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Volumn 33, Issue 2, 2013, Pages 381-388

The effect of various disease-modifying anti-rheumatic drugs on the suppressive function of CD4+CD25+ regulatory T cells

Author keywords

Antirheumatic agents; Infliximab; Leflunomide; Methotrexate; Regulatory T lymphocytes; Rheumatoid arthritis; Sulfasalazine

Indexed keywords

DISEASE MODIFYING ANTIRHEUMATIC DRUG; INFLIXIMAB; LEFLUNOMIDE; METHOTREXATE; SALAZOSULFAPYRIDINE;

EID: 84873990672     PISSN: 01728172     EISSN: 1437160X     Source Type: Journal    
DOI: 10.1007/s00296-012-2365-9     Document Type: Article
Times cited : (20)

References (49)
  • 1
    • 0033136302 scopus 로고    scopus 로고
    • Thymus and autoimmunity: Production of CD25+ CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance
    • 10228007 1:CAS:528:DyaK1MXislGgu7Y%3D
    • Itoh M, Takahashi T, Sakaguchi N, Kuniyasu Y, Shimizu J, Otsuka F, Sakaguchi S (1999) Thymus and autoimmunity: production of CD25+ CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J Immunol 162(9):5317-5326
    • (1999) J Immunol , vol.162 , Issue.9 , pp. 5317-5326
    • Itoh, M.1    Takahashi, T.2    Sakaguchi, N.3    Kuniyasu, Y.4    Shimizu, J.5    Otsuka, F.6    Sakaguchi, S.7
  • 2
    • 20344397363 scopus 로고    scopus 로고
    • Peripheral generation and function of CD4+ CD25+ regulatory T cells
    • 15981478 10.1007/3-540-27702-1-6 1:CAS:528:DC%2BD2MXhtVWgu7%2FO
    • Taams LS, Akbar AN (2005) Peripheral generation and function of CD4+ CD25+ regulatory T cells. Curr Top Microbiol Immunol 293:115-131
    • (2005) Curr Top Microbiol Immunol , vol.293 , pp. 115-131
    • Taams, L.S.1    Akbar, A.N.2
  • 4
    • 1842581857 scopus 로고    scopus 로고
    • Cutting edge: Human CD4+ CD25+ T cells restrain the maturation and antigen-presenting function of dendritic cells
    • 15067041 1:CAS:528:DC%2BD2cXivVSitLg%3D
    • Misra N, Bayry J, Lacroix-Desmazes S, Kazatchkine MD, Kaveri SV (2004) Cutting edge: human CD4+ CD25+ T cells restrain the maturation and antigen-presenting function of dendritic cells. J Immunol 172(8):4676-4680
    • (2004) J Immunol , vol.172 , Issue.8 , pp. 4676-4680
    • Misra, N.1    Bayry, J.2    Lacroix-Desmazes, S.3    Kazatchkine, M.D.4    Kaveri, S.V.5
  • 5
    • 65549136983 scopus 로고    scopus 로고
    • Mechanisms of foxp3+ T regulatory cell-mediated suppression
    • 10.1016/j.immuni.2009.04.010 19464986 10.1016/j.immuni.2009.04.010 1:CAS:528:DC%2BD1MXosVCks7g%3D
    • Shevach EM (2009) Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity 30(5):636-645. doi: 10.1016/j.immuni.2009.04.010
    • (2009) Immunity , vol.30 , Issue.5 , pp. 636-645
    • Shevach, E.M.1
  • 6
    • 4143066714 scopus 로고    scopus 로고
    • Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors
    • 10.1016/j.immuni.2004.07.009 15308106 10.1016/j.immuni.2004.07.009 1:CAS:528:DC%2BD2cXnsVKlt7c%3D
    • Hsieh CS, Liang Y, Tyznik AJ, Self SG, Liggitt D, Rudensky AY (2004) Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors. Immunity 21(2):267-277. doi: 10.1016/j.immuni.2004.07.009
    • (2004) Immunity , vol.21 , Issue.2 , pp. 267-277
    • Hsieh, C.S.1    Liang, Y.2    Tyznik, A.J.3    Self, S.G.4    Liggitt, D.5    Rudensky, A.Y.6
  • 7
    • 2442484053 scopus 로고    scopus 로고
    • Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses
    • 10.1146/annurev.immunol.21.120601.141122 15032588 10.1146/annurev. immunol.21.120601.141122 1:CAS:528:DC%2BD2cXktlOgsLo%3D
    • Sakaguchi S (2004) Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 22:531-562. doi: 10.1146/annurev.immunol.21.120601.141122
    • (2004) Annu Rev Immunol , vol.22 , pp. 531-562
    • Sakaguchi, S.1
  • 8
    • 0031821875 scopus 로고    scopus 로고
    • CD4+ CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
    • 9670041 10.1084/jem.188.2.287 1:CAS:528:DyaK1cXkvVaqt7g%3D
    • Thornton AM, Shevach EM (1998) CD4+ CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 188(2):287-296
    • (1998) J Exp Med , vol.188 , Issue.2 , pp. 287-296
    • Thornton, A.M.1    Shevach, E.M.2
  • 10
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+ CD25+ regulatory T cells
    • 10.1038/ni904 12612578 10.1038/ni904 1:CAS:528:DC%2BD3sXitlyqs74%3D
    • Fontenot JD, Gavin MA, Rudensky AY (2003) Foxp3 programs the development and function of CD4+ CD25+ regulatory T cells. Nat Immunol 4(4):330-336. doi: 10.1038/ni904
    • (2003) Nat Immunol , vol.4 , Issue.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 11
    • 0037385314 scopus 로고    scopus 로고
    • An essential role for Scurfin in CD4+ CD25+ T regulatory cells
    • 10.1038/ni909 12612581 10.1038/ni909 1:CAS:528:DC%2BD3sXitlyqs7s%3D
    • Khattri R, Cox T, Yasayko SA, Ramsdell F (2003) An essential role for Scurfin in CD4+ CD25+ T regulatory cells. Nat Immunol 4(4):337-342. doi: 10.1038/ni909
    • (2003) Nat Immunol , vol.4 , Issue.4 , pp. 337-342
    • Khattri, R.1    Cox, T.2    Yasayko, S.A.3    Ramsdell, F.4
  • 13
    • 0346969978 scopus 로고    scopus 로고
    • Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+ CD25- T cells
    • 10.1172/JCI19441 14597769 1:CAS:528:DC%2BD3sXovVGqsL4%3D
    • Walker MR, Kasprowicz DJ, Gersuk VH, Benard A, Van Landeghen M, Buckner JH, Ziegler SF (2003) Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+ CD25- T cells. J Clin Invest 112(9):1437-1443. doi: 10.1172/JCI19441
    • (2003) J Clin Invest , vol.112 , Issue.9 , pp. 1437-1443
    • Walker, M.R.1    Kasprowicz, D.J.2    Gersuk, V.H.3    Benard, A.4    Van Landeghen, M.5    Buckner, J.H.6    Ziegler, S.F.7
  • 14
    • 33947121146 scopus 로고    scopus 로고
    • Transient regulatory T-cells: A state attained by all activated human T-cells
    • 17185041 10.1016/j.clim.2006.10.014 1:CAS:528:DC%2BD2sXjtValtLo%3D
    • Pillai V, Ortega SB, Wang CK, Karandikar NJ (2007) Transient regulatory T-cells: a state attained by all activated human T-cells. Clin Immunol 123(1):18-29. doi: 10.1016/j.clim.2006.10.014
    • (2007) Clin Immunol , vol.123 , Issue.1 , pp. 18-29
    • Pillai, V.1    Ortega, S.B.2    Wang, C.K.3    Karandikar, N.J.4
  • 17
    • 20144370643 scopus 로고    scopus 로고
    • The role of regulatory T cells in antigen-induced arthritis: Aggravation of arthritis after depletion and amelioration after transfer of CD4+ CD25+ T cells
    • 15743476 10.1186/ar1484
    • Frey O, Petrow PK, Gajda M, Siegmund K, Huehn J, Scheffold A, Hamann A, Radbruch A, Brauer R (2005) The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+ CD25+ T cells. Arthritis Res Ther 7(2):R291-R301. doi: 10.1186/ar1484
    • (2005) Arthritis Res Ther , vol.7 , Issue.2
    • Frey, O.1    Petrow, P.K.2    Gajda, M.3    Siegmund, K.4    Huehn, J.5    Scheffold, A.6    Hamann, A.7    Radbruch, A.8    Brauer, R.9
  • 19
    • 3543140687 scopus 로고    scopus 로고
    • Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy
    • 10.1084/jem.20040165 15280421 10.1084/jem.20040165 1:CAS:528: DC%2BD2cXmsVCktbg%3D
    • Ehrenstein MR, Evans JG, Singh A, Moore S, Warnes G, Isenberg DA, Mauri C (2004) Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy. J Exp Med 200(3):277-285. doi: 10.1084/jem.20040165
    • (2004) J Exp Med , vol.200 , Issue.3 , pp. 277-285
    • Ehrenstein, M.R.1    Evans, J.G.2    Singh, A.3    Moore, S.4    Warnes, G.5    Isenberg, D.A.6    Mauri, C.7
  • 20
    • 33646370647 scopus 로고    scopus 로고
    • TNF downmodulates the function of human CD4+ CD25hi T-regulatory cells
    • 16537805 10.1182/blood-2005-11-4567 1:CAS:528:DC%2BD28XmsVOmurk%3D
    • Valencia X, Stephens G, Goldbach-Mansky R, Wilson M, Shevach EM, Lipsky PE (2006) TNF downmodulates the function of human CD4+ CD25hi T-regulatory cells. Blood 108(1):253-261. doi: 10.1182/blood-2005-11-4567
    • (2006) Blood , vol.108 , Issue.1 , pp. 253-261
    • Valencia, X.1    Stephens, G.2    Goldbach-Mansky, R.3    Wilson, M.4    Shevach, E.M.5    Lipsky, P.E.6
  • 21
    • 33747508561 scopus 로고    scopus 로고
    • Suppressor function of umbilical cord blood-derived CD4+ CD25+ T-regulatory cells exposed to graft-versus-host disease drugs
    • 10.1097/01.tp.0000225824.48931.af 16861937 10.1097/01.tp.0000225824. 48931.af
    • Porter SB, Liu B, Rogosheske J, Levine BL, June CH, Kohl VK, Wagner JE, Miller JS, Blazar BR (2006) Suppressor function of umbilical cord blood-derived CD4+ CD25+ T-regulatory cells exposed to graft-versus-host disease drugs. Transplantation 82(1):23-29. doi: 10.1097/01.tp.0000225824.48931.af
    • (2006) Transplantation , vol.82 , Issue.1 , pp. 23-29
    • Porter, S.B.1    Liu, B.2    Rogosheske, J.3    Levine, B.L.4    June, C.H.5    Kohl, V.K.6    Wagner, J.E.7    Miller, J.S.8    Blazar, B.R.9
  • 22
    • 4444300314 scopus 로고    scopus 로고
    • CD4(+)CD25(+) regulatory T cells in rheumatoid arthritis: Differences in the presence, phenotype, and function between peripheral blood and synovial fluid
    • 10.1002/art.20499 10.1002/art.20499
    • van Amelsfort JM, Jacobs KM, Bijlsma JW, Lafeber FP, Taams LS (2004) CD4(+)CD25(+) regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluid. Arthr Rheum 50(9):2775-2785. doi: 10.1002/art.20499
    • (2004) Arthr Rheum , vol.50 , Issue.9 , pp. 2775-2785
    • Van Amelsfort, J.M.1    Jacobs, K.M.2    Bijlsma, J.W.3    Lafeber, F.P.4    Taams, L.S.5
  • 23
    • 15244361536 scopus 로고    scopus 로고
    • CD25 bright CD4+ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease
    • 10.1186/ar1192 10.1186/ar1192 1:CAS:528:DC%2BD2cXmt1Gls7Y%3D
    • Cao D, van Vollenhoven R, Klareskog L, Trollmo C, Malmstrom V (2004) CD25 bright CD4+ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease. Arthr Res Ther 6(4):R335-R346. doi: 10.1186/ar1192
    • (2004) Arthr Res Ther , vol.6 , Issue.4
    • Cao, D.1    Van Vollenhoven, R.2    Klareskog, L.3    Trollmo, C.4    Malmstrom, V.5
  • 24
    • 26244456364 scopus 로고    scopus 로고
    • The presence of cytokine-suppressive CD4+ CD25+ T cells in the peripheral blood and synovial fluid of patients with rheumatoid arthritis
    • 10.1111/j.1365-3083.2005.01656.x 16179019 10.1111/j.1365-3083.2005.01656. x 1:CAS:528:DC%2BD2MXhtFyhsrnK
    • Liu MF, Wang CR, Fung LL, Lin LH, Tsai CN (2005) The presence of cytokine-suppressive CD4+ CD25+ T cells in the peripheral blood and synovial fluid of patients with rheumatoid arthritis. Scand J Immunol 62(3):312-317. doi: 10.1111/j.1365-3083.2005.01656.x
    • (2005) Scand J Immunol , vol.62 , Issue.3 , pp. 312-317
    • Liu, M.F.1    Wang, C.R.2    Fung, L.L.3    Lin, L.H.4    Tsai, C.N.5
  • 25
    • 0034933712 scopus 로고    scopus 로고
    • Anti-inflammatory mechanisms of methotrexate in rheumatoid arthritis
    • 11454634 10.1136/ard.60.8.729 1:CAS:528:DC%2BD3MXmtVKjt74%3D
    • Cutolo M, Sulli A, Pizzorni C, Seriolo B, Straub RH (2001) Anti-inflammatory mechanisms of methotrexate in rheumatoid arthritis. Ann Rheum Dis 60(8):729-735
    • (2001) Ann Rheum Dis , vol.60 , Issue.8 , pp. 729-735
    • Cutolo, M.1    Sulli, A.2    Pizzorni, C.3    Seriolo, B.4    Straub, R.H.5
  • 26
    • 77957196913 scopus 로고    scopus 로고
    • Rheumatoid arthritis
    • 20870100 10.1016/S0140-6736(10)60826-4
    • Scott DL, Wolfe F, Huizinga TW (2010) Rheumatoid arthritis. Lancet 376(9746):1094-1108. doi: 10.1016/S0140-6736(10)60826-4
    • (2010) Lancet , vol.376 , Issue.9746 , pp. 1094-1108
    • Scott, D.L.1    Wolfe, F.2    Huizinga, T.W.3
  • 27
    • 0142124934 scopus 로고    scopus 로고
    • Methotrexate as the "anchor drug" for the treatment of early rheumatoid arthritis
    • 14969073 1:STN:280:DC%2BD2c%2FotVSjtw%3D%3D
    • Pincus T, Yazici Y, Sokka T, Aletaha D, Smolen JS (2003) Methotrexate as the "anchor drug" for the treatment of early rheumatoid arthritis. Clin Exp Rheumatol 21(5 suppl 31):S179-S185
    • (2003) Clin Exp Rheumatol , vol.21 , Issue.SUPPL. 31
    • Pincus, T.1    Yazici, Y.2    Sokka, T.3    Aletaha, D.4    Smolen, J.S.5
  • 28
    • 0031865023 scopus 로고    scopus 로고
    • Mechanism of action of leflunomide in rheumatoid arthritis
    • 9666414 1:CAS:528:DyaK1cXks1Kjuro%3D
    • Fox RI (1998) Mechanism of action of leflunomide in rheumatoid arthritis. J Rheumatol Suppl 53:20-26
    • (1998) J Rheumatol Suppl , vol.53 , pp. 20-26
    • Fox, R.I.1
  • 29
    • 0029847123 scopus 로고    scopus 로고
    • A novel mechanism of action of the immunomodulatory drug, leflunomide: Augmentation of the immunosuppressive cytokine, TGF-beta 1, and suppression of the immunostimulatory cytokine, IL-2
    • 1:CAS:528:DyaK2sXisFGhtw%3D%3D
    • Cao WW, Kao PN, Aoki Y, Xu JC, Shorthouse RA, Morris RE (1996) A novel mechanism of action of the immunomodulatory drug, leflunomide: augmentation of the immunosuppressive cytokine, TGF-beta 1, and suppression of the immunostimulatory cytokine, IL-2. Transp Proc 28(6):3079-3080
    • (1996) Transp Proc , vol.28 , Issue.6 , pp. 3079-3080
    • Cao, W.W.1    Kao, P.N.2    Aoki, Y.3    Xu, J.C.4    Shorthouse, R.A.5    Morris, R.E.6
  • 30
    • 0029165758 scopus 로고
    • Effect of methotrexate alone or in combination with sulphasalazine on the production and circulating concentrations of cytokines and their antagonists. Longitudinal evaluation in patients with rheumatoid arthritis
    • 7551660 10.1093/rheumatology/34.8.747 1:STN:280:DyaK28%2FjsF2hsg%3D%3D
    • Barrera P, Haagsma CJ, Boerbooms AM, Van Riel PL, Borm GF, Van de Putte LB, Van der Meer JW (1995) Effect of methotrexate alone or in combination with sulphasalazine on the production and circulating concentrations of cytokines and their antagonists. Longitudinal evaluation in patients with rheumatoid arthritis. Br J Rheumatol 34(8):747-755
    • (1995) Br J Rheumatol , vol.34 , Issue.8 , pp. 747-755
    • Barrera, P.1    Haagsma, C.J.2    Boerbooms, A.M.3    Van Riel, P.L.4    Borm, G.F.5    Van De Putte, L.B.6    Van Der Meer, J.W.7
  • 31
    • 0025907050 scopus 로고
    • Effect of sulfasalazine on B cells
    • 1678997 1:STN:280:DyaK3MzkslGksw%3D%3D
    • Imai F, Suzuki T, Ishibashi T, Dohi Y (1991) Effect of sulfasalazine on B cells. Clin Exp Rheumatol 9(3):259-264
    • (1991) Clin Exp Rheumatol , vol.9 , Issue.3 , pp. 259-264
    • Imai, F.1    Suzuki, T.2    Ishibashi, T.3    Dohi, Y.4
  • 32
    • 0025107058 scopus 로고
    • Inhibition of proliferative responses and interleukin 2 productions by salazosulfapyridine and its metabolites
    • 1981793 10.1254/jjp.54.121 1:CAS:528:DyaK3cXmt1Cgsrc%3D
    • Fujiwara M, Mitsui K, Yamamoto I (1990) Inhibition of proliferative responses and interleukin 2 productions by salazosulfapyridine and its metabolites. Jpn J Pharmacol 54(2):121-131
    • (1990) Jpn J Pharmacol , vol.54 , Issue.2 , pp. 121-131
    • Fujiwara, M.1    Mitsui, K.2    Yamamoto, I.3
  • 33
    • 29744441553 scopus 로고    scopus 로고
    • Caspase activation and apoptosis induction by adalimumab: Demonstration in vitro and in vivo in a chimeric mouse model
    • 16374254 10.1097/01.MIB.0000194185.69800.07
    • Shen C, Van Assche G, Rutgeerts P, Ceuppens JL (2006) Caspase activation and apoptosis induction by adalimumab: demonstration in vitro and in vivo in a chimeric mouse model. Inflamm Bowel Dis 12(1):22-28. doi: 10.1097/01.MIB. 0000194185.69800.07
    • (2006) Inflamm Bowel Dis , vol.12 , Issue.1 , pp. 22-28
    • Shen, C.1    Van Assche, G.2    Rutgeerts, P.3    Ceuppens, J.L.4
  • 34
    • 14044252848 scopus 로고    scopus 로고
    • Adalimumab induces apoptosis of human monocytes: A comparative study with infliximab and etanercept
    • 15691299 10.1111/j.1365-2036.2005.02309.x 1:CAS:528:DC%2BD2MXit1ymurg%3D
    • Shen C, Assche GV, Colpaert S, Maerten P, Geboes K, Rutgeerts P, Ceuppens JL (2005) Adalimumab induces apoptosis of human monocytes: a comparative study with infliximab and etanercept. Aliment Pharmacol Ther 21(3):251-258. doi: 10.1111/j.1365-2036.2005.02309.x
    • (2005) Aliment Pharmacol Ther , vol.21 , Issue.3 , pp. 251-258
    • Shen, C.1    Assche, G.V.2    Colpaert, S.3    Maerten, P.4    Geboes, K.5    Rutgeerts, P.6    Ceuppens, J.L.7
  • 35
    • 36749070996 scopus 로고    scopus 로고
    • Mechanism of action of certolizumab pegol (CDP870): In vitro comparison with other anti-tumor necrosis factor alpha agents
    • 10.1002/ibd.20225 17636564 10.1002/ibd.20225
    • Nesbitt A, Fossati G, Bergin M, Stephens P, Stephens S, Foulkes R, Brown D, Robinson M, Bourne T (2007) Mechanism of action of certolizumab pegol (CDP870): in vitro comparison with other anti-tumor necrosis factor alpha agents. Inflamm Bowel Dis 13(11):1323-1332. doi: 10.1002/ibd.20225
    • (2007) Inflamm Bowel Dis , vol.13 , Issue.11 , pp. 1323-1332
    • Nesbitt, A.1    Fossati, G.2    Bergin, M.3    Stephens, P.4    Stephens, S.5    Foulkes, R.6    Brown, D.7    Robinson, M.8    Bourne, T.9
  • 36
    • 33750358659 scopus 로고    scopus 로고
    • Enrichment of CD4+ CD25high T cell population in patients with systemic lupus erythematosus treated with glucocorticoids
    • 16606650 10.1136/ard.2005.049924 1:CAS:528:DC%2BD28Xht1OjtLrM
    • Suarez A, Lopez P, Gomez J, Gutierrez C (2006) Enrichment of CD4+ CD25high T cell population in patients with systemic lupus erythematosus treated with glucocorticoids. Ann Rheum Dis 65(11):1512-1517. doi: 10.1136/ard.2005. 049924
    • (2006) Ann Rheum Dis , vol.65 , Issue.11 , pp. 1512-1517
    • Suarez, A.1    Lopez, P.2    Gomez, J.3    Gutierrez, C.4
  • 37
    • 69949189926 scopus 로고    scopus 로고
    • Glucocorticoid treatment restores the impaired suppressive function of regulatory T cells in patients with relapsing-remitting multiple sclerosis
    • 19737227 10.1111/j.1365-2249.2009.03987.x 1:CAS:528:DC%2BD1MXht1Cqt7zE
    • Xu L, Xu Z, Xu M (2009) Glucocorticoid treatment restores the impaired suppressive function of regulatory T cells in patients with relapsing-remitting multiple sclerosis. Clin Exp Immunol 158(1):26-30. doi: 10.1111/j.1365-2249. 2009.03987.x
    • (2009) Clin Exp Immunol , vol.158 , Issue.1 , pp. 26-30
    • Xu, L.1    Xu, Z.2    Xu, M.3
  • 40
    • 22144475453 scopus 로고    scopus 로고
    • Differential effect of calcineurin inhibitors, anti-CD25 antibodies and rapamycin on the induction of FOXP3 in human T cells
    • 16003241 10.1097/01.TP.0000164142.98167.4B 1:CAS:528:DC%2BD2MXlvVyltbc%3D
    • Baan CC, van der Mast BJ, Klepper M, Mol WM, Peeters AM, Korevaar SS, Balk AH, Weimar W (2005) Differential effect of calcineurin inhibitors, anti-CD25 antibodies and rapamycin on the induction of FOXP3 in human T cells. Transplantation 80(1):110-117. doi: 10.1097/01.TP.0000164142.98167.4B
    • (2005) Transplantation , vol.80 , Issue.1 , pp. 110-117
    • Baan, C.C.1    Van Der Mast, B.J.2    Klepper, M.3    Mol, W.M.4    Peeters, A.M.5    Korevaar, S.S.6    Balk, A.H.7    Weimar, W.8
  • 41
    • 33745633856 scopus 로고    scopus 로고
    • Inhibition of CD4+ CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production
    • 16522809 10.1182/blood-2006-01-0329 1:CAS:528:DC%2BD28XmsVOlsrs%3D
    • Zeiser R, Nguyen VH, Beilhack A, Buess M, Schulz S, Baker J, Contag CH, Negrin RS (2006) Inhibition of CD4+ CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production. Blood 108(1):390-399. doi: 10.1182/blood-2006-01-0329
    • (2006) Blood , vol.108 , Issue.1 , pp. 390-399
    • Zeiser, R.1    Nguyen, V.H.2    Beilhack, A.3    Buess, M.4    Schulz, S.5    Baker, J.6    Contag, C.H.7    Negrin, R.S.8
  • 43
    • 77956464307 scopus 로고    scopus 로고
    • Influence of immunosuppressive drugs on the development of CD4(+)CD25(high) Foxp3(+) T cells in liver transplant recipients
    • 10.1016/j.transproceed.2010.04.026 1:CAS:528:DC%2BC3cXhtFCltr7P
    • Chu Z, Zhang J, Zhao Y, Ji Q, Zhong J, Zhang C, Zhang B (2010) Influence of immunosuppressive drugs on the development of CD4(+)CD25(high) Foxp3(+) T cells in liver transplant recipients. Transp Proc 42(7):2599-2601. doi: 10.1016/j.transproceed.2010.04.026
    • (2010) Transp Proc , vol.42 , Issue.7 , pp. 2599-2601
    • Chu, Z.1    Zhang, J.2    Zhao, Y.3    Ji, Q.4    Zhong, J.5    Zhang, C.6    Zhang, B.7
  • 44
    • 0023238082 scopus 로고
    • Salicylate induced exacerbation of ulcerative colitis
    • 3596343 10.1136/gut.28.5.613 1:STN:280:DyaL2s3kvVagtw%3D%3D
    • Chakraborty TK, Bhatia D, Heading RC, Ford MJ (1987) Salicylate induced exacerbation of ulcerative colitis. Gut 28(5):613-615
    • (1987) Gut , vol.28 , Issue.5 , pp. 613-615
    • Chakraborty, T.K.1    Bhatia, D.2    Heading, R.C.3    Ford, M.J.4
  • 45
    • 0020045821 scopus 로고
    • Sulfasalazine-induced exacerbation of ulcerative colitis
    • 10.1056/NEJM198202183060708 6120459 10.1056/NEJM198202183060708 1:STN:280:DyaL387isFartw%3D%3D
    • Schwartz AG, Targan SR, Saxon A, Weinstein WM (1982) Sulfasalazine- induced exacerbation of ulcerative colitis. N Engl J Med 306(7):409-412. doi: 10.1056/NEJM198202183060708
    • (1982) N Engl J Med , vol.306 , Issue.7 , pp. 409-412
    • Schwartz, A.G.1    Targan, S.R.2    Saxon, A.3    Weinstein, W.M.4
  • 46
    • 76149091182 scopus 로고    scopus 로고
    • Leflunomide induces immunosuppression in collagen-induced arthritis rats by upregulating CD4+ CD25+ regulatory T cells
    • 10.1139/Y09-094 20130738 10.1139/Y09-094
    • Wang TY, Li J, Li CY, Jin Y, Lu XW, Wang XH, Zhou Q (2010) Leflunomide induces immunosuppression in collagen-induced arthritis rats by upregulating CD4+ CD25+ regulatory T cells. Can J Physiol Pharmacol 88(1):45-53. doi: 10.1139/Y09-094
    • (2010) Can J Physiol Pharmacol , vol.88 , Issue.1 , pp. 45-53
    • Wang, T.Y.1    Li, J.2    Li, C.Y.3    Jin, Y.4    Lu, X.W.5    Wang, X.H.6    Zhou, Q.7
  • 47
    • 84857626144 scopus 로고    scopus 로고
    • The effects of leflunomide on CD4(+)CD25 (+)Foxp3 (+) T regulatory cells in mice receiving allogeneic bone marrow transplantation
    • doi: 10.1007/s00011-011-0388-4
    • Jin D, Duan K, Zhang L, Peng J, Zhao Y (2011) The effects of leflunomide on CD4(+)CD25 (+)Foxp3 (+) T regulatory cells in mice receiving allogeneic bone marrow transplantation. Inflamm Res Off J Euro Histamine Res Soc (et al.). doi: 10.1007/s00011-011-0388-4
    • (2011) Inflamm Res off J Euro Histamine Res Soc (Et Al.)
    • Jin, D.1    Duan, K.2    Zhang, L.3    Peng, J.4    Zhao, Y.5
  • 48
    • 0031647622 scopus 로고    scopus 로고
    • Immunologic self-tolerance maintained by CD25+ CD4+ naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state
    • 9885918 10.1093/intimm/10.12.1969 1:CAS:528:DyaK1MXmtFehtQ%3D%3D
    • Takahashi T, Kuniyasu Y, Toda M, Sakaguchi N, Itoh M, Iwata M, Shimizu J, Sakaguchi S (1998) Immunologic self-tolerance maintained by CD25+ CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol 10(12):1969-1980
    • (1998) Int Immunol , vol.10 , Issue.12 , pp. 1969-1980
    • Takahashi, T.1    Kuniyasu, Y.2    Toda, M.3    Sakaguchi, N.4    Itoh, M.5    Iwata, M.6    Shimizu, J.7    Sakaguchi, S.8
  • 49
    • 55849126729 scopus 로고    scopus 로고
    • Patients with relapsing-remitting multiple sclerosis have normal Treg function when cells expressing IL-7 receptor alpha-chain are excluded from the analysis
    • 10.1172/JCI35365 18769633 1:CAS:528:DC%2BD1cXht1ChsrvL
    • Michel L, Berthelot L, Pettre S, Wiertlewski S, Lefrere F, Braudeau C, Brouard S, Soulillou JP, Laplaud DA (2008) Patients with relapsing-remitting multiple sclerosis have normal Treg function when cells expressing IL-7 receptor alpha-chain are excluded from the analysis. J Clin Invest 118(10):3411-3419. doi: 10.1172/JCI35365
    • (2008) J Clin Invest , vol.118 , Issue.10 , pp. 3411-3419
    • Michel, L.1    Berthelot, L.2    Pettre, S.3    Wiertlewski, S.4    Lefrere, F.5    Braudeau, C.6    Brouard, S.7    Soulillou, J.P.8    Laplaud, D.A.9


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