Antimycobacterial activity and possible mode of action of newly isolated neodiospyrin and other naphthoquinones from Euclea natalensis

South African Journal of Botany

Volumn 72, Issue 3, 2006, Pages 349-352

  van der Kooy, F ^a   Meyer, J J M ^a   Lall, N ^a  

^a UNIVERSITY OF PRETORIA   (South Africa)

Author keywords

Euclea; Mycobacterium; Naphthoquinones; Neodiospyrin

Indexed keywords

ANTIMICROBIAL ACTIVITY; BACTERIAL DISEASE; CHEMICAL COMPOUND; INDIGENOUS POPULATION; PLANT EXTRACT; TUBERCULOSIS;

AFRICA;

BACTERIA (MICROORGANISMS); EUCLEA NATALENSIS; MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS;

EID: 33646901619     PISSN: 02546299     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.sajb.2005.09.009     Document Type: Article

References (14)

1. Ferreira A.M., Alves A.C., Costa M.A.C., and Paul M.I. Naphthoquinone dimers and trimers from Euclea natalensis. Phytochemistry 12 (1977) 433-435
2. Garbe T.R. Co-induction of methyltransferase RvO560c by naphthoquinones and fibric acids suggests attenuation of isoprenoid quinone action in Mycobacterium tuberculosis. Canadian Journal of Microbiology 50 (2004) 771-778
3. Heifets L.B., and Good R.C. Current laboratory methods for the diagnoses of tuberculosis. In: Bloom B.R. (Ed). Tuberculosis: Pathogenesis, Prevention and Control (1994), ASM Press, Washington DC. 1-55581-072-1 85-108
4. Kumari L.K., Babu M.H., and Pardhasaradhi M. Synthesis of neodiospyrin and fixation of aryl-quinone linkage in its structure. Indian Journal of Chemistry 21B (1982) 619-621
5. Lall N., and Meyer J.J.M. Inhibition of drug-sensitive and drug-resistant strains of Mycobacterium tuberculosis by diospyrin, isolated from Euclea natalensis. Journal of Ethnopharmacology 78 (2001) 213-216
6. Lall N., Meyer J.J.M., Wang Y., Bapela N.B., van Rensburg C.E.J., Fourie B., and Franzblau S.G. Characterisation of intracellular activity of antitubercular constituents from the roots of Euclea natalensis. Pharmaceutical Biology 43 (2005) 353-357
7. Lillie T.J., and Musgrave O.C. Ebenaceae extractives: Part 7. Use of hydroxy proton shifts of juglone derivatives in structure elucidation. Journal of the Chemical Society. Perkin Transactions (1977) 355-359
8. Middlebrook G., Reggiards Z., and Tigertt W.D. Automable radiometric detection of growth of Mycobacterium tuberculosis in selective media. American Review of Respiratory Diseases 115 (1977) 1067-1069
9. Stander I., and Van Wyk C.W. Toothbrushing with the root of Euclea natalensis. Journal de Biologie Buccale 19 (1991) 167-172
10. 2 biosynthesis. Journal of Biological Chemistry 278 (2003) 42352-42360
11. Van der Vijver L.M., and Gerritsma K.W. Naphthoquinones of Euclea and Diospyros species. Phytochemistry 13 (1974) 2322-2323
12. Van Wyk B.-E., and Van Wyk P. Field guide to trees of Southern Africa (1997), Struik, McKenzie Street, Cape Town. 1-86825-922-6 184-185
13. Watt J.M., and Breyer-Brandwijk M.G. The medicinal and poisonous plants of southern and eastern Africa. 2nd edition (1962), Livingstone, Londen. B-0000E-GKU-O 390
14. Weigenand O., Hussein A.A., Lall N., and Meyer J.J.M. Antibacterial activity of naphthoquinones and triterpenoids from Euclea natalensis root bark. Journal of Natural Products 67 (2004) 1936-1938