Ion-suppression effects in liquid chromatography-tandem mass spectrometry due to a formulation agent, a case study in drug discovery bioanalysis

Journal of Pharmaceutical and Biomedical Analysis

Volumn 39, Issue 1-2, 2005, Pages 206-216

  Larger, Patrice J ^b   Breda, Massimo ^b   Fraier, Daniela ^a   Hughes, Heather ^a   James, Christopher A ^b  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^b NERVIANO MEDICAL SCIENCES   (Italy)

Author keywords

Bioanalysis; Excipients; Formulation; Ion suppression; LC MS MS; Polysorbate; Reverse phase HPLC; Tween

Indexed keywords

EXCIPIENT; POLYSORBATE 80;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DILUTION; DRUG CONCENTRATION; DRUG ELIMINATION; DRUG FORMULATION; DRUG HALF LIFE; LIQUID CHROMATOGRAPHY; NONHUMAN; PRIORITY JOURNAL; RAT; SEPARATION TECHNIQUE; TANDEM MASS SPECTROMETRY;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; PHARMACEUTICAL PREPARATIONS; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE STANDARDS; SENSITIVITY AND SPECIFICITY;

EID: 23444459375     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2005.03.009     Document Type: Article

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