Simultaneous online SPE-HPLC-MS/MS analysis of docetaxel, Temsirolimus and sirolimus in whole blood and human plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 921-922, Issue , 2013, Pages 35-42

  Navarrete, Alicia ^a   Martínez Alcázar, M Paz ^a   Durán, Ignacio ^b   Calvo, Emiliano ^b   Valenzuela, Belén ^c   Barbas, Coral ^a   García, Antonia ^a  

^a UNIVERSIDAD SAN PABLO CEU   (Spain)

^b Hospital Madrid Norte Sanchinarro   (Spain)

^c USP Hospital San Jaime   (Spain)

Author keywords

Anticancer; Blood; LC MS; Plasma; Solid tumor

Indexed keywords

ANALYTES; ANTI-CANCER AGENTS; ANTICANCER; ANTICANCER DRUG; CLINICAL RESEARCH; COMBINED TREATMENT; CONCENTRATION RANGES; CYTOTOXIC EFFECTS; DOCETAXEL; DOSE ADJUSTMENTS; HUMAN PLASMAS; INTERNAL STANDARDS; JET STREAMS; LC-MS; LC-MS/MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; MULTIPLE REACTIONS MONITORING; ON-LINE SPE; PACLITAXEL; POSITIVE MODE; PRECLINICAL STUDIES; PROTEIN PRECIPITATION; REAL SAMPLES; SAMPLE TREATMENT; SENSITIVE METHOD; SIMULTANEOUS IDENTIFICATION; SIROLIMUS; SOLID TUMORS; SOLID-PHASE; SPE-HPLC-MS; SULPHATES; TAXANES; THERAPEUTIC DOSE; WHOLE BLOOD;

CYTOTOXICITY; DRUG INTERACTIONS; ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PLASMAS; TUMORS;

BLOOD;

DOCETAXEL; METHANOL; PROTEIN; RAPAMYCIN; TEMSIROLIMUS; ZINC SULFATE;

ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MONITORING; MULTIPLE REACTION MONITORING; PRECIPITATION; PRIORITY JOURNAL; PROTEIN PROCESSING; QUANTITATIVE ANALYSIS; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY;

ANTINEOPLASTIC AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; SENSITIVITY AND SPECIFICITY; SIROLIMUS; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; TAXOIDS;

EID: 84874016310     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2013.01.017     Document Type: Article

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