Characterization and lysine control of expression of the lys1 gene of Penicillium chrysogenum encoding homocitrate synthase

Gene

Volumn 226, Issue 1, 1999, Pages 51-59

  Bañuelos, Oscar ^a   Casqueiro, Javier ^a   Fierro, Francisco ^a   Hijarrubia, Maria José ^a   Gutiérrez, Santiago ^a   Martín, Juan F ^a  

^a UNIVERSITY OF LEÓN   (Spain)

Author keywords

LYS20; Lysine biosynthesis; Lysine repression; Penicillin biosynthesis

Indexed keywords

LYSINE; SYNTHETASE;

AMINO ACID SEQUENCE; AMINO ACID SYNTHESIS; ANTIBIOTIC BIOSYNTHESIS; ARTICLE; CHROMOSOME 2; GENE EXPRESSION REGULATION; GENE LOCATION; GENE REPRESSION; NONHUMAN; PENICILLIUM CHRYSOGENUM; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; CHROMOSOME MAPPING; CLONING, MOLECULAR; FUNGAL PROTEINS; GENE DOSAGE; GENE EXPRESSION REGULATION, FUNGAL; LYSINE; MOLECULAR SEQUENCE DATA; OPEN READING FRAMES; OXO-ACID-LYASES; PENICILLIUM CHRYSOGENUM; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION, GENETIC;

EID: 0344958846     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(98)00551-4     Document Type: Article

References (44)

1. Affenzeller K., Jaklitsch W.M., Hönlinger C., Kubicek C.P. Lysine biosynthesis in Penicillium chrysogenum is regulated by feedback inhibition of α-aminoadipate reductase. FEMS Microbiol. Lett. 58:1989;293-298.
2. Aharonowitz Y., Cohen G., Martín J.F. Penicillin and cephalosporin biosynthetic genes: Structure, organization, regulation and evolution. Annu. Rev. Microbiol. 46:1992;461-495.
3. Ballance D.J. Sequences important for gene expression in filamentous fungi. Yeast. 2:1986;229-236.
4. Barredo J.L., Díez B., Alvarez E., Martín J.F. Large amplification of a 35-kb DNA fragment carrying two penicillin biosynthetic genes in high penicillin producing strains of Penicillium chrysogenum. Curr. Genet. 16:1989;453-459.
5. Beynon J., Ally A., Cannon M., Cannon F., Jacobson M., Cash V., Dean D. Comparative organization of nitrogen fixation-specific genes from Azotobacter vinelandii and Klebsiella pneumoniae: DNA sequence of the nifUSV genes. J. Bacteriol. 169:1987;4024-4029.
6. Bhattacharjee, J.K., 1985. α-Aminoadipate pathway for the biosynthesis of lysine in lower eukaryotes. In: Critical Reviews in Microbiology. CRC Press, Boca Raton, FL, vol. 12, pp. 131-151.
7. Brundidge S.P., Gaeta F.C.A., Hook D.J., Sapino C. Jr., Elander R.P., Morin R.B. Association of 6-oxo-piperidine-2-carboxylic acid with penicillin V production in Penicillium chrysogenum fermentations. J. Antibiot. 33:1980;1348-1351.
8. Cantoral J.M., Gutiérrez S., Fierro F., Gil-Espinosa S., van Liempt H., Martín J.F. Biochemical characterization and molecular genetics of nine mutants of Penicillium chrysogenum impaired in penicillin biosynthesis. J. Biol. Chem. 268:1993;737-744.
9. Casqueiro J., Gutiérrez S., Bañuelos O., Fierro F., Velasco J., Martín J.F. Characterization of the lys2 gene of Penicillium chrysogenum encoding α-aminoadipic acid reductase. Mol. Gen. Genet. 259:1998;549-556.
10. Chen S., Brockenbrough J.S., Dove J.E., Aris J.P. Homocitrate synthase is located in the nucleus in the yeast Saccharomyces cerevisiae. J. Biol. Chem. 272:1997;10839-10846.
11. Demain A.L., Masurekar P.S. Lysine inhibition of in vivo homocitrate synthesis in Penicillium chrysogenum. J. Gen. Microbiol. 82:1974;143-151.
12. Demain, A.L., 1983. Biosynthesis of β-lactam antibiotics. In: Demain, A.L., Solomon, N.A. (Eds.), Antibiotics Containing the β-lactam Structure. Springer, Berlin, pp. 189-228.
13. Esmahan C., Alvarez E., Montenegro E., Martín J.F. Catabolism of lysine in Penicillium chrysogenum leads to formation of α-aminoadipic acid, a precursor of penicillin biosynthesis. Appl. Environ. Microbiol. 60:1994;1705-1710.
14. Evans D.J., Jones R., Woodley P.R., Wilborn J.R., Robson R.L. Nucleotide sequence and genetic analysis of the Azotobacter chroococcum nifUSVWZM gene cluster, including a new gene (nifP) which encodes a serine acetyltransferase. J. Bacteriol. 173:1991;5457-5469.
15. Eikmanns B.J., Eggeling L., Sahm H. Molecular aspects of lysine, threonine and isoleucine biosynthesis in Corynebacterium glutamicum. Antonie van Leeuwenhoek. 64:1993;145-163.
16. Fernández F.J., Gutiérrez S., Velasco J., Montenegro E., Marcos A.T., Martín J.F. Molecular characterization of three loss-of-function mutations in the isopenicillin N acyltransferase gene (penDE) of Penicillium chrysogenum. J. Bacteriol. 176:1994;4941-4948.
17. Fierro F., Gutiérrez S., Díez B., Martín J.F. Resolution of four chromosomes in penicillin-producing filamentous fungi: the penicillin gene cluster is located on chromosome II (9.6 Mb) in Penicillium notatum and chromosome I (10.4 Mb) in Penicillium chrysogenum. Mol. Gen. Genet. 241:1993;573-578.
18. Fierro F., Barredo J.L., Díez B., Gutiérrez S., Fernández F.J., Martín J.F. The penicillin gene cluster is amplified in tandem repeats linked by conserved hexanucleotide sequences. Proc. Natl. Acad. Sci. USA. 92:1995;6200-6204.
19. Fierro F., Montenegro E., Gutiérrez S., Martín J.F. Mutants blocked in penicillin biosynthesis show a deletion of the entire penicillin gene cluster at a specific site within a conserved hexanucleotide sequence. Appl. Microbiol. Biotechnol. 44:1996;597-604.
20. Friedrich C.G., Demain A.L. Homocitrate synthase as a crucial site of the lysine effect on penicillin biosynthesis. J. Antibiot. 30:1977;760-761.
21. Friedrich C.G., Demain A.L. Uptake and metabolism of α-aminoadipic acid by Penicillium chrysogenum Wis 54-1255. Arch. Microbiol. 119:1978;43-47.
22. Gutiérrez S., Velasco J., Marcos A.T., Fernández F.J., Fierro F., Barredo J.L., Díez B., Martín J.F. Expression of the cefG gene is limiting for cephalosporin biosynthesis in Acremonium chrysogenum. Appl. Microbiol. Biotechnol. 48:1997;606-614.
23. Henikoff S. Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. Gene. 28:1984;351-359.
24. Hersbach, G.J.M., van der Beek, C.P., van Dijck, P.W.M., 1984. The penicillins: Properties, biosynthesis and fermentation. In: Vandamme, E.J. (Ed.), Biotechnology of Industrial Antibiotics. Dekker, New York, pp. 45-140.
25. Jaklitsch W.M., Hampel W., Röhr M., Kubicek C.P., Gamerith G. α-Aminoadipate pool concentration and penicillin biosynthesis in strains of Penicillium chrysogenum. Can. J. Microbiol. 32:1986;473-480.
26. Jaklitsch W.M., Kubicek C.P. Homocitrate synthase from Penicillium chrysogenum. Biochem. J. 269:1990;247-253.
27. Luengo J.M., Revilla G., Villanueva J.R., Martín J.F. Lysine regulation of penicillin biosynthesis in low-producing and industrial strains of Penicillium chrysogenum. J. Gen. Microbiol. 115:1979;207-211.
28. Luengo J.M., Revilla G., Villanueva J.R., Martín J.F. Inhibition and repression of homocitrate synthase by lysine in Penicillium chrysogenum. J. Bacteriol. 144:1980;869-876.
29. Malumbres M., Martín J.F. Molecular control mechanisms of lysine and threonine biosynthesis in amino acid-producing corynebacteria: Redirecting carbon flow. FEMS Microbiol. Lett. 143:1996;103-114.
30. Martín, J.F., Aharonowitz, Y., 1983. Regulation of the biosynthesis of β-lactam antibiotics. In: Demain, A.L., Solomon, N.A. (Eds.), Antibiotics Containing the β-lactam Structure, Part I. Springer, Berlin, pp. 229-254.
31. Martín J.F., Gutiérrez S. Genes for β-lactam antibiotic biosynthesis. Antonie van Leeuwenhoek. 67:1995;181-200.
32. Martín, J.F., Liras, P., 1989a. Enzymes involved in penicillin, cephalosporin and cephamycin biosynthesis. In: Fiechter, A. (Ed.), Advances in Biochemical Engineering/biotechnology. Springer, Berlin, vol. 39, pp. 153-187.
33. Martín J.F., Liras P. Organization and expression of genes involved in the biosynthesis of antibiotics and other secondary metabolites. Annu. Rev. Microbiol. 43:1989;173-206.
34. Martín, J.F., Gutiérrez, S., Demain, A.L., 1997. β-Lactams. In: Anke, T. (Ed.), Fungal Biotechnology. Chapman & Hall, Weinheim, Germany, pp. 91-127.
35. Meijer W.G., Tabita F.R. Isolation and characterization of the nifUSVW-rpoN gene cluster from Rhodobacter sphaeroides. J. Bacteriol. 174:1992;3855-3866.
36. Pérez-Campo F.M., Nicaud J.-M., Gaillardin C., Domínguez A. Cloning and sequencing of the LYS1 gene encoding homocitrate synthase in the yeast Yarrowia lipolytica. Yeast. 12:1996;1459-1469.
37. Ramos F., Verhasselt P., Feller A., Peeters P., Wach A., Dubois E., Volckaert G. Identification of a gene encoding a homocitrate synthase isoenzyme of Saccharomyces cerevisiae. Yeast. 12:1996;1315-1320.
38. Revilla, G., 1983. Regulación de la biosíntesis de penicilina en Penicillium chrysogenum. University of Salamanca Publications, Salamanca, Spain.
39. Sambrook, J., Fritsch, E.F., Maniatis, T., 1989. Molecular Cloning: A Laboratory Manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
40. Sanger F., Nicklen S., Coulson A.R. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA. 74:1977;5463-5467.
41. Stricker O., Masepohl B., Klipp W., Bohme H. Identification and characterization of the nifV-nifZ-nifT gene region from the filamentous cyanobacterium Anabaena sp. strain PCC 7120. J. Bacteriol. 179:1997;2930-2937.
42. Tucci A.F., Cecci L.N. Homocitrate synthase from yeast. Arch. Biochem. Biophys. 153:1972;742-750.
43. Verhasselt P., Voet M., Volckaert G. New open reading frames, one of which is similar to the nifV gene of Azotobacter vinclandii, found on a 12·5 kbp fragment of chromosome IV of Saccharomyces cerevisiae. Yeast. 11:1995;961-966.
44. Wang S., Dean D.R., Chen J., Johnson J.L. The N-terminal and C-terminal portions of NifV are encoded by two different genes in Clostridium pasteurianum. J. Bacteriol. 173:1991;3041-3046.