Leflunomide induces immunosuppression in collagen-induced arthritis rats by upregulating CD4+CD25+regulatory T cells

Canadian Journal of Physiology and Pharmacology

Volumn 88, Issue 1, 2010, Pages 45-53

  Wang, Ting Yu ^a   Li, Jun ^a   Li, Chang Yu ^a   Jin, Yong ^a   Lü, Xiong Wen ^a   Wang, Xiao Hua ^a   Zhou, Qian ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

A771726; Arthritis; CD25; Leflunomide; Regulatory

Indexed keywords

COLLAGEN TYPE 2; CONCANAVALIN A; LEFLUNOMIDE; MESSENGER RNA; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HISTOPATHOLOGY; IMMUNOFLUORESCENCE; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; REGULATORY T LYMPHOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLEEN LYMPHOCYTE; UPREGULATION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGENS, CD4; ARTHRITIS, EXPERIMENTAL; CATTLE; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; ISOXAZOLES; MALE; RATS; RATS, WISTAR; T-LYMPHOCYTES, REGULATORY; UP-REGULATION;

EID: 76149091182     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/Y09-094     Document Type: Article

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