res 2002;8:36-40.
    • (2002) Pathol Oncol Res , vol.8 , pp. 36-40
    • Akisik, E.1    Bavbek, S.2    Dalay, N.3
  • 6
    • 0033962047 scopus 로고    scopus 로고
    • Protein expression of CD44 (standard and variant isoforms) in hepatocellular carcinoma: Relationships with tumor grade, clinicopathologic parameters, p53 expression, and patient survival
    • Endo K, Terada T. Protein expression of CD44 (standard and variant isoforms) in hepatocellular carcinoma: relationships with tumor grade, clinicopathologic parameters, p53 expression, and patient survival. J Hepatol 2000;32:78-84.
    • (2000) J Hepatol , vol.32 , pp. 78-84
    • Endo, K.1    Terada, T.2
  • 7
    • 0030743447 scopus 로고    scopus 로고
    • The expression of the CD44 variant exon 6 is associated with lymph node metastasis in non-small cell lung cancer
    • Miyoshi T, Kondo K, Hino N, Uyama T, Monden Y. The expression of the CD44 variant exon 6 is associated with lymph node metastasis in non-small cell lung cancer. Clin Cancer Res 1997;3:1289-97.
    • (1997) Clin Cancer Res , vol.3 , pp. 1289-1297
    • Miyoshi, T.1    Kondo, K.2    Hino, N.3    Uyama, T.4    Monden, Y.5
  • 8
    • 0028818016 scopus 로고
    • Differential expression of CD44 splice variants in human pancreatic adenocarcinoma and in normal pancreas
    • Gansauge F, Gansauge S, Zobywalski A, Scharnweber C, Link KH, Nussler AK, et al. Differential expression of CD44 splice variants in human pancreatic adenocarcinoma and in normal pancreas. Cancer Res 1995;55:5499-503.
    • (1995) Cancer Res , vol.55 , pp. 5499-5503
    • Gansauge, F.1    Gansauge, S.2    Zobywalski, A.3    Scharnweber, C.4    Link, K.H.5    Nussler, A.K.6
  • 9
    • 0028919576 scopus 로고
    • Colorectal cancer prognosis and expression of exon-v6- containing CD44 proteins
    • Parker D. Colorectal cancer prognosis and expression of exon-v6- containing CD44 proteins. Lancet 1995;345:583-4.
    • (1995) Lancet , vol.345 , pp. 583-584
    • Parker, D.1
  • 10
    • 58149269566 scopus 로고    scopus 로고
    • CD44 is of functional importance for colorectal cancer stem cells
    • Du L, Wang H, He L, Zhang J, Ni B, Wang X, et al. CD44 is of functional importance for colorectal cancer stem cells. Clin Cancer Res 2008;14: 6751-60.
    • (2008) Clin Cancer Res , vol.14 , pp. 6751-6760
    • Du, L.1    Wang, H.2    He, L.3    Zhang, J.4    Ni, B.5    Wang, X.6
  • 12
    • 0030064334 scopus 로고    scopus 로고
    • Receptor-ligand interaction between CD44 and osteopontin (Eta-1)
    • Weber GF, Ashkar S, Glimcher MJ, Cantor H. Receptor-ligand interaction between CD44 and osteopontin (Eta-1). Science 1996;271: 509-12.
    • (1996) Science , vol.271 , pp. 509-512
    • Weber, G.F.1    Ashkar, S.2    Glimcher, M.J.3    Cantor, H.4
  • 13
    • 72949113024 scopus 로고    scopus 로고
    • Stromal cells and integrins: Conforming to the needs of the tumor microenvironment
    • Alphonso A, Alahari SK. Stromal cells and integrins: conforming to the needs of the tumor microenvironment. Neoplasia 2009;11:1264-71.
    • (2009) Neoplasia , vol.11 , pp. 1264-1271
    • Alphonso, A.1    Alahari, S.K.2
  • 14
    • 77950944395 scopus 로고    scopus 로고
    • Macrophages, innate immunity and cancer: Balance, tolerance, and diversity
    • Mantovani A, Sica A. Macrophages, innate immunity and cancer: balance, tolerance, and diversity. Curr Opin Immunol 2010;22:231-7.
    • (2010) Curr Opin Immunol , vol.22 , pp. 231-237
    • Mantovani, A.1    Sica, A.2
  • 15
    • 0030054043 scopus 로고    scopus 로고
    • Impaired tumor growth in colony-stimulating factor 1 (CSF-1)-deficient, macrophage-deficient op/op mouse: Evidence for a role of CSF-1-dependent macrophages in formation of tumor stroma
    • Nowicki A, Szenajch J, Ostrowska G, Wojtowicz A, Wojtowicz K, Kruszewski AA, et al. Impaired tumor growth in colony-stimulating factor 1 (CSF-1)-deficient, macrophage-deficient op/op mouse: evidence for a role of CSF-1-dependent macrophages in formation of tumor stroma. Int J Cancer 1996;65:112-9.
    • (1996) Int J Cancer , vol.65 , pp. 112-119
    • Nowicki, A.1    Szenajch, J.2    Ostrowska, G.3    Wojtowicz, A.4    Wojtowicz, K.5    Kruszewski, A.A.6
  • 16
    • 31044433663 scopus 로고    scopus 로고
    • Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis
    • Condeelis J, Pollard JW. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell 2006;124:263-6.
    • (2006) Cell , vol.124 , pp. 263-266
    • Condeelis, J.1    Pollard, J.W.2
  • 17
    • 77950950894 scopus 로고    scopus 로고
    • Macrophage diversity enhances tumor progression and metastasis
    • Qian BZ, Pollard JW. Macrophage diversity enhances tumor progression and metastasis. Cell 2010;141:39-51.
    • (2010) Cell , vol.141 , pp. 39-51
    • Qian, B.Z.1    Pollard, J.W.2
  • 18
    • 0020026263 scopus 로고
    • Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester
    • Tsuchiya S, Kobayashi Y, Goto Y, Okumura H, Nakae S, Konno T, et al. Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester. Cancer Res 1982;42:1530-6.
    • (1982) Cancer Res , vol.42 , pp. 1530-1536
    • Tsuchiya, S.1    Kobayashi, Y.2    Goto, Y.3    Okumura, H.4    Nakae, S.5    Konno, T.6
  • 20
    • 0032926684 scopus 로고    scopus 로고
    • CD44 variants but not CD44s cooperate with beta1-containing integrins to permit cells to bind to osteopontin independently of arginineglycine- aspartic acid, thereby stimulating cell motility and chemotaxis
    • Katagiri YU, Sleeman J, Fujii H, Herrlich P, Hotta H, Tanaka K, et al. CD44 variants but not CD44s cooperate with beta1-containing integrins to permit cells to bind to osteopontin independently of arginineglycine- aspartic acid, thereby stimulating cell motility and chemotaxis. Cancer Res 1999;59:219-26.
    • (1999) Cancer Res , vol.59 , pp. 219-226
    • Katagiri, Y.U.1    Sleeman, J.2    Fujii, H.3    Herrlich, P.4    Hotta, H.5    Tanaka, K.6
  • 21
    • 0023806075 scopus 로고
    • Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase
    • Smith DB, Johnson KS. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 1988;67:31-40.
    • (1988) Gene , vol.67 , pp. 31-40
    • Smith, D.B.1    Johnson, K.S.2
  • 23
    • 79961026922 scopus 로고    scopus 로고
    • Direct reprogramming of stem cell properties in colon cancer cells by CD44
    • Su YJ, Lai HM, Chang YW, Chen GY, Lee JL. Direct reprogramming of stem cell properties in colon cancer cells by CD44. EMBO J 2011;30: 3186-99.
    • (2011) EMBO J , vol.30 , pp. 3186-3199
    • Su, Y.J.1    Lai, H.M.2    Chang, Y.W.3    Chen, G.Y.4    Lee, J.L.5
  • 24
    • 84862849738 scopus 로고    scopus 로고
    • CD44 enhances the epithelial-mesenchymal transition in association with colon cancer invasion
    • Cho SH, Park YS, Kim HJ, Kim CH, Lim SW, Huh JW, et al. CD44 enhances the epithelial-mesenchymal transition in association with colon cancer invasion. Int J Oncol 2012;41:211-8.
    • (2012) Int J Oncol , vol.41 , pp. 211-218
    • Cho, S.H.1    Park, Y.S.2    Kim, H.J.3    Kim, C.H.4    Lim, S.W.5    Huh, J.W.6
  • 25
    • 33746068275 scopus 로고    scopus 로고
    • Establishment in severe combined immunodeficiency mice of subrenal capsule xenografts and transplantable tumor lines from a variety of primary human lung cancers: Potential models for studying tumor progression-related changes
    • Cutz JC, Guan J, Bayani J, Yoshimoto M, Xue H, Sutcliffe M, et al. Establishment in severe combined immunodeficiency mice of subrenal capsule xenografts and transplantable tumor lines from a variety of primary human lung cancers: potential models for studying tumor progression-related changes. Clin Cancer Res 2006;12: 4043-54.
    • (2006) Clin Cancer Res , vol.12 , pp. 4043-4054
    • Cutz, J.C.1    Guan, J.2    Bayani, J.3    Yoshimoto, M.4    Xue, H.5    Sutcliffe, M.6
  • 26
    • 34548324283 scopus 로고    scopus 로고
    • Epithelial cell adhesion molecule: More than a carcinoma marker and adhesion molecule
    • Trzpis M, McLaughlin PM, de Leij LM, Harmsen MC. Epithelial cell adhesion molecule: more than a carcinoma marker and adhesion molecule. Am J Pathol 2007;171:386-95.
    • (2007) Am J Pathol , vol.171 , pp. 386-395
    • Trzpis, M.1    McLaughlin, P.M.2    De Leij, L.M.3    Harmsen, M.C.4
  • 27
    • 52449148170 scopus 로고
    • In vitro and in vivo elimination of macrophage tumor cells using liposome-encapsulated dichloromethylene diphosphonate
    • van Rooijen N, Kors N, ter Hart H, Claassen E. In vitro and in vivo elimination of macrophage tumor cells using liposome-encapsulated dichloromethylene diphosphonate. Virchows Arch B Cell Pathol Incl Mol Pathol 1988;54:241-5.
    • (1988) Virchows Arch B Cell Pathol Incl Mol Pathol , vol.54 , pp. 241-245
    • Van Rooijen, N.1    Kors, N.2    Ter Hart, H.3    Claassen, E.4
  • 28
    • 79953042645 scopus 로고    scopus 로고
    • CD44: Can a cancer-initiating cell profit from an abundantly expressed molecule?
    • Zoller M. CD44: can a cancer-initiating cell profit from an abundantly expressed molecule? Nat Rev Cancer 2011;11:254-67.
    • (2011) Nat Rev Cancer , vol.11 , pp. 254-267
    • Zoller, M.1
  • 29
    • 0141627613 scopus 로고    scopus 로고
    • Motility of colon cancer cells: Modulation by CD44 isoform expression
    • Wong K, Rubenthiran U, Jothy S. Motility of colon cancer cells: modulation by CD44 isoform expression. Exp Mol Pathol 2003;75: 124-30.
    • (2003) Exp Mol Pathol , vol.75 , pp. 124-130
    • Wong, K.1    Rubenthiran, U.2    Jothy, S.3
  • 30
    • 0017883723 scopus 로고
    • Correlation of anchorage-independent growth with tumorigenicity of chemically transformed mouse epidermal cells
    • Colburn NH, Bruegge WF, Bates JR, Gray RH, Rossen JD, Kelsey WH, et al. Correlation of anchorage-independent growth with tumorigenicity of chemically transformed mouse epidermal cells. Cancer Res 1978;38:624-34.
    • (1978) Cancer Res , vol.38 , pp. 624-634
    • Colburn, N.H.1    Bruegge, W.F.2    Bates, J.R.3    Gray, R.H.4    Rossen, J.D.5    Kelsey, W.H.6
  • 31
    • 7044264360 scopus 로고    scopus 로고
    • Role of osteopontin in adhesion, migration, cell survival and bone remodeling
    • Standal T, Borset M, Sundan A. Role of osteopontin in adhesion, migration, cell survival and bone remodeling. Exp Oncol 2004;26: 179-84.
    • (2004) Exp Oncol , vol.26 , pp. 179-184
    • Standal, T.1    Borset, M.2    Sundan, A.3
  • 32
    • 0036005977 scopus 로고    scopus 로고
    • Osteopontin modulates prostate carcinoma invasive capacity through RGD-dependent upregulation of plasminogen activators
    • Angelucci A, Festuccia C, D'Andrea G, Teti A, Bologna M. Osteopontin modulates prostate carcinoma invasive capacity through RGD-dependent upregulation of plasminogen activators. Biol Chem 2002;383: 229-34.
    • (2002) Biol Chem , vol.383 , pp. 229-234
    • Angelucci, A.1    Festuccia, C.2    D'Andrea, G.3    Teti, A.4    Bologna, M.5
  • 33
    • 6344258588 scopus 로고    scopus 로고
    • The role of Osteopontin in tumor metastasis
    • Wai PY, Kuo PC. The role of Osteopontin in tumor metastasis. J Surg Res 2004;121:228-41.
    • (2004) J Surg Res , vol.121 , pp. 228-241
    • Wai, P.Y.1    Kuo, P.C.2
  • 34
    • 32644467590 scopus 로고    scopus 로고
    • Osteopontin: Role in cell signaling and cancer progression
    • Rangaswami H, Bulbule A, Kundu GC. Osteopontin: role in cell signaling and cancer progression. Trends Cell Biol 2006;16:79-87.
    • (2006) Trends Cell Biol , vol.16 , pp. 79-87
    • Rangaswami, H.1    Bulbule, A.2    Kundu, G.C.3
  • 35
    • 0036839143 scopus 로고    scopus 로고
    • Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    • Mantovani A, Sozzani S, Locati M, Allavena P, Sica A. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol 2002;23:549-55.
    • (2002) Trends Immunol , vol.23 , pp. 549-555
    • Mantovani, A.1    Sozzani, S.2    Locati, M.3    Allavena, P.4    Sica, A.5
  • 36
    • 79961074770 scopus 로고    scopus 로고
    • Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells
    • Jinushi M, Chiba S, Yoshiyama H, Masutomi K, Kinoshita I, Dosaka- Akita H, et al. Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells. Proc Natl Acad Sci U S A 2011;108:12425-30.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 12425-12430
    • Jinushi, M.1    Chiba, S.2    Yoshiyama, H.3    Masutomi, K.4    Kinoshita, I.5    Dosaka- Akita, H.6
  • 37
    • 79953096751 scopus 로고    scopus 로고
    • The potential of osteopontin as a therapeutic target for human colorectal cancer
    • Likui W, Hong W, Shuwen Z, Yuangang Y, Yan W. The potential of osteopontin as a therapeutic target for human colorectal cancer. J Gastrointest Surg 2011;15:652-9.
    • (2011) J Gastrointest Surg , vol.15 , pp. 652-659
    • Likui, W.1    Hong, W.2    Shuwen, Z.3    Yuangang, Y.4    Yan, W.5
  • 38
    • 77950498202 scopus 로고    scopus 로고
    • The density of macrophages in the invasive front is inversely correlated to liver metastasis in colon cancer
    • Zhou Q, Peng RQ, Wu XJ, Xia Q, Hou JH, Ding Y, et al. The density of macrophages in the invasive front is inversely correlated to liver metastasis in colon cancer. J Transl Med 2010;8:13.
    • (2010) J Transl Med , vol.8 , pp. 13
    • Zhou, Q.1    Peng, R.Q.2    Wu, X.J.3    Xia, Q.4    Hou, J.H.5    Ding, Y.6
  • 39
    • 0036233415 scopus 로고    scopus 로고
    • Close association between Fas ligand (FasL; CD95L)-positive tumor-associated macrophages and apoptotic cancer cells along invasive margin of colorectal carcinoma: A proposal on tumor-host interactions
    • Sugita J, Ohtani H, Mizoi T, Saito K, Shiiba K, Sasaki I, et al. Close association between Fas ligand (FasL; CD95L)-positive tumor-associated macrophages and apoptotic cancer cells along invasive margin of colorectal carcinoma: a proposal on tumor-host interactions. Jpn J Cancer Res 2002;93:320-8.
    • (2002) Jpn J Cancer Res , vol.93 , pp. 320-328
    • Sugita, J.1    Ohtani, H.2    Mizoi, T.3    Saito, K.4    Shiiba, K.5    Sasaki, I.6
  • 40
    • 81855166109 scopus 로고    scopus 로고
    • Tumor-associated macrophages (TAM) and inflammation in colorectal cancer
    • Erreni M, Mantovani A, Allavena P. Tumor-associated macrophages (TAM) and inflammation in colorectal cancer. Cancer Microenviron 2011;4:141-54.
    • (2011) Cancer Microenviron , vol.4 , pp. 141-154
    • Erreni, M.1    Mantovani, A.2    Allavena, P.3
  • 41
    • 34247576326 scopus 로고    scopus 로고
    • Chemokine expression is associated with the accumulation of tumourassociated macrophages (TAMs) and progression in human colorectal cancer
    • Bailey C, Negus R, Morris A, Ziprin P, Goldin R, Allavena P, et al. Chemokine expression is associated with the accumulation of tumourassociated macrophages (TAMs) and progression in human colorectal cancer. Clin Exp Metastasis 2007;24:121-30.
    • (2007) Clin Exp Metastasis , vol.24 , pp. 121-130
    • Bailey, C.1    Negus, R.2    Morris, A.3    Ziprin, P.4    Goldin, R.5    Allavena, P.6
  • 42
    • 77955472122 scopus 로고
    • Increased osteopontin-positive macrophage expression in colorectal cancer stroma with synchronous liver metastasis
    • Imano M, Okuno K, Itoh T, Ishimaru E, Satou T, Shiozaki H. Increased osteopontin-positive macrophage expression in colorectal cancer stroma with synchronous liver metastasis. World J Surg 2010;34: 1930-6.
    • (1930) World J Surg , vol.2010 , pp. 34
    • Imano, M.1    Okuno, K.2    Itoh, T.3    Ishimaru, E.4    Satou, T.5    Shiozaki, H.6
  • 43
    • 80755156378 scopus 로고    scopus 로고
    • Osteopontin induced by macrophages contribute to metachronous liver metastases in colorectal cancer
    • Imano M, Okuno K, Itoh T, Satou T, Ishimaru E, Yasuda T, et al. Osteopontin induced by macrophages contribute to metachronous liver metastases in colorectal cancer. Am Surg 2011;77:1515-20.
    • (2011) Am Surg , vol.77 , pp. 1515-1520
    • Imano, M.1    Okuno, K.2    Itoh, T.3    Satou, T.4    Ishimaru, E.5    Yasuda, T.6
  • 44
    • 33846077485 scopus 로고    scopus 로고
    • Hepatocyte growth factor-induced Ras activation requires ERM proteins linked to both CD44v6 and F-actin
    • Orian-Rousseau V, Morrison H, Matzke A, Kastilan T, Pace G, Herrlich P, et al. Hepatocyte growth factor-induced Ras activation requires ERM proteins linked to both CD44v6 and F-actin. Mol Biol Cell 2007;18:76-83.
    • (2007) Mol Biol Cell , vol.18 , pp. 76-83
    • Orian-Rousseau, V.1    Morrison, H.2    Matzke, A.3    Kastilan, T.4    Pace, G.5    Herrlich, P.6
  • 45
    • 22044442973 scopus 로고    scopus 로고
    • Tyrosine kinases as targets for cancer therapy
    • Krause DS, Van Etten RA. Tyrosine kinases as targets for cancer therapy. N Engl J Med 2005;353:172-87.
    • (2005) N Engl J Med , vol.353 , pp. 172-187
    • Krause, D.S.1    Van Etten, R.A.2
  • 46
    • 16444383635 scopus 로고    scopus 로고
    • Functional proteomic screen identifies a modulating role for CD44 in death receptor-mediated apoptosis
    • Hauptschein RS, Sloan KE, Torella C, Moezzifard R, Giel-Moloney M, Zehetmeier C, et al. Functional proteomic screen identifies a modulating role for CD44 in death receptor-mediated apoptosis. Cancer Res 2005;65:1887-96.
    • (2005) Cancer Res , vol.65 , pp. 1887-1896
    • Hauptschein, R.S.1    Sloan, K.E.2    Torella, C.3    Moezzifard, R.4    Giel-Moloney, M.5    Zehetmeier, C.6
  • 47
    • 0141723393 scopus 로고    scopus 로고
    • Role of JNK in tumor development
    • Kennedy NJ, Davis RJ. Role of JNK in tumor development. Cell Cycle 2003;2:199-201.
    • (2003) Cell Cycle , vol.2 , pp. 199-201
    • Kennedy, N.J.1    Davis, R.J.2
  • 48
    • 24644478136 scopus 로고    scopus 로고
    • Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development
    • Nateri AS, Spencer-Dene B, Behrens A. Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development. Nature 2005;437:281-5.
    • (2005) Nature , vol.437 , pp. 281-285
    • Nateri, A.S.1    Spencer-Dene, B.2    Behrens, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.