The expression of the CD44 variant exon 6 is associated with lymph node metastasis in non-small cell lung cancer

Clinical Cancer Research

Volumn 3, Issue 8, 1997, Pages 1289-1297

  Miyoshi, Takanori ^a   Kondo, Kazuya ^a   Hino, Naoki ^a   Uyama, Tadashi ^a   Monden, Yasumasa ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HERMES ANTIGEN;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; LYMPH NODE METASTASIS; MALE; PRIORITY JOURNAL; PROTEIN VARIANT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD; ANTIGENS, CD44; CARCINOMA, NON-SMALL-CELL LUNG; DNA PRIMERS; EXONS; FEMALE; GENETIC VARIATION; HUMANS; LUNG; LUNG NEOPLASMS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM STAGING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VARIATION (GENETICS);

EID: 0030743447     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Tanabe, K. K., Ellis, L. M., and Saya, H. Expression of CD44R1 adhesion molecule in colon carcinomas and metastases. Lancet, 341: 725-726, 1993.
2. Matsumura, Y., and Tarin, D. Significance of CD44 gene products for cancer diagnosis and disease evaluation. Lancet, 340: 1053-1058, 1992.
3. Dall, P., Heider, K. H., Hekele, A., von Minckwitz, G., Kaufmann, M., Ponta, H., and Herrlich, P. Surface protein expression and messenger RNA-splicing analysis of CD44 in uterine cervical cancer and normal cervical epithelium. Cancer Res., 54: 3337-3341, 1994.
4. Pals, S. T., Koopman, G., Heider, K. H., Griffioen, A., Adolf, G. R., van den Berg, F. M., Ponta, H., Herrlich, P., and Horst, E. CD44 splice variants: expression during lymphocyte activation and tumor progression. Behring Inst. Mitt., 92: 273-277, 1993.
5. Heider, K. H., Dammrich, J., Skroch, A. P., Muller, H. H., Vollmers, H. P., Herrlich, P., and Ponta, H. Differential expression of CD44 splice variants in intestinal-and diffuse-type human gastric carcinomas and normal gastric mucosa. Cancer Res., 53: 4197-4203, 1993.
6. Yokozaki, H., Ito, R., Nakayama, H., Kuniyasu, H., Taniyama, K., and Tahara, E. Expression of CD44 abnormal transcripts in human gastric carcinomas. Cancer Lett., 83: 229-234, 1994.
7. Gunthert, U., Hofmann, M., Rudy, W., Reber, S., Zoller, M., Haussmann, I., Matzku, S., Wenzel, A., Ponta, H., and Herrlich, P. A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell, 65: 13-24, 1991.
8. Herrlich, P., Zoller, M., Pals, S. T., and Ponta, H. CD44 splice variants: metastases meet lymphocytes. Immunol. Today, 14: 395-399, 1993.
9. Rudy, W., Hofmann, M., Schwartz, A. R., Zoller, M., Heider, K. H., Ponta, H., and Herrlich, P. The two major CD44 proteins expressed on a metastatic rat tumor cell line are derived from different splice variants: each one individually suffices to confer metastatic behavior. Cancer Res., 53: 1262-1268, 1993.
10. Wielenga, V. J., Heider, K. H., Offerhaus, G. J., Adolf, G. R., van den Berg, F. M., Ponta, H., Herrlich, P., and Pals, S. T. Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression. Cancer Res., 53: 4754-4756, 1993.
11. Washimi, O., Ueda, R., Ariyoshi, Y., Suyama, M., Seki, T., Takahashi, T., and Takahashi, T. Expression of CD44 variant isoforms in normal and neoplastic cells of the lung. Jpn. J. Cancer Res., 85: 1112-1116, 1994.
12. Givehchian, M., Woerner, S. M., Lacroix, J., Zoller, M., Drings, P., Becker, H., Kayser, K., Ridder, R., and Doeberitz, M. K. Expression of CD44 splice variants in normal respiratory epithelium and bronchial carcinomas: no evidence for altered CD44 splicing in metastasis. Oncogene, 12: 1137-1144, 1996.
13. Union Internationale Contre Cancer. Manual of Clinical Oncology, 4th ed., pp. 181-189. Berlin: Springer-Verlag, 1987.
14. WHO. Histological Typing of Lung Tumours, 2nd ed., pp. 25-26. Geneva: WHO, 1981.
15. Chomczynski, P., and Sacchi, N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol chloroform extraction. Anal Biochem., 162: 156-159, 1987.
16. Stamenkovic, I., Amiot, M., Pesando, J. M., and Seed, B. A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family. Cell, 56: 1057-1062, 1989.
17. Screaton, G. R., Bell, M. V., Jackson, D. G., Cornelis, F. B., Gerth, U., and Bell, J. I. Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons. Proc. Natl. Acad. Sci. USA, 89: 12160-12164, 1992.
18. Hofmann, M., Rudy, W., Zoller, M., Tolg, C., Ponta, H., Herrlich, P., and Gunthert, U. CD44 splice variants confer metastatic behavior in rats: homologous sequences are expressed in human tumor cell lines. Cancer Res., 51: 5292-5297, 1991.
19. Koopman, G., Heider, K. H., Horst, E., Adolf, G. R., Berg, F., Ponta, H., Herrlich, P., and Pals, S. T. Activated human lymphocytes and aggressive non-Hodgkin's lymphomas express a homologue of the rat metastasis-associated variant of CD44. J. Exp. Med., 177: 897-904, 1993.
20. Grube, D. Immunoperoxidase methods: increased efficiency using fluorescence microscopy for 3,3′-diaminobenzidine (DAB)-stained semithin sections. Histochemistry, 70: 19-22, 1980.
21. Penno, M. B., August, J. T., Baylin, S. B., Mabry, M., Linnoila, R. I., Lee, V. S., Croteau, D., Yang, X. L., and Rosada, C. Expression of CD44 in human lung tumors. Cancer Res., 54: 1381-1387, 1994.
22. Jackson, D. G., Schenker, T., Waibel, R., Bell, J. I., and Stahel, R. A. Expression of alternatively spliced forms of the CD44 extracellular matrix receptor on human lung carcinomas. Int. J. Cancer, 8 (Suppl.): 110-115, 1994.
23. Kasper, M., Gunthert, U., Dall, P., Kayser, K., Schuh, D., Haroske, G., and Muller, M. Distinct expression patterns of CD44 isoforms during human lung development and in pulmonary fibrosis. Am. J. Respir. Cell Mol. Biol., 13: 648-656, 1995.
24. Chou, P. Y., and Fasman, G. D. Prediction of protein conformation. Biochemistry, 13: 222-244, 1974.
25. Reber, S., Matzku, S., Gunthert, U., Ponta, H., Herrlich, P., and Zoller, M. Retardation of metastatic tumor growth after immunization with metastasis-specific monoclonal antibodies. Int. J. Cancer, 46: 919-927, 1990.
26. Seiter, S., Arch, R., Reber, S., Komitowski, D., Hofmann, M., Ponta, H., Herrlich, P., Matzku, S., and Zoller, M. Prevention of tumor metastasis formation by anti-variant CD44. J. Exp. Med., 177: 443-455, 1993.