Lignan production by cell cultures of Linum setaceum and Linum campanulatum

Pharmaceutical Biology

Volumn 43, Issue 6, 2005, Pages 509-511

  Vasilev, Nikolay ^a   Ionkova, Iliana ^a  

^a MEDICAL UNIVERSITY OF SOFIA   (Bulgaria)

Author keywords

Cell cultures; Lignans; Linum campanulatum L.; Linum setaceum Brot.

Indexed keywords

6 METHOXYPODOPHYLLOTOXIN; BETA PELTATIN; DEOXYPODOPHYLLOTOXIN; LIGNAN; LINUM CAMPANULATUM EXTRACT; LINUM SETACEUM EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG; YATEIN;

ARTICLE; CALLUS; CALLUS CULTURE; CELL CULTURE; NONHUMAN; PHYTOCHEMISTRY; SUSPENSION CELL CULTURE;

LINACEAE; LINUM;

EID: 27444441847     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.1080/13880200500220631     Document Type: Article

References (14)

1. Bedir E, Khan I, Moraes RM (2002): Bioprospecting for podophyllotoxin. In: Janick J, Whipkey A, eds., Trends in New Crops and New Uses. Alexandria, ASHS Press, pp. 545-549.
2. Broomhead JA, Dewick PM (1990): Aryltetralin lignans from Linum flavum and Linum capitatum. Phytochemistry 12: 3839-3844.
3. Davin LB, Wang H, Crowell AL, Bedgar DL, Martin DM, Sarkanen S, Lewis NG (1997): Stereoselective bimolecular phenoxy radical coupling by an auxiliary (dirigent) protein without an active centre. Science 275: 362-366.
4. Dinkova-Kostova AT, Gang DR, Davin LB, Bedgar DL, Chu A, Lewis NG (1996): (+)-Pinoresinol/(+) lariciresinol reductase from Forsythia intermedia. J Biol Chem 46: 29473-29482.
5. Konuklugil B (1996): Aryltetralin lignans from genus Linum. Fitoterapia 4: 379-381.
6. Mohagheghzadeh A, Schmidt TJ, Alfermann AW (2002): Arylnaphtalene lignans from in vitro cultures of Linum austriacum. J Nat Prod 65: 69-71.
7. Moss GP (2000): Nomenclature of lignans and neolignans. Pure Appl Chem 8: 1493-1523.
8. Murashige T, Skoog F (1962): A revised medium for rapid growth and bioassays with tobacco tissue culture. Physiol Plant Pathol 15: 473-497.
9. Petersen M, Alfermann AW (2001): The production of cytotoxic lignans by plant cell cultures. Appl Microbiol Biotechnol 55: 135-142.
10. Van Uden W, Bouma AS, Bracht Waker JF, Middel O, Wichers HJ, De Waard P, Woerdenbag HJ, Kellogg RM, Pras N (1995): The production of podophyllotoxin and its 5-methoxy derivative through bioconversion of cyclodextrin-complexed desoxypodophyllotoxin by plant cell cultures. Plant Cell Tissue Organ Cult 42: 73-79.
11. Van Uden W, Bos JA, Boeke GM, Woerdenbag HJ, Pras N (1997): The large-scale isolation of desoxypodophyllotoxin from rhizomes of Anthriscus sylvestris followed by its bioconversion into 5-methoxypodophyllotoxin β-D-glucoside by cell cultures of Linum flavum. J Nat Prod 60: 401-403.
12. Vasilev N, Nedialkov P, Ionkova I, Ninov S (2004): HPTLC densitometric determination of justicidin B in Linum cultures in vitro. Pharmazie 59: 528-529.
13. Ward RS (1999): Lignans, neolignans and related compounds. Nat Prod Rep 16: 75-96.
14. Wichers HJ, Versilus-De Haan GG, Marsman JW, Harkes MP (1991): Podophyllotoxin related lignans in plant and cell cultures of Linum flavum. Phytochemistry 11: 3601-3604.