Endocrine disrupting effects of ochratoxin A at the level of nuclear receptor activation and steroidogenesis

Toxicology Letters

Volumn 217, Issue 3, 2013, Pages 243-250

  Frizzell, C ^a   Verhaegen, S ^b   Ropstad, E ^b   Elliott, C T ^a   Connolly, L ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b NORWEGIAN UNIVERSITY OF LIFE SCIENCES   (Norway)

Author keywords

Endocrine disruptor; H295R; Ochratoxin A; Reporter Gene Assay; Steroidogenesis

Indexed keywords

ANDROGEN; AROMATASE; CELL NUCLEUS RECEPTOR; ENDOCRINE DISRUPTOR; ESTRADIOL; FORSKOLIN; GESTAGEN; GLUCOCORTICOID; OCHRATOXIN; STEROID RECEPTOR;

ANDROGEN SYNTHESIS; ARTICLE; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENDOCRINE SYSTEM; ESTROGEN SYNTHESIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; REPORTER GENE; STEROIDOGENESIS;

AROMATASE; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL SURVIVAL; ENDOCRINE DISRUPTORS; ESTRADIOL; GENES, REPORTER; HUMANS; OCHRATOXINS; RECEPTORS, ANDROGEN; RECEPTORS, ESTROGEN; RECEPTORS, GLUCOCORTICOID; RECEPTORS, PROGESTERONE;

EID: 84874017274     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2012.12.018     Document Type: Article

References (52)

1. Aish J.L., Rippon E.H., Barlow T., Hattersley S.J. Ochratoxin A. Chpt. 13. Mycotoxins in Food: Detection and Control 2004, 307-388. CRC, Press, Boca Raton, FL. N. Magan, M. Olsen (Eds.).
2. Bennett J.W., Klich M. Mycotoxins - Clinical Microbiology Reviews 2003, 16(3):497-516.
3. Biro K., Barna-Vetro I., Pecsi T., Szabo E., Winkler G., Fink-Gremmels J., Solti L. Evaluation of spermatological parameters in ochratoxin A-challenged boars. Theriogenology 2003, 60:199-207.
4. Breitholtz-Emanuelsson A., Fuchs R., Hult K., Appelgren L.E. Synthesis of 14C-ochratoxin A and 14C-ochratoxin B and a comparative study of their distribution in rats using whole body autoradiography. Pharmacology and Toxicology 1992, 70(4):255-261.
5. Castegnaro M., Canadas D., Vrabcheva T., Petkova-Bocharova T., Chernozemsky I.N., Pfohl-Leszkowicz A. Balkan endemic nephropathy: role of ochratoxins A through biomarkers. Molecular Nutrition and Food Research 2006, 50(6):519-529.
6. Clemons M., Goss P. Estrogen and the risk of breast cancer. New England Journal of Medicine 2001, 344(4):276-285.
7. Connolly L., Ropstad E., Verhaegen S. In vitro bioassays for the study of endocrine-disrupting food additives and contaminants. Trends in Analytical Chemistry 2011, 30(2):227-238.
8. Creppy E.E. Human ochratoxicosis. Journal of Toxicology - Toxin Reviews 1999, 18(3/4):277-293.
9. EFSA (European Food Safety Authority) Opinion of the scientific panel on contaminants in the food chain on a request from the commission related to ochratoxin A in food, EFSA-Q-2005-154. EFSA Journal 2006, 365:1-56.
10. European Commission (EC) Commission Regulation (EC) No 1881/2006 of 19 December 2006 setting maximum levels for certain contaminants in foodstuffs. Official Journal of the European Union 2006, L364:5-24.
11. European Commission (EC) Commission Recommendation 2006/576/EC of 17 August 2006 on the presence of deoxynivalenol, zearalenone, ochratoxin A, T-2 and HT-2 and fumonisins in products intended for animal feeding. Official Journal of the European Union 2006, L229:7-9.
12. European Commission (EC) Commission Regulation (EU) No. 105/2010 of 5 February 2010 amending Regulation (EC) No 1881/2006 setting maximum levels for certain contaminants in foodstuffs as regards ochratoxin A. Official Journal of the European Union 2010, L35:7-8.
13. Fenske M., Fink-Gremmels J. Effects of fungal metabolites on testosterone secretion in vitro. Archives of Toxicology 1990, 64(1):72-75.
14. Frizzell C., Ndossi D., Verhaegen S., Dahl E., Eriksen G., Sørlie M., Ropstad E., Muller M., Elliott C.T., Connolly L. Endocrine disrupting effects of zearalenone, alpha- and beta-zearalenol at the level of nuclear receptor binding and steroidogenesis. Toxicology Letters 2011, 206(2):210-217.
15. Galtier P., Charpenteau J.L., Alvinerie M., Labouche C. The pharmacokinetic profile of ochratoxin A in the rat after oral and intravenous administration. Drug Metabolism and Disposition 1979, 7:429-434.
16. Gharbi A., Trillon O., Betbeder A.M., Counord J., Gauret M.F., Pfohl-Leszkowicz A., Dirheimer G., Creppy E.E. Some effects of ochratoxin A, a mycotoxin contaminating feeds and food, on rat testis. Toxicology 1993, 83(1-3):9-18.
17. Gracia T., Hilscherova K., Jones P.D., Newsted J.L., Zhang X., Hecker M., Higley E.B., Sanderson J.T., Yu R.M., Wu R.S., Giesy J.P. The H295R system for evaluation of endocrine-disrupting effects. Ecotoxicology and Environment Safety 2006, 65(3):293-305.
18. Gracia T., Hilscherova K., Jones P.D., Newsted J.L., Higley E.B., Zhang X., Hecker M., Murphy M.B., Yu R.M., Lam P.K.S., Wu R.S., Giesy J.P. Modulation of steroidogenic gene expression and hormone production of H295R cells by pharmaceuticals and other environmentally active compounds. Toxicology and Applied Pharmacology 2007, 225(2):142-153.
19. Gupta M., Bandyopadhyay S., Paul B., Mazumdar S.K. Onset of puberty and ovarian steroidogenesis following administration of ochratoxin A. Endokrinologie 1980, 75(3):292-298.
20. Gupta M., Bandyopadhyay S., Paul B., Mazumdar S.K. Histochemical determination of adrenal steroidogenesis in rat after treatment with ochratoxin A. Endokrinologie 1980, 75(3):369-372.
21. Gupta M., Bandyopadhyay S., Paul B., Mazumdar S.K. Ovarian steroidogenesis and development of fetuses following ochratoxin A treatment in pregnant rats. Endokrinologie 1981, 77(2):152-160.
22. Hassan A.A., Rashid M.A., Koratum K.M. Effect Of aflatoxin B1, zearalenone and ochratoxin A on some hormones related to fertility in male rats. Life Science Journal 2010, 7(3):64-72.
23. Hecker M., Giesy J.P. Novel trends in endocrine distributor testing: the H295R steroidogenesis assay for identification of inducers and inhibitors of hormone production. Analytical and Bioanalytical Chemistry 2008, 390:287-291.
24. Hecker M., Newsted J.L., Murphy M.B., Higley E.B., Jones P.D., Wu R., Giesy J.P. Human adrenocarcinoma (H295R) cells for rapid in vitro determination of effects on steroidogenesis: hormone production. Toxicology and Applied Pharmacology 2006, 217(1):114-124.
25. Henderson B.E., Benton B., Jing J., Yu M.C., Pike M.C. Risk factors for cancer of the testis in young men 1979, 23(5):598-602.
26. Henderson B.E., Ross R.K., Pike M.C., Casagrande J.T. Endogenous hormones as a major factor in human cancer. Cancer Research 1982, 42:3232-3239.
27. Higley E.B., Newsted J.L., Zhang X., Giesy J.P., Hecker M. Assessment of chemical effects on aromatase activity using the H295R cell line. Environmental Science and Pollution Research 2010, 17(5):1137-1148.
28. Hilscherova K., Jones P.D., Gracia T., Newsted J.L., Zhang X., Sanderson J.T., Yu R.M., Wu R.S., Giesy J.P. Assessment of the effects of chemicals on the expression of ten steroidogenic genes in the H295R cell line using real-time PCR. Toxicological Sciences 2004, 81(1):78-89.
29. Jennings-Gee J.E., Tozlovanu M., Manderville R., Miller M.S., Pfohl-Leszkowicz A., Schwartz G.G. Ochratoxin A: in utero exposure in mice induces adducts in testicular DNA. Toxins 2010, 2:1428-1444.
30. Joint FAO/WHO Expert Committee on Food Additives (JECFA), 2001. Ochratoxin A, In Safety evaluation of certain mycotoxins in food. WHO Food Additives Series: 47, 281-415.
31. Krogh P. Epidemiology of mycotoxic porcine nephropathy. Nordisk Veterinaermedicin 1976, 28(9):452-458.
32. Krogh P. Role of ochratoxin A in disease causation. Food and Chemical Toxicology 1992, 30:213-224.
33. Kuiper-Goodman T., Scott P.M. Risk assessment of the mycotoxin ochratoxin A. Biomedical and Environmental Sciences 1989, 2(3):179-248.
34. Kumar S.N., Telang A.G., Singh K.P., Jain A.K., Afroz M., Patil R.D. Experimentally induced toxicity of ochratoxin A and endosulfan in male wistar rats: a hormonal disorder in adult male rats. Journal of Animal and Veterinary Advances 2011, 10(13):1750-1755.
35. Maaroufi K., Achour A., Betbeder A.M., Hammami M., Ellouz F., Bacha H. Foodstuffs and human blood contamination by the mycotoxin ochratoxin A: correlation with chronic interstitial nephropathy in Tunisia. Archives of Toxicology 1995, 69:552-558.
36. Märtlbauer E., Usleber E., Dietrich R., Schneide E. Ochratoxin A in human blood serum-retrospective long-term data. Mycotoxin Research 2009, 25:175-186.
37. Murphy P.A., Hendrich S., Landgren C., Bryant C.M. Food mycotoxins: an update. Journal of Food Science 2006, 71:51-65.
38. Nicol M.R., Papacleovoulou G., Evans D.B., Penning T.M., Strachand M.W.J., Advani A., Johnson S.J., Quinton R., Mason J.I. Estrogen biosynthesis in human H295 adrenocortical carcinoma cells. Molecular and Cellular Endocrinology 2009, 300(1/2):115-120.
39. Peraica M., Radic B., Lucic A., Pavlovic M. Toxic effects of mycotoxins in humans. Bulletin of the World Health Organization 1999, 77(9):754-766.
40. Petkova-Bocharova T., Chernozemsky I.N., Castegnaro M. Ochratoxin A in human blood in relation to Balkan endemic nephropathy and urinary system tumours in Bulgaria. Food Additives and Contaminants 1988, 5(3):299-301.
41. Plotan M., Elliott C.T., Scippo M.L., Muller M., Antignac J.P., Malone E., Bovee T.F.H., Mitchell S., Connolly L. The application of reporter gene assays for the detection of endocrine disruptors in sport supplements. Analytica Chimica Acta 2011, 700:34-40.
42. Reubel G.H., Gareis M., Amselgruber W.M. Cytotoxicity evaluation of mycotoxins by an MTT-bioassay. Mycotoxin Research 1987, 3(2):85-96.
43. Ringot D., Chango A., Schneider Y.-J., Larondelle Y. Toxicokinetics and toxicodynamics of ochratoxin A, an update. Chemico-Biological Interactions 2006, 159(1):18-46.
44. Rodrigues I., Naehrer K. Biomin survey 2010: mycotoxins inseparable from animal commodities and feed. All About Feed 2011, 2(2):17-20.
45. Schwartz G.G. Hypothesis: does ochratoxin A cause testiular cancer?. Cancer Causes and Control 2002, 13(1):91-100.
46. Solti L., Pécsi T., Barna-Vetró I., Szász F. Jr. Biró K., Szabó E. Analysis of serum and seminal plasma after feeding ochratoxin A with breeding boars. Animal Reproduction Science 1999, 56(2):123-132.
47. Tabb M.M., Blumberg B. New modes of action for endocrine-disrupting chemicals. Molecular Endocrinology 2005, 20:475-482.
48. Taxvig C., Elleby A., Sonne-Hansen K., Bonefeld-Jørgensen E.C., Vinggaard A.M., Lykkesfeldt A.E., Nellemann C. Effects of nutrition relevant mixtures of phytoestrogens on steroidogenesis, aromatase, estrogen, and androgen activity. Nutrition and Cancer 2010, 62(1):122-131.
49. Vrabcheva T., Petkova-Bocharova T., Grosso F., Nikolov I., Chernozemsky I.N., Castegnaro M., Dragacci S. Analysis of ochratoxin A in foods consumed by inhabitants from an area with Balkan Endemic Nephropathy: a 1 month follow-up study. Journal of Agricultural and Food Chemistry 2004, 52:2404-2410.
50. Willemsen P., Scippo M., Kausel G., Figueroa J., Maghuin-Rogister G., Martial J. Use of reporter cell lines for detection of endocrine-disrupter activity. Analytical and Bioanalytical Chemistry 2004, 378(3):655-663.
51. Wu Q., Dohnal V., Huang L., Kuca K., Wang X., Chen G., Yuan Z. Metabolic pathways of ochratoxin A. Current Drug Metabolism 2011, 12:1-10.
52. Zimmerli B., Dick R. Determination of ochratoxin A at the ppt level in human blood, serum, milk and some foodstuffs by high-performance liquid chromatography with enhanced fluorescence detection and immunoaffinity column cleanup: methodology and Swiss data. Journal of Chromatography B: Biomedical Applications 1995, 666(1):85-99.