The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action

Journal of Biological Chemistry

Volumn 288, Issue 7, 2013, Pages 5149-5156

  Karkare, Shantanu ^a,d   Chung, Terence T H ^a   Collin, Frederic ^a   Mitchenall, Lesley A ^a   McKay, Adam R ^b   Greive, Sandra J ^a,e   Meyer, Jacobus J M ^c   Lall, Namrita ^c   Maxwell, Anthony ^a  

^a JOHN INNES CENTRE   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF PRETORIA   (South Africa)

^d NOVARTIS PHARMA AG   (Switzerland)

^e Norwich Bioincubator Norwich Research Park   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBACTERIAL COMPOUNDS; DNA GYRASES; MECHANISM OF ACTION; NAPHTHOQUINONE; NAPHTHOQUINONES;

DNA;

KETONES;

ANTIINFECTIVE AGENT; DIOSPYRIN; DNA TOPOISOMERASE (ATP HYDROLYSING); GYRASE INHIBITOR; IODIOSPYRIN; MENADIONE; NAPHTHOQUINONE DIOSPYRIN; NEODIOSPYRIN; RAMENTACEONE; SHINANOLONE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ANALYSIS; DRUG DNA INTERACTION; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ESCHERICHIA COLI; IC 50; MASS SPECTROMETRY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

ADENOSINE TRIPHOSPHATE; ANTI-INFECTIVE AGENTS; BINDING SITES; CATALYTIC DOMAIN; DNA; DNA GYRASE; ESCHERICHIA COLI; HUMANS; INHIBITORY CONCENTRATION 50; MASS SPECTROMETRY; MODELS, CHEMICAL; MYCOBACTERIUM TUBERCULOSIS; NAPHTHOQUINONES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; STAPHYLOCOCCUS AUREUS; SURFACE PLASMON RESONANCE; TUBERCULOSIS;

EID: 84874050246     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.419069     Document Type: Article

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