Adipose tissue as a target for dehydroepiandrosterone and its sulfate

DHEA in Human Health and Aging

Volumn , Issue , 2011, Pages 313-330

  Pérez de Heredia, Fátima ^a   Hernández Morante, Juan Jose ^b   Garaulet, Marta ^c  

^a INSTITUTO DEL FRÍO CSIC   (Spain)

^b CATHOLIC UNIVERSITY OF MURCIA   (Spain)

^c UNIVERSITY OF MURCIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84873983177     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (98)

1. Abadie, J. M., G. T. Malcom, J. R. Porter, and F. Svec. 2001. Dehydroepiandrosterone alters Zucker rat soleus and cardiac muscle lipid profiles. Exp Biol Med 226:782-9
2. Ailhaud, G., F. Massiera, P. Weill, P. Legrand, J. M. Alessandri, and P. Guesnet. 2006. Temporal changes in dietary fats: Role of n-6 polyunsaturated fatty acids in excessive adipose tissue development and relationship to obesity. Prog Lipid Res 45:203-36
3. Apostolova, G., R. A. S. Schweizer, Z. Balazs, R. M. Kostadinova, and A. Odermatt. 2005. Dehydroepiandrosterone inhibits the amplification of glucocorticoid action in adipose tissue. Am J Physiol Endocrinol Metab 288:E957-64
4. Arlt, W., F. Callies, I. Koehler et al. 2001. Dehydroepiandrosterone supplementation in healthy men with an age-related decline of dehydroepiandrosterone secretion. J Clin Endocrinol Metab 86(10):4686-792
5. Arlt, W., F. Callies, J. C. van Vlijmen et al. 1999. Dehydroepiandrosterone replacement in women with adrenal insufficiency. N Engl J Med 341(14):1013-20
6. Barnhart, K. T., E. Freeman, J. A. Grisso et al. 1999. The effect of dehydroepiandrosterone supplementation to symptomatic perimenopausal women on serum endocrine profiles, lipid parameters, and health-related quality of life. J Clin Endocrinol Metab 84(11):3896-902
7. Bazin, M. A., L. El Kihel, M. Boulouard, V. Bouët, and S. Rault. 2009. The effects of DHEA, 3beta-hydroxy-5alpha-androstane-6,17-dione, and 7-amino-DHEA analogues on short term and long term memory in the mouse. Steroids 74(12):931-7
8. Bélanger, C., F. S. Hould, S. Lebel, S. Biron, G. Brochu, and A. Tchernof. 2006. Omental and subcutaneous adipose tissue steroid levels in obese men. Steroids 71(8):674-82
9. Bellei, M., D. Batelli, C. Fornieri et al. 1992. Changes in liver structure and function after short-term and long-term treatment of rats with dehydroepiandrosterone. J Nutr 122:967-76
10. Bergeron, R., C. de Montigny, and G. Debonnel. 1996. Potentiation of neuronal NMDA response induced by dehydroepiandrosterone and its suppression by progesterone: Effects mediated via sigma receptors. J Neurosci 16:1193-202
11. Brandt, J. M., F. Djouadi, and D. P. Kelly. 1998. Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor alpha. J Biol Chem 273:23786-92
12. Callies, F., M. Fassnacht, J. C. van Vlijmen et al. 2001. Dehydroepiandrosterone replacement in women with adrenal insufficiency: Effects on body composition, serum leptin, bone turnover, and exercise capacity. J Clin Endocrinol Metab 86(5):1968-72
13. Campbell, C. S., L. C. Caperuto, A. E. Hirata et al. 2004. The phosphatidylinositol/AKT/atypical PKC pathway is involved in the improved insulin sensitivity by DHEA in muscle and liver of rats in vivo. Life Sci 76:57-70
14. Casabiell, X., V. Piñeiro, R. Peinó et al. 1998. Gender differences in both spontaneous and stimulated leptin secretion by omental adipose tissue in vitro: Dexamethasone and estradiol stimulate leptin release in women but not in men samples. J Clin Endocrinol Metab 83:2149-55
15. Casson, P. R., N. Santoro, K. Elkind-Hirsch et al. 1998. Postmenopausal dehydroepiandrosterone administration increases free insulin-like growth factor-I and decreases high-density lipoprotein: A six-month trial. Fertil Steril 70(1):107-10
16. Das, U. N. 2005. A defect in the activity of Delta6 and Delta5 desaturases may be a factor predisposing to the development of insulin resistance syndrome. Prostaglandins Leukot Essent Fatty Acids 72:343-50
17. de Pergola, G., M. Zamboni, M. Sciaraffia et al. 1996. Body fat accumulation is possibly responsible for lower dehydroepiandrosterone circulating levels in premenopausal obese women. Int J Obes Relat Metab Disord 20:1105-10
18. Dhatariya, K., M. L. Bigelow, and K. S. Nair. 2005. Effect of dehydroepiandrosterone replacement on insulin sensitivity and lipids in hypoadrenal women. Diabetes 54(3):765-9
19. Diamond, P., L. Cusan, J. L. Gomez, A. Bélanger, and F. Labrie. 1996. Metabolic effects of 12-month percutaneous dehydroepiandrosterone replacement therapy in postmenopausal women. J Endocrinol 150(Suppl):S43-50
20. Field, C. J., E. A. Ryan, A. B. Thomson et al. 1990. Diet fat composition alters membrane phospholipid composition, insulin binding, and glucose metabolism in adipocytes from control and diabetic animals. J Biol Chem 265:11143-50
21. Flynn, M. A., D. Weaver-Osterholtz, K. L. Sharpe-Timms, S. Allen, and G. Krause. 1999. Dehydroepiandrosterone replacement in aging humans. J Clin Endocrinol Metab 84(5):1527-33
22. Frenkel, R. A., C. A. Slaughter, K. Orth et al. 1990. Peroxisomal proliferation and induction of peroxisomal enzymes in mouse and rat liver by dehydroepiandrosterone feeding. J Steroid Biochem 35:333-42
23. Garaulet, M., F. Pérez-Llamas, T. Fuente, S. Zamora, and F. J. Tébar. 2000. Anthropometric, computed tomography and fat cell data in an obese population: Relationship with insulin, leptin, tumor necrosis factor-alpha, sex hormone-binding globulin and sex hormones. Eur J Endocrinol 143:657-66
24. Ghafoorunissa, A. Ibrahim, and S. Natarajan. 2005. Substituting dietary linoleic acid with alpha-linolenic acid improves insulin sensitivity in sucrose fed rats. Biochim Biophys Acta 1733:67-75
25. Gómez, E. F., M. Miyazaki, Y. C. Kim et al. 2002. Molecular differences caused by differentiation of 3T3-L1 preadipocytes in the presence of either dehydroepiandrosterone (DHEA) or 7-oxo-DHEA. Biochemistry 41:5473-82
26. Grunfeld, C., K. L. Baird, and C. R. Kahn. 1981. Maintenance of 3T3-L1 cells in culture media containing saturated fatty acids decreases insulin binding and insulin action. Biochem Biophys Res Commun 103:219-26
27. Guerre-Millo, M. 2008. Adiponectin: An update. Diabetes Metab 34:12-8
28. Haffner, S. M., and R. A. Valdez. 1994. Decreased testosterone and dehydroepiandrosterone sulphate concentrations are associated with increased insulin and glucose concentrations in nondiabetic men. Metabolism 43:599-603
29. Hernández-Morante, J. J., D. Cerezo, R. M. Cruz, E. Larqué, S. Zamora, and M. Garaulet. 2011. Dehydroepiandrosterone-sulphate modifies human fatty acid composition of different adipose tissue depots. Obes Surg 21(1):102-11. doi: 10.1007/s11695-009-0064-8
30. Hernández-Morante, J. J., F. Milagro, J. A. Gabaldon, J. A. Martinez, S. Zamora, and M. Garaulet. 2006. Effect of DHEA-sulfate on adiponectin gene expression in adipose tissue from different fat depots in morbidly obese humans. Eur J Endocrinol 155(4):593-600
31. Hernández-Morante, J. J., F. Pérez-de-Heredia, J. A. Luján, S. Zamora, and M. Garaulet. 2008. Role of DHEA-S on body fat distribution: Gender-and depot-specific stimulation of adipose tissue lipolysis. Steroids 73(2):209-15
32. Ishizawa, M., T. Ishizuka, K. Kajita et al. 2001. Dehydroepiandrosterone (DHEA) stimulates glucose uptake in rat adipocytes: Activation of phospholipase D. Comp Biochem Physiol B Biochem Mol Biol 130(3):359-64
33. Ishizuka, T., A. Miura, K. Kajita et al. 2007. Effect of dehydroepiandrosterone on insulin sensitivity in Otsuka Long-Evans Tokushima-fatty rats. Acta Diabetol 44(4):219-26
34. Jedrzejuk, D., M. Medras, A. Milewicz, and M. Demissie. 2003. Dehydroepiandrosterone replacement in healthy men with age-related decline of DHEA-S: Effects on fat distribution, insulin sensitivity and lipid metabolism. Aging Male 6(3):151-6
35. Kajita, K., T. Ishizuka, A. Miura, M. Ishizawa, Y. Kanoh, and K. Yasuda. 2000. The role of atypical and conventional PKC in dehydroepiandrosterone-induced glucose uptake and dexamethasone-induced insulin resistance. Biochem Biophys Res Commun 277(2):361-7
36. Kajita, K., T. Ishizuka, T. Muna et al. 2003. Dehydroepiandrosterone down-regulates the expression of peroxisome proliferator-activated receptor-γ in adipocytes. Endocrinology 144:253-9
37. Karbowska, J., and Z. Kochan. 2005. Effect of DHEA on endocrine functions of adipose tissue. The involvement of PPARγ. Biochem Pharmacol 70:249-57
38. Kawano, H., H. Yasue, A. Kitagawa et al. 2003. Dehydroepiandrosterone supplementation improves endothelial function and insulin sensitivity in men. J Clin Endocrinol Metab 88(7):3190-5
39. Kimura, M., S. Tanaka, Y. Yamada, Y. Kiuchi, T. Yamakawa, and H. Sekihara. 1998. Dehydroepiandrosterone decreases serum tumor necrosis factor-alpha and restores insulin sensitivity: Independent effect from secondary weight reduction in genetically obese Zucker fatty rats. Endocrinology 139(7):3249-53
40. Kochan, Z., and J. Karbowska. 2004. Dehydroepiandrosterone up-regulates resistin gene expression in white adipose tissue. Mol Cell Endocrinol 218:57-64
41. Lea-Currie, Y. R., P. Wen, and M. K. McIntosh. 1997. Dehydroepiandrosterone-sulphate (DHEAS) reduces adipocyte hyperplasia associated with feeding rats a high-fat diet. Int J Obes Relat Metab Disord 21(11):1058-64
42. Lea-Currie, Y. R., P. Wen, and M. K. McIntosh. 1998. Dehydroepiandrosterone reduces proliferation and differentiation of 3T3-L1 preadipocytes. Biochem Biophys Res Commun 248:497-504
43. Lea-Currie, Y. R., S. M. Wu, and M. K. McIntosh. 1997. Effects of acute administration of dehydroepiandrosterone-sulphate on adipose tissue mass and cellularity in male rats. Int J Obes Relat Metab Disord 21:147-54
44. Lemieux, C., F. Picard, F. Labrie, D. Richard, and Y. Deshaies. 2003. The estrogen antagonist EM-652 and dehydroepiandrosterone prevent diet-and ovariectomy-induced obesity. Obes Res 11:477-90
45. Liu, D., and J. S. Dillon. 2002. Dehydroepiandrosterone activates endotelial cell nitric-oxide synthase by a specific plasma membrane receptor coupled to Gai2,3. J Biol Chem 277:21379-88
46. Løvås, K., G. Gebre-Medhin, T. S. Trovik et al. 2003. Replacement of dehydroepiandrosterone in adrenal failure: No benefit for subjective health status and sexuality in a 9-month, randomized, parallel group clinical trial. J Clin Endocrinol Metab 88(3):1112-8
47. Machinal-Quélin, F., M. N. Dieudonne, R. Pecquery, M. C. Leneveu, and Y. Giudicelli. 2002. Direct in vitro effects of androgens and estrogens on ob gene expression and leptin secretion in human adipose tissue. Endocrine 18(2):179-84
48. Majewska, M. D., S. Demirgoren, C. E. Spivak, and E. D. London. 1990. The neurosteroid dehydroepiandrosterone sulfate is an allosteric antagonist of the GABAA receptor. Brain Res 526:143-6
49. Marks, P. A., and J. Banks. 1960. Inhibition of mammalian glucose-6-phosphate dehydrogenase by steroids. Proc Natl Acad Sci U S A 46(4):447-52
50. Marwah, A., F. E. Gomez, P. Marwah, J. M. Ntambi, B. G. Fox, and H. Lardy. 2006. Redox reactions of dehydroepiandrosterone and its metabolites in differentiating 3T3-L1 adipocytes: A liquid chromatographic-mass spectrometric study. Arch Biochem Biophys 456(1):1-7
51. Mauriège, P., C. Martel, D. Langin et al. 2003. Chronic effects of dehydroepiandrosterone on rat adipose tissue metabolism. Metabolism 52(3):264-72
52. McCormick, K. L., X. Wang, and G. J. Mick. 2006. Evidence that the 11β-hydroxysteroid dehydrogenase (11β-HSD1) is regulated by pentose pathway flux. Studies in rat adipocytes and microsomes. J Biol Chem 281:341-7
53. McIntosh, M., D. Hausman, R. Martin, and G. Hausman. 1998. Dehydroepiandrosterone attenuates preadipocyte growth in primary cultures of stromal-vascular cells. Am J Physiol Endocrinol Metab 275:E285-93
54. Meikle, A. W., R. W. Dorchuck, B. A. Araneo et al. 1992. The presence of a dehydroepiandrosterone-specific receptor binding complex in murine T cells. J Steroid Biochem Mol Biol 42:293-304
55. Morales, A. J., J. J. Nolan, J. C. Nelson, and S. S. Yen. 1994. Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age. J Clin Endocrinol Metab 78(6):1360-7
56. Mortola, J. F., and S. S. Yen. 1990. The effects of oral dehydroepiandrosterone on endocrine-metabolic parameters in postmenopausal women. J Clin Endocrinol Metab 71(3):696-704
57. Morton, N. M., J. M. Paterson, H. Masuzaki et al. 2004. Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice. Diabetes 53:931-8
58. Muoio, D. M., J. M. Way, C. J. Tanner et al. 2002. Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells. Diabetes 51:901-9
59. Nakashima, N., M. Haji, Y. Sakai, Y. Ono, F. Umeda, and H. Nawata. 1995. Effect of dehydroepiandrosterone on glucose uptake in cultured human fibroblasts. Metabolism 44:543-8
60. Navar, D., D. Saulis, C. Corll, F. Svec, and J. R. Porter. 2006. Dehydroepiandrosterone (DHEA) blocks the increase in food intake caused by neuropeptide Y (NPY) in the Zucker rat. Nutr Neurosci 9(5-6):225-32
61. Nestler, J. E., C. O. Barlascini, J. N. Clore, and W. G. Blackard. 1988. Dehydroepiandrosterone reduces serum low density lipoprotein levels and body fat but does not alter insulin sensitivity in normal men. J Clin Endocrinol Metab 66(1):57-61
62. Nishio, E., K. Tomiyama, H. Nakata, and Y. Watanabe. 1996. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor impairs cell differentiation in cultured adipogenic cells (3T3-L1). Eur J Pharmacol 301(1-3):203-6
63. Park, J., S. S. Choe, A. H. Choi et al. 2006. Increase in glucose-6-phosphate dehydrogenase in adipocytes stimulates oxidative stress and inflammatory signals. Diabetes 55(11):2939-49
64. Pascale, R. M., M. M. Simile, M. R. De Miglio et al. 1995. Inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase activity and gene expression by dehydroepiandrosterone in preneoplastic liver nodules. Carcinogenesis 16(7):1537-42
65. Pedersen, S. B., J. M. Bruun, F. Hube, K. Kristensen, H. Hauner, and B. Richelsen. 2001. Demonstration of estrogen receptor subtypes alpha and beta in human adipose tissue: Influences of adipose cell differentiation and fat depot localization. Mol Cell Endocrinol 182:27-37
66. Percheron, G., J. Y. Hogrel, S. Denot-Ledunois et al. 2003. Effect of 1-year oral administration of dehydroepiandrosterone to 60-to 80-year-old individuals on muscle function and cross-sectional area: A double-blind placebo-controlled trial. Arch Intern Med 163(6):720-7
67. Pérez de Heredia, F., D. Cerezo, S. Zamora, and M. Garaulet. 2007. Effect of dehydroepiandrosterone (DHEA) on protein and fat digestibility, body protein and muscular composition in high-fat-diet-fed old rats. Br J Nutr 97:464-70
68. Pérez de Heredia, F., E. Larqué, S. Zamora, and M. Garaulet. 2009. DHEA modifies rat fatty acid composition of serum and different adipose tissue depots towards an insulin-sensitizing profile. J Endocrinol 201:67-74
69. Pérez de Heredia, F., J. Sánchez, T. Priego et al. 2008. Adiponectin is involved in the protective effect of DHEA against metabolic risk in aged rats. Steroids 73:1128-36
70. Perrini, S., A. Natalicchio, L. Laviola et al. 2004. Dehydroepiandrosterone stimulates glucose uptake in human and murine adipocytes by inducing GLUT1 and GLUT4 translocation to the plasma membrane. Diabetes 53:41-52
71. Pham, J., J. Porter, D. Svec, C. Eiswirth, and F. Svec. 2000. The effect of dehydroepiandrosterone on Zucker rats selected for fat food preference. Physiol Behav 70:431-41
72. Piñeiro, V., X. Casabiell, R. Peinó et al. 1999. Dihydrotestosterone, stanozolol, androstenedione and dehydroepiandrosterone sulphate inhibit leptin secretion in female but not in male samples of omental adipose tissue in vitro: Lack of effect of testosterone. J Endocrinol 160(3):425-32
73. Porter, J., and F. Svec. 1995. DHEA diminishes fat food intake in lean and obese Zucker rats. Ann NY Acad Sci 774:329-31
74. Powell, D. J., S. Turban, A. Gray et al. 2004. Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells. Biochem J 382:619-29
75. Richards, R. J., J. R. Porter, and F. Svec. 2000. Serum leptin, lipids, free fatty acids and fat-pads in long-term dehydroepiandrosterone-treated Zucker rats. Proc Soc Exp Biol Med 223:258-62
76. Riediger, N. D., R. Othman, E. Fitz, G. N. Pierce, M. Suh, and M. H. Moghadasian. 2008. Low n-6:n-3 fatty acid ratio, with fish-or flaxseed oil, in a high fat diet improves plasma lipids and beneficially alters tissue fatty acid composition in mice. Eur J Nutr 47:153-60
77. Ryu, J. W., M. S. Kim, C. H. Kim et al. 2003. DHEA administration increases brown fat uncoupling protein 1 levels in obese OLETF rats. Biochem Biophys Res Commun 303:726-31
78. Sánchez, J., F. Pérez-Heredia, T. Priego et al. 2008. Dehydroepiandrosterone prevents age-associated alterations, increasing insulin sensitivity. J Nutr Biochem 19:809-18
79. Saraç, F., S. Yildiz, F. Saygili et al. 2006. Dehydroepiandrosterone and human adipose tissue. J Endocrinol Invest 29(5):393-8
80. Steppan, C. M., S. T. Bailey, S. Bhat et al. 2001. The hormone resistin links obesity to diabetes. Nature 409:307-12
81. Tagliaferro, A. R., J. R. Davis, S. Truchon, and N. Van Hamont. 1986. Effects of dehydroepiandrosterone acetate on metabolism, body weight and composition of male and female rats. J Nutr 116:1977-83
82. Tagliaferro, A. R., A. M. Ronan, J. Payne, L. D. Meeker, and S. Tse. 1995. Increased lipolysis to β-adrenergic stimulation after dehydroepiandrosterone treatment in rats. Am J Physiol 268 (Regulatory Integrative Comp Physiol 37):R1374-80
83. Takahashi, Y., and T. Ide. 2000. Dietary n-3 fatty acids affect mRNA level of brown adipose tissue uncoupling protein 1, and white adipose tissue leptin and glucose transporter 4 in the rat. Brit J Nutr 84:175-84
84. Tan, B. K., J. Chen, H. Lehnert, R. Kennedy, and H. S. Randeva. 2007. Raised serum, adipocyte, and adipose tissue retinol-binding protein 4 in overweight women with polycystic ovary syndrome: Effects of gonadal and adrenal steroids. J Clin Endocrinol Metab 92(7):2764-72
85. Trayhurn, P., and I. S. Wood. 2004. Adipokines: Inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 92:347-55
86. Tsuji, K., D. Furutama, M. Tagami, and N. Ohsawa. 1999. Specific binding and effects of dehydroepiandrosterone sulphate (DHEA-S) on skeletal muscle. Possible implications for DHEA-S replacement therapy in patients with miotonic dystrophy. Life Sci 65:17-26
87. Villareal, D. T., and J. O. Holloszy. 2004. Effect of DHEA on abdominal fat and insulin action in elderly women and men: A randomized controlled trial. JAMA 292(18):2243-8
88. Villareal, D. T., J. O. Holloszy, and W. M. Kohrt. 2000. Effects of DHEA replacement on bone mineral density and body composition in elderly women and men. Clin Endocrinol (Oxf) 53(5):561-8
89. Villena, J. A., K. H. Kim, and H. S. Sul. 2002. Pref-1 and ADSF/resistin: Two secreted factors inhibiting adipose tissue development. Horm Metab Res 34:664-70
90. Vogiatzi, M. G., M. A. Boeck, E. Vlachopapadopoulou, R. el-Rashid, and M. I. New. 1996. Dehydroepiandrosterone in morbidly obese adolescents: Effects on weight, body composition, lipids, and insulin resistance. Metabolism 45(8):1011-5
91. Wajchenberg, B. L. 2000. Subcutaneous and visceral adipose tissue: Their relation to the metabolic syndrome. Endocr Rev 21(6):697-738
92. Wang, Y., Y. Sun, and H. Qiu. 2004. Expression of resistin mRNA in adipose tissue of rat model with polycystic ovarian syndrome and its implication. J Huazhong Univ Sci Technolog Med Sci 24(6):621-4
93. Webb, S. J., T. E. Geoghegan, R. A. Prough, and K. K. Michael Miller. 2006. The biological actions of dehydroepiandrosterone involve multiple receptors. Drug Metab Rev 38(1-2):89-116
94. Welle, S., R. Jozefowicz, and M. Statt. 1990. Failure of dehydroepiandrosterone to influence energy and protein metabolism in humans. J Clin Endocrinol Metab 71(5):1259-64
95. Widstrom, R. L., and J. S. Dillon. 2004. Is there a receptor for dehydroepiandrosterone or dehydroepiandrosterone sulfate? Semin Reprod Med 22:289-96
96. Xu, A., K. W. Chan, R. L. Hoo et al. 2005. Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes. J Biol Chem 280:18073-80
97. Yamada, J., M. Sakuma, and T. Suga. 1992. Induction of peroxisomal B-oxidation enzymes by dehydroepiandrosterone and its sulfate in primary cultures of rat hepatocytes. Biochim Biophys Acta 1137:231-6
98. Zhang, Y. Y., R. Proenca, M. Maffei, M. Barone, L. Leopold, and J. M. Friedman. 1994. Positional cloning of the mouse obese gene and its human homolog. Nature 372:425-32