Simultaneous determination of cyclosporine a, tacrolimus, sirolimus, and everolimus in whole-blood samples by LC-MS/MS

The Scientific World Journal

Volumn 2012, Issue , 2012, Pages

  Karapirli, Mustafa ^a   Kizilgun, Murat ^b   Yesilyurt, Ozgur ^c   Gul, Husamettin ^c   Kunak, Zeki Ilker ^c   Akgul, Emin Ozgur ^c   MacIt, Enis ^c   Cayci, Tuncer ^c   Gulcan Kurt, Yasemin ^c   Aydin, Ibrahim ^c   Yaren, Hakan ^c   Seyrek, Melik ^c   Cakir, Erdinc ^c   Yaman, Halil ^c  

^a Department of Chemistry Sefkat Mah Dr Omer Besim Cad   (Turkey)

^b MINISTRY OF HEALTH   (Turkey)

^c GULHANE SCHOOL OF MEDICINE   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; EVEROLIMUS; RAPAMYCIN; TACROLIMUS; CYCLOSPORIN; DRUG DERIVATIVE; IMMUNOSUPPRESSIVE AGENT;

ARTICLE; BLOOD SAMPLING; CLINICAL PRACTICE; COST EFFECTIVENESS ANALYSIS; DRUG BLOOD LEVEL; DRUG DETERMINATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; SOLID PHASE EXTRACTION; BLOOD; BLOOD ANALYSIS; HUMAN; METHODOLOGY; SENSITIVITY AND SPECIFICITY; TRANSPLANTATION;

BLOOD CHEMICAL ANALYSIS; CHROMATOGRAPHY, LIQUID; CYCLOSPORINE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MASS SPECTROMETRY; SENSITIVITY AND SPECIFICITY; SIROLIMUS; TACROLIMUS; TRANSPLANTS;

EID: 84862313186     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1100/2012/571201     Document Type: Article

References (23)

1. Kaufman D. B., Shapiro R., Lucey M. R., Cherikh W. S., Bustami R. T., Dyke D. B., Immunosuppression: practice and trends American Journal of Transplantation 2004 4 supplement 9 38 53 (Pubitemid 38858994)
2. Flanagan W. M., Corthesy B., Bram R. J., Crabtree G. R., Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A Nature 1991 352 6338 803 807 (Pubitemid 21912434)
3. Taylor A. L., Watson C. J. E., Bradley J. A., Immunosuppressive agents in solid organ transplantation: mechanisms of action and therapeutic efficacy Critical Reviews in Oncology/Hematology 2005 56 1 23 46 (Pubitemid 41278644)
4. Nashan B., Maximizing the clinical outcome with mTOR inhibitors in the renal transplant recipient: defining the role of calcineurin inhibitors Transplant International 2004 17 6 279 285 (Pubitemid 39050194)
5. Rezzani R., Cyclosporine A and adverse effects on organs: histochemical studies Progress in Histochemistry and Cytochemistry 2004 39 2 85 128 (Pubitemid 38902918)
6. Holt D. W., Therapeutic drug monitoring of immunosuppressive drugs in kidney transplantation Current Opinion in Nephrology and Hypertension 2002 11 6 657 663 (Pubitemid 35440849)
7. Yang Z., Peng Y., Wang S., Immunosuppressants: pharmacokinetics, methods of monitoring and role of high performance liquid chromatography/mass spectrometry Clinical and Applied Immunology Reviews 2005 5 6 405 430 (Pubitemid 43224938)
8. Shaw L. M., Holt D. W., Keown P., Venkataramanan R., Yatscoff R. W., Current opinions on therapeutic drug monitoring of immunosuppressive drugs Clinical Therapeutics 1999 21 10 1632 1652 (Pubitemid 29523360)
9. Seger C., Tentschert K., Stggl W., Griesmacher A., Ramsay S. L., A rapid HPLC-MS/MS method for the simultaneous quantification of cyclosporine A, tacrolimus, sirolimus and everolimus in human blood samples Nature Protocols 2009 4 4 526 534
10. Yang Z., Wang S., Recent development in application of high performance liquid chromatography-tandem mass spectrometry in therapeutic drug monitoring of immunosuppressants Journal of Immunological Methods 2008 336 2 98 103
11. Ansermot N., Fathi M., Veuthey J. L., Desmeules J., Rudaz S., Hochstrasser D., Simultaneous quantification of cyclosporine, tacrolimus, sirolimus and everolimus in whole blood by liquid chromatography-electrospray mass spectrometry Clinical Biochemistry 2008 41 9 728 735
12. Koster R. A., Dijkers E. C. F., Uges D. R. A., Robust, high-throughput LC-MS/MS method for therapeutic drug monitoring of cyclosporine, tacrolimus, everolimus, and sirolimus in whole blood Therapeutic Drug Monitoring 2009 31 1 116 125
13. Christians U., Jacobsen W., Serkova N., Benet L. Z., Vidal C., Sewing K. F., Manns M. P., Kirchner G. I., Automated, fast and sensitive quantification of drugs in blood by liquid chromatography-mass spectrometry with on-line extraction: immunosuppressants Journal of Chromatography B 2000 748 1 41 53
14. Koal T., Deters M., Casetta B., Kaever V., Simultaneous determination of four immunosuppressants by means of high speed and robust on-line solid phase extraction-high performance liquid chromatography-tandem mass spectrometry Journal of Chromatography B 2004 805 2 215 222 (Pubitemid 38596740)
15. Ceglarek U., Lembcke J., Fiedler G. M., Werner M., Witzigmann H., Hauss J. P., Thiery J., Rapid simultaneous quantification of immunosuppressants in transplant patients by turbulent flow chromatography combined with tandem mass spectrometry Clinica Chimica Acta 2004 346 2 181 190 (Pubitemid 38901049)
16. Ceglarek U., Casetta B., Lembcke J., Baumann S., Fiedler G. M., Thiery J., Inclusion of MPA and in a rapid multi-drug LC-tandem mass spectrometric method for simultaneous determination of immunosuppressants Clinica Chimica Acta 2006 373 1-2 168 171 (Pubitemid 44292187)
17. Deters M., Kirchner G., Resch K., Kaever V., Simultaneous quantification of sirolimus, everolimus, tacrolimus and cyclosporine by liquid chromatography-mass spectrometry (LC-MS) Clinical Chemistry and Laboratory Medicine 2002 40 3 285 292 (Pubitemid 34428858)
18. Bogusz M. J., Enazi E. A., Hassan H., Abdel-Jawaad J., Ruwaily J. A., Tufail M. A., Simultaneous LC-MS-MS determination of cyclosporine A, tacrolimus, and sirolimus in whole blood as well as mycophenolic acid in plasma using common pretreatment procedure Journal of Chromatography B 2007 850 2 471 480 (Pubitemid 46618201)
19. van Gelder T., Domke I., Engelmayer J., Fijter H. D., Kuypers D., Budde K., Koeger R., Luthe H., Oellerich M., Clinical utility of a new enzymatic assay for determination of mycophenolic acid in comparison with an optimized lc-ms/ms method Therapeutic Drug Monitoring 2009 31 2 218 223
20. Prémaud A., Rousseau A., le Meur Y. L., Lachtre G., Marquet P., Comparison of liquid chromatography-tandem mass spectrometry with a commercial enzyme-multiplied immunoassay for the determination of plasma MPA in renal transplant recipients and consequences for therapeutic drug monitoring Therapeutic Drug Monitoring 2004 26 6 609 619 (Pubitemid 39579141)
21. Keevil B. G., Tierney D. P., Cooper D. P., Morris M. R., Machaal A., Yonan N., Simultaneous and rapid analysis of cyclosporin A and creatinine in finger prick blood samples using liquid chromatography tandem mass spectrometry and its application in C2 monitoring Therapeutic Drug Monitoring 2002 24 6 757 767
22. Falck P., Guldseth H., Asberg A., Midtvedt K., Reubsaet J. L. E., Determination of ciclosporin A and its six main metabolites in isolated T-lymphocytes and whole blood using liquid chromatography-tandem mass spectrometry Journal of Chromatography B 2007 852 1-2 345 352 (Pubitemid 46830123)
23. Streit F., Armstrong V. W., Oellerich M., Rapid liquid chromatography-tandem mass spectrometry routine method for simultaneous determination of sirolimus, everolimus, tacrolimus, and cyclosporin A in whole blood Clinical Chemistry 2002 48 6 955 958 (Pubitemid 34587603)