Analysis of 6-methoxy podophyllotoxin and podophyllotoxin in hairy root cultures of Linum album Kotschy ex Boiss

Medicinal Chemistry Research

Volumn 22, Issue 2, 2013, Pages 745-752

  Chashmi, Najmeh Ahmadian ^a   Sharifi, Mozafar ^a   Yousefzadi, Morteza ^b   Behmanesh, Mehrdad ^a   Rezadoost, Hassan ^c   Cardillo, Alejandra ^d   Palazon, Javier ^e  

^a TARBIAT MODARES UNIVERSITY   (Iran)

^b UNIVERSITY OF HORMOZGAN   (Iran)

^c SHAHID BEHESHTI UNIVERSITY   (Iran)

^d UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^e UNIVERSITY OF BARCELONA   (Spain)

Author keywords

6 methoxy podophyllotoxin (MPTOX); Agrobacterium; Hairy roots; Linum album; Podophyllotoxin (PTOX)

Indexed keywords

6 METHOXY PODOPHYLLOTOXIN; PLANT EXTRACT; PODOPHYLLOTOXIN; PODOPHYLLOTOXIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIUM TRANSFORMATION; CIRCULAR DICHROISM; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; ENANTIOMER; HAIRY ROOT CULTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LINUM ALBUM; MEDICINAL PLANT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLANT LEAF; RHIZOBIUM RADIOBACTER; RHIZOBIUM RHIZOGENES; ROOT GROWTH;

EID: 84873988551     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-012-0067-1     Document Type: Article

References (30)

1. Bais HP, Sudha G, George J, Ravishankar GA (2001) Influence of exogenous hormones on growth and secondary metabolite production in hairy root cultures of Cichorium intybus L. Cv. Lucknow local. In Vitro Cell Dev Biol Plant 37:293-299
2. Botta B, Delle Monache G, Misiti D, Vitali A, Zappia G (2001) Aryltetralin lignans: chemistry, pharmacology and biotransformation. Curr Med Chem 8:1363-1381
3. Chattopadhyay S, Srivastava AK, Bisaria VS (2002) Optimization of culture parameters for production of podophyllotoxin in suspension culture of Podophyllum hexandrum. Appl Biochem Biotechnol 102:381-393
4. Chattopadhyay S, Bisaria VS, Srivastava AK (2003a) Enhanced production of podophyllotoxin by Podophyllum hexandrum using in situ cell retention bioreactor. Biotechnol Prog 19:1026-1028
5. Chattopadhyay S, Bisaria VS, Bhojwani SS, Srivastava AK (2003b) Enhanced production of podophyllotoxin by fed-batch cultivation of Podophyllum hexandrum. Can J Chem Eng 81:1-8
6. Chattopadhyay S, Farkya S, Srivastava AK, Bisaria VS (2003c) Bioprocess considerations for production of secondary metabolites by plant cell suspension cultures. Biotechnol Bioprocess Eng 7:138-149
7. Dewik PM (2002) Medicinal natural products, a biosynthetic approach. Wiley, Chichester, pp 121-136
8. Eberhardt TL, Bernards MA, He L, Davin LB, Wooten JB, Lewis NG (1993) Lignification in cell suspension cultures of Pinus taeda: in situ characterization of a Gymnosperm lignin. J Biol Chem 268:21088-21096
9. Farkya S, Bisaria VS (2008) Exogenous hormones affecting morphology and biosynthetic potential of hairy root line (LYR2i) of Linum album. J Biosci Bioeng 105:140-146
10. Farkya S, Bisaria VS, Srivastava AK (2004) Biotechnological aspects of the production of the anticancer drug podophyllotoxin. Appl Microbiol Biotechnol 65:504-519
11. Giri A, Narasu ML (2000) Transgenic hairy roots: recent trends and applications. Biotechnol Adv 18:1-22
12. Giri A, Giri CC, Dhingra V, Narasu ML (2001) Enhanced podophyllotoxin production from Agrobacterium rhizogenes transformed cultures of Podophyllum hexandrum. Nat Prod Lett 15:229-235
13. Gordaliza M, Garc PA, del Corral M, Castro MA, Gomez-Zurita MA (2004) Podophyllotoxin: distribution, sources, applications and new cytotoxic derivatives. Toxicon 44:441-459
14. Khan S, Irfan Qureshi M, Kamaluddin Alam T, Abdin MZ (2007) Protocol for isolation of genomic DNA from dry and fresh roots of medicinal plants suitable for RAPD and restriction digestion. Afr J Biotechnol 6:175-178
15. Kuhlmann S, Kranz K, Lücking B, Alfermann AW, Petersen M (2002) Aspects of cytotoxic lignan biosynthesis in suspension cultures of Linum nodiflorum. Phytochem Rev 1:37-43
16. Li Q, Yan G, Ge T (2007) A fragmentation study of podophyllotoxin and its 40-demethyl-4b-substituted derivatives by electrospray ionization ion-trap time-of-flight tandem mass spectrometry. Rapid Commun Mass Spectrom 21:2843-2852
17. Lin H, Kwok KH, Doran PM (2003) Development of Linum flavum hairy root cultures for production of Coniferin. Biotechnol Lett 25:521-525
18. Lin MC, Lin JH, Chen SK, Cheng YW, Cheng HW (2008) Simultaneous determination of podophyllotoxin, quercetin and kaempferol in podophyllin by liquid chromatography tandem mass Spectrometry. J Food Drug Anal 16:29-40
19. Mishra J, Bhandari H, Singh M, Rawat S, Agnihotri RK, Mishra S, Purohit S (2011) Hairy root culture of Picrorhiza kurroa Royle ex Benth.: a promising approach for the production of picrotin and picrotoxinin. Acta Physiol Plant 33(5):1841-1846
20. Murashige T, Skoog F (1962) A revised medium for rapid growth and bioassays with tobacco tissue cultures. Plant Physiol 15:473-497
21. Nikolay V, Ionkova I (2005) Lignan production by cell cultures of Linum setaceum and Linum campanulatum. Pharm Biol 43:509-511
22. Park S, Facchini P (2000) Agrobacterium rhizogenes-mediated transformation of opium poppy, Papaver somniferum L., and California poppy, Escholizia californica cham., root cultures. J Exp Bot 51:1005-1016
23. Ramachandra RS, Ravishankar GA (2002) Plant cell cultures: chemical factories of secondary metabolites. Biotechnol Adv 20:101-153
24. Smollny T, Wichers H, Kalenberg S, Shahsavari A, Petersen M, Alfermann WA (1998) Accumulation of podophyllotoxin and related lignans in cell suspension cultures of Linum album. Phytochemistry 48:975-979
25. Van Uden W, Pras N, Visser JF, Malingre TM (1989) Detection and identification of podophyllotoxin produced by cell cultures derived from Podophyllum hexandrum Royle. Plant Cell Rep 8:165-168
26. Verma PC, Rahman L, Negi AS, Jain DC, Khanuja SPS, Banerjee S (2007) Agrobacterium rhizogenes mediated transformation of Picrorhiza kurroa Royle ex Benth.: establishment and selection of superior hairy root clone. Plant Biotechnol Rep 1:169-174
27. Wang B, Zhang G, Zhu L, Chen L, Zhang Y (2006) Genetic transformation of Echinacea purpurea with Agrobacterium rhizogenes and bioactive ingredient analysis in transformed cultures. Colloid Surface B 53:101-104
28. Yousefzadi M, Sharifi M, Behmanesh M, Ghasempour A, Moyano E, Palazon J (2010a) Salicylic acid improves podophyllotoxin production in cell cultures of Linum album by increasing the expression of genes related with its biosynthesis. Biotechnol Lett 32:1739-1743
29. Yousefzadi M, Sharifi M, Ahmadian Chashmi N, Behmanesh M, Ghasempour A (2010b) Optimization of podophyllotoxin extraction method from Linum album cell cultures. Pharm Biol 48:1421-1425
30. Zhong JJ (2002) Plant cell culture for production of paclitaxel and other taxanes. J Biosci Bioeng 94:591-599