Bioprocess considerations for production of secondary metabolites by plant cell suspension cultures

Biotechnology and Bioprocess Engineering

Volumn 7, Issue 3, 2002, Pages 138-149

  Chattopadhyay, Saurabh ^a   Farkya, Sunita ^a   Srivastava, Ashok K ^a   Bisaria, Virendra S ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY DELHI   (India)

Author keywords

Bioprocessing; Bioreactors; Phytochemicals; Plant cell cultures; Secondary metabolites

Indexed keywords

EID: 0012874028     PISSN: 12268372     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02932911     Document Type: Article

References (87)

1. DiCosmo, F., P. J. Facchini, and M. M. Kraml (1989) Cultured plant cells: The chemical factory within. Chemistry in Britain 25: 1001-1004.
2. Flores, H. E. and W. R. Curtis (1992) Approaches to understanding and manipulating the biosynthetic potential of plant roots. Ann. New York Acad. Sci. 665: 188-209.
3. Chattopadhyay S., A. K. Srivastava, S. S. Bhojwani, and V. S. Bisaria (2001) Development of suspension culture of Podophyllum hexandrum for the production of podophyllotoxin. Biotechnol. Lett. 23: 2063-2066.
4. Payne, G. F., M. L. Shuler, and P. Brodelius (1987) Plant cell culture, pp. 193-229. In: B. K. Lydensen (ed). Large Scale Cell Culture Technology. Hanser Publishers, New York, USA.
5. Memelink, J., J. W. Kijne, R. van der Heijden, and R. Verpoorte (2001) Genetic modification of plant secondary metabolite pathways using transcriptional regulators. Adv. Biochem. Eng./Biotechnol. 72: 103-125.
6. Panda, A. K., S. Mishra, V. S. Bisaria, and S. S. Bhojwani (1989) Plant cell reactors: A perspective. Enzyme Microb. Technol. 11:386-397.
7. Bisaria, V. S. and A. K. Panda (1991) Large scale plant cell culture methods, applications and products. Curr. Opin. Biotechnol. 2: 370-374.
8. Scragg, A. H. (1995) The problems associated with high biomass levels in plant cell suspensions. Plant Cell Tiss. Org. Cult. 43: 163-170.
9. Kieran, P. M., P. F. MacLoughlin, and D. M. Malone (1997) Plant cell suspension cultures: some engineering considerations. J. Biotechnol. 59: 39-52.
10. Taticek, R. A., M. Moo-Young, and R. L. Legge (1991) The scale-up of plant cell cultures: engineering considerations. Plant Cell Tiss. Org. Cult. 24: 139-158.
11. Wagner, F. and H. Vogelman (1977) Cultivation of plant tissue cultures in bioreactors and formation of secondary metabolites, pp. 245-252. In: W. Barz, E. Reinhard, M. H. Zenk (eds). Plant Tissue Culture audits Biotechnological Applications. Springer-Verlag, Berlin, Germany.
12. Tanaka, H. (2000) Technological problems in cultivation of plant cells at high density. Biotechnol. Bioeng. 67: 1203-1218.
13. Tanaka, H. (1982) Some properties of pseudocells of plant cells. Biotechnol. Bioeng. 24: 2591-2596.
14. Jolicoeur, M., C. Chavarre, P. J. Carreau, and J. Archambault (1992) Development of helical-ribbon impeller bioreactor for high density plant cell suspension culture. Biotechnol. Bioeng. 39:511-521.
15. Chattopadhyay S., A. K. Srivastava, S. S. Bhojwani, and V. S. Bisaria (2002) Production of podophyllotoxin by plant cell cultures of Podophyllum hexandrum in bioreactor. J. Biosci. Bioeng. 93: 215-220.
16. La on the growth and alkaloid accumulation by cultures of Catharanthus roseus. Biotechnol. Bioeng. 37: 364-370.
17. Zhong, J. J., T. Seki, S. Kinoshita, and T. Yoshida (1992) Effects of surfactants on cell growth and pigment production in suspension cultures of Perilla frutescens. World J. Microbiol. Biotechnol. 8: 106-109.
18. Wongasmuth, M. and P. M. Doran (1994) Foaming and cell floatation in suspended plant cell cultures and the effect of chemical antifoams. Biotechnol. Bioeng. 44: 481-488.
19. Drapeau, D., H. W. Blanch, and C. R. Wilke (1986) Growth kinetics of Dioscorea deltoidea and Catharanthus roseus in batch culture. Biotechnol. Bioeng. 28: 1555-1563.
20. Scragg, A. H., E. J. Allan, and F. Leckie (1988) Effect of shear on the viability of plant cell suspensions. Enzyme Microb. Technol. 10: 361-367.
21. Meijer, J. J., H. J. G. ten Hoopen, K. C. A. M. Luyben, and K. R. Libbenga (1993) Effects of hydrodynamic stress on cultured plant cells: a literature survey. Enzyme Microb. Technol. 15: 234-238.
22. Kieran, P. M., H. J. O'Donnell, D. M. Malone, and P. F. MacLoughlin (1995) Fluid shear effects on suspension cultures of Morinda citrifolia. Biotechnol. Bioeng. 45: 415-425.
23. Zhong, J. J., K. Fujiyama, T. Seki, and T. Yoshida (1994) A quantitative analysis of shear effects on cell suspension and cell cultures of Perilla frutescens in bioreactors. Biotechnol. Bioeng. 44: 649-654.
24. Kieran, P. M., D. M. Malone, and P. F. MacLoughlin (2000) Effect of hydrodynamic and interfacial forces on plant cell systems, pp. 139-177. In: T. Scheper, K. Schugerl, and G. Kretzmer (eds). Adv. Biochem. Eng./Biotechnol. Vol 67, Springer-Verlag, Berlin, Germany.
25. Plackett, R. L. and J. P. Burman (1946) The design of optimum multifactorial experiments. Biometrika 33: 305-325.
26. Bowman, L. and E. Geiger (1984) Optimization of fermentation conditions for alcohol production. Biotechnol. Bioeng. 26: 1492-1497.
27. Roseiro, J. C., M. E. Esgalhado, A. M. T. Collaco, and A. N. Emery (1992) Medium development for xanthan production. Process Biochem. 27: 167-175.
28. Narang, S., V. Sahai, and V. S. Bisaria (2001) Optimization of xylanase production by Melanocarpus albomyces IIS68 in solid-state fermentation using response surface methodology. J. Biosci. Bioeng. 91: 425-427.
29. Cochran, W. G. and G. M. Cox (1957) Experimental Design. 2nd ed. John Wiley & Sons, New York, USA.
30. Deming, S. N. and S. L. Morgan (1987) Experimental Design: A Chemometric Approach, 1st ed. Elsevier Science Publishers BV, New York, USA.
31. Cheynier, V., M. Feinberg, C. Chararas, and C. Ducauze (1983) Application of response surface methodology for evaluation of bioconversion experimental conditions. Appl. Environ. Microbiol. 45: 634-639.
32. Harris, P. V., S. L. Cuppett, and L. B. Bullerman (1990) Optimization of lipase synthesis by Pseudomonas fluorescens by response surface methodology. J. Food Protect. 53: 481-483.
33. Botta, B., G. Dall'Olio, F. Ferrari, B. Monaceli, G. Pasqua, R. Scurria, and D. G. Monache (1989) Cell suspension cultures of Cassia didymobotrya: optimization of growth and secondary metabolite production by application of orthogonal design method. J. Plant Physiol. 135: 290-294.
34. Tuominen, U., L. Toivonen, V. Kauppinen, P. Markkanen, and L. Bjork (1989) Studies on the growth and cardenolide production of Digitalis lanata tissue cultures. Biotechnol. Bioeng. 33: 558-562.
35. Schlatmann, J. E., H. J. G. ten Hoopen, and J. J. Heijnen (1992) Optimization of the medium composition for alkaloid production by Catharanthus roseus using statistical experimental designs. Med. Fac. Landbouw Univ. Gent. 57: 1567-1569.
36. Chattopadhyay S., A. K. Srivastava, and V. S. Bisaria (2002) Optimization of culture parameters for production of podophyllotoxin in suspension culture of Podophyllum hexandrum. Appl. Biochem. Biotechnol. (in press).
37. ten Hoopen, H. J. G., W. M. van Gulik, J. E. Schlatman, P. R. H. Moreno, J. Vinke, J. J. Heijnen, and R. Verpoorte (1994) Ajmalicine production by cell cultures of Catharanthus roseus: from shake flask to bioreactor. Plant Cell Tiss. Org. Cult. 38: 85-91.
38. Fulzele, D., W. Kreis, and E. Reinhard (1992) Cardenolide biotransformation by cultured Digitalis lanata cells: Semi-continuous cell growth and production of deacetyllanatoside-C in a 40-L stirred tank bioreactor. Planta Med. 58: A601-A602.
39. Zhong, J. J., F. Chen, and W. W. Hu (2000) High density cultivation of Panax notoginseng cells in stirred bioreactors for the production of ginseng biomass and ginseng saponin. Process Biochem. 35: 491-496.
40. Srinivasan, V., L. Pestchanker, S. Moser, T. J. Hirasuma, R. A. Taticek, and M. L. Shuler (1995) Taxol production in bioreactors: kinetics of biomass accumulation, nutrient uptake, and taxol production by cell suspensions of Taxus baccata. Biotechnol. Bioeng. 47: 666-676.
41. Son, S. H., S. M. Choi, Y. H. Lee, K. B. Choi, S. R. Yun, J. K. Kim, H. J. Park, O. W. Kwon, E. W. Noh, J. H. Seon, and Y. J. Park (2000) Large-scale growth and taxane production in cell cultures of Taxus cuspidata (Japanese Yew) using a novel bioreactor. Plant Cell Rep. 19: 628-638.
42. Zhao, J., W. H. Zhu, and Q. Hu (2001) Enhanced catharanthine production in Catharanthus roseus cell cultures by combined elicitor treatment in shake flasks and bioreactors. Enzyme Microb. Technol. 28: 673-681.
43. Reinhard, E., W. Kreis, U. Barthlen, and U. Helmbold (1989) Semicontinuous cultivation of Digitalis lanata cells: production of |3-methyldigoxin in a 300 1 airlift bioreactor. Biotechnol. Bioeng. 34: 502-508.
44. Tanaka H. (1987) Large-scale cultivation of plant cells at high density: A review. Process Biochem. 22: 106-113.
45. Pan, Z. W., H. Q. Wang, and J. J. Zhong (2000) Scale-up study of suspension culture of Taxus chinensis cells for production of taxane diterpene. Enzyme Microb. Technol. 27: 714-723.
46. Goldstein, W. E., L. L. Lasure, and M. B. Ingle (1980) Product cost analysis, pp. 191-234. In: E. J. Staba (ed). Plant Tissue Culture as a Source of Biochemicals. CRC Press, Boca Raton, USA.
47. Sajc, L., D. Grubisic, G. V. Novakovic (2000) Bioreactors for plant engineering: an outlook for further research. Biochem. Eng. J. 4:89-99.
48. Hooker, B. S., J. M. Lee, and G. An (1990) Cultivation of plant cells in stirred vessel: effect of impeller designs. Biotechnol. Bioeng. 35: 296-304.
49. Furuya, T. (1988) Saponins (ginseng saponins). In: I. K. Vasil (ed). pp. 213-234. Cell Culture and Somatic Cell Genetics of Plants Vol 5. Academic Press, CA, USA.
50. Wu, J. and J. J. Zhong (1999) Production of ginseng and its bioactive components in plant cell culture: current technological and applied aspects. J. Biotechnol. 68: 89-99.
51. Matsubara, K., S. Kitani, T. Yoshioka, T. Morimoto, Y. Fujita, and Y. Yamada (1989) High density culture of Coptis japonica cells increases berberine production. J. Chem. Technol. Biotechnol. 46: 61-69.
52. Hara, Y. (1996) Research on the production of useful compounds by plant cell cultures in Japan, pp. 187-201. In: F. DiCosmo and M. Misawa (eds). Plant Cell Culture Secondary Metabolism Toward Industrial Application. CRC Press, New York, USA.
53. Wu, J. and K. P. Ho (1999) Assessment of various carbon sources and nutrient feeding strategies for Panax ginseng cell culture. Appl. Biochem. Biotechnol. 82: 17-26.
54. Wang, H. Q., J. T. Yu, and J. J. Zhong (1999) Significant improvement of taxane production in suspension cultures of Taxus chinensis by sucrose feeding strategy. Process Biochem. 35: 479-483.
55. Schiel, O., J. K. Redecker, G. W. Piehl, J. Lehmann, and J. Berlin (1984) Increased formation of cinnamoyl putrescines by fedbatch fermentation of cell suspension cultures of Nicotiana tabacum. Plant Cell Rep. 3: 18-20.
56. Su, W. W. F. Lei, and N. P. Kao (1995) High density cultivation of Anchusa officinalis in a stirred tank bioreactor with in situ filtration. Appl. Microbiol. Biotechnol. 44: 293-299.
57. Kobayashi, Y., M. Akita, K. Sakamoto, H. Liu, T. Shigeoka, and T. Koyano (1993) Large-scale production of anthocyanin by Aralia cordata cell suspension cultures Appl. Microbiol. Biotechnol. 40: 215-218.
58. Zhao, J., W. H. Zhu, and Q. Hu (2001) Enhanced catharanthine production in Catharanthus roseus cell cultures by combined elicitor treatment in shake flasks and bioreactors. Enzyme Microb. Technol. 28: 673-681.
59. Panda, A. K., V. S. Bisaria, and S. Mishra (1992) Alkaloid production by plant cell cultures of Holarrhena antidysenterica: II Effect of precursor feeding and cultivation in stirred tank bioreactor. Biotechnol. Bioeng. 39: 1052-1057.
60. Tabata, M. and Y. Fujita (1985) Production of shikonin by plant cell cultures, pp. 207-218. In: M. Zaitlin, P. Day and A. Hollaender (eds). Biotechnology in Plant Science. Relevance to Agriculture in the Eighties. Acedemic Press, San Diego, USA.
61. Zhong, J. J., F. Chen, and W. W. Hu (1999) High density cultivation of Panax notoginseng cells in stirred tank bioreactors for the production of ginseng biomass and ginseng saponin. Process Biochem. 35: 491-496.
62. Woragidbumrung, K., P. S. Tang, H. Yao, J. Han, S. Chauvatcharin, and J. J. Zhong (2001) Impact of conditioned medium on cell cultures of Panax notoginseng in an airlift bioreactor. Process Biochem. 37: 209-213.
63. Zhang, Y. H. and J. J. Zhong (1997) Hyperproduction of ginseng saponin and polysaccharide by high density cultivation of Panax notoginseng cells. Enzyme Microb. Technol. 21:59-63.
64. Zhong, J. J. and T. Yoshida (1995) High-density cultivation of Perilla frutescens cell suspensions for anthocyanin production: effects of sucrose concentration and inoculum size. Enzyme Microb. Technol. 17: 1073-1079.
65. Choi, H. K., J. H. Yun, S. I. Kim, J. S. Son, H. R. Kim, J. H. Kim, H. J. Choi and S. S. Hong (2001) Enhanced production of paclitaxel by semi-continuous batch process (SCBP) in suspension culture of Taxus chinensis. Enzyme Microb. Technol. 29: 583-586.
66. Pestchanker, L. J., S. C. Roberts, and M. L. Shuler (1996) Kinetics of taxol production and nutrient use in suspension cultures of Taxus cuspidata in shake flasks and a Wilson-type bioreactor. Enzyme Microb. Technol. 19: 256-260.
67. Park, H. H., S. K. Choi, J. K. Kang, and H. Y. Lee (1990) Enhancement of producing catharanthine by suspension growth of Catharanthus roseus. Biotechnol. Lett. 12: 603-608.
68. Hashimoto, T., S. Azechi, S. Sugita, and K. Suzuki (1982) Large scale production of tobacco cells by continuous cultivation. In: A. Fujiwara (ed). pp. 403-404. Plant Tissue Culture. Japan Association of Plant Tissue Culture, Tokyo, Japan.
69. Goswami, V. and A. K. Srivastava (2001) Propionic acid production in an in situ cell retention bioreactor. Appl. Microbiol. Biotechnol. 56: 676-680.
70. Wheat, D., R. P. Bondaryk, and J. Nystrom (1986) Spin filter bioreactor technology as applied to industrial plant propagation. Hort. Sci. 21: 819.
71. Scragg, A. H., S. Ashton, A. York, P. Bond, G. Stephan-Sarkissan, and D. Grey (1990) Growth of Catharanthus roseus suspension for maximum biomass and alkaloid accumulation. Enz. Microbial Technol. 12: 292-298.
72. Kries, W. and E. Reinhard (1990) Two stage cultivation of Digitalis lanata cells: semicontinuous production of deacetyl lantoside C in 20 litre air-lift bioreactor. J. Biotechnol. 16: 123-126.
73. Kim, D. I., H. Pederson, and C. C. Chin (1990) Two stage culture for the production of berberine in cell suspension culture of Thalictrum rugosum. J. Biotechnol. 16: 297-304.
74. van Gulik, W. M., H. J. G. ten Hoopen, and J. J. Heijnen (1993) A structured model describing carbon and phosphate limited growth of Catharanthus roseus plant cell suspensions in batch and chemostat cultures. Biotechnol. Bioeng. 41:771-780.
75. Bailey, C. M. and H. Nicholson (1990) Optimal temperature control for a structured model of plant cell culture. Biotechnol. Bioeng. 35: 252-259.
76. Glicklis, R., D. Mills, D. Sitton, W. Stortelder, and J. C. Merchuk (1998) Polysaccharide production by plant cells in suspension: experiments and mathematical modeling. Biotechnol. Bioeng. 57: 732-740.
77. Nuutila, A. M., U. Kurten, and V. Kauppinen (1991) Optimization of sucrose and inorganic nitrogen concentrations for somatic embryogenesis of birch (Betula pendula Roth.) callus cultures: a statistical approach. Plant Cell Tiss. Org. Cult. 24: 73-77.
78. Suvarnalatha, G., N. Chand, G. A. Ravishanker, and L. V. Venkataraman (1993) Computer-aided modeling and optimization for capsaicinoid production by immobilized Capsicum frutescens cells. Enzyme Microb. Technol. 15: 710-715.
79. Smith, J. M., S. W. Davison, and G. F. Payne (1990) Development of a strategy to control the dissolved concentration of oxygen and carbon dioxide at constant shear in a plant cell bioreactor. Biotechnol. Bioeng. 35: 1088-1101.
80. Contin, A., R. van der Heijden, and R. Verpoorte (1999) Effects of alkaloid precursor feeding and elicitation on the accumulation of secologanin in a Catharanthus roseus cell suspension culture. Plant Cell Tiss. Org. Cult. 56: 111-119.
81. Moreno, P. R. H., R. van der Heijden, and R. Verpoorte (1993) Effect of terpenoid precursor feeding and elicitation on formation of indole alkaloids in cell suspension cultures of Catharanthus roseus. Plant Cell Rep. 12: 702-705.
82. Fett-Neto, A. G. and G. DiCosmo (1996) Production of paclitaxel and related taxoids in cell cultures of Taxus cuspidata: perspectives for industrial applications, pp. 139-166. In: F. DiCosmo and M. Misawa (eds). Plant Cell Culture Secondary Metabolism Toward Industrial Application. CRC Press, New York, USA.
83. Brodelius, P. E. (1988) Permeabilization of plant cells for release of intracellularly stored products: Viability studies. Appl. Microbiol. Biotechnol. 27: 561-566.
84. Wang, C., J. Wu, and X. Mei (2001) Enhanced taxol production and release in Taxus chinensis cell suspension cultures with selected organic solvents and sucrose feeding. Biotechnol. Prog. 17: 89-94.
85. Laane, C., S. Boeren, K. Vos, and C. Veeger (1987) Rules for the optimization of biocatalysis in organic solvents. Biotechnol. Bioeng. 30: 81-87.
86. Buitelaar, R. M., M. H. Vermue, J. E. Schlatmann, and J. Tramper (1990) The influence of various organic solvents on the respiration of free and immobilized cells of Tagetes minuta. Biotechnol. Tech. 4: 415-418.
87. Buitelaar, R. M., A. A. M. Langenhoff, R. Heidstra, and J. Tramper (1991) Growth and thiophene production by hairy root cultures of Tagetes patula in various two-liquid-phase bioreactors. Enzyme Microb. Technol. 13: 487-494.